Higher Serum Uric Acid Level Predicts Non-alcoholic Fatty Liver Disease: A 4-Year Prospective Cohort Study

BACKGROUND/AIM: Non-alcoholic Fatty Liver Disease (NAFLD) is one of the main causes that promote chronic liver disease in developing countries. Uric acid is correlated to metabolic syndrome. Based on this issue, we studied the correlation between uric acid level and the occurrence of NASH in non-alcoholic fatty liver disease (NAFLD) with or without obesity.  METHODS: The research subjects were 149 patients diagnosed with NAFLD. The data were collected from the medical record by purposive sampling method. The subjects were taken from inpatient and outpatient data from Wahidin Sudirohusodo hospital. The medical record included demography, clinical, radiology and laboratory records. Statistical analysis were performed through descriptive statistical calculations, Pearson Correlation and multinomial logistic. RESULTS: There was a significant correlation between NAFLD and uric acid level (p=.000). Based on gender, the correlation between NAFLD and uricemia was significant in female patients (with p=.000); but insignificant in male patients (p=.137). Based on age, in age of >40 years old, NAFLD was significantly associated with uric acid level (p=.000). There was a significant correlation between hyperuricemia and NASH in obese and non-obese patients (p <0.001) for which the higher the uric acid level the greater the NAFLD degree was. CONCLUSION: There is a correlation between uric acid level and NASH occurrence in NAFLD with or without obesity.

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Association of Serum Uric acid Level and BMI in NAFLD and Healthy Volunteers

European Journal of Medical and Health Sciences ◽

10.24018/ejmed.2020.2.4.351 ◽

2020 ◽

Vol 2 (4) ◽

Author(s):

Ajoy Tiwari ◽

Jay Tewari ◽

Vineeta Tewari

Keyword(s):

Uric Acid ◽

Liver Disease ◽

Healthy Volunteers ◽

Serum Uric Acid ◽

Fatty Liver Disease ◽

Acid Level ◽

Serum Uric Acid Level ◽

Alcoholic Fatty Liver ◽

Alcoholic Fatty Liver Disease

A number of studies have reported that exact aetiology of non alcoholic fatty liver disease NAFLD is unknown. Serum uric acid is often incriminated as the etiological agent. Hence this study was taken up explore the role of BMI and serum uric acid in occurrence of NAFLD. A case control study was undertaken to compare the role of serum acid in occurrence of 100 NAFLD cases with 100 healthy volunteers. All the cases and controls were subjected for ultrasound examination and serum uric acid estimation with height and weight. Most of study subjects belonged to 21 – 40 years of age group and females outnumbered males. The Mean BMI among the cases was 25.34 (± 4.44) and controls was 25.12 (± 4.08). Mean serum uric acid level among the cases was 5.68 mg/dl and 4.14 mg/dl among the controls. BMI was more than 25 in 51% of the cases and 54% of the controls. Hyperurecemia was present in 37% of the NAFLD cases and 16% of the healthy volunteers. The author concludes that, the increased serum uric acid was demonstrated as risk factor for non alcoholic fatty liver disease.

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7. Screening diabetic patients for non-alcoholic fatty liver disease with controlled attenuation parameter and E score measurements: a prospective cohort study

Journal of Clinical and Experimental Hepatology ◽

10.1016/j.jceh.2018.06.337 ◽

2018 ◽

Vol 8 ◽

pp. S37

Author(s):

Pranav Kumar Raghuwanshi ◽

Sanjay Kumar ◽

Varun Janardan Khandagale ◽

Vinod Narkhede ◽

Satish Kapil ◽

...

Keyword(s):

Cohort Study ◽

Liver Disease ◽

Fatty Liver ◽

Prospective Cohort Study ◽

Prospective Cohort ◽

Fatty Liver Disease ◽

Diabetic Patients ◽

Controlled Attenuation Parameter ◽

Alcoholic Fatty Liver ◽

Alcoholic Fatty Liver Disease

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De novo Portal Vein Thrombosis in Non-Cirrhotic Non-Alcoholic Fatty Liver Disease: A 9-Year Prospective Cohort Study

Frontiers in Medicine ◽

10.3389/fmed.2021.650818 ◽

2021 ◽

Vol 8 ◽

Author(s):

Ahmed Abdel-Razik ◽

Nasser Mousa ◽

Walaa Shabana ◽

Ahmed H. Yassen ◽

Mostafa Abdelsalam ◽

...

Keyword(s):

Cohort Study ◽

Liver Disease ◽

Portal Vein ◽

Fatty Liver ◽

Portal Vein Thrombosis ◽

Prospective Cohort ◽

Fatty Liver Disease ◽

Alcoholic Fatty Liver ◽

Vein Thrombosis ◽

Alcoholic Fatty Liver Disease

Background and Aims: Approximately 30–40% of portal vein thrombosis (PVT) remains of unknown origin. The association between non-alcoholic fatty liver disease (NAFLD) and PVT is a matter of debate. This study aimed to investigate the association between PVT and NAFLD.Methods: We included 94 out of 105 consecutive NAFLD patients in this prospective cohort study in addition to 94 from the healthy control group. We evaluated biochemical, clinical, immunological, and histopathological parameters; waist circumference (WC); leptin; adiponectin; and leptin/adiponectin ratio (LAR) for all participants at baseline and every 3 years thereafter. We described the characteristics of participants at baseline and showed individual WC, LAR, and PVT characteristics. Potential parameters to predict PVT development within 9 years were determined.Results: PVT developed in eight (8.5%) patients, mainly in the portal trunk. Univariate analysis showed three PVT-associated factors: diabetes mellitus (P = 0.013), WC (P < 0.001), and LAR (P = 0.002). After adjusting multiple confounding variables, the multivariate model showed that the only significant variables were WC and LAR. By applying the receiver operating characteristic curve, WC had 98.8% specificity, 87.5% sensitivity, and 0.894 area under the curve (AUC) for prediction of PVT (P < 0.001) at cutoff values of > 105 cm. In comparison, LAR had 60.5% specificity, 87.5% sensitivity, and 0.805 AUC for PVT prediction (P < 0.001) at cutoff values of >7.5.Conclusions: This study suggests that increased central obesity and LAR were independently associated with PVT development in non-cirrhotic NAFLD patients, and they should be considered risk factors that may participate in PVT multifactorial pathogenesis.

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