Role of LATS1/2 in Prognosis of Advanced Gastric Cancer and Its Relationship With the Tumor Immune Microenvironment

Abstract The majority of high-grade serous ovarian cancers (HGSCs) are deficient in homologous recombination (HR) DNA repair, most commonly due to mutations or hypermethylation of the BRCA1/2 genes. We aimed to discover how BRCA1/2 mutations shape the cellular phenotypes and spatial interactions of the tumor microenvironment. Using a highly multiplex immunofluorescence and image analysis we generated spatial proteomic data for 21 markers in 124,623 single cells from 112 tumor cores originating from 31 tumors with BRCA1/2 mutation (BRCA1/2mut), and from 13 tumors without alterations in HR genes (HRwt). We identified a phenotypically distinct tumor microenvironment in the BRCA1/2mut tumors with evidence of increased immunosurveillance. Importantly, we found an opposing prognostic role of a proliferative tumor-cell phenotypic subpopulation in the HR-genotypes, which associated with enhanced spatial tumor-immune interactions by the CD8+ and CD4+T-cells in BRCA1/2mut tumors. The single-cell spatial landscapes indicate distinct patterns of spatial immunosurveillance with the premise to improve immunotherapeutic strategies and patient stratification in HGSC.

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Role of Mean Platelet Volume in the Prognosis of Locally Advanced Gastric Cancer: A Tertiary Cancer Center Experience

Cureus ◽

10.7759/cureus.9109 ◽

2020 ◽

Author(s):

Manjunath K V ◽

Pavan Jonnada ◽

Sai Kiran N ◽

Ali Anwar

Keyword(s):

Gastric Cancer ◽

Advanced Gastric Cancer ◽

Mean Platelet Volume ◽

Locally Advanced ◽

Cancer Center ◽

Platelet Volume ◽

Locally Advanced Gastric Cancer ◽

Tertiary Cancer Center

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New approaches to prediction and treatment of advanced gastric cancer based on molecular-biological parameters

Clinical Medicine (Russian Journal) ◽

10.18821/0023-2149-2016-94-11-812-820 ◽

2017 ◽

Vol 94 (11) ◽

pp. 812-820

Author(s):

Evgeniya S. Fedoseeva ◽

M. V. Savostikova ◽

M. N. Narimanov ◽

A. A. Pashaev ◽

S. S. Kirichenko ◽

...

Keyword(s):

Gastric Cancer ◽

Advanced Gastric Cancer ◽

Predictive Value ◽

Biological Parameters ◽

Hereditary Predisposition ◽

New Approaches ◽

Brca 1 ◽

Neoplastic Process

This review is designed to discuss possibilities for the treatment of advanced gastric cancer with reference to the prognostic and predictive value of molecular-biological parameters and the influence of hereditary predisposition to the development of neoplastic process. The data on modern pharmacotherapy of this disease based on the knowledge of molecular-biological parameters are presented including the following markers: HER2/neu, VGFR, c-met, TUBB3, CDH-1, BRCA-1, EGFR, TGF-ß, p53, Ki67 and PCNA. It is emphasized that the role of molecular-biological parameters associated with advanced gastric cancer is ambiguous. The prognostic and predictive significance of some of the markers is confirmed while that of others remains to be elucidated and requires further research.

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