scholarly journals Innate Lymphoid Cells in Human Pregnancy

2020 ◽  
Vol 11 ◽  
Author(s):  
João Mendes ◽  
Ana Luísa Areia ◽  
Paulo Rodrigues-Santos ◽  
Manuel Santos-Rosa ◽  
Anabela Mota-Pinto
Keyword(s):  
Nk Cells ◽  
Innate Lymphoid Cells ◽  
Adverse Outcomes ◽  
Lymphoid Cells ◽  
Perinatal Medicine ◽  
Effector Cells ◽  
Human Pregnancy ◽  
Group 3 ◽  
Group 2 ◽  
In Pregnancy

Innate lymphoid cells (ILCs) are a new set of cells considered to be a part of the innate immune system. ILCs are classified into five subsets (according to their transcription factors and cytokine profile) as natural killer cells (NK cells), group 1 ILCs, group 2 ILCs, group 3 ILCs, and lymphoid tissue inducers (LTi). Functionally, these cells resemble the T helper population but lack the expression of recombinant genes, which is essential for the formation of T cell receptors. In this work, the authors address the distinction between peripheral and decidual NK cells, highlighting their diversity in ILC biology and its relevance to human pregnancy. ILCs are effector cells that are important in promoting immunity, inflammation, and tissue repair. Recent studies have directed their attention to ILC actions in pregnancy. Dysregulation or expansion of pro-inflammatory ILC populations as well as abnormal tolerogenic responses may directly interfere with pregnancy, ultimately resulting in pregnancy loss or adverse outcomes. In this review, we characterize these cells, considering recent findings and addressing knowledge gaps in perinatal medicine in the context of ILC biology. Moreover, we discuss the relevance of these cells not only to the process of immune tolerance, but also in disease.

scholarly journals NK Cells Alleviate Lung Inflammation by Negatively Regulating Group 2 Innate Lymphoid Cells

2017 ◽  
Vol 198 (8) ◽  
pp. 3336-3344 ◽  
Author(s):  
Jiacheng Bi ◽  
Lulu Cui ◽  
Guang Yu ◽  
Xiaolu Yang ◽  
Youhai Chen ◽  
...  
Keyword(s):  
Nk Cells ◽  
Lung Inflammation ◽  
Innate Lymphoid Cells ◽  
Lymphoid Cells ◽  
Group 2

scholarly journals STAT1 Represses Cytokine-Producing Group 2 and Group 3 Innate Lymphoid Cells during Viral Infection

2017 ◽  
Vol 199 (2) ◽  
pp. 510-519 ◽  
Author(s):  
Matthew T. Stier ◽  
Kasia Goleniewska ◽  
Jacqueline Y. Cephus ◽  
Dawn C. Newcomb ◽  
Taylor P. Sherrill ◽  
...  
Keyword(s):  
Viral Infection ◽  
Innate Lymphoid Cells ◽  
Lymphoid Cells ◽  
Group 3 ◽  
Group 2

scholarly journals IL-12 drives functional plasticity of human group 2 innate lymphoid cells

2016 ◽  
Vol 213 (4) ◽  
pp. 569-583 ◽  
Author(s):  
Ai Ing Lim ◽  
Silvia Menegatti ◽  
Jacinta Bustamante ◽  
Lionel Le Bourhis ◽  
Matthieu Allez ◽  
...  
Keyword(s):  
Ex Vivo ◽  
Human Peripheral Blood ◽  
Innate Lymphoid Cells ◽  
Lymphoid Cells ◽  
Functional Plasticity ◽  
Effector Cells ◽  
Ifn Γ ◽  
Group 2 ◽  
Innate Effector

Group 2 innate lymphoid cells (ILC2) include IL-5– and IL-13–producing CRTh2+CD127+ cells that are implicated in early protective immunity at mucosal surfaces. Whereas functional plasticity has been demonstrated for both human and mouse ILC3 subsets that can reversibly give rise to IFN-γ–producing ILC1, plasticity of human or mouse ILC2 has not been shown. Here, we analyze the phenotypic and functional heterogeneity of human peripheral blood ILC2. Although subsets of human CRTh2+ ILC2 differentially express CD117 (c-kit receptor), some ILC2 surface phenotypes are unstable and can be modulated in vitro. Surprisingly, human IL-13+ ILC2 can acquire the capacity to produce IFN-γ, thereby generating plastic ILC2. ILC2 cultures demonstrated that IFN-γ+ ILC2 clones could be derived and were stably associated with increased T-BET expression. The inductive mechanism for ILC2 plasticity was mapped to the IL-12–IL-12R signaling pathway and was confirmed through analysis of patients with Mendelian susceptibility to mycobacterial disease due to IL-12Rβ1 deficiencies that failed to generate plastic ILC2. We also detected IL-13+IFN-γ+ ILC2 ex vivo in intestinal samples from Crohn’s disease patients. These results demonstrate cytokine production plasticity for human ILC2 and further suggest that environmental cues can dictate ILC phenotype and function for these tissue-resident innate effector cells.

scholarly journals Therapeutic Potential of Innate Lymphoid Cells for Multiple Myeloma Therapy

Cancers ◽  
2021 ◽  
Vol 13 (19) ◽  
pp. 4806
Author(s):  
Aneta Szudy-Szczyrek ◽  
Sean Ahern ◽  
Magdalena Kozioł ◽  
Daria Majowicz ◽  
Michał Szczyrek ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Therapeutic Potential ◽  
Antitumour Activity ◽  
Specific Antigen ◽  
Innate Lymphoid Cells ◽  
Lymphoid Cells ◽  
Group 3 ◽  
Group 2 ◽  
Group 1

Innate lymphoid cells (ILCs) are a recently identified family of lymphocyte-like cells lacking a specific antigen receptor. They are part of the innate immune system. They play a key role in tissue homeostasis and also control inflammatory and neoplastic processes. In response to environmental stimuli, ILCs change their phenotype and functions, and influence the activity of other cells in the microenvironment. ILC dysfunction can lead to a wide variety of diseases, including cancer. ILC can be divided into three subgroups: ILC Group 1, comprising NK cells and ILC1; Group 2, including ILC2 alone; and Group 3, containing Lymphoid Tissue inducers (LTi) and ILC3 cells. While Group 1 ILCs mainly exert antitumour activity, Group 2 and Group 3 ILCs are protumorigenic in nature. A growing body of preclinical and clinical data support the role of ILCs in the pathogenesis of multiple myeloma (MM). Therefore, targeting ILCs may be of clinical benefit. In this manuscript, we review the available data on the role of ILCs in MM immunology and therapy.

scholarly journals IL-33 promotes the egress of group 2 innate lymphoid cells from the bone marrow

2017 ◽  
Vol 215 (1) ◽  
pp. 263-281 ◽  
Author(s):  
Matthew T. Stier ◽  
Jian Zhang ◽  
Kasia Goleniewska ◽  
Jacqueline Y. Cephus ◽  
Mark Rusznak ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Critical Role ◽  
Allergic Inflammation ◽  
Allergen Challenge ◽  
Innate Lymphoid Cells ◽  
Lymphoid Cells ◽  
Effector Cells ◽  
Group 2 ◽  
Fungal Allergen ◽  
Key Participants

Group 2 innate lymphoid cells (ILC2s) are effector cells within the mucosa and key participants in type 2 immune responses in the context of allergic inflammation and infection. ILC2s develop in the bone marrow from common lymphoid progenitor cells, but little is known about how ILC2s egress from the bone marrow for hematogenous trafficking. In this study, we identified a critical role for IL-33, a hallmark peripheral ILC2-activating cytokine, in promoting the egress of ILC2 lineage cells from the bone marrow. Mice lacking IL-33 signaling had normal development of ILC2s but retained significantly more ILC2 progenitors in the bone marrow via augmented expression of CXCR4. Intravenous injection of IL-33 or pulmonary fungal allergen challenge mobilized ILC2 progenitors to exit the bone marrow. Finally, IL-33 enhanced ILC2 trafficking to the lungs in a parabiosis mouse model of tissue disruption and repopulation. Collectively, these data demonstrate that IL-33 plays a critical role in promoting ILC2 egress from the bone marrow.

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