scholarly journals Patient-Reported Control of Asthma, Nasal Polyposis, and Middle-Ear Symptoms in NSAID-Exacerbated Respiratory Disease

2021 ◽  
Vol 2 ◽  
Author(s):  
Anna Suikkila ◽  
Lena Hafrén ◽  
Annina Lyly ◽  
Tuomas Klockars ◽  
Riitta Saarinen
Keyword(s):  
Disease Control ◽  
Respiratory Disease ◽  
Middle Ear ◽  
Nasal Polyposis ◽  
Symptom Control ◽  
Ear Infection ◽  
Tertiary Referral Center ◽  
Middle Ear Infection ◽  
Patient Reported ◽  
Ear Symptoms

Non-steroidal anti-inflammatory drug (NSAID)—exacerbated respiratory disease (NERD) is an adult-onset inflammatory condition of the upper and lower airways. It is characterized by the co-existence of asthma, nasal polyposis, and hypersensitivity to NSAIDs. Over one-fourth of patients also have symptoms of chronic middle-ear infection. The clinical course of NERD is often severe and generally requires multimodal treatment with recurrent surgical measures. Studies presenting the disease burden and subjective symptom control of NERD are limited. In this qualitative questionnaire study, we present the clinical characteristics of asthma, nasal polyposis, NSAID intolerance and possible recurrent or chronic middle-ear infection of 66 confirmed NERD patients treated at our tertiary referral center between January 2016 and May 2017. Additionally, we present the patient-reported disease control of asthma, nasal polyposis, and middle-ear symptoms on a four-category Likert scale. The proportion of NERD patients with recurrent or chronic middle-ear infection was 18%. The proportion of good or very good subjective disease control was 83% for asthma, 58% for nasal polyposis, and 33% for chronic middle-ear infection, if present. Chronic middle-ear infection is common among NERD patients and should more often be recognized as part of the entity. Together with nasal polyposis, chronic middle-ear infection seems to affect patients more than asthma. The patient's perspective of disease control should be considered when planning the interdisciplinary follow-up and treatment of NERD.

scholarly journals Salvage Eustachian Tube Cartilage Chip Insertion After Multiple Transnasal Shim Operations in Intractable Patulous Eustachian Tube

2021 ◽  
pp. 014556132199500
Author(s):  
Wei-Ting Lee ◽  
Heng-Jui Hsu
Keyword(s):  
Surgical Technique ◽  
Eustachian Tube ◽  
Middle Ear ◽  
Repeat Surgery ◽  
Ear Infection ◽  
Middle Ear Infection ◽  
Tube Lumen ◽  
Management Method ◽  
Patulous Eustachian Tube

This article presents 2 cases of extremely intractable patulous Eustachian tube following multiple transnasal shim insertion. These cases highlight the disadvantages of repeat transnasal shim operations, including enlargement of the Eustachian tube lumen, frequent dislocation, repeat surgery, recurrent middle ear infection, and shim misswallowing. The patients in these cases were successfully treated with Eustachian tube cartilage chip insertion through a postauricular approach. We describe the surgical technique and advantages of this promising management method.

Middle Ear Infection (Otitis Media)

1990 ◽  
Vol 9 (12) ◽  
pp. 936
Author(s):  
S. Michael Marcy ◽  
Michael E. Pichichero ◽  
Richard H. Schwartz
Keyword(s):  
Otitis Media ◽  
Middle Ear ◽  
Ear Infection ◽  
Middle Ear Infection

scholarly journals Luc Abscess: A Rare Complication of a Common Pediatric Ear Infection

2021 ◽  
Vol 27 (1) ◽  
pp. 20-24
Author(s):  
Nurfadhilah Aisyah Murad ◽  
Zalilah Musa ◽  
Kharudin Abdullah ◽  
Irfan Mohamad
Keyword(s):  
Inflammatory Response ◽  
Bacterial Infection ◽  
Otitis Media ◽  
Middle Ear ◽  
Rare Complication ◽  
Bone Involvement ◽  
Ear Infection ◽  
Temporal Muscle ◽  
Middle Ear Infection ◽  
The Difference

Middle ear infection occurs when fluid accumulate in middle ear as a result of inflammatory response to viral or bacterial infection. Infections may spread from the middle ear, resulting in a subperiosteal collection beneath the temporal muscle. Luc abscess is a rare complication of otitis media. The difference of this complication with other extracranial abscesses relating to otitis media is, it may not be associated with mastoid bone involvement. Therefore, it is defined as benign complication of otitis media. Here, we report a case of 10-month-old baby boy diagnosed with Luc abscess with mastoid involvement.

Frequency of hearing impairment in children between the age of 2 to 10 years with middle ear infection

2021 ◽  
pp. 1-10
Author(s):  
Sultan Badar Munir ◽  
Imran Saeed ◽  
Sikander Ghayas Khan ◽  
Syed Shakeel Ur Rehman ◽  
Rabia Ghayas ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Hearing Impairment ◽  
Middle Ear ◽  
Sampling Technique ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Ear Infection ◽  
Middle Ear Infection ◽  
Ear Infections ◽  
Convenience Sampling

Abstract This study was conducted to find out frequency of hearing impairment in middle ear infection. The study design was a cross- sectional survey, conducted from August 2018 to January 2019 in the ENT Department of Children's Hospital Lahore. The data was collected through convenience sampling technique among 52 patients of middle ear infection. The measurements for level of hearing impairment were taken. The data was analyzed using statistical package for social sciences, SPSS 20.0 Out of total 52, There were found 15 (28.8%) had once a month ear infection and 37 (71.2%) had off and 35 (67.3%) patients had mild hearing, 13 (25%) had moderate, 2(3.8%) severe and 2 (3.8%) had normal hearing loss. It was concluded that most of the participants having middle ear infections had hearing loss. Keywords: Hearing Impairment, Middle Ear Infection, Continuous...

Phase I study of autolytic immunotherapy of metastatic neuroendocrine tumors using intralesional rose bengal disodium.

2021 ◽  
Vol 39 (15_suppl) ◽  
pp. 4115-4115
Author(s):  
Timothy Jay Price ◽  
Gabby Cehic ◽  
Eric Andrew Wachter ◽  
Ian D. Kirkwood ◽  
Jessica Reid ◽  
...  
Keyword(s):  
Disease Control ◽  
Rose Bengal ◽  
Treatment Cycle ◽  
Phase 1 ◽  
Systemic Disease ◽  
Symptom Control ◽  
Objective Response ◽  
Neuroendocrine Neoplasms ◽  
Contrast Enhanced Ct ◽  
Patient Reported

4115 Background: Metastatic neuroendocrine neoplasms (mNEN) originating in the gastrointestinal tract are frequently slow growing yet both symptom and disease control remain important. Treatment options include resection, systemic somatostatin analogues (SSA), and systemic peptide receptor radionuclide therapy (PRRT). Additional options are needed; we have explored intralesional (IL) rose bengal disodium (PV-10), an investigational autolytic immunotherapy that can yield immunogenic cell death and disease-specific functional adaptive immunity. Methods: This phase 1 study evaluated safety, tolerability and impact on symptoms and biochemical markers resulting from IL PV-10 administered percutaneously to hepatic lesions in patients (pts) with progressive mNEN not amenable to resection or other potentially curative therapy. Eligible lesion(s) were 1.0 - 3.9 cm in longest diameter with amount of PV-10 administered proportional to size. Cohort 1 (n = 6 pts) received PV-10 to a single lesion per treatment cycle; Cohort 2 (n = 6) could receive injection to multiple lesions per treatment cycle. Pts could receive further PV-10 ≥6 weeks after prior injection. The primary endpoint was safety. Secondary endpoints included objective response rate (ORR) assessed by contrast enhanced CT (RECIST 1.1) and 68Ga-DOTATATE PET, biochemical response (CgA) and patient-reported outcome (EORTC QLQ-C30 and GI.NET21 QOL instruments). Results: Twelve pts were enrolled, 50% male, median age 66 yrs (range 47-79). Primary sites: 7 small bowel, 2 pancreas, 1 caecal, 2 unknown; grade: Gd1 = 5, Gd2 = 7. All pts had received SSA and PRRT as part of previous therapy and all had symptomatic, progressive disease. Median CgA was 1585 (range 35-10370). One lesion was injected per cycle for all 12 pts; none were suitable for multiple injections. One pt received 4 sequential PV-10 treatment cycles, 3 received 2 cycles, and 8 received 1 cycle. Toxicity was consistent with experience in other hepatic malignancies: post-procedure pain was reported by most pts; grade 3 photosensitivity reaction occurred in 1 pt; and grade 1 elevation of hepatic enzymes attributed to PV-10 occurred in 2 pts, resolving by day 7. Additionally, carcinoid flare occurred in 1 pt. ORR of injected lesions was 42%; patient-level disease control was 84%. Estimated PFS was 9.2 months; median OS was 22.5 months. CgA remained stable in 10 pts and upregulation of NK and activated CD4+ T lymphocytes was observed post-injection. QOL data at months 1 and 3 showed stable or improved carcinoid symptoms and global health status in 9 pts. Conclusions: PV-10 elicited no safety concerns with encouraging evidence of both local and systemic disease and symptom control in a heavily pre-treated population. Multiple cycles were delivered safely in suitable patients. Adaptive immune upregulation is consistent with other solid tumors and supports potential systemic benefit. Clinical trial information: NCT02693067.

The effect of adenoidectomy on occlusal development and nasal cavity volume in children with recurrent middle ear infection

2015 ◽  
Vol 79 (12) ◽  
pp. 2115-2119 ◽  
Author(s):  
P. Niemi ◽  
J. Numminen ◽  
M. Rautiainen ◽  
M. Helminen ◽  
H. Vinkka-Puhakka ◽  
...  
Keyword(s):  
Nasal Cavity ◽  
Middle Ear ◽  
Cavity Volume ◽  
Ear Infection ◽  
Middle Ear Infection

scholarly journals Middle Ear Infection in Children and Its Association with Dental Caries

2018 ◽  
Author(s):  
Nilotpol Kashyap ◽  
Tulsi Katlam ◽  
Alok Avinash ◽  
Brij Kumar ◽  
Reena Kulshrestha ◽  
...  
Keyword(s):  
Dental Caries ◽  
Middle Ear ◽  
Saliva Sample ◽  
P Value ◽  
Normal Children ◽  
Ear Infection ◽  
Feeding Method ◽  
Middle Ear Infection ◽  
Significant Difference ◽  
The Difference

Introduction. Middle ear infection affects mostly infants and children, associated with elevatedlevel of S. mutans, which increases the chances of developing caries.Aim. To evaluate the difference in level of Streptococcus mutans between normal children & children affected by middle ear infection.Method. This descriptive study was carried out on 120 children aged 5 years and younger. They were selected randomly from schools and medical hospitals. S. mutans was counted from saliva sample and a questionnaire was given to be filled by their parents about the feeding method, pattern and specific childhood illness.Result. Out of 120 children examined, 62 were boys and 58 were girls. Mean CFU in middle ear infection group was 5.60+9.53, whereas in children with no middle ear infection it was 1.70+3.34. Unpaired ‘t’ test revealed statistically significant difference among the two groups (p value = 0.001).Conclusion. S. mutans count was comparatively higher in children having middle ear infection rather than non-infected children, which may cause dental caries in the future.

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