scholarly journals Abnormal Coagulation Function of Patients With COVID-19 Is Significantly Related to Hypocalcemia and Severe Inflammation

2021 ◽  
Vol 8 ◽  
Author(s):  
Xu Qi ◽  
Hui Kong ◽  
Wenqiu Ding ◽  
Chaojie Wu ◽  
Ningfei Ji ◽  
...  
Keyword(s):  
Infectious Disease ◽  
Blood Coagulation ◽  
Ct Images ◽  
Inflammatory Factors ◽  
Infectious Disease Hospital ◽  
X Ray ◽  
Coagulation Function ◽  
Disease Hospital ◽  
Coagulation Dysfunction ◽  
D Dimer

This study aimed to detect, analyze, and correlate the clinical characteristics, blood coagulation functions, blood calcium levels, and inflammatory factors in patients with mild and severe COVID-19 infections. The enrolled COVID-19 infected patients were from Wuhan Jin Yin-tan Hospital (17 cases, Wuhan, China), Suzhou Infectious Disease Hospital (87 cases, Suzhou, China), and Xuzhou Infectious Disease Hospital (14 cases, Xuzhou, China). After admission, basic information was collected; X-ray and chest CT images were obtained; and data from routine blood tests, liver and kidney function, myocardial enzymes, electrolytes, blood coagulation function, (erythrocyte sedimentation rate) ESR, C-reactive protein (CRP), IL-6, procalcitonin (PCT), calcitonin, and other laboratory tests were obtained. The patients were grouped according to the clinical classification method based on the pneumonia diagnosis and treatment plan for new coronavirus infection (trial version 7) in China. The measurements from mild (56 cases) and severe cases (51 cases) were compared and analyzed. Most COVID-19 patients presented with fever. Chest X-ray and CT images showed multiple patchy and ground glass opacities in the lungs of COVID 19 infected patients, especially in patients with severe cases. Compared with patients with mild infection, patients with severe infection were older (p = 0.023) and had a significant increase in AST and BUN. The levels of CK, LDH, CK-MB, proBNP, and Myo in patients with severe COVID-19 infection were also increased significantly compared to those in patients with mild cases. Patients with severe COVID-19 infections presented coagulation dysfunction and increased D-dimer and fibrin degradation product (FDP) levels. Severe COVID-19 patients had low serum calcium ion (Ca2+) concentrations and high calcitonin and PCT levels and exhibited serious systemic inflammation. Ca2+ in COVID-19 patients was significantly negatively correlated with PCT, calcitonin, D-dimer, PFDP, ESR, CRP and IL-6. D-dimer in COVID-19 patients was a significantly positively correlated with CRP and IL-6. In conclusion, patients with severe COVID-19 infection presented significant metabolic dysfunction and abnormal blood coagulation, a sharp increase in inflammatory factors and calcitonin and procalcitonin levels, and a significant decrease in Ca2+. Decreased Ca2+ and coagulation dysfunction in COVID-19 patients were significantly correlated with each other and with inflammatory factors.

scholarly journals Clinical Mortality Review of COVID-19 Patients at Sukraraj Tropical and Infectious Disease Hospital, Nepal; A Retrospective Study

2021 ◽  
Vol 6 (3) ◽  
pp. 137
Author(s):  
Anup Bastola ◽  
Sanjay Shrestha ◽  
Richa Nepal ◽  
Kijan Maharjan ◽  
Bikesh Shrestha ◽  
...  
Keyword(s):  
Infectious Disease ◽  
Hospital Stay ◽  
Secondary Infection ◽  
Treatment Strategies ◽  
Chronic Obstructive ◽  
Female Ratio ◽  
Infectious Disease Hospital ◽  
Neutrophil Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Disease Hospital

Coronavirus Disease 2019 (COVID-19) has challenged the health system worldwide, including the low and middle income countries like Nepal. In view of the rising number of infections and prediction of multiple waves of this disease, mortalities due to COVID-19 need to be critically analyzed so that every possible effort could be made to prevent COVID-19 related mortalities in future. Main aim of this research was to study about the mortalities due to COVID-19 at a tertiary level hospital, in Nepal. This was a retrospective, observational study that included all inpatients from Sukraraj Tropical and Infectious Disease Hospital, who were reverse transcriptase polymerase chain reaction positive for SARS-COV-2 and died during hospital stay from January 2020 till January 2021. Medical records of the patients were evaluated. Out of 860 total admissions in a year, there were 50 mortalities in the study center. Out of 50 mortalities, majority were males (76%) with male to female ratio of 3.17:1. Most were above 65 years of age (72%) and had two or more comorbidities (64%). The most common comorbidities among the patients who had died during hospital stay were hypertension (58%) followed by diabetes mellitus (50%) and chronic obstructive airway disease (24%). The median duration from the symptom onset to death was 18 days, ranged from the minimum of 2 days till maximum of 39 days. D-dimer was found to be >1 mg/L in 58% cases and ferritin was >500 ng/ml in 42% patients at presentation. A total of 42% patients had thrombocytopenia, 80% patients had lymphocytopenia and 60% had Neutrophil to Lymphocyte ratio >11.75 with the mean NLR of 18.38. Of total mortalities, 16% patients also showed microbiological evidence of secondary infection; Male gender, age more than 65 years, multiple comorbidities with lymphocytopenia, elevated Neutrophil lymphocyte ratio and elevated inflammatory markers were risk factors found in majority of mortalities in our study. These findings could be utilized for early triage and risk assessment in COVID-19 patients so that aggressive treatment strategies could be employed at the earliest to reduce mortalities due to COVID-19 in future.

scholarly journals Establishment and Application of Hospital BIM Based on Point Cloud and Image Fusion for Infectious Disease (Novel Corona Virus Pneumonia)

CONVERTER ◽  
2021 ◽  
pp. 46-52
Author(s):  
Guizhen He, Jun Yang, Qixiang Nie
Keyword(s):  
Infectious Disease ◽  
High Precision ◽  
Point Cloud ◽  
Texture Mapping ◽  
Hospital Infection ◽  
Infectious Disease Hospital ◽  
The Real ◽  
Processing Level ◽  
Disease Hospital ◽  
Whole Life Cycle

Since neither a single high-precision 3D coordinate laser point cloud nor a oblique image of high-precision spectral information can make the computer understand the data as human, in order to accurately and completely understand the object in the real world, in this paper, the fusion of the point cloud and the oblique image is studied for the understanding and application of the real object buildings by establishing a BIM model. Firstly, point cloud data and image data are acquired by different data acquisition methods. Laser point cloud and oblique image are fused by installation parameters so that geometric elements are consistent and benchmark is unified. Processing level is not limited to element level only, so as to ensure the integrity of information, and the fused mutual information remains consistent in scale, texture and direction. Secondly, under the condition of space-time synchronization, the relationship between point cloud and image in geometric space is established, and the alternating "energy transfer" is used for shape prediction and visual filling by matching under texture mapping constraints to enhance the semantic information of the 3D scene. Finally, a 3D building information model is established. Using the experimental results to track the whole life cycle (design, construction, operation) in real time saves the cost of building rework, reduces the building cycle, and improves the building accuracy. Especially based on BIM during Novel Coronavirus Pneumonia: analyze hospital space resource management and elastic function; construct medical unit model of infectious disease hospital; simulate and optimize medical process in infectious disease hospital; rapidly construct prefabricated infectious disease emergency hospital; simulate hospital infection path and dynamics; the auxiliary design and construction of infectious disease treatment in existing hospitals; The monitoring analysis and automatic control of hospital infection safety operation.

scholarly journals A Retrospective Analysis of the Coagulation Dysfunction in COVID-19 Patients

2020 ◽  
Vol 26 ◽  
pp. 107602962096486
Author(s):  
Xu Chen ◽  
Qinghua Wang ◽  
Min Xu ◽  
Chengbin Li
Keyword(s):  
Prothrombin Time ◽  
Retrospective Analysis ◽  
Sensitivity And Specificity ◽  
Area Under The Curve ◽  
Thrombin Time ◽  
Coagulation Function ◽  
Severe Group ◽  
New Biomarkers ◽  
Coagulation Dysfunction ◽  
D Dimer

To discuss the coagulation dysfunction in COVID-19 patients and to find new biomarkers to separate severe COVID-19 patients from mild ones. We use a retrospective analysis of 88 COVID-19 patients, and compare the coagulation function between severe and mild groups. We found the prothrombin time (PT), thrombin time (TT), D-dimer were significantly higher in the severe group ( P < 0.05), and the highest area under the curve (AUC) is 0.91 for D-dimer, while the AUC of PT and TT were 0.80 and 0.61 respectively. We identified that D-dimer has a better value in predicting patients who are likely to develop into severe cases, with the sensitivity and specificity were 84.4% and 88.8%, respectively. D-dimer may be a good biomarker to separate the severe COVID-19 patients from the mild ones.

Five-year (January 2004–December 2008) surveillance on animal bite and rabies vaccine utilization in the Infectious Disease Hospital, Dhaka, Bangladesh

Vaccine ◽  
2011 ◽  
Vol 29 (5) ◽  
pp. 1036-1040 ◽  
Author(s):  
Moazzem Hossain ◽  
Tania Bulbul ◽  
Kamruddin Ahmed ◽  
Ziauddin Ahmed ◽  
Mohammad Salimuzzaman ◽  
...  
Keyword(s):  
Infectious Disease ◽  
Rabies Vaccine ◽  
Infectious Disease Hospital ◽  
Disease Hospital

scholarly journals Prevalence of HBV and HIV coinfection from an infectious disease hospital in Mumbai

2014 ◽  
Vol 14 (S3) ◽  
Author(s):  
Jayanthi Shastri ◽  
Nita Gangurde ◽  
Manish Pathak ◽  
Sandhya Sawant ◽  
Sachee Agrawal
Keyword(s):  
Infectious Disease ◽  
Infectious Disease Hospital ◽  
Hiv Coinfection ◽  
Disease Hospital
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