scholarly journals Case Report: Genomic Characteristics of the First Known Case of SARS-CoV-2 Imported From Spain to Sichuan, China

2021 ◽  
Vol 8 ◽  
Author(s):  
Chao Liu ◽  
Bin Tang ◽  
Can Gao ◽  
Jianjun Deng ◽  
Min Shen ◽  
...  

The pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been basically under control in China since March 2020, but the import of domestic SARS-CoV-2 has begun to increase. This study reported the first case of asymptomatic SARS-CoV-2 infection imported from Spain into Sichuan Province, China, on March 11, 2020. The infected male had a body temperature of 37.5°C, normal blood oxygen saturation levels, and a computed tomography (CT) examination showed that his lungs had no shadows. However, a throat swab from the subject tested positive for SARS-CoV-2 using qPCR assay. In this study, we conducted transcriptome sequencing on respiratory throat swabs from the subject and found that the dominant SARS-CoV-2 sequence (Gene Bank ID: MW301121) was a spike protein D614G mutant strain, which is currently popular throughout world. We downloaded and analyzed SARS-CoV-2 sequences collected from cases in China and Spain for comparison and tracing purposes. After March 11, 2020, the Chinese domestic clade was naturally divided into the imported SARS-CoV-2 D614G mutant strain and evolutionarily-related similar sequences and that of sequences collected in the original Wuhan area. The sequence reported in this study was located on a small branch, far from the evolution of Wuhan sequences. As expected, the identified sequence was closely related to the evolution of the SARS-CoV-2 D614G mutant strain circulating in Spain.

2020 ◽  
Vol 98 (Supplement_4) ◽  
pp. 422-422
Author(s):  
Rebecca L Moore ◽  
Cierrah J Kassetas ◽  
Leslie A LeKatz ◽  
Bryan W Neville

Abstract One hundred and twenty-six yearling angus steers (initial body weight 445.87 ± 7.13 kg) were utilized in a 2 x 2 factorial design to evaluate the impacts of bunk management and modified distillers grains plus solubles (mDGS) inclusion on feedlot performance, hydrogen sulfide concentrations and blood oxygen saturation. Treatments included bunk management strategy either control bunk management (CON; clean bunks at the time of next day’s feeding) or long bunk management (LONG; feed remaining at time of next day’s feeding), and two inclusion rates of mDGS either 25% or 50% (DM Basis). On d 0, 7, 14, 21, 28 and 35 rumen gas samples were collected via rumenocentesis, and arterial blood samples were collected on two steers from each pen. No differences (P ≥ 0.09) were observed for dry matter intake, average daily gain and gain-to-feed ratio for bunk management or mDGS inclusion. Hot carcass weight, ribeye area, marbling score and quality grade were not affected (P ≥ 0.48) by either bunk management or mDGS inclusion. Back fat was greater (P = 0.04) for CON steers compared to LONG (1.30 vs 1.12 ± 0.05cm, respectively), but was not affected (P = 0.59) by mDGS inclusion. Steers on CON had greater (P = 0.03) yield grades compared to LONG (3.21 vs 2.96 ± 0.11, respectively). Bunk management strategy did not impact hydrogen sulfide concentrations or blood oxygen saturation (P = 0.82). Hydrogen sulfide concentrations increased (P < 0.001) with increasing mDGS inclusion. Blood oxygen saturation was influenced by day of sampling (P = 0.01). Blood oxygen saturation was not affected (P = 0.07) by mDGS inclusion. The fact that ruminal hydrogen sulfide concentrations increased while blood oxygen saturation remained similar raises questions about the quantity of hydrogen sulfide and metabolic fate of excess hydrogen sulfide in the blood of ruminant animals.


Biofeedback ◽  
2012 ◽  
Vol 40 (4) ◽  
pp. 137-141 ◽  
Author(s):  
Christopher Gilbert

Small pulse oximeters have become widely available and can be useful for noninvasive monitoring of blood oxygen saturation by nonmedical personnel. When training control of breathing, an oximeter helps to reassure clients who hyperventilate that their oxygenation is adequate, offsetting their perception that they are not getting enough air. Low saturation may indicate a medical condition that impairs oxygen absorption. In that case, hyperventilation is a biological compensation that should not be tampered with.


2017 ◽  
Vol 17 (12) ◽  
pp. 3900-3908 ◽  
Author(s):  
Deepak Mishra ◽  
Neha Priyadarshini ◽  
Supriya Chakraborty ◽  
Mukul Sarkar

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Satoko Kakino ◽  
Shinya Kushibiki ◽  
Azusa Yamada ◽  
Zenzo Miwa ◽  
Yuzo Takagi ◽  
...  

The applicability of arterial pulse oximetry to dental pulp was demonstrated using in vitro and in vivo measurements. First, porcine blood of known oxygen saturation (SO2) was circulated through extracted human upper incisors, while transmitted-light plethysmography was performed using three different visible wavelengths. From the light intensity waveforms measured in vitro, a parameter that is statistically correlated to SO2 was calculated using the pulsatile/nonpulsatile component ratios of two wavelengths for different SO2. Then, values were measured in vivo for living incisors, and the corresponding SO2 values were calculated using the results of in vitro measurements. The estimated SO2 values of the upper central incisors measured in vivo were from 71.0 to 92.7%. This study showed the potential to measure the oxygen saturation changes to identify the sign of pulpal inflammation.


Author(s):  
Matthew E. Funke ◽  
Joel S. Warm ◽  
Gerald Matthews ◽  
Michael Riley ◽  
Victor Finomore ◽  
...  

2021 ◽  
Vol 2 (1) ◽  
pp. 38-43
Author(s):  
Abdullajon Komilov ◽  
◽  
Madinabonu Sultonova ◽  
Durdona Orifjonova

Today, the COVID-19 pandemic is one of the most pressing problems facing humanity. Therefore, reducing the population's level of infection with this virus is one of our government's main tasks.Therefore, it is necessary to isolate patients with chronic diseases as much as possible. Clients are more likely to be infected with caronavirus due to their age and the presence of underlying medical conditions.Limiting direct contact between such patients and observing healthcare professionals significantly reduces the patient's chances of contracting caronavirus.The article proposes a device design that allows for remote automatic monitoring of patients' condition being treated at home by an observing medical professional.With the proposed device's help, the patient's blood oxygen saturation level is automatically and remotely controlled. The device is built on an Arduino board.The use of the device greatly reduces the likelihood of contracting caronavirus in patients receiving home treatment.This could be one of the most important decisions in maintaining the health of the population today.


2015 ◽  
Vol 27 (01) ◽  
pp. 1550004 ◽  
Author(s):  
Audrey K. C. Huong ◽  
Xavier T. I. Ngu

We present the use of Extended Modified Lambert–Beer model for optical monitoring of mean blood oxygen saturation ( S m O 2) via a fitting procedure. This work focuses on the absorption characteristics of hemoglobin derivatives in the wavelength range of 520–600 nm to give the best estimates of S m O 2. The study of the feasibility of applying this analytic method to skin oximetry is via spectroscopy data collected from fingertips of four healthy volunteers both at rest and during arterial blood occlusion condition. The results revealed a decrease in the mean of mean and standard deviation of S m O 2 value of fingertips from 94.5 ± 2.19% when volunteers were at rest to 56.76 ± 5.8% during the arterial blood occlusion measurement. The larger variation in the value estimated for blood occlusion condition could be a result of differences in volunteers' physical fitness and hypertension status. These estimated S m O 2 values agreed reasonably well with the value reported in most of the previous studies. This work concluded that the proposed technique can potentially be used as a complementary technique to clinical assessment of skin grafts and burnt skin.


2015 ◽  
Vol 77 (7) ◽  
Author(s):  
Sheena P. Philimon ◽  
Audrey K. C. Huong ◽  
Xavier T. I. Ngu

This paper presents the use of Extended Modified Lambert Beer (EMLB) model for quantification of transcutaneous blood oxygen saturation (StO2) via a noninvasive approach. Continuous wave (CW) reflectance spectroscopy system is employed for measurement of intensity reflected from left index finger of an Asian nonsmoking volunteer at resting condition. Multispectral images captured in the wavelength range of 520 − 600 nm at an interval of 10 nm are mathematically analyzed and fitted using the developed fitting algorithm to give the best estimation of StO2. The result from this preliminary study revealed a mean StO2 value of 75 ± 5% for the participating individual, which value agreed considerably well with that presented in previous works. This work concluded that the developed spectroscopy system and quantification technique can potentially be used as an alternative means to clinical assessment of wound healing progress


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