scholarly journals Alterations of Electrophysiological Properties and Ion Channel Expression in Prefrontal Cortex of a Mouse Model of Schizophrenia

2019 ◽  
Vol 13 ◽  
Author(s):  
Zhen Mi ◽  
Jun Yang ◽  
Quansheng He ◽  
Xiaowen Zhang ◽  
Yujie Xiao ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Mouse Model ◽  
Ion Channel ◽  
Electrophysiological Properties ◽  
Channel Expression

scholarly journals Cardiac Transmembrane Ion Channels and Action Potentials: Cellular Physiology and Arrhythmogenic Behavior

2020 ◽  
Author(s):  
András Varró ◽  
Jakub Tomek ◽  
Norbert Nagy ◽  
Laszlo Virag ◽  
Elisa Passini ◽  
...  
Keyword(s):  
Ion Channel ◽  
Action Potentials ◽  
Cardiac Electrophysiology ◽  
Current Knowledge ◽  
Animal Experiments ◽  
Cardiac Cells ◽  
Cellular Mechanisms ◽  
Electrophysiological Properties ◽  
Channel Expression ◽  
Ionic Mechanisms

Cardiac arrhythmias are among the leading causes of mortality. They often arise from alterations in the electrophysiological properties of cardiac cells, and their underlying ionic mechanisms. It is therefore critical to further unravel the patho-physiology of the ionic basis of human cardiac electrophysiology in health and disease. In the first part of this review, current knowledge on the differences in ion channel expression and properties of the ionic processes that determine the morphology and properties of cardiac action potentials and calcium dynamics from cardiomyocytes in different regions of the heart are described. Then the cellular mechanisms promoting arrhythmias in congenital or acquired conditions of ion channel function (electrical remodelling) are discussed. The focus is human relevant findings obtained with clinical, experimental and computational studies, given that interspecies differences make the extrapolation from animal experiments to the human clinical settings difficult. Deepening the understanding of the diverse patholophysiology of human cellular electrophysiology will help developing novel and effective antiarrhythmic strategies for specific subpopulations and disease conditions.

Changes in ion channel expression and function associated with cardiac arrhythmogenic remodeling by Sorbs2

2021 ◽  
Vol 1867 (12) ◽  
pp. 166247
Author(s):  
Ling-Ling Qian ◽  
Xiaojing Sun ◽  
Jingchun Yang ◽  
Xiao-Li Wang ◽  
Michael J. Ackerman ◽  
...  
Keyword(s):  
Ion Channel ◽  
Channel Expression ◽  
And Function

scholarly journals Ion channel expression patterns in glioblastoma stem cells with functional and therapeutic implications for malignancy

PLoS ONE ◽  
2017 ◽  
Vol 12 (3) ◽  
pp. e0172884 ◽  
Author(s):  
Julia Pollak ◽  
Karan G. Rai ◽  
Cory C. Funk ◽  
Sonali Arora ◽  
Eunjee Lee ◽  
...  
Keyword(s):  
Stem Cells ◽  
Ion Channel ◽  
Expression Patterns ◽  
Glioblastoma Stem Cells ◽  
Therapeutic Implications ◽  
Channel Expression

A role for substance P and acid-sensing ion channel 1a in prolotherapy with dextrose-mediated analgesia in a mouse model of chronic muscle pain

Pain ◽  
2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Der-Sheng Han ◽  
Cheng-Han Lee ◽  
Yih-Dar Shieh ◽  
Chu-Ting Chang ◽  
Min-Hsuan Li ◽  
...  
Keyword(s):  
Substance P ◽  
Mouse Model ◽  
Ion Channel ◽  
Muscle Pain ◽  
Chronic Muscle Pain
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