Negative pressure therapy with the ULTRAVAC instillation in the therapy of infected laparotomies with fascitis − temporary results of a prospective randomized study

2019 ◽  
Vol 98 (4) ◽  
pp. 152-158
Keyword(s):  
Negative Pressure ◽  
Randomized Study ◽  
Prospective Randomized Study ◽  
Vacuum System ◽  
Control Group ◽  
Pressure Therapy ◽  
Financial Costs ◽  
Bacterial Spectrum ◽  
Hospitalization Costs ◽  
Experimental Group

Introduction: Negative pressure wound therapy is a healing modality utilizing continuous or intermittently applied vacuum to the wound bed. Nowadays is available a vacuum system supported by an automated instillation with volumetric control. It`s main therapeutic benefit is the dilution of the exudate, which reduces the viscosity and secures the «delicate» necrectomy. Method: Presentation of the temporary results of a prospective randomized study comparing the effectiveness of both therapeutic techniques. Entirely 41 patients were enrolled in the study from November 2016 to September 2018. The primary goal of the project is to compare the length of therapy, the number of surgical debridements and evaluation the financial costs. Secondary targets are observed changes in biological load and bacterial spectrum. Results: The duration of the therapy was 2 days shorter in the experimental group compared to the control sample. However, the average number of applications was higher. Defects with the instillation system were characterized by a shorter cleaning phase (p=0.057). The secondary suture was reached in the experimental group at 84.2% and in the control group at 72.7%. The differences in these parameters were not statistically significant. Fascial disruption was observed in the trial group in 2 patients. The financial costs of the material used was significantly higher in patients with irrigation system (p<0.001). However, the total hospitalization costs did not differ statistically (p=0.097). There were no significant changes in the bacterial spectrum observed during therapy. There was a significant reduction in the bacterial burden during therapy in the experimental group (p= 0,035). Conclusion: Vacuum system supported by automated instillation is an effective method, accelerating cleaning phase of the wound healing. A potential risk could be the disruption of the fascia during instillation of the solution. However, the results of our work are not definitive and a larger group of patients is needed for valid conclusions.

scholarly journals Modification of Breast Pump as a Negative Pressure Wound Therapy for Accelerating Wound Healing of Diabetic Ulcer

Jurnal NERS ◽  
2015 ◽  
Vol 10 (1) ◽  
pp. 104 ◽  
Author(s):  
Yunita Sari ◽  
Iwan Purnawan ◽  
Hartono Hartono
Keyword(s):  
Wound Healing ◽  
Negative Pressure ◽  
Negative Pressure Wound Therapy ◽  
Control Group ◽  
Necrotic Tissue ◽  
Wound Therapy ◽  
Diabetic Ulcer ◽  
Pressure Therapy ◽  
Breast Pump ◽  
Experimental Group

Introduction: Negative Pressure Wound Therapy (NPWT) is considered as the best treatment for accelerating wound healing, including diabetic ulcer. However, this device is still not available in Indonesia. Therefore, the purpose of this study were to make NPWT by using modifi cation of breast pump, and to elucidate the effect of this device on acceleration of wound healing in diabetic ulcer. Method: NPWT was made by using digital breast pump. Wounds were divided into two groups; wound-treated by NPWT (experimental group) and wound-untreated by NPWT (control). The negative pressure used for this study was 85 mmHg. Rats were sacrifi ced on day 7, and wound samples and surrounding skin were stained with Hematoxylin and Eosyn. Infl ammation, intensity of necrotic tissue, and wound closure were observed. Result: The device could deliver a negative pressure at a range of 85–140 mmHg. Wound size in the experimental group was smaller than in control group. Infl ammation was also less in the experimental group than control group. Discussion: The modifi cation of breast pump could be used as a negative pressure therapy for wounds, and has effect on reducing infl ammation and necrotic tissue. Further study is needed to elucidate the effect of this device on human subject.Keywords: diabetic wound, breast pump, negative pressure, wound healing

scholarly journals PO-097 The effect of 4 weeks intermittent negative pressure treatment on the functional state of excellent rowers

2018 ◽  
Vol 1 (3) ◽  
Author(s):  
Huihui Dong ◽  
Binghong Gao
Keyword(s):  
Functional State ◽  
Negative Pressure ◽  
Control Group ◽  
Pressure Treatment ◽  
Regeneration System ◽  
Male Athletes ◽  
Pressure Therapy ◽  
Significant Difference ◽  
Before And After ◽  
Experimental Group

Objective To study the effect of intermittent negative pressure treatment on the functional state of elite rowers ,and providing theoretical basis for the application of this method in sports science. Methods The 15 elite male athletes selected from the national rowing training team were divided into experimental group and control group. The daily training plans of the two groups were the same. The members of experimental group were treated for 20 minutes by the Vacusport Regeneration System from German, five times one week, for a total of 4-weeks. The control group did not use any intervention. Before and after 4 weeks, venous blood from 15 male athletes was used to test athletes 'red blood cells(RBC), hemoglobin(HGB), hematocrit (HCT), creatine kinase(CK), blood urea nitrogen(BU), testosterone(T), cortisol(C) et, Observing the changes about data from two tests. Results There was no statistically significant difference between the experimental group and the control group before and after the intervention. The results of the intra-group comparison were as follows:(1) The RBC, HGB, and HCT of the experimental group decreased by 2.90 %, 3.80 %, and 1.08 % respectively. The RBC, HGB, and HCT of the control group decreased by 6.55 %, 7.02%, 4.03% respectively, and the decline of RBC and HGB showed statistically significant changes(p<0.05).（2）The CK and BU values of the experimental group increased by 1.26 % and 27.08 % respectively, and the increase of BU had statistically significant changes(p<0.05). The CK and BU values of the control group increased by 33.10 % and 9.54 % respectively. (3) The values of T, C and T / C in experimental group decreased by 11.85 %, 7.6 % and 4.31 % respectively. The values of T, C and T / C in the control group decreased by 16.38 %, 4.03 % and 19.39 % respectively, and the decrease of T values was statistically significant(p<0.05). Conclusions The intermittent negative pressure therapy can promote the athletes' metabolism, relieve the degree of the decline of functional state, and prevent the occurrence of fatigue.

scholarly journals Effect of Negative Pressure Therapy on Open Abdomen Treatments. Prospective Randomized Study With Two Commercial Negative Pressure Systems

2021 ◽  
Vol 7 ◽  
Author(s):  
Thomas Auer ◽  
Siegfried Sauseng ◽  
Pavle Delcev ◽  
Peter Kohek
Keyword(s):  
Negative Pressure ◽  
Randomized Study ◽  
Secondary Peritonitis ◽  
Repeated Measure ◽  
Fascial Closure ◽  
Fistula Formation ◽  
Intestinal Damage ◽  
Closure Rate ◽  
Pressure Therapy ◽  
Significant Difference

Introduction: The use of negative pressure dressings for open abdominal therapy has made a great impact on strategies for open abdominal treatment. Observed intestinal damage and developement of fistula formation raises questions about safety of commonly used systems (AB-Thera). The most common used system uses foils for shielding intestines directly from negative pressure. As an alternative a system with open pore dressing in double layer film was introduced (Suprasorb CNP) and proved to safe in animal studies. We compared the effects of this two systems on patients requiring open abdominal treatment.Materials and methods: Patients with secondary peritonitis in at least two abdominal quadrants were included in this randomized study. Inclusion criteria were secondary peritonitis (ACS), abdominal compartment syndrome, and abdominal trauma combined with ACS and/or contaminated abdomen. Patients with active bleeding and pancreatitis were not included. We examined Mannheim peritonitis Index (MPI), bloodcount, PCT, amount of fluid collected, and morphological changes on the bowel. Data were collected on day 2, 4, 7, 14, 21, and 28. Primary end point was fascial closure. Examination was terminated in case of death and damage to the abdominal organs. Groups were compared using Mann Whitney U-test and chi square test. Trend evaluation was evaluated using an one way repeated measure analysis of variance. P-values below 0.05 was considered significat.Results: Thirty four patients were included between August 2010 and September 2012. There were no significant difference between two groups in MPI, age, and gender. Mean duration of treatment, WBC, CRP, and abdominal closure rate were not significantly different between groups. Suprasorb CNP System collected twice more fluid than AB-Thera and decreased PCT on significantly faster rate than AB-Thera. Four patients died (11%) and four patients developed enteric fistula (11%). Closure rate was achieved in 27 out of 34 Patients (79.5%). Closure rate was not significantly different between groups.Conclusion: The use of both systems proved to be efficient and safe. The application of well-dosed, moderate negative pressure on contaminated areas of the abdomen seems to have a lot of potential and it is worth directing greater research potential in this direction.

Subvastus Exposure Compared to Parapatellar Approach in Navigated Sequential Bilateral Total Knee Arthroplasty (SBTKA): A Prospective Randomized Study

2019 ◽  
Author(s):  
Anoop Jhurani ◽  
Piyush Agarwal ◽  
Mukesh Aswal ◽  
Chetan Rasquinha ◽  
Mudit Srivastava
Keyword(s):  
Blood Loss ◽  
Range Of Motion ◽  
Knee Arthroplasty ◽  
Randomized Study ◽  
Prospective Randomized Study ◽  
Functional Score ◽  
Control Group ◽  
Subvastus Approach ◽  
Bilateral Knee ◽  
Significant Difference

AbstractSubvastus approach preserves the quadriceps mechanism and may lead to improved early functional outcomes as compared with a parapatellar approach in primary knee arthroplasty. We performed a prospective randomized study to test the hypothesis if subvastus approach improves patient- and physician-reported outcomes in navigated sequential bilateral knee arthroplasty when compared with the standard parapatellar approach. A total of 93 patients were allotted in each group after power analysis and randomization done by computer-generated sequence: group S by subvastus approach and control group P by parapatellar approach. The patient's ability to walk without an aid, range of motion, blood loss, tourniquet time, complications, Knee Society Score (KSS), Knee Society Functional Score (KSFS), Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), Knee Injury and Osteoarthritis Outcome Score (KOOS), High Flexion Knee Score (HFKS), and visual analog scale (VAS) for pain were recorded preoperatively and postoperatively at 2 and 6 weeks and 3, 6, and 12 months. Final follow-up was done at 2 years. There was no statistical difference in the patient's ability to achieve a straight leg raise (p = 0.88), walk without an aid (p = 0.25), leaving pain medication (p = 0.48), and mean duration of hospital stay (p = 0.58) between both groups. There was no difference in KSS, FS, KOOS, WOMAC, HFKS, and VAS at 2 weeks and later follow-ups. There was no significant difference in range of motion or lateral retinacular release in both groups. Blood loss was significantly less in group S (p < 0.05), but there was a higher rate of proximal wound dehiscence and delayed healing in subvastus group (p = 0.03). Subvastus approach does not improve patient- and physician-reported outcome measures except blood loss in computer-navigated sequential bilateral knee arthroplasty and has an increased incidence of wound healing problems. The Level of evidence for the study is I.

scholarly journals A Prospective Randomized Study: The Usefulness and Efficacy of Negative Pressure Wound Therapy with Lipidocolloid Polyester Mesh Compared to Traditional Negative Pressure Wound Therapy for Treatment of Pressure Ulcers

Pharmaceutics ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 813
Author(s):  
Wooyeol Baek ◽  
Nara Lee ◽  
Eun Jin Han ◽  
Tai Suk Roh ◽  
Won Jai Lee
Keyword(s):  
Wound Healing ◽  
Pressure Ulcer ◽  
Negative Pressure ◽  
Negative Pressure Wound Therapy ◽  
Randomized Study ◽  
Contact Layer ◽  
Control Group ◽  
Wound Therapy ◽  
Group 2 ◽  
Group 1

To improve healing of pressure ulcer wounds, it is important to optimize the conditions of the area surrounding the wound. Negative pressure wound therapy (NPWT) promotes wound healing, however, the removal of NPWT can cause pain or focal bleeding, delaying wound healing or causing infection. In this study, we reviewed the efficacy of the lipidocolloid non-adherent dressing (Urgotul®) as a wound contact layer. A total of 38 patients from the same facility who applied NPWT from April 2016 to October 2019 were included and divided into two groups; NPWT with the lipidocolloid non-adherent dressing (group 1, experimental group, 19 patients) and NPWT only (group 2, control group, 19 patients). The condition of the wound was examined prior to NPWT application, at one week, and again at three weeks after application. No significant differences were found between groups for general characteristics, bacterial culture or photo analysis. However, when comparing groups based on the time of examination, there was a significant reduction of the wound size in group 1 (p = 0.001) but not in group 2 (p = 0.082). Therefore, the current study finds that using the lipidocolloid non-adherent dressing as a wound contact layer in NPWT stimulates healing by shrinking the size of the pressure ulcer wound.

scholarly journals Feasibility of a Brazilian samba protocol for patients with Parkinson's disease: a clinical non-randomized study

2020 ◽  
Vol 78 (1) ◽  
pp. 13-20 ◽  
Author(s):  
Ana Cristina TILLMANN ◽  
Alessandra SWAROWSKY ◽  
Clynton Lourenço CORRÊA ◽  
Alexandro ANDRADE ◽  
Jéssica MORATELLI ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Randomized Study ◽  
General Information ◽  
Control Group ◽  
Action Strategies ◽  
And Control ◽  
Experimental Group

Abstract Background: New protocols applied in the rehabilitation of Parkinson's disease enable different action strategies for health professionals, as well as a new range of activities for these individuals. However, no valid samba protocol with activity prescription for this population was found in the literature. Objective: To investigate the feasibility of a Brazilian samba protocol in individuals with Parkinson's disease. Methods: Twenty participants, mean age of 66.4±10.7 years, diagnosed with idiopathic Parkinson 's disease, divided into: experimental group that received the intervention of Brazilian samba dance classes (10 individuals); and control group that maintained their routine activities (10 individuals). For data collection, a divided questionnaire was used: General Information; Disability stages scale; Balance and Quality of Life. Results: During class implementation, there were no falls, as all dance activities adhered to the details of the protocol steps without any changes. On average, patients completed 82.7% of activities. After 12 weeks, the experimental group had improvements in the UPDRS global score, in daily activities, and on motor examination. There was also improvement in balance scores and in the mobility domain of the quality of life in the experimental group. Conclusion: The samba protocol seems to be feasible and safe for patients with PD. Moreover, it has pleasant characteristics and offers sufficient physical benefits for combination with drug treatment. There were also benefits in social relationships and as a possible rehabilitation tool in individuals with Parkinson's disease.

scholarly journals Evaluation of silver nanoparticles for the prevention of SARS-CoV-2 infection in health workers: in vitro and in vivo

2021 ◽  
Author(s):  
Horacio Almanza-Reyes ◽  
Sandra Moreno ◽  
Ismael Plascencia-Lopez ◽  
Martha Alvarado-Vera ◽  
Leslie Patron-Romero ◽  
...  
Keyword(s):  
Silver Nanoparticles ◽  
High Risk ◽  
Cultured Cells ◽  
Health Workers ◽  
Randomized Study ◽  
Healthcare Personnel ◽  
Control Group ◽  
Experimental Group

SARS-CoV-2 infection in hospital areas is of a particular concern, since the close interaction between health care personnel and patients diagnosed with COVID-19, which allows virus to be easily spread between them and subsequently to their families and communities. Preventing SARS-CoV-2 infection among healthcare personnel is essential to reduce the frequency of infections and outbreaks during the pandemic considering that they work in high-risk areas. In this research, silver nanoparticles (AgNPs) were tested in vitro and shown to have an inhibitory effect on SARS-CoV-2 infection in cultured cells. Subsequently, we assess the effects of mouthwash and nose rinse with ARGOVIT silver nanoparticles (AgNPs), in the prevention of SARS-CoV-2 contagion in health workers consider as high-risk group of acquiring the infection in the General Tijuana Hospital, Mexico, a hospital for the exclusive recruitment of patients diagnosed with COVID-19. We present a prospective randomized study of 231 participants that was carried out for 9 weeks (during the declaration of a pandemic). The "experimental" group was instructed to do mouthwash and nose rinse with the AgNPs solution; the "control" group was instructed to do mouthwashes and nose rinse in a conventional way. The incidence of SARS-CoV-2 infection was significantly lower in the "experimental" group (two participants of 114, 1.8%) compared to the "control" group (thirty-three participants of 117, 28.2%), with a 84.8% efficiency. We conclude that the mouth and nasal rinse with AgNPs helps in the prevention of SARS-CoV-2 infection in health personnel who are exposed to patients diagnosed with COVID-19.

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