scholarly journals Comparison of Dose and Effectiveness of a Single-Session Ultrasound-Guided High-Intensity Focused Ultrasound Ablation of Uterine Fibroids With Different Sizes

2021 ◽  
Vol 11 ◽  
Author(s):  
Mei-Jie Yang ◽  
Ren-Qiang Yu ◽  
Jin-Yun Chen ◽  
Zhi-Biao Wang
Keyword(s):  
High Intensity ◽  
Focused Ultrasound ◽  
Uterine Fibroids ◽  
Volume Ratio ◽  
High Intensity Focused Ultrasound ◽  
Single Session ◽  
Ultrasound Guided ◽  
Hifu Ablation ◽  
Hyperintense Signal ◽  
Significant Difference

PurposeThis study aimed to compare the dose and effectiveness of ultrasound-guided high-intensity focused ultrasound (USgHIFU) ablation of uterine fibroids with different sizes and explore the effect of uterine fibroid size on dose, which provided dose evaluation for clinicians in accordance with the size of uterine fibroids.Materials and MethodsA total of 1,000 patients with symptomatic uterine fibroids who received a single-session USgHIFU treatment were enrolled in this study. The size of fibroids was divided into seven groups: 3–4 cm, 4–5 cm, 5–6 cm, 6–7 cm, 7–8 cm, 8–9 cm, and 9–11 cm. The dose was expressed on the basis of the energy efficiency factor (EEF) as the energy required for ablation per unit volume of tissue, and the non-perfused volume ratio (NPVR) was used to assess the effect of HIFU ablation.ResultsThe median NPVR of 88.3% (IQR: 80.3%–94.8%) was obtained, and no significant difference was observed among the seven groups. The classification of T2-weighted image signal intensity fibroids in the 4–5 cm group was compared with that in the 6–7 cm and 8–9 cm groups, and the difference was significant (p < 0.05). However, the proportion of T2WI hyperintense signal fibroids had no significant difference among the seven groups (p > 0.05). The median EEF was 3.88 J/mm3, and a significant difference was observed among the seven groups of EEF (p < 0.05). The EEF of groups with a fibroid size less than 6 cm was more than double the EEF of groups with a fibroid size above 6 cm. In addition, the EEF of groups with a fibroid size of 4–5 cm and 3–4 cm was 3–4 times higher than those with a fibroid size above 7 cm (p < 0.05).ConclusionsA single-session HIFU ablation for uterine fibroids of 3–11 cm can obtain an NPVR of more than 80%. The EEF decreased with the increase of the size of uterine fibroids. A fibroid size of 6.5 cm was considered as a clinical meaningful point affecting EEF.

scholarly journals Oxytocin Administration in High-Intensity Focused Ultrasound Treatment of Myomata

2018 ◽  
Vol 2018 ◽  
pp. 1-5 ◽  
Author(s):  
Tomasz Lozinski ◽  
Justyna Filipowska ◽  
Piotr Krol ◽  
Anna Kubaty ◽  
Piotr Wegrzyn
Keyword(s):  
High Intensity ◽  
Focused Ultrasound ◽  
Uterine Fibroids ◽  
Volume Ratio ◽  
High Intensity Focused Ultrasound ◽  
Control Group ◽  
Significant Difference ◽  
Before And After ◽  
Registration Number

Objectives. The aim of the study was to evaluate the clinical efficacy of magnetic resonance-guided High-Intensity Focused Ultrasound (HIFU) in patients with symptomatic uterine fibroids (myomata) after application of oxytocin. Methods. 156 women with symptomatic uterine fibroids were treated using MR-guided HIFU procedure. 51 patients had additional IV administration of 40 IU of oxytocin in 5% Glucose or 0,9% NaCl solution during therapy. Before and after the procedure we performed MR and measured initial perfused volume, final perfused volume, nonperfused volume (NPV), and treated volume ratio (TVR). The follow-up was up to 15 months to assess efficacy of treatment and relief of symptoms. Results. Nonperfused volume was statistically significantly larger in oxytocin group than in control group (p=0.0019). The remaining parameters did not show significant difference between both groups. Conclusion. Oxytocin administration seems to improve efficiency of HIFU therapy although further research is required to assess its value. This study’ clinical registration number is DRKS00014794.

Single-session high-intensity focused ultrasound (HIFU) ablation for benign thyroid nodules: a systematic review

2020 ◽  
Vol 17 (8) ◽  
pp. 759-771
Author(s):  
Eleftherios Spartalis ◽  
Sotirios P. Karagiannis ◽  
Nikolaos Plakopitis ◽  
Maria Anna Theodori ◽  
Dimosthenis Chrysikos ◽  
...  
Keyword(s):  
Systematic Review ◽  
High Intensity ◽  
Focused Ultrasound ◽  
Thyroid Nodules ◽  
High Intensity Focused Ultrasound ◽  
Single Session ◽  
Hifu Ablation ◽  
Benign Thyroid Nodules ◽  
Benign Thyroid

Immune response after high-intensity focused ultrasound ablation for H22 tumor

2007 ◽  
Vol 25 (18_suppl) ◽  
pp. 21169-21169 ◽  
Author(s):  
P. Zhou ◽  
M. Fu ◽  
J. Bai ◽  
Z. Wang ◽  
F. Wu
Keyword(s):  
Immune Response ◽  
Tumor Immunity ◽  
High Intensity ◽  
Focused Ultrasound ◽  
Survival Rates ◽  
High Intensity Focused Ultrasound ◽  
Control Group ◽  
Term Survival ◽  
Hifu Ablation ◽  
Significant Difference

21169 Background: Previous results have shown that high intensity focused ultrasound (HIFU) ablation can potentially activate a host anti-tumor immunity. This study was to investigate whether acoustic cavitaion may enhance host immune responses after HIFU treatment for solid malignancy, and to explore the potential mechanisms regarding the enhanced anti-tumor immunity. Methods: (1) Tumor cell vaccine preparation: H22 cells were irradiated with HIFU (0.8MHz, 1050W/cm2, 90s); H22 cells were heated for one hour in 65°C water bath. (2) Animal study: 150 KM mice were randomly divided into three groups: control group, thermal group, and HIFU group. Each group had 50 mice for immune experiments. By using hypodermic injection, the mice in thermal group and HIFU group received either 0.2ml heat-treated H22 vaccine or 0.2ml HIFU-treated H22 vaccine in the left flank of each mouse. Those in control group received only injection with same amount of saline solution. The vaccination times were 4 sessions, once a week for 4 consecutive weeks. One week after last vaccination, each mouse was challenged with H22 tumor cells. All mice were followed up to observe the long-term survival in each group, and peripheral blood was collected to detect changes in T lymphocytes and their subsets by flow cytometry technique. Results: The tumor incidences and 6-week survival rates were observed 100% and 88% of mice in control group, 72.5% and 40% in thermal group, and 42.5% and 14% in HIFU group respectively. Compared to the values in either control group or thermal group, there was a significant decrease of tumor incidences and 6-week survival rates in HIFU group. The volume of tumor was obviously lower in HIFU group, and a significant difference was observed between HIFU group and thermal group or control group. Compared to the values in control group, there were a significant increase of CD4+ levels and CD4+/CD8+ ratio, and a significant decrease of CD8+ level in both HIFU group and thermal group. Conclusions: Antitumor immune response could be enhanced after HIFU ablation for H22 implanted tumor in mice, and acoustic cavitation could play an important role to stimulate host antitumor immune system. No significant financial relationships to disclose.

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