scholarly journals Successful Prevention of Fetal Autoimmune-Mediated Heart Block by Combined Therapies With Hydroxychloroquine and Intravenous Immunoglobulin: A Case Report

2021 ◽  
Vol 8 ◽  
Author(s):  
Li Zhao ◽  
Yan Zhou ◽  
Chuan Wang ◽  
Yifei Li ◽  
Qi Zhu ◽  
...  

A fetal autoimmune-mediated atrioventricular block is a passively acquired autoimmune disease in which maternal autoantibodies enter the fetal circulation via the placenta and subsequently cause inflammation and fibrosis of the atrioventricular node. Once fetal autoimmune-mediated atrioventricular block occurs, it only takes a short time to progress from first-degree atrioventricular block to complete atrioventricular block, meaning that the damage is often irreversible. Autoimmune—associated AVB, a rare but life—threatening disorder, occurs in 2–5% of pregnancies with positive anti—Ro/SSA (the most common one) and La/SSB antibodies. The perinatal mortality of neonates with AVB outlined in research is approximately 30%. Thus far, for autoimmune-associated AVB fetuses, currently used treatments include corticosteroids, hydroxychloroquine, intravenous immunoglobulin (IVIG), b—sympathomimetic agent, and even plasma exchange. Currently, approaches for preventing the progression and recurrence of a fetal atrioventricular block are still controversial. Here, we reported a baby of successful prevention from the fate of the fetal atrioventricular block by adopting prophylactic comprehensive prenatal therapy.

2021 ◽  
pp. 1-10
Author(s):  
Sezen Gulumser Sisko ◽  
Sezen Ugan Atik ◽  
Cem Karadeniz ◽  
Alper Guzeltas ◽  
Yakup Ergul

Abstract A young child presented with hepatomegaly, ascites, and bradycardia in the setting of coronavirus disease-2019. Permanent complete atrioventricular block and severe right heart failure were diagnosed. He was treated with surgical epicardial pacemaker implantation. This report is the first description of coronavirus disease-2019–induced permanent complete atrioventricular block in a child.


2008 ◽  
Vol 168 (6) ◽  
pp. 757-759 ◽  
Author(s):  
L. Welzing ◽  
J. C. von Kleist-Retzow ◽  
A. Kribs ◽  
F. Eifinger ◽  
C. Huenseler ◽  
...  

2003 ◽  
Vol 13 (4) ◽  
pp. 380-383 ◽  
Author(s):  
Jacintha Sivarajah ◽  
Ian C. Huggon ◽  
Eric Rosenthal

At 32 weeks, a fetus was found to be hydropic with congenitally complete heart block in an asymptomatic mother who was positive to anti-Ro antibodies. Maternal therapy with oral salbutamol was successful in prolonging gestation for a period of 3 weeks so that preterm delivery was delayed until the 35th week of gestation. Following treatment with inotropes and diuretics, a permanent transvenous pacemaker was implanted at 8 weeks of age. The child is now thriving at 20 months of age.


2009 ◽  
Vol 36 (8) ◽  
pp. 1744-1748 ◽  
Author(s):  
ANTONIO BRUCATO ◽  
CHIARA GRAVA ◽  
MARIA BORTOLATI ◽  
KEIGO IKEDA ◽  
ORNELLA MILANESI ◽  
...  

Objective.To study anti-Ro/La-negative congenital heart block (CHB).Methods.Forty-five fetuses with CHB were evaluated by analysis of anti-Ro/La antibodies using sensitive laboratory methods.Results.There were 9 cases of anti-Ro/La-negative CHB; 3 died (33.3%). Only 3 (33.3%) were complete in utero and 5 (55.5%) were unstable. No specific etiology was diagnosed. Six infants (66.6%) were given pacemakers. There were 36 cases of anti-Ro/La-positive CHB. All except 2 infants (94.4%) had complete atrioventricular block in utero. Ten died (27.8%), one (2.7%) developed severe dilated cardiomyopathy, and 26 (72.2%) were given pacemakers.Conclusion.Nine of the 45 consecutive CHB cases (20%) were anti-Ro/La-negative with no known cause. They were less stable and complete than the anti-Ro/La positive cases.


1994 ◽  
Vol 4 (1) ◽  
pp. 79-81 ◽  
Author(s):  
Juan Calderón-Colmenero ◽  
Mario Baltazares ◽  
Alfonso Buendía

SummaryWe report a 12-year-old boy with hypertrophic cardiomyopathy presenting with syncope. His electrocardiogram showed first-degree atrioventricular block, complete right bundle branch block, conduction delay in the anterior fascicle of the left bundle branch, and intermittent complete atrioventricular block. We detected hypertrophic cardiomyopathy in the mother. The relationship between the diseases is discussed, and interpreted in the light of previous descriptions.


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