scholarly journals The neuroprotective effects of garlic, ginger, and sodium selenite on mercuric chloride toxicity in mice

2019 ◽  
Vol 1 (2) ◽  
pp. 1-14
Keyword(s):  
Mercuric Chloride ◽  
Sodium Selenite ◽  
Neuroprotective Effects ◽  
Chloride Toxicity

Effect of Sodium Selenite on Metallothionem Induction by the Treatment of Mercuric Chloride to Rats

1989 ◽  
Vol 1 (2) ◽  
pp. 236
Author(s):  
Yo Hwan Yang ◽  
Hyo Min Lee ◽  
Dong Chun Shin ◽  
Yong Chung
Keyword(s):  
Mercuric Chloride ◽  
Sodium Selenite

Histochemical and functional evaluation of mercuric chloride toxicity in cultured macrophages

1991 ◽  
Vol 23 (1-4) ◽  
pp. 306-315 ◽  
Author(s):  
M. Christensen ◽  
S. Ellermann-Eriksen ◽  
J. Rungby ◽  
S.C. Mogensen ◽  
G. Danscher
Keyword(s):  
Mercuric Chloride ◽  
Functional Evaluation ◽  
Chloride Toxicity

In vivo Amelioration of Oxidative Stress by Artemisia absinthium L. Administration on Mercuric Chloride Toxicity in Brain Regions

2016 ◽  
Vol 16 (5) ◽  
pp. 167-177 ◽  
Author(s):  
N. Hallal ◽  
O. Kharoubi ◽  
I. Benyettou ◽  
K. Tair ◽  
M. Ozaslan ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Mercuric Chloride ◽  
Brain Regions ◽  
Artemisia Absinthium ◽  
Chloride Toxicity

scholarly journals NEUROPROTECTIVE EFFECTS OF AQUEOUS EXTRACT OF HYDROCOTYLE JAVANICA IN AMELIORATING NEUROBEHAVIORAL ALTERATION INDUCED BY MERCURY

2019 ◽  
Vol 12 (1) ◽  
pp. 374
Author(s):  
Pankaj Phukan ◽  
Sanjit Namasudra ◽  
Meenakshi Bawari ◽  
Mahuya Sengupta
Keyword(s):  
Locomotor Activity ◽  
Aqueous Extract ◽  
Mercuric Chloride ◽  
Path Length ◽  
Low Dose ◽  
Escape Latency ◽  
Learning Ability ◽  
High Dose ◽  
Neuroprotective Effects ◽  
Group I

Objective: This study aims to assess the effects of the aqueous extract of Hydrocotyle javanica (HJ) in ameliorating mercury-induced neurobehavioral toxicity.Methods: For the study, 36 adult male Swiss albino mice of 25–30 g in weight were taken. They were equally divided into six groups. Group I was treated with distilled water, Group II was treated with mercuric chloride (1.5 mg/kg), Group III was treated with HJ extract low dose (100 mg/kg), Group IV was treated with HJ extract high dose (200 mg/kg), Group V was treated with mercuric chloride plus HJ extract low dose, and Group VI was treated with mercuric chloride plus TB extract high dose. In all the groups, the doses were administered orally through oral gavage tube and the treatment lasted for 14 days. The behavioral effects evaluated were locomotor activity in the open field test, immobility in forced swimming test and anxiety in elevated plus maze test, spatial learning ability, and memory in the Morris water maze test.Results: The present study showed that mercury exposure significantly decreased the locomotor activity (p<0.001), number of annulus crossovers (p<0.001), number of open arm entries (p<0.01), time spent in open arms (p<0.001), and increased escape latency (p<0.01), path length (p<0.001), and immobility (p<0.001) in mice. The aqueous extract of HJ significantly alleviated the neurotoxic effects of mercury. The aqueous extract of HJ showed to increase the locomotor activity (p<0.01), number of annulus crossovers (p<0.001), number of open arm entries (p<0.05), and time spent in open arms (p<0.05), which was decreased in mercury-exposed mice. The HJ extract also showed to decrease the immobility (p<0.001), escape latency (p<0.05), and path length (p<0.001) in mercury-exposed mice.Conclusion: The result of the study shows that neurobehavioral changes induced by mercuric chloride were significantly reversed by the aqueous extract of HJ. Thus, base on the present study, it is concluded that HJ is effective in ameliorating the neurobehavioral deficits induced by mercury.

Effect of administration sequence of mercuric chloride and sodium selenite on their fates and toxicities in mice

1984 ◽  
Vol 8 (6) ◽  
pp. 572-580 ◽  
Author(s):  
Akira Naganuma ◽  
Yasuhiro Ishii ◽  
Nobumasa Imura
Keyword(s):  
Mercuric Chloride ◽  
Sodium Selenite
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