scholarly journals COMPARISON OF PLASMA THEOPHYLLINE CONCENTRATION BETWEEN THEOLONG® AND SLO-BID® IN ASTHMATIC CHILDREN

1997 ◽  
Vol 11 (1) ◽  
pp. 1-5
Author(s):  
Shozo Maeda ◽  
Sachiyo Suzuki
Keyword(s):  
Theophylline Concentration ◽  
Asthmatic Children ◽  
Plasma Theophylline

Indirect Plasma-Theophylline Monitoring in Asthmatic Children by Determination of Theophylline Concentration in Saliva

PEDIATRICS ◽  
1974 ◽  
Vol 53 (6) ◽  
pp. 873-876
Author(s):  
Gerhard Levy ◽  
Elliot F. Ellis ◽  
Renu Koysooko
Keyword(s):  
Flow Rate ◽  
Maintenance Dose ◽  
Theophylline Concentration ◽  
Asthmatic Children ◽  
Plasma Theophylline ◽  
Mixed Saliva

The concentration of theophylline in mixed saliva and in plasma of 16 asthmatic children on regular theophylline therapy was obtained two and four hours after a maintenance dose. There is a strong and highly statistically significant correlation between the theophylline concentration in saliva and plasma. This correlation is not affected by the pH or flow rate of saliva. The concentration of theophylline in plasma could be predicted from the concentration in saliva within ± 10% in 20, and within ± 20% in all of the 32 samples. Determination of theophylline concentrations in saliva is an effective, convenient, noninvasive, and painless method for routine indirect monitoring of plasma-theophylline concentrations in asthmatic children on regular theophylline therapy.

scholarly journals Studies on the Latex Agglutination Inhibition Method for Assay of Plasma Theophylline Concentration.

1996 ◽  
Vol 22 (4) ◽  
pp. 330-341
Author(s):  
JUNKO KIZU ◽  
SHIGEKAZU WATANABE ◽  
HIDEKI ONO ◽  
JUN INATOMI ◽  
KYOKO SASAKI ◽  
...  
Keyword(s):  
Latex Agglutination ◽  
Theophylline Concentration ◽  
Plasma Theophylline

Absolute and Relative Bioavailability of a Slow Release Theophylline Preparation in Asthmatic Children

1987 ◽  
Vol 15 (5) ◽  
pp. 282-292
Author(s):  
A. L Boner ◽  
G. De Stefano ◽  
G. Vallone ◽  
M. Plebani ◽  
P. Ventura
Keyword(s):  
Slow Release ◽  
Compartmental Analysis ◽  
Relative Bioavailability ◽  
Crossover Design ◽  
Maximum Plasma ◽  
Relative Percentage ◽  
Asthmatic Children ◽  
Slow Release Formulations ◽  
Theophylline Preparation ◽  
Plasma Theophylline

This study was carried out on 14 asthmatic childen aged 7–13 years. They all received three preparations (aminophylline by intravenous infusion, lysine theophyllinate orally in solution and slow release theophylline orally as capsules) in a single dose of 100 mg active ingredient in a crossover design. Plasma theophylline concentrations, determined by a fluorescent polarization immunoassay, were evaluated both by compartmental and non-compartmental analysis. After administration of slow release theophylline, its maximum plasma concentration and the time needed to reach this were (± SD) 3.19 ± 0.63 μg/ml and 8.71 ± 2.30 h, respectively, compared to 4.51 ± 0.94 μg/ml and 1.96 ± 0.85 h, respectively, for the oral normal release solution. Mean absolute and relative percentage bioavailabilities for slow release theophylline in asthmatic children were (± SD) 92.7 ± 23.2% and 83.14 ± 14.69%, respectively. These are similar to the values found with other slow release formulations in paediatric patients.

Bioavailability of a New Sustained-Release Anhydrous Theophylline Product

1996 ◽  
Vol 24 (4) ◽  
pp. 331-339 ◽  
Author(s):  
G Tatsis ◽  
G Tsoukalas ◽  
A Haviaras ◽  
A Peristerakis ◽  
V Filaditaki ◽  
...  
Keyword(s):  
Sustained Release ◽  
Adverse Reactions ◽  
Chronic Obstructive Lung Disease ◽  
New Product ◽  
Chronic Obstructive ◽  
Maximum Plasma ◽  
Theophylline Concentration ◽  
Time Curve ◽  
Plasma Theophylline ◽  
Anhydrous Theophylline

The bioavailability of a new sustained-release anhydrous theophylline product (Theophylline Lavipharm®) was evaluated and compared with the bioavailability of a well-established product, Theodur®. Two groups of 12 healthy non-smokers were given single doses of 200 or 300 mg of each product and two groups of 12 patients with asthma or chronic obstructive lung disease were given doses of 200 or 300 mg of each product every 12 h for 5-day periods. The values of the area under the plasma theophylline concentration against time curve (AUC), the maximum plasma theophylline concentration ( Cmax) and the time taken to reach Cmax (Tmax) for the two products did not differ significantly in the healthy groups or in the patients. The minimum and the average plasma theophylline concentrations and the fluctuation index were also calculated for the patients and there were no significant differences between the values for the two products. The new anhydrous theophylline product, Theophylline Lavipharm®, appears to show very similar bioavailability to Theodur®. No adverse reactions to the new product were reported.

Plasma Theophylline Concentrations and Airway Function in Asthmatic Children Receiving Standard and Modified RTC Therapy

1992 ◽  
Vol 29 (4) ◽  
pp. 235-243 ◽  
Author(s):  
H. Arakawa ◽  
A. Morikawa ◽  
M. Shigeta ◽  
M. Kato ◽  
T. Kuroume ◽  
...  
Keyword(s):  
Asthmatic Children ◽  
Airway Function ◽  
Plasma Theophylline

Treatment of Chronic Obstructive Pulmonary Disease with Two Sustained-Release Theophylline Preparations

1987 ◽  
Vol 15 (6) ◽  
pp. 352-360
Author(s):  
S. Giosue' ◽  
D Bernocchi ◽  
D. Parola ◽  
R. Munno ◽  
P. Mancini
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Sustained Release ◽  
Slow Release ◽  
Chronic Obstructive ◽  
Theophylline Concentration ◽  
Obstructive Pulmonary Disease ◽  
Blood Samples ◽  
Theophylline Preparation ◽  
Plasma Theophylline ◽  
Sustained Release Theophylline

A sustained-release theophylline preparation in capsule form was compared with standard slow-release theophylline tablets for variation in plasma theophylline concentration, effectiveness and tolerability in 30 adults with chronic broncho-obstructive pathology. They were administered every 12 h and blood samples were collected after 8 days of treatment during the steady-state period. In this double-dummy crossover study, the sequence of the two regimens (sustained-release capsules versus tablets) was selected at random. The results of this study demonstrate that plasma theophylline levels remain within the therapeutic range for both preparations. Effectiveness and tolerability of the two drugs were satisfactory.

Should theophyllines be sold over the counter?

1992 ◽  
Vol 30 (25) ◽  
pp. 99-100
Keyword(s):  
Therapeutic Range ◽  
Plasma Levels ◽  
Theophylline Concentration ◽  
Over The Counter ◽  
Plasma Theophylline

Theophylline preparations are difficult to use. Ideally doses should be adjusted to give a plasma theophylline concentration in the therapeutic range.1 This goal can be achieved when the drug is prescribed by a doctor and plasma levels are regularly measured.2 Problems could arise when these drugs are bought over the counter. This article discusses how difficulties can be avoided.

Comparison of theophylline concentrations in venous blood and capillary blood in asthmatic children.

1979 ◽  
Vol 25 (10) ◽  
pp. 1837-1839 ◽  
Author(s):  
G S Umstead ◽  
J P Rosen
Keyword(s):  
Statistical Difference ◽  
Venous Blood ◽  
Capillary Blood ◽  
T Test ◽  
Serum Concentrations ◽  
Theophylline Concentration ◽  
Asthmatic Children ◽  
Capillary Method ◽  
The Mean ◽  
Paired T Test

Abstract Twenty children, five to 16 years old, diagnosed as having asthma, were studied to compare the serum concentrations of theophylline obtained by standard venipuncture with capillary concentrations obtained by finger lancet. The mean theophylline concentration in venous samples was 9.27 mg/L and in capillary samples was 9.26 mg/L. Comparison by the paired t-test showed no statistical difference between kinds of samples. When surveyed as to their preference, nine patients preferred the venous method, five the capillary method, and six had no preference.

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