scholarly journals Early Life Adversity as a Risk Factor for Visceral Pain in Later Life: Importance of Sex Differences

2013 ◽  
Vol 7 ◽  
Author(s):  
Aaron Chaloner ◽  
Beverley Greenwood-Van Meerveld
2018 ◽  
Vol 154 (6) ◽  
pp. S-431
Author(s):  
Arpana Gupta ◽  
Vadim Osadchiy ◽  
Jennifer S. Labus ◽  
Lisa A. Kilpatrick ◽  
Claudia P. Sanmiguel ◽  
...  

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Claire Green ◽  
Aleks Stolicyn ◽  
Mathew A. Harris ◽  
Xueyi Shen ◽  
Liana Romaniuk ◽  
...  

AbstractHypothalamic–pituitary–adrenal (HPA) axis dysregulation has been commonly reported in major depressive disorder (MDD), but with considerable heterogeneity of results; potentially due to the predominant use of acute measures of an inherently variable/phasic system. Chronic longer-term measures of HPA-axis activity have yet to be systematically examined in MDD, particularly in relation to brain phenotypes, and in the context of early-life/contemporaneous stress. Here, we utilise a temporally stable measure of cumulative HPA-axis function (hair glucocorticoids) to investigate associations between cortisol, cortisone and total glucocorticoids with concurrent measures of (i) lifetime-MDD case/control status and current symptom severity, (ii) early/current-life stress and (iii) structural neuroimaging phenotypes, in N = 993 individuals from Generation Scotland (mean age = 59.1 yrs). Increased levels of hair cortisol were significantly associated with reduced global and lobar brain volumes with reductions in the frontal, temporal and cingulate regions (βrange = −0.057 to −0.104, all PFDR < 0.05). Increased levels of hair cortisone were significantly associated with MDD (lifetime-MDD status, current symptoms, and severity; βrange = 0.071 to 0.115, all PFDR = < 0.05), with early-life adversity (β = 0.083, P = 0.017), and with reduced global and regional brain volumes (global: β = −0.059, P = 0.043; nucleus accumbens: β = −0.075, PFDR = 0.044). Associations with total glucocorticoids followed a similar pattern to the cortisol findings. In this large community-based sample, elevated glucocorticoids were significantly associated with MDD, with early, but not later-life stress, and with reduced global and regional brain phenotypes. These findings provide important foundations for future mechanistic studies to formally explore causal relationships between early adversity, chronic rather than acute measures of glucocorticoids, and neurobiological associations relevant to the aetiology of MDD.


2021 ◽  
Vol 15 ◽  
Author(s):  
Lauren Granata ◽  
Alissa Valentine ◽  
Jason L. Hirsch ◽  
Jennifer Honeycutt ◽  
Heather Brenhouse

Caretaking stability in the early life environment supports neurobehavioral development, while instability and neglect constitute adverse environments that can alter maturational processes. Research in humans suggests that different types of early life adversity (ELA) can have differential effects on caretaker relationships and later cognitive and social development; however, identifying mechanistic underpinnings will require animal models with translational validity. Two common rodent models, maternal separation (MS) and limited bedding (LB), influence the mother-infant relationship during a critical window of development. We hypothesized that these paradigms may affect the development of communication strategies on the part of the pup. Ultrasonic vocalizations (USVs) are a care-eliciting mechanism and ethologically relevant response to stressors in the rat pup. USV emission rates and acoustic parameters change throughout early development, presenting the opportunity to define developmental milestones in USVs that would reflect neurobehavioral aberrations if disrupted. This study investigated the effects of MS or LB on the dam-pup relationship by quantifying pup USVs, maternal behavior, and the relationship between the two. First, we used a generalized additive model approach to establish typical developmental trajectories of USV acoustic properties and determine windows of change in MS or LB rearing. Additionally, we quantified maternal behaviors and the predictability of maternal care sequences using an entropy rate calculation. MS and LB each shifted the developmental trajectories of USV acoustic parameters and call types in a sex-specific manner. MS more often impacted male USVs, while LB impacted female USVs. MS dams spent more time passive nursing, and LB dams spent more time on the nest. The predictability of maternal care was associated with the rate of USV emissions exclusively in females. Taken together, findings demonstrate sex- and model-specific effects of rearing environments on a novel developmental trajectory involving the mother-infant relationship, facilitating the translation of animal ELA paradigms to assess later-life consequences.


2020 ◽  
Vol 4 (Supplement_1) ◽  
pp. 924-924
Author(s):  
Janae Briggs ◽  
Stephanie Child

Abstract Early life adversity (ELA) is associated with poor health through social and economic pathways. ELA also shapes cognitive and emotional development, including self-perception, social attachment and mental well-being. As such, ELA may shape later life health through social relationships, yet few studies have examined these associations. Data from the UC Berkeley Social Network Study were used to examine ELA measured retrospectively and current personal network characteristics among young (21-30 years) and older adults (50-70 years). ELA was operationalized as a summary of six experiences occurring before age 18 (e.g., parents’ divorce/separation, violence/drug use in the home, etc.). Personal network characteristics included objective measures, such as the number of ties who provide or receive various types of support, and subjective assessments about the adequacy of support received. Multivariate regression models adjusted for gender, race/ethnicity, and level of education. Among young adults, ELA was associated with more ties who rely upon the ego for support (b=0.15, 95% CI: 0.02, 0.28, p=0.02). Among older adults, ELA was associated with more ties named as either an advisor (b=0.14, 95% CI: 0.04, 0.21, p=0.02) or difficult/demanding (b=0.12, 95% CI: 0.04, 0.21, p&lt;0.01). Furthermore, ELA was associated with less confidence in family support available (b= -0.09, 95% CI: -0.16, -0.03, p&lt;0.01) and fewer emotionally close family members (b= -0.18, 95% CI: -0.32, -0.03, p=0.02) among older adults. In conclusion, clear differences emerged in network characteristics by exposure to ELA, particularly among older adults. The findings highlight potential pathways through which ELA patterns later life health.


2014 ◽  
Vol 28 (4) ◽  
pp. 372-390 ◽  
Author(s):  
Nadya Dich ◽  
Åse Marie Hansen ◽  
Kirsten Avlund ◽  
Rikke Lund ◽  
Erik Lykke Mortensen ◽  
...  

2019 ◽  
Vol 3 (Supplement_1) ◽  
pp. S576-S577
Author(s):  
Claudia Recksiedler ◽  
Boris Cheval ◽  
Stefan Sieber ◽  
Robert S Stawski ◽  
Stephane Cullati

Abstract Research documented the impact of marital transitions—particularly marital loss—on depression in old age, yet its severity depends multiple factors. Individuals’ capability to cope with transitions depends on available resources and previous exposure to stressors, such as early-life adversity, which buffers or aggravates the impact of marital transitions on later-life depression. Although studies documented the pivotal link between early-life adversity and negative health trajectories, our study is the first attempt to examine whether early-life adversity influences the relationship between prospectively-tracked, later-life marital transitions and depression. We drew data from SHARE, which samples individuals aged 50+ across Europe (N = 13,258; 2004-2016). Using multilevel linear models, we found that women who became widowed had higher levels of depression compared to coupled and single women, but experienced lower increases in depression over time. After adjusting for early-life and adulthood SES, losing a partner remained significantly associated with depression. Life-course SES was associated with levels of depression, yet interactions between marital transitions and SES were not, with some exceptions: single women who reported difficulties in their ability to make ends meet experience higher increases of depression over time. Overall, results were similar for men. Interactions between family transitions and SES were again not significant, with a few exceptions for single men: those born in more childhood conditions, and those with high education, had lower levels of depression. We interpret and discuss our findings through the lens of life-course and stress-resiliency perspectives and in light of changing family dynamics for this age group.


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