Toad Intoxication in the Dog by Rhinella marina: The Clinical Syndrome and Current Treatment Recommendations

2016 ◽  
Vol 52 (4) ◽  
pp. 205-211 ◽  
Author(s):  
Stephanie Johnnides ◽  
Tiffany Green ◽  
Paul Eubig
Keyword(s):  
Cardiac Arrhythmias ◽  
Current Treatment ◽  
Treatment Recommendations ◽  
Clinical Syndrome ◽  
Bufo Marinus ◽  
Oral Exposure ◽  
Fatality Rate ◽  
Rhinella Marina ◽  
Appropriate Treatment ◽  
High Fatality Rate

ABSTRACT Oral exposure to the secretions of Rhinella marina (formerly Bufo marinus) can carry a high fatality rate without early and appropriate treatment. In dogs, the clinical syndrome, which is evident almost immediately, manifests in profuse ptyalism along with gastrointestinal, respiratory, and neurologic signs. Severe cardiac arrhythmias develop less frequently. This review will cover the history, toxicology, and clinical syndrome of Rhinella marina intoxication, and will discuss the recommended therapies for stabilization.

scholarly journals Vaccine Induced Immune Thrombotic Thrombocytopenia Causing a Severe Form of Cerebral Venous Thrombosis With High Fatality Rate: A Case Series

2021 ◽  
Vol 12 ◽  
Author(s):  
Markus Wiedmann ◽  
Thor Skattør ◽  
Arne Stray-Pedersen ◽  
Luis Romundstad ◽  
Ellen-Ann Antal ◽  
...  
Keyword(s):  
Venous Thrombosis ◽  
Cerebral Venous Thrombosis ◽  
Clinical Course ◽  
Fatal Outcome ◽  
Case Series ◽  
Severe Form ◽  
Clinical Syndrome ◽  
Fatality Rate ◽  
High Fatality Rate ◽  
Progression Of Disease

During a 2-week period, we have encountered five cases presenting with the combination of cerebral venous thrombosis (CVT), intracerebral hemorrhage and thrombocytopenia. A clinical hallmark was the rapid and severe progression of disease in spite of maximum treatment efforts, resulting in fatal outcome in for 4 out of 5 patients. All cases had received ChAdOx1 nCov-19 vaccine 1–2 weeks earlier and developed a characteristic syndrome thereafter. The rapid progressive clinical course and high fatality rate of CVT in combination with thrombocytopenia in such a cluster and in otherwise healthy adults is a recent phenomenon. Cerebral autopsy findings were those of venous hemorrhagic infarctions and thrombi in dural venous sinuses, including thrombus material apparently rich in thrombocytes, leukocytes and fibrin. Vessel walls were free of inflammation. Extra-cerebral manifestations included leech-like thrombi in large veins, fibrin clots in small venules and scattered hemorrhages on skin and membranes. CVT with thrombocytopenia after adenovirus vectored COVID-19 vaccination is a new clinical syndrome that needs to be recognized by clinicians, is challenging to treat and seems associated with a high mortality rate.

scholarly journals Feasibility of Mesenchymal Stem Cell Therapy for COVID-19: A Mini Review

2020 ◽  
Vol 20 (4) ◽  
pp. 285-288
Author(s):  
Jingwen Li ◽  
Xinyi Wang ◽  
Na Li ◽  
Ying Jiang ◽  
Heqing Huang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Distress Syndrome ◽  
Current Treatment ◽  
Therapeutic Effects ◽  
Fatality Rate ◽  
Clinical Safety ◽  
Multiple Systems ◽  
Mesenchymal Stem Cell Therapy ◽  
High Fatality Rate ◽  
Regulatory Functions

Patients infected with SARS-CoV-2 carry the coronavirus disease 2019 (COVID-19) which involves multiple systems and organs with acute respiratory distress syndrome (ARDS) as the most common complication, largely due to cytokine storms or dysregulated immunity. As such, there are many severe patients with complications such as cytokine storm syndrome (CSS), who have a high fatality rate. Neither specific anti-SARS-CoV-2 drugs nor vaccines exist currently. Current treatment relies mainly on self-recovery through patients' immune function. Mesenchymal stem cells (MSCs) is a kind of multipotent tissue stem cells, which have powerful anti-inflammatory and immune regulatory functions, inhibiting the cytokine storms. In addition, MSCs have a strong ability to repair tissue damage and reduce the risk of severe complications such as acute lung injury and ARDS, and hopefully, reduce the fatality rate in these patients. There are several clinical types of research completed for treating COVID-19 with MSCs, all reporting restoration of T cells and clinical safety. Here we discuss the clinical prospect and conclude the therapeutic effects and potential mechanism for MSCs in treating COVID-19.

scholarly journals Acute locking of the cervical spine - An analysis of fourteen incidents treated in a Johannesburg practice

2019 ◽  
Vol 50 (1) ◽  
pp. 9-10
Author(s):  
Helen David
Keyword(s):  
Young Adults ◽  
Cervical Spine ◽  
Clinical Syndrome ◽  
Accurate Diagnosis ◽  
Adolescents And Young Adults ◽  
Upper Cervical Spine ◽  
Physiotherapy Practice ◽  
Appropriate Treatment ◽  
Upper Cervical

Thirteen patients with acute locking of the cervical spine were treated in a physiotherapy practice and their data were analysed. The patients were mostly adolescents and young adults of both sexes. The upper cervical spine was involved in most cases. The accurate diagnosis and appropriate treatment of this clinical syndrome is described. This condition responds readily to specific mobilisation or manipulation techniques.

Magnetic Resonance Imaging in Non-Traumatic Canalicular Peripheral Neuropathy of the Arm

1998 ◽  
Vol 11 (1) ◽  
pp. 39-42
Author(s):  
F.A. Lupo ◽  
A. Paladini
Keyword(s):  
Morphological Analysis ◽  
Morphological Changes ◽  
Clinical Syndrome ◽  
Nerve Lesion ◽  
Resonance Imaging ◽  
Anatomical Changes ◽  
Appropriate Treatment ◽  
Electrophysiological Findings ◽  
The Cost

The term canalicular neuropathy is applied to nerve lesions arising on nerve segments passing through the osteofibrous canals or other narrow orifices and resulting in nerve compression and entrapment. We studied 31 patients referred to us for non-traumatic canalicular syndromes in the upper limbs. After clinical, electrophysiological and morphological analysis of each case, we emphasize the role of MR imaging in establishing prognosis and selecting treatment. Anatomosurgical specimens correlated well with MR features, whereas there was little correlation between electrophysiological severity and anatomical changes. In summary, canalicular neuropathy is a clinical syndrome. The aim of MR investigation is to document the morphological changes which will serve to institute appropriate treatment. When patients have clinical and electrophysiological evidence of neuropathy without MR demonstration of the nerve lesion, therapy will be conservative, thus saving the cost and risk of surgery. On the other hand, when clinical and electrophysiological findings are flanked by MR demonstration of the neuropathy, the disease is known to be advanced and surgery will be indicated to prevent neurotmesis.

scholarly journals SARS-CoV-2 Inflammatory Syndrome. Clinical Features and Rationale for Immunological Treatment

2020 ◽  
Vol 21 (9) ◽  
pp. 3377 ◽  
Author(s):  
Marcella Prete ◽  
Elvira Favoino ◽  
Giacomo Catacchio ◽  
Vito Racanelli ◽  
Federico Perosa
Keyword(s):  
Acute Respiratory Distress Syndrome ◽  
Distress Syndrome ◽  
Fatality Rate ◽  
Intensive Care Therapy ◽  
Contagious Nature ◽  
High Fatality Rate ◽  
Number Of Patients ◽  
Inflammatory Stimuli ◽  
Immunological Treatment ◽  
Inflammatory Syndrome

The current pandemic coronavirus, SARS-CoV-2, is a global health emergency because of its highly contagious nature, the great number of patients requiring intensive care therapy, and the high fatality rate. In the absence of specific antiviral drugs, passive prophylaxis, or a vaccine, the treatment aim in these patients is to prevent the potent virus-induced inflammatory stimuli from leading to the acute respiratory distress syndrome (ARDS), which has a severe prognosis. Here, the mechanism of action and the rationale for employing immunological strategies, which range from traditional chemically synthesized drugs, anti-cytokine antibodies, human immunoglobulin for intravenous use, to vaccines, are reviewed.

scholarly journals A large outbreak of acute encephalitis with high fatality rate in children in Andhra Pradesh, India, in 2003, associated with Chandipura virus

The Lancet ◽  
2004 ◽  
Vol 364 (9437) ◽  
pp. 869-874 ◽  
Author(s):  
BL Rao ◽  
Atanu Basu ◽  
Niteen S Wairagkar ◽  
Milind M Gore ◽  
Vidya A Arankalle ◽  
...  
Keyword(s):  
Andhra Pradesh ◽  
Fatality Rate ◽  
Acute Encephalitis ◽  
Chandipura Virus ◽  
High Fatality Rate ◽  
Large Outbreak

Current Treatment Recommendations for Correcting Vitamin D Deficiency in Pediatric Patients with Cystic Fibrosis Are Inadequate

2008 ◽  
Vol 153 (4) ◽  
pp. 554-559.e2 ◽  
Author(s):  
Deanna Green ◽  
Kathryn Carson ◽  
Amanda Leonard ◽  
J. Erin Davis ◽  
Beryl Rosenstein ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Pediatric Patients ◽  
Current Treatment ◽  
Treatment Recommendations

Preparing solidly for algebra… using prime numbers

1964 ◽  
Vol 11 (6) ◽  
pp. 418-420
Author(s):  
W.A. Leonard
Keyword(s):  
High School ◽  
Elementary School ◽  
Prime Numbers ◽  
Statistical Evidence ◽  
Fatality Rate ◽  
Social Implication ◽  
High School Algebra ◽  
High Fatality Rate ◽  
Ways Of Thinking ◽  
First Time

It was once suggested that beginning the study of freshman high school algebra is not totally unlike embarking upon the sea of matrimony. Both are milestones in one's life, involving opportunities for excitement, adventure, growth, and rich and lasting reward; but, nonetheless, both tend to necessitate some different approaches to problems, some new ways of thinking, and certainly, in more than a few cases, some amount of adjustment. Without intending to attach social implication to algebra, we as teachers cannot fail to recognize that the first exposure to high school algebra can be a foreboding experience to many elementary school graduates, particularly in the light of the statistical evidence for the high fatality rate of students taking algebra for the first time.

Disproportionately high fatality rate of women compared to men in patients with gemcitabine-associated lung injury: Preliminary findings from RADAR

2005 ◽  
Vol 23 (16_suppl) ◽  
pp. 6034-6034
Author(s):  
N. Slimack ◽  
S. M. Belknap ◽  
K. R. Carson ◽  
T. M. Kuzel ◽  
S. Trifilio ◽  
...  
Keyword(s):  
Lung Injury ◽  
Fatality Rate ◽  
High Fatality Rate
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