YTH Domain Proteins: A Family of m6A Readers in Cancer Progression

N6-methyladenosine (m6A) is the most abundant internal modification in eukaryotic messenger RNAs (mRNAs). m6A RNA methylation is involved in all stages of RNA life cycle, from RNA processing, nuclear output, translation regulation to RNA degradation, indicating that m6A has various functions affecting RNA metabolism positively or negatively. Reading proteins are vital in regulating the translation and stability of m6A mRNAs positively or negatively. Recent studies have enhanced the understanding of the molecular mechanism of the YT521-B homology (YTH) domain family and the modification of m6A. This study aimed to review the specific mechanisms, functions, and interactions of the YTH domain protein family. It also discussed future research directions, thus providing new ideas for the clinical diagnosis and targeted therapy of cancer.

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The Central Roles of Noncoding RNA in Estrogen-Dependent Female Reproductive System Tumors

International Journal of Endocrinology ◽

10.1155/2021/5572063 ◽

2021 ◽

Vol 2021 ◽

pp. 1-10

Author(s):

Jiajie Tu ◽

Huan Yang ◽

Lei Jiang ◽

Yu Chen ◽

...

Keyword(s):

Reproductive System ◽

Noncoding Rna ◽

Noncoding Rnas ◽

Future Research ◽

Female Reproductive System ◽

Research Directions ◽

New Ideas ◽

Future Research Directions

The pathogenesis of ovarian and endometrial cancers is closely associated with estrogen-related pathways. These estrogen-dependent tumors seriously threaten the health and quality of life in women. Noncoding RNAs (ncRNAs) are defined as RNAs that do not encode proteins, including microRNAs (miRNAs) and long noncoding RNAs (lncRNAs), both of which have been reported in estrogen-dependent female reproductive system tumors. This review systematically summarizes the role of ncRNAs in estrogen-dependent tumors and common patterns of regulatory mechanisms to explore their future research directions in tumor diagnosis, treatment, and prognosis. This may provide new ideas for the potential application of ncRNAs in estrogen-dependent female reproductive system tumors.

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The Importance of Review Articles & its Prospects in Scholarly Literature

10.21467/exr.1.1.4293 ◽

2021 ◽

Vol 1 (1) ◽

pp. 1-6

Author(s):

Adam A Bahishti

Keyword(s):

Future Research ◽

Extensive Review ◽

Research Information ◽

Policy And Practice ◽

Research Directions ◽

Review Articles ◽

Scholarly Publications ◽

New Ideas ◽

Future Research Directions ◽

Published Research

With the growing number of scholarly publications around the world, it is becoming more and more difficult to keep up to date with all of it. To address this issue, authors often write an insightful review article on their study's position within the field based on a critical review of already published research data. Review articles are papers that compile, summarize, critique, and synthesize the available research information on a topic. Reviews can serve as a basis for knowledge development, create guidelines for policy and practice, provide evidence of an application, highlight research gap, and if well conducted, have the capacity to engender new ideas and serve as the grounds for future research directions. To be concise, extensive review articles play an important role as a foundation for all types of research & its application. In this editorial, I will highlight the importance of review articles along with expectations from the author who intends to submit their insightful reviews to this journal “Extensive Reviews”. I encourage research scholars to write insightful and extensive review articles as a service to the scientific community and to enhance their own knowledge.

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