scholarly journals Design of Cyclodextrin-Based Functional Systems for Biomedical Applications

2021 ◽  
Vol 9 ◽  
Author(s):  
Wanjia Xu ◽  
Xiumei Li ◽  
Liang Wang ◽  
Siyuan Li ◽  
Shengnan Chu ◽  
...  
Keyword(s):  
Biomedical Applications ◽  
Enzymatic Catalysis ◽  
Functional Materials ◽  
Hydroxyl Groups ◽  
Guest Molecules ◽  
Functional Systems ◽  
Starting Point ◽  
Recognition Ability ◽  
Biomedical Diagnosis ◽  
Metal Organic

Cyclodextrins (CDs) are a family of α-1,4-linked cyclic oligosaccharides that possess a hydrophobic cavity and a hydrophilic outer surface with abundant hydroxyl groups. This unique structural characteristic allows CDs to form inclusion complexes with various guest molecules and to functionalize with different substituents for the construction of novel sophisticated systems, ranging from derivatives to polymers, metal-organic frameworks, hydrogels, and other supramolecular assemblies. The excellent biocompatibility, selective recognition ability, and unique bioactive properties also make these CD-based functional systems especially attractive for biomedical applications. In this review, we highlight the characteristics and advantages of CDs as a starting point to design different functional materials and summarize the recent advances in the use of these materials for bioseparation, enzymatic catalysis, biochemical sensing, biomedical diagnosis and therapy.

scholarly journals Gas Adsorption Selectivity in Topologically Disordered Metal–Organic Frameworks

2021 ◽  
Author(s):  
Adam Sapnik ◽  
Christopher W. Ashling ◽  
Lauren K. Macreadie ◽  
Seok J. Lee ◽  
Tim Johnson ◽  
...  
Keyword(s):  
Gas Adsorption ◽  
Metal Organic Frameworks ◽  
Interaction Strength ◽  
Functional Materials ◽  
Adsorption Selectivity ◽  
Guest Molecules ◽  
Sorption Behaviour ◽  
Ideal Adsorbed Solution Theory ◽  
Industrial Gases ◽  
Metal Organic

<div><p>Disordered metal–organic frameworks are emerging as an attractive class of functional materials, however their applications in gas storage and separation have yet to be fully explored. Here, we investigate gas adsorption in the topologically disordered Fe-BTC framework and its crystalline counterpart, MIL‑100. Despite their similar chemistry and local structure, they exhibit very different sorption behaviour towards a range of industrial gases, noble gases and hydrocarbons. Virial analysis reveals that Fe-BTC has enhanced interaction strength with guest molecules compared to MIL‑100. Most notably, we observe striking discrimination between the adsorption of C<sub>3</sub>H<sub>6</sub> and C<sub>3</sub>H<sub>8</sub> in Fe‑BTC, with over a twofold increase in the amount of C<sub>3</sub>H<sub>6</sub> being adsorbed than C<sub>3</sub>H<sub>8</sub>. Thermodynamic selectivity towards a range of industrially relevant binary mixtures is probed using ideal adsorbed solution theory (IAST). Together, this suggests the disordered material may possess powerful separation capabilities that are rare even amongst crystalline frameworks.</p></div>

Atomistic Insight into the Host-Guest Interaction of a Photo-Responsive Metal-Organic Framework

2019 ◽  
Author(s):  
Elena Kolodzeiski ◽  
Saeed Amirjalayer
Keyword(s):  
Metal Organic Framework ◽  
Functional Materials ◽  
Light Metal ◽  
Guest Molecules ◽  
Molecular Switching ◽  
Adsorption Sites ◽  
Metal Organic ◽  
The Impact ◽  
Unique Potential ◽  
Insight Into

<p>Photo-responsive functional materials have gained increasing attention due to their externally tunable properties. Molecular switches embedded in these materials enable to control phenomena at the atomic level by light. Metal-Organic Frameworks (MOFs) provide a versatile platform to immobilize these photo-responsive units within defined molecular environments to optimize the intended functionality. For the application of these photo-responsive MOFs (pho-MOFs), it is crucial to understand the influence of the switching state on the host-guest interaction. Therefore, we present a detailed insight into the impact of molecular switching the intermolecular interaction. By performing atomistic simulations, we revealed that due to different interactions of the guest molecules with the two isomeric states of an azobenzene-functionalized MOF, both the adsorption sites and the orientation of the molecules within the pores are modulated. By shedding light on the host-guest interaction, our study highlights the unique potential of pho-MOFs to tailor molecular interaction by light.</p>

scholarly journals Porphyrin Molecules Decorated on Metal–Organic Frameworks for Multi-Functional Biomedical Applications

Biomolecules ◽  
2021 ◽  
Vol 11 (11) ◽  
pp. 1714
Author(s):  
Navid Rabiee ◽  
Mohammad Rabiee ◽  
Soheil Sojdeh ◽  
Yousef Fatahi ◽  
Rassoul Dinarvand ◽  
...  
Keyword(s):  
Biomedical Applications ◽  
Limit Of Detection ◽  
Metal Organic Frameworks ◽  
Protein Structures ◽  
Cellular Protein ◽  
Hydroxyl Groups ◽  
One Pot ◽  
Hydrogen Bond Formation ◽  
Surface Hydroxyl ◽  
Metal Organic

Metal–organic frameworks (MOFs) have been widely used as porous nanomaterials for different applications ranging from industrial to biomedicals. An unpredictable one-pot method is introduced to synthesize NH2-MIL-53 assisted by high-gravity in a greener media for the first time. Then, porphyrins were deployed to adorn the surface of MOF to increase the sensitivity of the prepared nanocomposite to the genetic materials and in-situ cellular protein structures. The hydrogen bond formation between genetic domains and the porphyrin’ nitrogen as well as the surface hydroxyl groups is equally probable and could be considered a milestone in chemical physics and physical chemistry for biomedical applications. In this context, the role of incorporating different forms of porphyrins, their relationship with the final surface morphology, and their drug/gene loading efficiency were investigated to provide a predictable pattern in regard to the previous works. The conceptual phenomenon was optimized to increase the interactions between the biomolecules and the substrate by reaching the limit of detection to 10 pM for the Anti-cas9 protein, 20 pM for the single-stranded DNA (ssDNA), below 10 pM for the single guide RNA (sgRNA) and also around 10 nM for recombinant SARS-CoV-2 spike antigen. Also, the MTT assay showed acceptable relative cell viability of more than 85% in most cases, even by increasing the dose of the prepared nanostructures.

Atomistic Insight into the Host-Guest Interaction of a Photo-Responsive Metal-Organic Framework

2019 ◽  
Author(s):  
Elena Kolodzeiski ◽  
Saeed Amirjalayer
Keyword(s):  
Metal Organic Framework ◽  
Functional Materials ◽  
Light Metal ◽  
Guest Molecules ◽  
Molecular Switching ◽  
Adsorption Sites ◽  
Metal Organic ◽  
The Impact ◽  
Unique Potential ◽  
Insight Into

<p>Photo-responsive functional materials have gained increasing attention due to their externally tunable properties. Molecular switches embedded in these materials enable to control phenomena at the atomic level by light. Metal-Organic Frameworks (MOFs) provide a versatile platform to immobilize these photo-responsive units within defined molecular environments to optimize the intended functionality. For the application of these photo-responsive MOFs (pho-MOFs), it is crucial to understand the influence of the switching state on the host-guest interaction. Therefore, we present a detailed insight into the impact of molecular switching the intermolecular interaction. By performing atomistic simulations, we revealed that due to different interactions of the guest molecules with the two isomeric states of an azobenzene-functionalized MOF, both the adsorption sites and the orientation of the molecules within the pores are modulated. By shedding light on the host-guest interaction, our study highlights the unique potential of pho-MOFs to tailor molecular interaction by light.</p>

scholarly journals Macrocyclic Receptors for Identification and Selective Binding of Substrates of Different Nature

Molecules ◽  
2021 ◽  
Vol 26 (17) ◽  
pp. 5292
Author(s):  
Galina Mamardashvili ◽  
Nugzar Mamardashvili ◽  
Oscar Koifman
Keyword(s):  
Enzymatic Catalysis ◽  
Immunological Response ◽  
Prolonged Release ◽  
Guest Molecules ◽  
Macrocyclic Receptors ◽  
Structure Recognition ◽  
Recognition Ability ◽  
Selective Delivery ◽  
Energy Processes ◽  
Regulatory Functions

Molecular recognition of host/guest molecules represents the basis of many biological processes and phenomena. Enzymatic catalysis and inhibition, immunological response, reproduction of genetic information, biological regulatory functions, the effects of drugs, and ion transfer—all these processes include the stage of structure recognition during complexation. The goal of this review is to solicit and publish the latest advances in the design and sensing and binding abilities of porphyrin-based heterotopic receptors with well-defined geometries, the recognition ability of which is realized due to ionic, H-bridge, charge transfer, hydrophobic, and hydrophilic interactions. The dissection of the considered low-energy processes at the molecular scale expands our capabilities in the development of effective systems for controlled recognition, selective delivery, and prolonged release of substrates of different natures (including drugs) to their sites of functioning.

scholarly journals Gas Adsorption Selectivity in Topologically Disordered Metal–Organic Frameworks

2021 ◽  
Author(s):  
Adam Sapnik ◽  
Christopher W. Ashling ◽  
Lauren K. Macreadie ◽  
Seok J. Lee ◽  
Tim Johnson ◽  
...  
Keyword(s):  
Gas Adsorption ◽  
Metal Organic Frameworks ◽  
Interaction Strength ◽  
Functional Materials ◽  
Adsorption Selectivity ◽  
Guest Molecules ◽  
Sorption Behaviour ◽  
Ideal Adsorbed Solution Theory ◽  
Industrial Gases ◽  
Metal Organic

<div><p>Disordered metal–organic frameworks are emerging as an attractive class of functional materials, however their applications in gas storage and separation have yet to be fully explored. Here, we investigate gas adsorption in the topologically disordered Fe-BTC framework and its crystalline counterpart, MIL‑100. Despite their similar chemistry and local structure, they exhibit very different sorption behaviour towards a range of industrial gases, noble gases and hydrocarbons. Virial analysis reveals that Fe-BTC has enhanced interaction strength with guest molecules compared to MIL‑100. Most notably, we observe striking discrimination between the adsorption of C<sub>3</sub>H<sub>6</sub> and C<sub>3</sub>H<sub>8</sub> in Fe‑BTC, with over a twofold increase in the amount of C<sub>3</sub>H<sub>6</sub> being adsorbed than C<sub>3</sub>H<sub>8</sub>. Thermodynamic selectivity towards a range of industrially relevant binary mixtures is probed using ideal adsorbed solution theory (IAST). Together, this suggests the disordered material may possess powerful separation capabilities that are rare even amongst crystalline frameworks.</p></div>

Multifunctional metal–organic framework heterostructures for enhanced cancer therapy

2021 ◽  
Author(s):  
Jintong Liu ◽  
Jing Huang ◽  
Lei Zhang ◽  
Jianping Lei
Keyword(s):  
Cancer Therapy ◽  
General Principle ◽  
Biomedical Applications ◽  
Metal Organic Framework ◽  
Metal Organic ◽  
Functional Modulation ◽  
Organic Framework

We review the general principle of the design and functional modulation of nanoscaled MOF heterostructures, and biomedical applications in enhanced therapy.

Synthesis and Structure of a Clathrated Two-Dimensional Metal-Organic Framework: [Cd(4,4'-bpy)2(H2O)2](ClO4)2·(L)2·H2O (L = Bis(1-pyrazinylethylidene)hydrazine)

2008 ◽  
Vol 73 (1) ◽  
pp. 24-31
Author(s):  
Dayu Wu ◽  
Genhua Wu ◽  
Wei Huang ◽  
Zhuqing Wang
Keyword(s):  
Metal Organic Framework ◽  
Channel Structure ◽  
Two Dimensional ◽  
X Ray Diffraction ◽  
Guest Molecules ◽  
X Ray ◽  
Square Planar ◽  
Metal Organic ◽  
Aqueous Meoh ◽  
Organic Framework

The compound [Cd(4,4'-bpy)2(H2O)2](ClO4)2·(L)2 was obtained by the reaction of Cd(ClO4)2, bis(1-pyrazinylethylidene)hydrazine (L) and 4,4'-bipyridine in aqueous MeOH. Single-crystal X-ray diffraction has revealed its two-dimensional metal-organic framework. The 2-D layers superpose on each other, giving a channel structure. The square planar grids consist of two pairs of shared edges with Cd(II) ion and a 4,4'-bipyridine molecule each vertex and side, respectively. The square cavity has a dimension of 11.817 × 11.781 Å. Two guest molecules of bis(1-pyrazinylethylidene)hydrazine are clathrated in every hydrophobic host cavity, being further stabilized by π-π stacking and hydrogen bonding. The results suggest that the hydrazine molecules present in the network serve as structure-directing templates in the formation of crystal structures.

scholarly journals Selective Detection of nano-molar range Noxious Anions in Water by a Luminescent Metal-Organic Framework

2021 ◽  
Author(s):  
Sudip Kumar Mondal ◽  
Partha Mahata ◽  
Pooja Daga ◽  
Sourav Sarkar ◽  
Prakash Majee ◽  
...  
Keyword(s):  
Aqueous Medium ◽  
Metal Organic Framework ◽  
Selective Detection ◽  
Recognition Ability ◽  
Oxo Anions ◽  
Metal Organic ◽  
Organic Framework

A new metal-organic framework (MOF) showed excellent recognition ability towards five toxic oxo-anions viz. arsenate (HAsO42-), phosphate (PO43-), permanganate (MnO4-), chromate (CrO42-) and dichromate (Cr2O72-) in aqueous medium upon irradiation...

Core-shell ZIF-8@polydopamine nanoparticles obtained by mitigating polydopamine coating induced self-etching of MOFs: prototypical metal ion reservoirs for sticking to and killing bacteria

2021 ◽  
Author(s):  
Yingxue Tu ◽  
Caifen Lei ◽  
Fei Deng ◽  
Yiang Chen ◽  
Ying Wang ◽  
...  
Keyword(s):  
Metal Ions ◽  
Metal Ion ◽  
Biomedical Applications ◽  
Metal Organic Frameworks ◽  
Core Shell ◽  
Metal Organic

Metal organic frameworks (MOFs) have the potential to boost the undervalued biomedical applications of metal ions. Such endeavor has been hindered by the challenge of how to avoid the (cyto)toxicity...

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