scholarly journals Vaccine Induced Immune Thrombotic Thrombocytopenia Causing a Severe Form of Cerebral Venous Thrombosis With High Fatality Rate: A Case Series

2021 ◽  
Vol 12 ◽  
Author(s):  
Markus Wiedmann ◽  
Thor Skattør ◽  
Arne Stray-Pedersen ◽  
Luis Romundstad ◽  
Ellen-Ann Antal ◽  
...  
Keyword(s):  
Venous Thrombosis ◽  
Cerebral Venous Thrombosis ◽  
Clinical Course ◽  
Fatal Outcome ◽  
Case Series ◽  
Severe Form ◽  
Clinical Syndrome ◽  
Fatality Rate ◽  
High Fatality Rate ◽  
Progression Of Disease

During a 2-week period, we have encountered five cases presenting with the combination of cerebral venous thrombosis (CVT), intracerebral hemorrhage and thrombocytopenia. A clinical hallmark was the rapid and severe progression of disease in spite of maximum treatment efforts, resulting in fatal outcome in for 4 out of 5 patients. All cases had received ChAdOx1 nCov-19 vaccine 1–2 weeks earlier and developed a characteristic syndrome thereafter. The rapid progressive clinical course and high fatality rate of CVT in combination with thrombocytopenia in such a cluster and in otherwise healthy adults is a recent phenomenon. Cerebral autopsy findings were those of venous hemorrhagic infarctions and thrombi in dural venous sinuses, including thrombus material apparently rich in thrombocytes, leukocytes and fibrin. Vessel walls were free of inflammation. Extra-cerebral manifestations included leech-like thrombi in large veins, fibrin clots in small venules and scattered hemorrhages on skin and membranes. CVT with thrombocytopenia after adenovirus vectored COVID-19 vaccination is a new clinical syndrome that needs to be recognized by clinicians, is challenging to treat and seems associated with a high mortality rate.

scholarly journals Cerebral Venous Thrombosis Case Series at a Tertiary Care Hospital: Exploring Treatment Safety and Efficacy of Direct Oral Anticoagulants

Blood ◽  
2019 ◽  
Vol 134 (Supplement_1) ◽  
pp. 3658-3658
Author(s):  
Mohammed Abdullah Alsheef ◽  
Mukhtar Alomar ◽  
Abdul Rehman Z. Zaidi ◽  
Ghaydaa Juma Kullab ◽  
Mohammed AlHazzaa ◽  
...  
Keyword(s):  
Venous Thrombosis ◽  
Cerebral Venous Thrombosis ◽  
Oral Anticoagulants ◽  
Direct Oral Anticoagulants ◽  
Tertiary Care ◽  
Case Series ◽  
Case Report Form ◽  
Care Hospital ◽  
Safety And Efficacy ◽  
Number Of Patients

Background: Cerebral venous thrombosis (CVT) is an uncommon cause of stroke that mainly affects young adults and children. Initial treatment with heparin followed by wafarin is the mainstay of treatment. Only insufficient experience is available for direct oral anticoagulants (DOACs). Aims: The study aims to demonstrate the efficacy and safety of DOACs such as (Rivaroxaban and Dabigatran) in patients with objectively confirmed CVT. Methods: Data of 46 cases of CVT collected using a standardized case report form. Inclusion criteria were patients diagnosed with CVT, confirmed by CT or MRI imaging. Results: The total number of patients was 46 (9 males and 37 females). The mean age of the patients was 35.2± 5 years. The most common clinical manifestations among our patients were headache followed by seizure. 52% of cases were unprovoked, while 48% were provoked by pregnancy and oral contraceptive pills. Superior sagittal sinus (55%) and transverse sinus (44.9%) were the most common sites. Involvement of more than three venous sinuses was 34.8%. Thrombophilic abnormality was detected in 21.7% of patients. Initiation of anticoagulation (AC) was mostly low molecular weight heparin (LMWH) (80%), followed by unfractionated heparin (UFH) (17.7%) and fondaparinex (2%). Maintenance AC with Rivaroxaban after heparin (LMWH/UFH) was in 63% of our patients, the rest were switched from Warfarin to Rivaroxaban (34.8%), and one was treated by Dabigatran (2%). CVT recurrence was observed in one patient. Major bleeding (according to ISTH criteria) was not reported in our case series. Conclusions: DOACs demonstrated good safety and efficacy profile and can potentially replace warfarin in CVT patients. Disclosures No relevant conflicts of interest to declare.

A case series of cerebral venous thrombosis as the first manifestation of homocystinuria

2021 ◽  
pp. 239698732110594
Author(s):  
Antonio Ochoa-Ferraro ◽  
Subadra Wanninayake ◽  
Charlotte Dawson ◽  
Adam Gerrard ◽  
Mary Anne Preece ◽  
...  
Keyword(s):  
Venous Thrombosis ◽  
Effective Treatment ◽  
Cerebral Venous Thrombosis ◽  
Thrombotic Event ◽  
Case Series ◽  
Autosomal Recessive Disorder ◽  
Retrospective Case ◽  
Tertiary Referral Centre ◽  
Physician Awareness ◽  
The Mean

Background Cerebral venous thrombosis (CVT) is an important cause of stroke particularly in younger patients and potentially fatal if diagnosis is delayed. The presentation of symptoms is highly variable and consequently the diagnosis and underlying cause is often delayed or overlooked. Homocystinuria, a rare autosomal recessive disorder is an identified risk factor for CVT. Purpose A timely diagnosis and treatment of the underlying cause of CVT could result in improved outcome and prevent further events. This case series describes the clinical course of six adults presented with unprovoked CVT, in whom the diagnosis of underlying homocystinuria was delayed with adverse consequences. We aim to highlight the importance of recognising homocystinuria as an underlying cause of CVT and offer a practical approach to the diagnosis and management. Methods This is a retrospective case series of a cohort of 30 consecutive patients seen in a UK tertiary referral centre. Result Six out of 30 patients presented with CVT prior to homocystinuria diagnosis. The mean and range of age at the time of the first CVT episode was 22.6 (range 11–31) years. The mean ±SD age at diagnosis of homocystinuria as the underlying cause was 26 ± 4.2 years. The time between first CVT and diagnosis of homocystinuria ranged from 1.6 to 11 years resulting in a delay to introduction of effective treatment and, in some cases, a further large vessels thrombotic event. Conclusion Physician awareness of homocystinuria as an underlying cause for an unprovoked CVT will facilitate timely introduction of effective treatment to prevent a further event.

Cerebral Venous Thrombosis and Headache - A Case-Series

2015 ◽  
Vol 55 (6) ◽  
pp. 806-814 ◽  
Author(s):  
Marco Sparaco ◽  
Michele Feleppa ◽  
Marcelo E. Bigal
Keyword(s):  
Venous Thrombosis ◽  
Cerebral Venous Thrombosis ◽  
Case Series

scholarly journals The effect of intraarterial heparin flushing to autism symptoms when used to treat the concomitant cerebral venous thrombosis: a case series

2019 ◽  
Vol 8 (3) ◽  
pp. 713
Author(s):  
Erwin Setiawan ◽  
Ristaniah Soetikno ◽  
Nelly Amalia Risan ◽  
Shelly Shelly ◽  
Tugas Ratmono ◽  
...  
Keyword(s):  
Venous Thrombosis ◽  
Cerebral Venous Thrombosis ◽  
Case Series ◽  
Autism Symptoms

Toad Intoxication in the Dog by Rhinella marina: The Clinical Syndrome and Current Treatment Recommendations

2016 ◽  
Vol 52 (4) ◽  
pp. 205-211 ◽  
Author(s):  
Stephanie Johnnides ◽  
Tiffany Green ◽  
Paul Eubig
Keyword(s):  
Cardiac Arrhythmias ◽  
Current Treatment ◽  
Treatment Recommendations ◽  
Clinical Syndrome ◽  
Bufo Marinus ◽  
Oral Exposure ◽  
Fatality Rate ◽  
Rhinella Marina ◽  
Appropriate Treatment ◽  
High Fatality Rate

ABSTRACT Oral exposure to the secretions of Rhinella marina (formerly Bufo marinus) can carry a high fatality rate without early and appropriate treatment. In dogs, the clinical syndrome, which is evident almost immediately, manifests in profuse ptyalism along with gastrointestinal, respiratory, and neurologic signs. Severe cardiac arrhythmias develop less frequently. This review will cover the history, toxicology, and clinical syndrome of Rhinella marina intoxication, and will discuss the recommended therapies for stabilization.

Cerebral Venous Thrombosis and Inflammatory Bowel Disease: A Case Series: Presidential Poster

2014 ◽  
Vol 109 ◽  
pp. S432
Author(s):  
Ersilia DeFilippis ◽  
Elaine Barfield ◽  
Dana Leifer ◽  
Adam Steinlauf ◽  
Brian Bosworth ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Venous Thrombosis ◽  
Bowel Disease ◽  
Cerebral Venous Thrombosis ◽  
Case Series ◽  
Inflammatory Bowel
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