Neuroimmune mechanisms of pruritus in atopic dermatitis

2022 ◽  
pp. 12-16
Author(s):  
Y. A. Kandrashkina ◽  
E. A. Orlova ◽  
A. A. Pribytkov
Keyword(s):  
Quality Of Life ◽  
Atopic Dermatitis ◽  
Skin Disease ◽  
Neurogenic Inflammation ◽  
New Methods ◽  
Neuroimmune Interactions ◽  
High Prevalence ◽  
Depth Study

Atopic dermatitis is a chronic hereditary recurrent skin disease. One of the most pronounced symptoms of this dermatosis is itchy skin. Pruritus accompanies atopic dermatitis in more than 80% of cases. This review presents modern data on the mechanisms of pruritus formation in atopic dermatitis. The issues of etiological factors, neuroimmune interactions, peculiarities of skin dysfunction, as well as the role of stress are considered. The relevance of studying the topic is due to the high prevalence of atopic dermatitis among the population, a decrease in the quality of life and the lack of effective therapy. Analysis of the literature indicates the need for a comprehensive assessment of the pathogenetic mechanisms of the development of pruritus in atopic dermatitis. A more in-depth study of the mechanisms of neurogenic inflammation in atopic dermatitis will contribute to the development of new methods of diagnosis and treatment.

scholarly journals PSYCHOSOCIAL IMPACT OF COMMON SKIN DISORDERS – A REVIEW STUDY

2021 ◽  
Vol 9 (7) ◽  
pp. 1452-1456
Author(s):  
Manish Choudhari ◽  
Nikita Jamadari ◽  
Naresh Jain
Keyword(s):  
Quality Of Life ◽  
Atopic Dermatitis ◽  
Skin Disease ◽  
Skin Diseases ◽  
Fungal Infections ◽  
Acne Vulgaris ◽  
Well Being ◽  
Psychosocial Impact ◽  
Common Skin

Objective - To increase awareness of the psychosocial impact of Kushtha, Visarpa, Mukhadushika, Sheetpitta, Udarda and Kotha in Ayurveda and Acne vulgaris, Urticaria, Various types of fungal infections, Atopic dermatitis, Psoriasis etc. in modern point of view. Quality Of Evidence - A literature review was based on a MEDLINE search (1966 to 2000). Selected articles from the dermatologic and psychiatric literature, as well as other relevant medical journals, were reviewed and used as the basis for discussion of how skin disease affects patients’ lives and of appropriate management. Message - Dermatologic problems hurt patients’ quality of life. skin disease can produce stress, anxiety, anger, depression, low self-esteem, embarrassment, and other psychological, personal, professional and social life problems that affect patients’ lives in ways comparable to arthritis or other disabling illnesses, as well as showing a bidirectional relationship between skin disease and psychological distress. This review focuses on the effects of five common skin diseases seen by family physicians- Acne, Urticaria, Various types of fungal infections, Atopic dermatitis and Psoriasis. Conclusion - How skin disease affects psychosocial well-being is un- derappreciated. Increased understanding of the psychiatric comorbidity associated with skin disease and a biopsy- chosocial approach to management will ultimately improve patients’ lives. Keywords: Skin disease, Psychosocial Impact, Quality of life.

Stress and skin disease quality of life: the moderating role of anxiety sensitivity social concerns

2018 ◽  
Vol 178 (4) ◽  
pp. 951-957 ◽  
Author(s):  
L.J. Dixon ◽  
S.M. Witcraft ◽  
N.K. McCowan ◽  
R.T. Brodell
Keyword(s):  
Quality Of Life ◽  
Anxiety Sensitivity ◽  
Skin Disease ◽  
Social Concerns ◽  
Moderating Role

scholarly journals The role of the dentist and orthodontist in recognizing oro-facial manifestations of acromegaly: a questionnaire-based study

Pituitary ◽  
2021 ◽  
Author(s):  
Giorgia Preo ◽  
Alberto De Stefani ◽  
Francesca Dassie ◽  
Alexandra Wennberg ◽  
Roberto Vettor ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Early Recognition ◽  
Sella Turcica ◽  
Mandibular Prognathism ◽  
Oral Manifestation ◽  
Number Of Patients ◽  
High Prevalence ◽  
Strategic Role

Abstract Purpose Oro-facial manifestations of acromegaly are among the earliest signs of the disease and are reported by a significant number of patients at diagnosis. Despite this high prevalence of acromegaly oral manifestation, dentists do not play a pivotal role in acromegaly identification and diagnosis. The aim of our study was to evaluate the ability of dentists and orthodontists in the early recognition of the oro-facial manifestations of acromegaly. Methods A telematic questionnaire was administered to dentists and orthodontists. The questionnaire included photos with facial and oral-dental details and lateral teleradiography of acromegaly patients (ACRO). Results The study included 426 participants: 220 dentists and 206 orthodontists. Upon reviewing the photos, dentists most often observed mandibular prognathism and lips projection, while orthodontists also reported the impairment of relative soft tissue. Orthodontists, who usually use photos to document patients’ oral-facial characteristics, paid more attention to oral-facial impairment than dentists. During dental assessment, 90% of the participants usually evaluated tongue size and appearance, diastemas presence, and signs of sleep impairment (mainly orthodontists). Orthodontists were also more able to identify sella turcica enlargement at teleradiography. A total of 10.8% of the participants had ACRO as patients and 11.3% referred at least one patient for acromegaly suspicion. Conclusion The study highlighted dentists’ strategic role in identifying ACRO. Increasing dentists’ awareness about acromegaly clinical issues may improve early diagnosis, potentially resulting in an increased quality of life and decreased mortality among ACRO.

scholarly journals The Role of Probiotics in Preventing Allergic Disease

Children ◽  
2019 ◽  
Vol 6 (2) ◽  
pp. 24 ◽  
Author(s):  
Helen T. Wang ◽  
Sara Anvari ◽  
Katherine Anagnostou
Keyword(s):  
Quality Of Life ◽  
Allergic Rhinitis ◽  
Atopic Dermatitis ◽  
Optimal Dosing ◽  
Atopic Individual ◽  
Prevention And Treatment ◽  
Microbiome Research ◽  
Allergic Disorders

The prevalence of allergic disorders has been increasing worldwide and significantly impacts the quality of life of the atopic individual. There has been an increased interest in the role of probiotics for the prevention and treatment of allergic disorders, given the recent evidence that atopy risk may be associated with a dysbiosis of the gut microbiome. Research in this area is ongoing with some studies showing possible benefits of probiotics, with seemingly little to no risk. While these studies suggest that there may be a promise in probiotic use for the prevention or treatment of allergy, further evidence is needed to determine its efficacy, optimal dosing, and strains needed for treatment. In this review, we discuss recently published studies examining the benefits, risks, and role of probiotics in preventing atopic dermatitis, asthma, allergic rhinitis, and food allergy.

Adherence to Guideline-Oriented Preventive Measures in Patients with Atopic Dermatitis in Germany

Dermatology ◽  
2021 ◽  
pp. 1-6
Author(s):  
Birgit-Christiane Zyriax ◽  
Matthias Augustin ◽  
Finn Abeck ◽  
Nicole Mohr ◽  
Natalia Kirsten ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Atopic Dermatitis ◽  
Skin Disease ◽  
Preventive Measures ◽  
Routine Care ◽  
The Self ◽  
Evidence Based ◽  
Relaxation Techniques ◽  
Cross Sectional

<b><i>Background:</i></b> Atopic dermatitis (AD) is a chronic inflammatory skin disease that is often associated with comorbidities and quality of life losses. The implementation of evidence-based preventive measures strengthens patient participation and offers the potential to improve quality of care for AD. <b><i>Objectives:</i></b> To assess adherence to guideline-oriented preventive measures in adult patients with AD in dermatological routine care in Germany. <b><i>Methods:</i></b> The self-responsible application of preventive measures, clinical features, pruritus, disease severity, and duration of disease as well as skin disease-related quality of life were assessed in two independent cross-sectional studies in 2010 and 2017–2019. <b><i>Results:</i></b> Between 2017 and 2019, 706 patients (55.8% female, mean age 41 years) were recruited in a comparable way to the survey in 2010 with 1,678 patients (60.5% female, mean age 38 years). Regular skin care was applied by 99.5% (2010: 94.9%), 90.9% avoided skin irritants (2010: 84.6%), and 80.2% (2010: 61.6%) did not smoke at home. Relaxation techniques were applied by 44.4% (2010: 29.9%). Advice on self-help measures was taken by 36.4% (2010: 27.1%) and 29.2% (2010: 15.4%) attended AD patient education courses. All six preventive measures categorized as obligatory were performed by 13.9% of the patients (2010: 6.7%). Predictors for the number of obligatory preventive measures applied were a high level of education, a longer disease duration, and a lower quality of life. <b><i>Conclusions:</i></b> Although the self-reported use of evidence-based preventive measures in the 2017–2019 study appears to be more frequent than in 2010, important measures are still insufficiently established. Hence, more implementation, including education, is needed to increase the use of guideline-oriented preventive measures.

scholarly journals The role of the nurse in the care and management of patients with atopic dermatitis

BMC Nursing ◽  
2020 ◽  
Vol 19 (1) ◽  
Author(s):  
Harmieke van Os-Medendorp ◽  
Elfie Deprez ◽  
Nele Maes ◽  
Sheila Ryan ◽  
Karina Jackson ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Atopic Dermatitis ◽  
Treatment Adherence ◽  
Self Management ◽  
Severe Atopic Dermatitis ◽  
Main Body ◽  
Wide Range

Abstract Background The purpose of this paper is to provide an overview of key aspects of specialised dermatology nursing practice in the management of patients with moderate to severe atopic dermatitis. The role of dermatology nurse specialists in supporting patients and promoting disease understanding, education and treatment adherence continues to evolve. As features of specialised nursing care can also inform other nursing staff in a wide range of care settings, an overview of key components is examined. Observations presented are from a pan-European perspective and represent the collected view of a group of dermatology nurse specialists, dermatologists and patient advocates following two round-table discussions. Main body Atopic dermatitis is a common, chronic, inflammatory disease characterised by erythematous/scaling skin lesions, with often intense pruritus. Disease course is cyclic with periodic disease flares of varying intensity, presenting management challenges to patients and families. Dermatology nurse specialists play a key role in providing education and substantial patient support to improve treatment outcomes and quality of life to patients and their family, delivered within a multidisciplinary team framework. Nurse-led education and 'eczema schools’ are of benefit in reducing disease severity and improving quality of life by enhancing self-management, adherence and patient engagement. eHealth tools, such as patient portals or online training platforms, can provide online learning, individualised education, and help to improve engagement. These and other initiatives, such as written action plans, are all essential to improve or maintain treatment adherence, self-management and quality of life. Conclusions Dermatology nurse specialists play a central role in the assessment and management of moderate to severe atopic dermatitis patients and families. This places them in an ideal position to build strong and often long-term relationships with patients and parents. Such engagement promotes trust, assists in setting realistic expectations of treatment and outcomes, and enhances self-management and engagement in their own care. Providing emotional support, as well as formal and systematic education (including individualised practical advice) all contribute to improved treatment adherence and can enhance the quality of life of patients and their families throughout the course of this long-term condition.

scholarly journals Pruritus and Atopic Dermatitis: from Etiological Features to Management

2020 ◽  
Vol 19 (6) ◽  
pp. 468-476
Author(s):  
Nikolay N. Murashkin ◽  
Leonid A. Opryatin ◽  
Roman V. Epishev ◽  
Alexander I. Materikin ◽  
Eduard T. Ambarchian ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Atopic Dermatitis ◽  
Immune System ◽  
Clinical Studies ◽  
Clinical Manifestations ◽  
Skin Barrier ◽  
Current Data ◽  
Scientific Images

Pruritus is one of the main clinical manifestations of atopic dermatitis, and it significantly reduces the quality of life of patients in childhood. Scientific images on its pathophysiological basis have now undergone significant changes. The histamine exceptional role in pruritus development was confounded, as well as data on immune system involvement in its maintenance was given. This article presents current data on differential approaches to pruritus management depending on its etiopathogenetic characteristics. The role of dermocosmetics in restoration of the skin barrier as the first stage prevention of pruritus in atopic dermatitis was considered. The results of clinical studies showing efficacy of topical agents (innovative component with anti-pruritic action — STIMU-TEX) application are presented.

scholarly journals EDUCATION IN ORAL HEALTH: A Reflective Approach for Quality of Life.

2020 ◽  
Vol 2 (8) ◽  
pp. 73-85
Author(s):  
Antonio Carlos Eber Mendes Sá
Keyword(s):  
Quality Of Life ◽  
Oral Health ◽  
Periodontal Diseases ◽  
Low Cost ◽  
Oral Diseases ◽  
Social Relevance ◽  
Prevention Services ◽  
High Prevalence

This work aims at critical reflection on the actions that determine a good level of oral health. Health promotion is a process that can positively affect the quality of life of a population. Dental problems have a low priority compared to diseases considered to be of social relevance. Prevention of oral diseases must be developed at three levels: primary, secondary and tertiary. Self-diagnosis is extremely important, because the sooner the problem is detected and prevention services are activated, the greater the chances of an effective treatment. Among oral health problems, dental caries is considered a damage that deserves higher priority due to its high prevalence. Oral cancer gained the second degree of priority, due to its severity, followed by periodontal diseases. Education in oral health has been increasingly required, taking into account the low cost and the possibilities of dental impact on public health. Therefore, the role of educating should not be the exclusive responsibility of the professional conventionally called teacher, but of any citizen.

scholarly journals THE ROLE OF STAPHYLOCOCCUS AUREUS IN NASAL POLYPOSIS

2013 ◽  
Vol 10 (6) ◽  
pp. 5-8
Author(s):  
G P Bondareva ◽  
A B Turovsky ◽  
O V Semkina
Keyword(s):  
Quality Of Life ◽  
Staphylococcus Aureus ◽  
Nasal Polyposis ◽  
Improve Quality ◽  
Eosinophilic Inflammation ◽  
New Methods ◽  
Methods Of Treatment

Nasal polyposis is associated with colonization of S. aureus, which secretes enterotoxine that acts as superantigen and induces formation of monoclonal IgE by analogy with severe eosinophilic inflammation. This article describes the current insights of features of inflammation caused by S. aureus. Further research aimed at a deeper study of the role of S. aureus in pathogenesis of nasal polyposis, as well as new methods of treatment that would prevent the recurrence of the disease and improve quality of life of the patients are needed.

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