Reference Intervals for Serum Thyroid-Stimulating Hormone Based on a Recent Nationwide Cross-Sectional Study and Meta-Analysis

ObjectiveThe aim of our study was to compare the reference intervals (RIs) [median (2.5th-97.5th percentiles)] for thyroid-stimulating hormone (TSH) between subgroups stratified by ethnicity and iodine status in a global context.Design and MethodsPrimary data were derived from a recently published cross-sectional study in mainland China. Secondary data were obtained from online databases. The RIs for TSH were calculated in the reference population according to the National Academy of Clinical Biochemistry (NACB) standard and in the disease-free population. A meta-analysis of ethnicity- and iodine status-specific TSH RIs was performed.ResultsThe primary data showed that the TSH RI (mU/L) in the disease-free population was 2.33 (0.67, 7.87), which is wider than the published RI [2.28 (0.74, 7.04)] in the reference population. The meta-analysis showed that whether in the reference or disease-free population, the RIs in Yellows were much higher than those in Caucasians. In the reference population, the median and 2.5th percentile in the iodine-sufficient subgroup were both lower than the iodine-deficient or more-than-adequate subgroup, while the 97.5th percentile showed a positive trend with increasing sufficiency of iodine. However, in the disease-free population, the iodine-sufficient subgroup had a lower median and 97.5th percentile but higher 2.5th percentile than the iodine-deficient subgroup.ConclusionYellows have a higher TSH RI than Caucasians. In the reference population, both the median and 2.5th percentile TSH in the iodine-sufficient population were the lowest among the different iodine status subgroups, while the 97.5th percentile of TSH showed an upward trend with increasing iodine sufficiency.

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Erratum to: Reference intervals for thyroid stimulating hormone and free thyroxine derived from neonates undergoing routine screening for congenital hypothyroidism at a university teaching hospital in Nairobi, Kenya: a cross sectional study

BMC Endocrine Disorders ◽

10.1186/s12902-017-0171-9 ◽

2017 ◽

Vol 17 (1) ◽

Cited By ~ 1

Author(s):

Geoffrey Omuse ◽

Ali Kassim ◽

Francis Kiigu ◽

Syeda Ra’ana Hussain ◽

Mary Limbe

Keyword(s):

Congenital Hypothyroidism ◽

Teaching Hospital ◽

Cross Sectional Study ◽

Reference Intervals ◽

Thyroid Stimulating Hormone ◽

Free Thyroxine ◽

Routine Screening ◽

University Teaching ◽

Sectional Study ◽

Cross Sectional

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Reference intervals for thyroid stimulating hormone and free thyroxine derived from neonates undergoing routine screening for congenital hypothyroidism at a university teaching hospital in Nairobi, Kenya: a cross sectional study

BMC Endocrine Disorders ◽

10.1186/s12902-016-0107-9 ◽

2016 ◽

Vol 16 (1) ◽

Cited By ~ 9

Author(s):

Geoffrey Omuse ◽

Ali Kassim ◽

Francis Kiigu ◽

Syeda Ra’ana Hussain ◽

Mary Limbe

Keyword(s):

Congenital Hypothyroidism ◽

Teaching Hospital ◽

Cross Sectional Study ◽

Reference Intervals ◽

Thyroid Stimulating Hormone ◽

Free Thyroxine ◽

Routine Screening ◽

University Teaching ◽

Sectional Study ◽

Cross Sectional

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Association between metabolic syndrome and thyroid stimulating hormone - A cross sectional study

Medpusle International Journal of Medicine ◽

10.26611/1021922 ◽

2019 ◽

Vol 9 (2) ◽

pp. 87-90

Author(s):

Karanam Madhuri ◽

◽

Rishi Kumar Venkatachalam ◽

A Nasreen Begum ◽

Shamsheer Khan P ◽

...

Keyword(s):

Metabolic Syndrome ◽

Cross Sectional Study ◽

Thyroid Stimulating Hormone ◽

Sectional Study ◽

Cross Sectional ◽

Stimulating Hormone

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Decreased choroidal and scleral thicknesses in highly myopic eyes with posterior staphyloma

Scientific Reports ◽

10.1038/s41598-021-87065-6 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Un Chul Park ◽

Eun Kyoung Lee ◽

Bo Hee Kim ◽

Baek-Lok Oh

Keyword(s):

Choroidal Thickness ◽

Structural Changes ◽

Meta Analysis ◽

Cross Sectional Study ◽

Pathologic Myopia ◽

Sectional Study ◽

Cross Sectional ◽

Swept Source ◽

Posterior Staphyloma ◽

Myopic Maculopathy

AbstractIn this cross-sectional study, we investigated choroidal thickness (CT) and scleral thickness (ST) in highly myopic eyes and their associations with ocular factors. Patients underwent widefield swept-source optical coherence tomography (OCT) to measure the CT and ST at the subfovea and 3000 μm superior, inferior, temporal, and nasal to the fovea and macular curvature. A total of 237 eyes (154 patients) were included. At all five measurement points, thinner CTs and STs were associated with longer axial lengths (r = − 0.548 to − 0.357, all P < 0.001) and greater macular curvatures (r = − 0.542 to − 0.305, all P < 0.001). The CT and ST were significantly thinner in eyes with posterior staphyloma than in those without at all measurement points (all P ≤ 0.006) but did not differ between eyes with the wide macular and narrow macular type of staphyloma. Eyes with myopic maculopathy of category ≥ 3 according to the International Meta-Analysis for Pathologic Myopia classification had significantly thinner CTs and STs than those with category ≤ 2 (all P ≤ 0.005). In highly myopic eyes, a decrease in the CT and ST was more pronounced in eyes with more structural changes, such as longer axial length, steeper macular curvature, and the presence of posterior staphyloma.

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Association between Hyperhomocysteinemia and Thyroid Hormones in Euthyroid Diabetic Subjects

BioMed Research International ◽

10.1155/2015/196379 ◽

2015 ◽

Vol 2015 ◽

pp. 1-5

Author(s):

Yun Zhang ◽

Qiong Wang ◽

Quanzhong Li ◽

Ping Lu

Keyword(s):

Blood Pressure ◽

Fasting Glucose ◽

Cross Sectional Study ◽

Thyroid Stimulating Hormone ◽

Diabetic Patients ◽

Biomedical Data ◽

Sectional Study ◽

Free Triiodothyronine ◽

Cross Sectional ◽

Elderly Males

Objectives. The concept now emerging is that higher thyroid-stimulating hormone (TSH) and lower thyroid hormone levels within the euthyroid range may adversely affect atherosclerosis. The present study aimed to investigate the potential associations between thyroid parameters and hyperhomocysteinaemia in a cohort of euthyroid diabetic subjects.Material and Methods. Two hundred and seventy-three euthyroid diabetic subjects (167 males and 106 females) were consecutively recruited in this cross-sectional study. Clinical and biomedical data was collected.Results. TSH level was higher in females than males. Compared to normal-homocysteine group, hyperhomocysteinaemia group was more likely to be elderly, males, with longer diabetes history, and with lower diastolic blood pressure. Free thyroxine (FT4) level was lower in hyperhomocysteinaemia group than in normal-homocysteine group; however, it was not statistically significant. Adjusted for age, sex, body mass index, duration of diabetes, blood pressure, fasting glucose, total cholesterol, and triglyceride in logistic regression analyses, hyperhomocysteinaemia was significantly correlated with FT4 (P=0.021). No significant association was found with TSH or free triiodothyronine. When analyzed in subjects with TSH < 2.5 uIU/mL separately, we got similar results.Conclusions. In conclusion, we identified a relation between hyperhomocysteinemia and FT4 in a group of euthyroid diabetic patients.

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The association between meat consumption and the metabolic syndrome: a cross-sectional study and meta-analysis

British Journal Of Nutrition ◽

10.1017/s0007114521002452 ◽

2021 ◽

pp. 1-15

Author(s):

Khemayanto Hidayat ◽

Wan-Zhan Zhu ◽

Si-Min Peng ◽

Jin-Jin Ren ◽

Meng-Lan Lu ◽

...

Keyword(s):

Metabolic Syndrome ◽

Fish Consumption ◽

Meta Analysis ◽

Meat Consumption ◽

Cross Sectional Study ◽

Red Meat ◽

Inverse Association ◽

Sectional Study ◽

Cross Sectional ◽

The Metabolic Syndrome

Abstract The findings regarding the associations between red meat, fish and poultry consumption, and the metabolic syndrome (Mets) have been inconclusive, and evidence from Chinese populations is scarce. A cross-sectional study was performed to investigate the associations between red meat, fish and poultry consumption, and the prevalence of the Mets and its components among the residents of Suzhou Industrial Park, Suzhou, China. A total of 4424 participants were eligible for the analysis. A logistic regression model was used to estimate the OR and 95 % CI for the prevalence of the Mets and its components according to red meat, fish and poultry consumption. In addition, the data of our cross-sectional study were meta-analysed under a random effects model along with those of published observational studies to generate the summary relative risks (RR) of the associations between the highest v. lowest categories of red meat, fish and poultry consumption and the Mets and its components. In the cross-sectional study, the multivariable-adjusted OR for the highest v. lowest quartiles of consumption was 1·23 (95 % CI 1·02, 1·48) for red meat, 0·83 (95 % CI 0·72, 0·97) for fish and 0·93 (95 % CI 0·74, 1·18) for poultry. In the meta-analysis, the pooled RR for the highest v. lowest categories of consumption was 1·20 (95 % CI 1·06, 1·35) for red meat, 0·88 (95 % CI 0·81, 0·96) for fish and 0·97 (95 % CI 0·85, 1·10) for poultry. The findings of both cross-sectional studies and meta-analyses indicated that the association between fish consumption and the Mets may be partly driven by the inverse association of fish consumption with elevated TAG and reduced HDL-cholesterol and, to a lesser extent, fasting plasma glucose. No clear pattern of associations was observed between red meat or poultry consumption and the components of the Mets. The current findings add weight to the evidence that the Mets may be positively associated with red meat consumption, inversely associated with fish consumption and neutrally associated with poultry consumption.

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