scholarly journals The Crosstalk Between Regulatory Non-Coding RNAs and Nuclear Factor Kappa B in Hepatocellular Carcinoma

2021 ◽  
Vol 11 ◽  
Author(s):  
Yina Zhang ◽  
Jiajia Shao ◽  
Shuangshuang Li ◽  
Yanning Liu ◽  
Min Zheng
Keyword(s):  
Hepatocellular Carcinoma ◽  
Cancer Biology ◽  
Nuclear Factor Kappa B ◽  
Effective Means ◽  
Future Research ◽  
Nuclear Factor ◽  
Human Beings ◽  
Great Loss ◽  
Nuclear Factor Kappa ◽  
Non Coding Rnas

Hepatocellular carcinoma (HCC) is a highly lethal type of malignancies that possesses great loss of life safety to human beings worldwide. However, few effective means of curing HCC exist and its specific molecular basis is still far from being fully elucidated. Activation of nuclear factor kappa B (NF-κB), which is often observed in HCC, is considered to play a significant part in hepatocarcinogenesis and development. The emergence of regulatory non-coding RNAs (ncRNAs), particularly microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), is a defining advance in cancer biology, and related research in this branch has yielded many diagnostic and therapeutic opportunities. Recent studies have suggested that regulatory ncRNAs act as inhibitors or activators in the initiation and progression of HCC by targeting components of NF-κB signaling or regulating NF-κB activity. In this review, we attach importance to the role and function of regulatory ncRNAs in NF-κB signaling of HCC and NF-κB-associated chemoresistance in HCC, then propose future research directions and challenges of regulatory ncRNAs mediated-regulation of NF-κB pathway in HCC.

Nuclear factor kappa B-mediated CD47 up-regulation promotes sorafenib resistance and its blockade synergizes the effect of sorafenib in hepatocellular carcinoma in mice

Hepatology ◽  
2015 ◽  
Vol 62 (2) ◽  
pp. 534-545 ◽  
Author(s):  
Jessica Lo ◽  
Eunice Yuen Ting Lau ◽  
Rachel Hiu Ha Ching ◽  
Bowie Yik Ling Cheng ◽  
Mark Kin Fai Ma ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Nuclear Factor Kappa B ◽  
Nuclear Factor ◽  
Nuclear Factor Kappa

scholarly journals Role of Nuclear Factor Kappa B (NF-κB) Signalling in Neurodegenerative Diseases: An Mechanistic Approach

2020 ◽  
Vol 18 (10) ◽  
pp. 918-935 ◽  
Author(s):  
Shareen Singh ◽  
Thakur Gurjeet Singh
Keyword(s):  
Neurodegenerative Diseases ◽  
Signaling Pathway ◽  
Nuclear Factor Kappa B ◽  
Autoimmune Disorder ◽  
Nuclear Factor ◽  
Human Beings ◽  
Inhibitor Molecule ◽  
Nuclear Factor Kappa ◽  
Iκb Kinase

A transcriptional regulatory nuclear factor kappa B (NF-κB) protein is a modulator of cellular biological activity via binding to a promoter region in the nucleus and transcribing various protein genes. The recent research implicated the intensive role of nuclear factor kappa B (NF-κB) in diseases like autoimmune disorder, inflammatory, cardiovascular and neurodegenerative diseases. Therefore, targeting the nuclear factor kappa B (NF-κB) protein offers a new opportunity as a therapeutic approach. Activation of IκB kinase/NF-κB signaling pathway leads to the development of various pathological conditions in human beings, such as neurodegenerative, inflammatory disorders, autoimmune diseases, and cancer. Therefore, the transcriptional activity of IκB kinase/NF- κB is strongly regulated at various cascade pathways. The nuclear factor NF-kB pathway plays a major role in the expression of pro-inflammatory genes, including cytokines, chemokines, and adhesion molecules. In response to the diverse stimuli, the cytosolic sequestered NF-κB in an inactivated form by binding with an inhibitor molecule protein (IkB) gets phosphorylated and translocated into the nucleus further transcribing various genes necessary for modifying various cellular functions. The various researches confirmed the role of different family member proteins of NF-κB implicated in expressing various genes products and mediating various cellular cascades. MicroRNAs, as regulators of NF- κB microRNAs play important roles in the regulation of the inflammatory process. Therefore, the inhibitor of NF-κB and its family members plays a novel therapeutic target in preventing various diseases. Regulation of NF- κB signaling pathway may be a safe and effective treatment strategy for various disorders.

scholarly journals Perturbation of MicroRNA-370/Lin-28 homolog A/nuclear factor kappa B regulatory circuit contributes to the development of hepatocellular carcinoma

Hepatology ◽  
2013 ◽  
Vol 58 (6) ◽  
pp. 1977-1991 ◽  
Author(s):  
Wen-Ping Xu ◽  
Min Yi ◽  
Qian-Qian Li ◽  
Wei-Ping Zhou ◽  
Wen-Ming Cong ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Nuclear Factor Kappa B ◽  
Nuclear Factor ◽  
Nuclear Factor Kappa ◽  
Regulatory Circuit

scholarly journals Nuclear factor-κB p65 regulates glutaminase 1 expression in human hepatocellular carcinoma

2018 ◽  
Vol Volume 11 ◽  
pp. 3721-3729 ◽  
Author(s):  
Meng Dong ◽  
Lin Miao ◽  
Fengmei Zhang ◽  
Shengshui Li ◽  
Jingzhi Han ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Nuclear Factor Kappa B ◽  
Human Hepatocellular Carcinoma ◽  
Nuclear Factor ◽  
Nuclear Factor Kappa ◽  
Glutaminase 1

scholarly journals MicroRNA-657 promotes tumorigenesis in hepatocellular carcinoma by targeting transducin-like enhancer protein 1 through nuclear factor kappa B pathways

Hepatology ◽  
2013 ◽  
Vol 57 (5) ◽  
pp. 1919-1930 ◽  
Author(s):  
Lisheng Zhang ◽  
Lixin Yang ◽  
Xiyong Liu ◽  
Wei Chen ◽  
Lufen Chang ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Nuclear Factor Kappa B ◽  
Nuclear Factor ◽  
Nuclear Factor Kappa

scholarly journals Hepatocellular Carcinoma with Osteoclast-Like Giant Cells: Report of the Seventh Case in the Literature

2015 ◽  
Vol 2015 ◽  
pp. 1-3 ◽  
Author(s):  
Lorenzo Dioscoridi ◽  
Damiano Bisogni ◽  
Giancarlo Freschi
Keyword(s):  
Hepatocellular Carcinoma ◽  
Nuclear Factor Kappa B ◽  
Wedge Resection ◽  
Liver Neoplasm ◽  
Giant Cells ◽  
Nuclear Factor ◽  
Nuclear Factor Kappa ◽  
Receptor Activator ◽  
Upper Abdominal ◽  
The Right

Hepatocellular carcinoma with osteoclast-like giant cells is extremely rare, and only six cases have been previously reported. Its histogenesis is at the moment controversial. The authors report a case of hepatocellular carcinoma with osteoclast-like giant cells found in a 74-year-old woman. The patient came with a dull pain in the right upper abdominal quadrants due to a liver neoplasm described at CT scan. A wedge resection of the fifth hepatic segment with appendectomy, omentectomy, and debulking of the major peritoneal implants was performed. Histologically, the diagnosis of hepatocellular carcinoma with high grade differentiation associated with giant osteoclast-like cells was done without any evidence of hepatitis or cirrhosis in the surrounding hepatic parenchyma. Immunohistochemistry was positive for CD10 and CD68 and in situ hybridization revealed the expression of receptor activator of nuclear factor-kappa B (RANK) in the giant cells and receptor activator of nuclear factor-kappa B ligand (RANKL) in the tumor cells.

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