Efficacy of autologous plasma microneedling with cells in patients with post-acne atrophic scars

2021 ◽  
pp. 97-100
Author(s):  
A. P. Talybova ◽  
N. V. Gryazeva
Keyword(s):  
Plasma Cell ◽  
Global Assessment ◽  
Ultrasound Examination ◽  
Social Effects ◽  
Acne Scar ◽  
Global Assessment Scale ◽  
Autologous Plasma ◽  
Acne Scars ◽  
Atrophic Scars ◽  
Ultrasound Scanner

Objective: to studythe effectiveness of autologous plasma-cell microneedling in patients with different phenotypes of post-acne atrophic scars. Group 1A (n = 32) included patients with post – acne atrophic scars: ice pick – 12 patients; boxcar – 11; rolling – 9 patients. Group 1B consisted of 34 patients with scars ice pick – 12; boxcar – 12; rolling – 10 patients. In group 1A, patients underwent a microneedling procedure. In group 1B, microneedling was performed with autologous plasma with cells. To evaluate the effectiveness of the therapy methods, we used the IGA (Investigators Global Assessment) scale modified for post-acne scars, adapted for post-acne scars by the Assessment of the Psychological and Social Effects of Acne (APSEA). Special methods included ultrasound examination using an ultrasound scanner IU 22. The end result for different post-acne scar phenotypes showed the advantages of the developed complex for boxcar and rolling AR and slightly lower for ice pick. The recommended course of therapy is three procedures performed once in 4 weeks.

scholarly journals Combined use of laser therapy and autologous plasma with cells in patients with post-acne atrophic scars

2020 ◽  
Vol 19 (6) ◽  
pp. 366-370
Author(s):  
Aliya P. Talibova ◽  
Natalia V. Gryazeva
Keyword(s):  
Laser Therapy ◽  
Nd:Yag Laser ◽  
Tissue Loss ◽  
Laser Exposure ◽  
Point System ◽  
Complex Treatment ◽  
Autologous Plasma ◽  
Acne Scars ◽  
Atrophic Scars ◽  
Group 1

Background. Acne scar formation is a common consequence of acne vulgaris, in most cases atrophic scars resulting from tissue loss caused by inflammation of the pilosebial units. Aims: To study the effectiveness of combined laser therapy with Nd:YAG laser and Er: YAG laser with autologous plasma with cells in patients with different phenotypes of post-acne atrophic scars. Materials and methods. Depending on the method of treatment of post-acne scars, the patients were divided into 2 groups: Group 1 (n=28) with ice pick scars 10 patients; boxcar 9 patients; rolling 9 patients and group 1 (n=30) among them with ice pick scars 10; boxcar 9; rolling 11 patients. In group 1A, phototherapy was performed using a combination of Nd:YAG laser and Er:YAG laser. Immediately after laser exposure, autologous plasma was applied to the skin of the face of group 1B patients. To assess the effectiveness, the Manchester scale of assessment of scar deformities was used. The effectiveness was also evaluated using the Global Aesthetic Scale (GAIS) on a 3-point system. In this study, cutometry and ultrasound were performed to assess the elasticity of the skin in the foci of atrophy. Results. The indicator "color" on the MSS scale improved in the 1st group by 54.8%, in the 2nd by 83.7%, the indicator "texture" by 57.1 and 78.1%, the indicator "relief" by 43.8 and 66.7%, the indicator "displacement" by 54.9 and 82.1%, respectively. There were no patients with a deterioration or lack of effect on the GAIS scale in any of the study groups. According to the ultrasound scan data, the greatest effectiveness was observed in the group of complex treatment . Conclusion. Complex treatment, including the use of combined laser therapy (erbium and neodymium lasers) and autologous plasma with cells, is a highly effective technique for the treatment of atrophic post-acne scars.

scholarly journals Salicylic Acid Peel and Fusion Peel with Salicylic & Mandelic Acid Peel for Treatment of Acne Scars - A Comparative Study

2020 ◽  
Vol 12 (3) ◽  
pp. 69-78
Author(s):  
Monisha B. Muthu ◽  
Gopalan Kannan ◽  
Madhumitha Muthu
Keyword(s):  
Salicylic Acid ◽  
Comparative Study ◽  
Global Assessment ◽  
Mandelic Acid ◽  
Assessment Scale ◽  
Global Assessment Scale ◽  
Acne Scars ◽  
Group A ◽  
Grade Ii ◽  
Group B

Abstract Introduction. Acne vulgaris is one of the most common skin diseases affecting more than 85% of individuals worldwide. The study aimed to compare the therapeutic efficacy of Salicylic acid peel and Salicylic acid - mandelic acid peel for treatment of acne scars. Material and Methods. A comparative study was conducted on 41 patients, divided into two groups based on treatment choice by the subjects. Group A (23) were treated with 30% salycilic acid peels, and group B (18) were treated with 20% salycilic acid and 10% mandelic acid peels at an interval of 2 weeks for three sessions. The physician’s global assessment scale and clinical photographs were used at the end of three sessions. All the data were analysed using SPSS considering P<0.05 as significant. Results. Of the total 41 patients analyzed, the mean age in both the groups were comparable. (Group A: 20.4 years; Group B: 20.5 years). Duration of acne was >12 months in both the groups 13 (56.52%) & 10 (55.56%)). Thirteen patients (56.52%) in group A and 1 (5.56%) in group B had no side effects which was statistically significant (p=0.01). Using the physician’s global assessment scale 51-75% (Good) an improvement was seen in grade I 4 (17%) and 18 (78%) in grade II in group A and 2 (11%) in grade I and 12 (67%) in grade II in group B, respectively which was statistically significant (p=0.001). Conclusion. Both agents showed almost equal efficacy in improving mild-to-moderate acne scars. Adverse effects were less with Salicylic acid peel compared with mandelic acid peel..

scholarly journals The Effectiveness of Microneedling Therapy on The Severity of Acne Scars According to Goodman and Baron: A Systematic review and meta-analysis

2022 ◽  
pp. 48
Author(s):  
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Control Group ◽  
Skin Damage ◽  
Acne Scar ◽  
Acne Scars ◽  
Significant Difference ◽  
Acne Scarring ◽  
The Mean ◽  
Z Value

Background: The emergence of acne scars due to skin damage in the acne healing process and causes psychological effects. The management of acne scars can be done in several methods. Microneedling is a very simple, safe, effective, and minimally invasive therapeutic technique compared to other therapeutic modalities in acne scars. The resulting wound is micro-sized, and promotes the growth of growth factors and collagen production. We aimed to assess the effectiveness of using microneedling as an acne scar treatment option. A systematic review and meta-analysis were qualitatively and quantitatively conducted from RCTs, assessing the effectiveness of microneedling in reducing the severity of acne scars according to Goodman and Baron in the treatment of acne scars. Methods: Medline Pubmed, PMC, Scopus, Google Scholar, and JDC library, eligible search. Ten studies (n=514) were analyzed qualitatively with 2 studies (n=53 subjects) and quantitatively analyzed by 2 studies (n=90 subjects). Both analyzes were included in the meta-analysis. The mean age of the participants was 40.5 years. The application of microneedling intervention as monotherapy or a combination in patients with acne scarring was followed for at least 16 weeks, the results obtained were the mean reduction in the degree of acne scarring after microneedling. Result: The combination of microneedling treatment obtained a qualitative decrease in the degree of acne scars according to Goodman and Baron with a Z value (-4.299) and P=<0.001 lower than the control (PRP) with a significant difference. The quantitative decrease in the degree of acne scars according to Goodman and Baron obtained a Z value (-4.681) and P=<0.001 lower than the control (PRP) with a significant difference. Quantitative reduction in the degree of acne scars according to Goodman and Baron on single therapy between treatment and control with a value of Z (-3.536) and P=<0.001 lower than control (fractional CO2) with a significant difference. The results of the degree of acne scars in the group treated with microneedling alone or in combination were lower than the control group. The mean before and after therapy compared to the control there was a significant difference. Conclusion. The results of a systematic review, concluded that the group treated with microneedling had a decrease in the degree of acne scarring according to Goodman and Baron with P=<0.001 compared to before treatment. The decrease was shown in the difference in Z values, which was significantly greater than the control given other therapies. Microneedling therapy can be an alternative therapy option for acne scar patients who are unresponsive to previous therapy or in conditions where there are contraindications to other therapies.

Cardiovascular Fitness in Children With Asthma Correlates With Psychologic Functioning of the Child

PEDIATRICS ◽  
1989 ◽  
Vol 84 (3) ◽  
pp. 460-464 ◽  
Author(s):  
Robert C. Strunk ◽  
David A. Mrazek ◽  
Jolene T. Fukuhara ◽  
Jim Masterson ◽  
Susan K. Ludwick ◽  
...  
Keyword(s):  
Global Assessment ◽  
Child Behavior Checklist ◽  
Asthma Severity ◽  
Forced Expiratory Volume ◽  
Cardiovascular Fitness ◽  
Assessment Scale ◽  
Bicycle Ergometry ◽  
Global Assessment Scale ◽  
Asthmatic Children ◽  
Children With Asthma

Abnormalities in fitness in asthmatic children are assumed to derive from illness severity. We studied 90 children with moderately severe to severe but stable asthma for (1) fitness levels using bicycle ergometry, (2) measures of asthma severity, (3) clinician's impression of child (Child Global Assessment Scale), and (4) mother's rating of child's behavior (Child Behavior Checklist). Fitness values ranged from 15% to 120% of normal values for age, sex, and body surface area: 48% were abnormal (&lt;2 SD below mean) and 5% were borderline (1 to 2 SD below mean). Associations between levels of fitness and medical and psychologic criteria were tested using regression analyses. Of the 11 medical variables used to define the severity of asthma, recent exacerbation of disease, forced expiratory volume in 1 second, and specific airway conductance together accounted for 8.1% of the variability in the workload ratios (ie, R2 = 0.081). The importance of the psychologic factors in determining the variability in the workload ratios was tested after the importance of the medical variables had been considered: Child Global Assessment Scale accounted for a significant amount of variability, improving the R2 to 0.180 (an increase to 0.100, P = .003). These data suggest that, within the spectrum of disease presented by the patients in this study, adjustment to the disease is at least as important as severity of disease in determining fitness.

scholarly journals Whole Area versus Focal Acne Scar Treatment (FAST) of Post Acne-Scars by Fractional CO2 Laser: A Comparative Study

QJM ◽  
2020 ◽  
Vol 113 (Supplement_1) ◽  
Author(s):  
M A Abdallah ◽  
C K T Gobrial ◽  
S G H Gomah
Keyword(s):  
Comparative Study ◽  
Co2 Laser ◽  
Acne Scar ◽  
Fractional Co2 Laser ◽  
Acne Scars ◽  
Scar Treatment ◽  
Acne Scarring ◽  
Facial Area ◽  
The Right ◽  
Split Face

Abstract Background Acne scarring is often the primary concern of a patient with acne. Acne scarring can cause depression and is a risk factor for suicide. Patients feel their appearance interferes with their relationships and chances of future employment. Acne scars can be classified into 3 different types: atrophic, hypertrophic, or keloidal. Atrophic acne scars are the most common type. Atrophic acne scars are divided into three main types: ice pick, rolling and boxcar scars. Aim of the Work To compare the results of whole facial area versus Focal Acne Scar Treatment (FAST) by factional CO2 laser in a split face study. Patients and Methods The present study is a split face comparative study which included 20 adult patients with atrophic acne scars ranged from 18 to 44 years old of both sex. The study was approved by the Research Ethical Committee, Faculty of Medicine, Ain Shams University and fulfilled all the ethical aspects required in human research. All patients received full information about description of the procedure of treatment, possible side effects, photo documentation and they all provided written consent. Results Patients were asked to compare the pain, peeling and complications between the right and left sides post CO2 fractional treatment: pain was more at right side in 35% of cases and more at left side in 30% of cases and equal in the rest of cases, peeling was faster at the right side in 60% of cases, faster at the left side in 20% of cases and equal at the rest of cases, 4 of the patients had post inflammatory hyperpigmentation (1 patient at right side, 2 patients at left side and 1 patient at both sides), no other complications were recorded as secondary infection, scaring keloid and prolonged erythema. Conclusion We compared the results of whole facial area treatment in the right side of the face versus Focal Acne Scar Treatment (FAST) in the left side by factional CO2 laser. We discovered that there is a statistically highly significant relationship between the improvement of acne scars and treatment with fractional CO2 laser by the either techniques. Both techniques are preferable in treating acne scars in equal degree.

scholarly journals Problematic parent-infant relationships in two-parent families: prevalence and risk factors in a Brazilian neighborhood

2012 ◽  
Vol 34 (3) ◽  
pp. 139-146 ◽  
Author(s):  
Olga Garcia Falceto ◽  
Elsa R. J. Giugliani ◽  
Carmen Luiza C. Fernandes
Keyword(s):  
Risk Factors ◽  
Global Assessment ◽  
Population Group ◽  
Public Hospitals ◽  
Self Report ◽  
Global Assessment Scale ◽  
Cross Sectional ◽  
Early Parent ◽  
Infant Birth ◽  
Parent Child

Introduction: Although the quality of parent-child relationships is known to be associated with the offspring's mental health, little is known about the prevalence of problematic relationships in this scenario. This cross-sectional study aims to investigate the prevalence and risk factors of different types of early parent-infant relationships in a Brazilian population group. Methods: During 1 year, all families (n = 230) from an urban community of Porto Alegre, southern Brazil, with 4-month-old infants born in public hospitals were identified, and 148 were fully investigated by two family therapists. This study describes data on the 116 infants with two-parent families. Demographic, obstetric, and relational variables were collected through questionnaires and scales (Parent-Infant Relationship Global Assessment Scale, Global Assessment of Relational Functioning, and Self-Report Questionnaire). Prevalence ratios were calculated, and Poisson regression with robust variance was performed to adjust for covariates. Results: Almost 10% of mothers and 12% of fathers showed at least a significantly perturbed relationship with their 4-month-old infants. Inadequate mother-infant bonding coincided with evidence of paternal mental disorder, poor maternal social network, and discontinuation of breastfeeding at 4 months. A problematic father-infant relationship was associated with a dysfunctional couple relationship and with low infant birth weight. Conclusions: There is a high prevalence of early parent-child relationship problems, suggesting a need for health system interventions. Parent-infant relational problems are prevalent very early in life and more associated with other relational problems than with socioeconomic burden.

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