scholarly journals Gamma Band Oscillations Reflect Sensory and Affective Dimensions of Pain

2022 ◽  
Vol 12 ◽  
Author(s):  
Yuanyuan Lyu ◽  
Francesca Zidda ◽  
Stefan T. Radev ◽  
Hongcai Liu ◽  
Xiaoli Guo ◽  
...  
Keyword(s):  
Pain Intensity ◽  
Pain Perception ◽  
Emotional Valence ◽  
Gamma Band ◽  
Emotional Modulation ◽  
Time Frequency ◽  
Dimensions Of Pain ◽  
Gamma Band Oscillations ◽  
Cortical Distribution ◽  
Pain Unpleasantness

Pain is a multidimensional process, which can be modulated by emotions; however, the mechanisms underlying this modulation are unknown. We used pictures with different emotional valence (negative, positive, and neutral) as primes and applied electrical painful stimuli as targets to healthy participants. We assessed pain intensity and unpleasantness ratings and recorded electroencephalograms (EEGs). We found that pain unpleasantness and not pain intensity ratings were modulated by emotion, with increased ratings for negative and decreased ratings for positive pictures. We also found two consecutive gamma band oscillations (GBOs) related to pain processing from time frequency analyses of the EEG signals. The early GBO had a cortical distribution contralateral to the painful stimulus and its amplitude was positively correlated with intensity and unpleasantness ratings, but not with prime valence. The late GBO had a centroparietal distribution and its amplitude was larger for negative compared to neutral and positive pictures. The emotional modulation effect (negative vs. positive) of the late GBO amplitude was positively correlated with pain unpleasantness. The early GBO might reflect the overall pain perception, possibly involving the thalamocortical circuit, while the late GBO might be related to the affective dimension of pain and top-down-related processes.

89. GAMMA-band oscillations: A direct and mandatory correlation of subjective pain intensity

2017 ◽  
Vol 128 (12) ◽  
pp. e436
Author(s):  
K. Ricci ◽  
E. Vecchio ◽  
M. Delussi ◽  
A. Montemurno ◽  
E. Gentile ◽  
...  
Keyword(s):  
Pain Intensity ◽  
Gamma Band ◽  
Subjective Pain ◽  
Gamma Band Oscillations

scholarly journals Emotional Components of Pain Perception in Borderline Personality Disorder and Major Depression—A Repetitive Peripheral Magnetic Stimulation (rPMS) Study

2020 ◽  
Vol 10 (12) ◽  
pp. 905
Author(s):  
Kathrin Malejko ◽  
André Huss ◽  
Carlos Schönfeldt-Lecuona ◽  
Maren Braun ◽  
Heiko Graf
Keyword(s):  
Borderline Personality Disorder ◽  
Major Depression ◽  
Personality Disorder ◽  
Magnetic Stimulation ◽  
Pain Perception ◽  
Emotional Valence ◽  
Borderline Personality ◽  
Emotional Modulation ◽  
Cutaneous Sensation ◽  
Affective Components

Various studies suggested alterations in pain perception in psychiatric disorders, such as borderline personality disorder (BPD) and major depression (MD). We previously investigated affective components of pain perception in BPD compared to healthy controls (HC) by increasing aversive stimulus intensities using repetitive peripheral magnetic stimulation (rPMS) and observed alterations in emotional rather than somatosensory components in BPD. However, conclusions on disorder specific alterations in these components of pain perception are often limited due to comorbid depression and medication in BPD. Here, we compared 10 patients with BPD and comorbid MD, 12 patients with MD without BPD, and 12 HC. We applied unpleasant somatosensory stimuli with increasing intensities by rPMS and assessed pain threshold (PT), cutaneous sensation, emotional valence, and arousal by a Self-Assessments Manikins scale. PTs in BPD were significantly higher compared to HC. The somatosensory discrimination of stimulus intensities did not differ between groups. Though elevated rPMS intensities led to increased subjective aversion and arousal in MD and HC, these emotional responses among intensity levels remained unchanged in BPD. Our data give further evidence for disorder-specific alterations in emotional components of pain perception in BPD with an absent emotional modulation among varying aversive intensity levels.

Pain perception in chronic knee osteoarthritis with varying levels of pain inhibitory control: an exploratory study

2020 ◽  
Vol 20 (4) ◽  
pp. 651-661
Author(s):  
Paulo E. P. Teixeira ◽  
Hanan I. Zehry ◽  
Swapnali Chaudhari ◽  
Laura Dipietro ◽  
Felipe Fregni
Keyword(s):  
Knee Osteoarthritis ◽  
Pain Intensity ◽  
Pain Perception ◽  
Small Sample Size ◽  
Linear Regression Analysis ◽  
Small Sample ◽  
Pain Modulation ◽  
Clinical Variables ◽  
Pain Scores ◽  
Intensity Perception

AbstractBackground and aimsPain is a disabling symptom in knee osteoarthritis (KOA) and its underlying mechanism remains poorly understood. Dysfunction of descending pain modulatory pathways and reduced pain inhibition enhance pain facilitation in many chronic pain syndromes but do not fully explain pain levels in chronic musculoskeletal conditions. The objective of this study is to explore the association of clinical variables with pain intensity perception in KOA individuals with varying levels of Conditioned Pain Modulation (CPM) response.MethodsThis is a cross-sectional, exploratory analysis using baseline data of a randomized clinical trial investigating the effects of a non-invasive brain stimulation treatment on the perception of pain and functional limitations due to KOA. Sixty-three subjects with KOA were included in this study. Data on pain perception, mood perception, self-reported depression, physical function, quality of life, and quantitative sensory testing was collected. Multiple linear regression analysis was performed to explore the association between the clinical variables with pain perception for individuals with different levels of CPM response.ResultsFor KOA patients with limited CPM response, perception of limitations at work/other activities due to emotional problems and stress scores were statistically significantly associated with pain scores, F(2, 37) = 7.02, p < 0.01. R-squared = 0.275. For KOA patients with normal CPM response, general health perception scores were statistically significantly associated with pain scores, F(1, 21) = 5.60, p < 0.05. R-squared = 0.2104. Limitations of this study include methodology details, small sample size and study design characteristics.ConclusionsPain intensity perception is associated differently with clinical variables according to the individual CPM response. Mechanistic models to explain pain perception in these two subgroups of KOA subjects are discussed.

Neurobiology of REM Sleep, NREM Sleep Homeostasis, and Gamma Band Oscillations

2017 ◽  
pp. 55-77 ◽  
Author(s):  
James T. McKenna ◽  
Mark R. Zielinski ◽  
Robert W. McCarley
Keyword(s):  
Rem Sleep ◽  
Nrem Sleep ◽  
Gamma Band ◽  
Sleep Homeostasis ◽  
Gamma Band Oscillations

scholarly journals Low-frequency alternating current stimulation rhythmically suppresses gamma-band oscillations and impairs perceptual performance

NeuroImage ◽  
2019 ◽  
Vol 184 ◽  
pp. 440-449 ◽  
Author(s):  
Jim D. Herring ◽  
Sophie Esterer ◽  
Tom R. Marshall ◽  
Ole Jensen ◽  
Til O. Bergmann
Keyword(s):  
Low Frequency ◽  
Alternating Current ◽  
Gamma Band ◽  
Perceptual Performance ◽  
Gamma Band Oscillations

scholarly journals Early Changes in Pain Acceptance Predict Pain Outcomes in Interdisciplinary Treatment for Chronic Pain

2019 ◽  
Vol 8 (9) ◽  
pp. 1373 ◽  
Author(s):  
Probst ◽  
Jank ◽  
Dreyer ◽  
Seel ◽  
Wagner ◽  
...  
Keyword(s):  
Chronic Pain ◽  
Pain Intensity ◽  
Pain Perception ◽  
Rating Scale ◽  
Post Treatment ◽  
Interdisciplinary Treatment ◽  
Binary Logistic Regression Analysis ◽  
Pain Acceptance ◽  
Pain Outcomes ◽  
The Impact

Studies have shown that pain acceptance is associated with a better pain outcome. The current study explored whether changes in pain acceptance in the very early treatment phase of an interdisciplinary cognitive-behavioral therapy (CBT)-based treatment program for chronic pain predict pain outcomes. A total of 69 patients with chronic, non-malignant pain (at least 6 months) were treated in a day-clinic for four-weeks. Pain acceptance was measured with the Chronic Pain Acceptance Questionnaire (CPAQ), pain outcomes included pain intensity (Numeric Rating Scale, NRS) as well as affective and sensory pain perception (Pain Perception Scale, SES-A and SES-S). Regression analyses controlling for the pre-treatment values of the pain outcomes, age, and gender were performed. Early changes in pain acceptance predicted pain intensity at post-treatment measured with the NRS (B = −0.04 (SE = 0.02); T = −2.28; p = 0.026), affective pain perception at post-treatment assessed with the SES-A (B = −0.26 (SE = 0.10); T = −2.79; p = 0.007), and sensory pain perception at post-treatment measured with the SES-S (B = -0.19 (SE = 0.08); T = -2.44; p = 0.017) . Yet, a binary logistic regression analysis revealed that early changes in pain acceptance did not predict clinically relevant pre-post changes in pain intensity (at least 2 points on the NRS). Early changes in pain acceptance were associated with pain outcomes, however, the impact was beneath the threshold defined as clinically relevant.

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