Short-Term Plasticity in a Monosynaptic Reflex Pathway to Forearm Muscles after Continuous Robot-Assisted Passive Stepping

Abstract Background It remains no clear conclusion about which is better between robot-assisted thoracic surgery (RATS) and video-assisted thoracic surgery (VATS) for the treatment of patients with non-small cell lung cancer (NSCLC). Therefore, this meta-analysis aimed to compare the short-term and long-term efficacy between RATS and VATS for NSCLC. Methods Pubmed, Cochrane Library, Embase, China National Knowledge Infrastructure (CNKI), Medline, and Web of Science databases were comprehensively searched for studies published before December 2020. The quality of the articles was evaluated using the Newcastle-Ottawa Scale (NOS) and the data analyzed using the Review Manager 5.3 software. Fixed or random effect models were applied according to heterogeneity. Subgroup analysis and sensitivity analysis were conducted. Results A total of 18 studies including 11,247 patients were included in the meta-analyses, of which 5114 patients were in the RATS group and 6133 in the VATS group. Compared with VATS, RATS was associated with less blood loss (WMD = − 50.40, 95% CI -90.32 ~ − 10.48, P = 0.010), lower conversion rate (OR = 0.50, 95% CI 0.43 ~ 0.60, P < 0.001), more harvested lymph nodes (WMD = 1.72, 95% CI 0.63 ~ 2.81, P = 0.002) and stations (WMD = 0.51, 95% CI 0.15 ~ 0.86, P = 0.005), shorter duration of postoperative chest tube drainage (WMD = − 0.61, 95% CI -0.78 ~ − 0.44, P < 0.001) and hospital stay (WMD = − 1.12, 95% CI -1.58 ~ − 0.66, P < 0.001), lower overall complication rate (OR = 0.90, 95% CI 0.83 ~ 0.99, P = 0.020), lower recurrence rate (OR = 0.51, 95% CI 0.36 ~ 0.72, P < 0.001), and higher cost (WMD = 3909.87 USD, 95% CI 3706.90 ~ 4112.84, P < 0.001). There was no significant difference between RATS and VATS in operative time, mortality, overall survival (OS), and disease-free survival (DFS). Sensitivity analysis showed that no significant differences were found between the two techniques in conversion rate, number of harvested lymph nodes and stations, and overall complication. Conclusions The results revealed that RATS is a feasible and safe technique compared with VATS in terms of short-term and long-term outcomes. Moreover, more randomized controlled trials comparing the two techniques with rigorous study designs are still essential to evaluate the value of robotic surgery for NSCLC.

Download Full-text

Author Correction: Presynaptic endoplasmic reticulum regulates short-term plasticity in hippocampal synapses

Communications Biology ◽

10.1038/s42003-021-02519-x ◽

2021 ◽

Vol 4 (1) ◽

Author(s):

Nishant Singh ◽

Thomas Bartol ◽

Herbert Levine ◽

Terrence Sejnowski ◽

Suhita Nadkarni

Keyword(s):

Endoplasmic Reticulum ◽

Short Term ◽

Short Term Plasticity ◽

Hippocampal Synapses

Download Full-text

Robot assisted minimally invasive esophagectomy: safety, perioperative morbidity and short-term oncological outcome—a single institution experience

Journal of Robotic Surgery ◽

10.1007/s11701-021-01274-9 ◽

2021 ◽

Author(s):

Assif Iqbal Sayed ◽

Shaifali Goel ◽

Abhishek Aggarwal ◽

Shivendra Singh

Keyword(s):

Minimally Invasive ◽

Minimally Invasive Esophagectomy ◽

Oncological Outcome ◽

Single Institution ◽

Robot Assisted ◽

Short Term ◽

Perioperative Morbidity ◽

Invasive Esophagectomy

Download Full-text

Unc13A and Unc13B contribute to the decoding of distinct sensory information in Drosophila

Nature Communications ◽

10.1038/s41467-021-22180-6 ◽

2021 ◽

Vol 12 (1) ◽

Author(s):

Atefeh Pooryasin ◽

Marta Maglione ◽

Marco Schubert ◽

Tanja Matkovic-Rachid ◽

Sayed-mohammad Hasheminasab ◽

...

Keyword(s):

Sensory Information ◽

Projection Neuron ◽

Physical Distance ◽

Neural Decoding ◽

Short Term ◽

Short Term Plasticity ◽

Appetitive Stimuli ◽

Excitatory Projection ◽

Direct Genetic Evidence ◽

Nanoscale Level

AbstractThe physical distance between presynaptic Ca2+ channels and the Ca2+ sensors triggering the release of neurotransmitter-containing vesicles regulates short-term plasticity (STP). While STP is highly diversified across synapse types, the computational and behavioral relevance of this diversity remains unclear. In the Drosophila brain, at nanoscale level, we can distinguish distinct coupling distances between Ca2+ channels and the (m)unc13 family priming factors, Unc13A and Unc13B. Importantly, coupling distance defines release components with distinct STP characteristics. Here, we show that while Unc13A and Unc13B both contribute to synaptic signalling, they play distinct roles in neural decoding of olfactory information at excitatory projection neuron (ePN) output synapses. Unc13A clusters closer to Ca2+ channels than Unc13B, specifically promoting fast phasic signal transfer. Reduction of Unc13A in ePNs attenuates responses to both aversive and appetitive stimuli, while reduction of Unc13B provokes a general shift towards appetitive values. Collectively, we provide direct genetic evidence that release components of distinct nanoscopic coupling distances differentially control STP to play distinct roles in neural decoding of sensory information.

Download Full-text