scholarly journals Characterization of Uterine Cervix Cancers in Women from Appalachian Kentucky

2021 ◽  
Vol 11 ◽  
Author(s):  
Charles A. Kunos ◽  
Denise Fabian ◽  
Mahesh Kudrimoti ◽  
Rachel W. Miller ◽  
Frederick R. Ueland ◽  
...  
Keyword(s):  
Uterine Cervix ◽  
Chart Review ◽  
The United States ◽  
Stage At Diagnosis ◽  
University Of Kentucky ◽  
Standard Population ◽  
Appalachian Kentucky ◽  
Seer Data ◽  
The University

Uterine cervix cancer (UCCx) is clinically and socioeconomically diverse among women in the United States (US), which obscures the discovery of effective radiochemotherapy approaches for this disease. UCCx afflicts 7.5 per 100,000 American women nationally but 11.7 per 100,000 women in Appalachian Kentucky (AppKY), when age-adjusted to the 2000 US standard population. Epidemiological chart review was performed on 212 women with UCCx treated at the University of Kentucky (UKY) between January 2001 and July 2021. Demographics, tumor characteristics, and relative radiochemotherapy dose and schedule intensity were compared among AppKY and non-AppKY cohorts as well as Surveillance, Epidemiology, and End Results (SEER) data. One hundred thirty-eight (65%) of 212 women seeking radiochemotherapy treatment for UCCx resided in AppKY. Most (80%) sought external-beam radiochemotherapy close to their AppKY residence. Brachytherapy was then most frequently (96%) conducted at UKY. Cancer stage at diagnosis was significantly more advanced in AppKY residents. Women residing in AppKY had a median 10-week radiochemotherapy course, longer than an 8-week guideline. Estimated survival in women residing in AppKY was 8% lower than US national averages. In summary, this study identified an increased percentage of advanced-stage UCCx cancer at diagnosis arising in AppKY residents, with a confounding population-specific delay in radiochemotherapy schedule intensity lowering survival.

scholarly journals Trends in Esophageal Cancer Mortality and Stage at Diagnosis by Race and Ethnicity in the United States

2021 ◽  
Author(s):  
Edgar Corona ◽  
Liu Yang ◽  
Eric Esrailian ◽  
Kevin A. Ghassemi ◽  
Jeffrey L. Conklin ◽  
...  
Keyword(s):  
United States ◽  
Esophageal Cancer ◽  
Race And Ethnicity ◽  
The United States ◽  
Disease Stage ◽  
Stage Migration ◽  
Stage At Diagnosis ◽  
Annual Percent Change ◽  
Seer Data ◽  
Race Ethnicity

Abstract Introduction Esophageal cancer (EC) is an aggressive malignancy with poor prognosis. Mortality and disease stage at diagnosis are important indicators of improvements in cancer prevention and control. We examined United States trends in esophageal adenocarcinoma (EAC) and esophageal squamous cell carcinoma (ESCC) mortality and stage at diagnosis by race and ethnicity. Methods We used Surveillance, Epidemiology, and End Results (SEER) data to identify individuals with histologically confirmed EAC and ESCC between 1 January 1992 and 31 December 2016. For both EAC and ESCC, we calculated age-adjusted mortality and the proportion presenting at each stage by race/ethnicity, sex, and year. We then calculated the annual percent change (APC) in each indicator by race/ethnicity and examined changes over time. Results The study included 19,257 EAC cases and 15,162 ESCC cases. EAC mortality increased significantly overall and in non-Hispanic Whites from 1993 to 2012 and from 1993 to 2010, respectively. EAC mortality continued to rise among non-Hispanic Blacks (NHB) (APC = 1.60, p = 0.01). NHB experienced the fastest decline in ESCC mortality (APC = − 4.53, p < 0.001) yet maintained the highest mortality at the end of the study period. Proportions of late stage disease increased overall by 18.5 and 24.5 percentage points for EAC and ESCC respectively; trends varied by race/ethnicity. Conclusion We found notable differences in trends in EAC and ESCC mortality and stage at diagnosis by race/ethnicity. Stage migration resulting from improvements in diagnosis and treatment may partially explain recent trends in disease stage at diagnosis. Future efforts should identify factors driving current esophageal cancer disparities.

Our Rightful Place

2020 ◽  
Author(s):  
Terry L. Birdwhistell ◽  
Deirdre A. Scaggs
Keyword(s):  
Women Students ◽  
The United States ◽  
University Of Kentucky ◽  
Campus Environment ◽  
Rightful Place ◽  
Women's Culture ◽  
History Of ◽  
The 1960S ◽  
The University ◽  
The Impact

Since women first entered the University of Kentucky (UK) in 1880 they have sought, demanded, and struggled for equality within the university. The period between 1880 and 1945 at UK witnessed women’s suffrage, two world wars, and an economic depression. It was during this time that women at UK worked to take their rightful place in the university’s life prior to the modern women’s movement of the 1960s and beyond. The history of women at UK is not about women triumphant, and it remains an untidy story. After pushing for admission into a male-centric campus environment, women created women’s spaces, women’s organizations, and a women’s culture often patterned on those of men. At times, it seemed that a goal was to create a woman’s college within the larger university. However, coeducation meant that women, by necessity, competed with men academically while still navigating the evolving social norms of relationships between the sexes. Both of those paths created opportunities, challenges, and problems for women students and faculty. By taking a more women-centric view of the campus, this study shows more clearly the impact that women had over time on the culture and environment. It also allows a comparison, and perhaps a contrast, of the experiences of UK women with other public universities across the United States.

scholarly journals Menstrual bleeding patterns in adolescents using etonogestrel (ENG) implant

2011 ◽  
Vol 23 (1) ◽  
Author(s):  
Amit M. Deokar ◽  
Wendy Jackson ◽  
Hatim A. Omar
Keyword(s):  
Chart Review ◽  
Adolescent And Young Adult ◽  
Menstrual Bleeding ◽  
Adolescent Medicine ◽  
University Of Kentucky ◽  
Menstrual Irregularities ◽  
The Mean ◽  
Adolescent Clinic ◽  
Long Acting ◽  
The University

Abstract Background: Etonogestrel (ENG) implant is an effective method of contraception. The implant is designed to provide contraceptive efficacy for 3 years with a relatively quick return of fertility upon its removal. Menstrual irregularities are not uncommon on long-acting progestins and can often be the factor for discontinuation or removal. A retrospective chart analysis was done on 58 patients who chose to be on the ENG implant. Age ranged from 12 to 24 years. The cycle ranged from 1 to 17 months. The mean length of use of the implant was 10.9 months. Over the 20-month period, 13 ENG implants were removed because of menstrual bleeding problems. Method: We conducted a chart review of the adolescent patients who received the ENG implant in our adolescent clinic. An analysis was done based on symptoms experienced by patients who were on the ENG implant and their management, which in some cases resulted in its removal. Setting: The data is presented on adolescent and young adult patients who receive their reproductive care in the Adolescent Medicine Clinic at the University of Kentucky, Lexington, KY, USA. Conclusions: ENG implant when used correctly and as indicated is extremely effective in providing contraception for up to 3 years. However, menstrual irregularities can be very troublesome and often a reason for its removal. In our experience, 22.4% (13 out of the 58 subjects) had menstrual problems post-insertion that led to its removal. It is crucial for a clinician to inform and be informed about such side effects.

Estimating 1- and 5-year relative survival trends in colorectal cancer (CRC) in the United States: 2004 to 2014.

2018 ◽  
Vol 36 (4_suppl) ◽  
pp. 587-587 ◽  
Author(s):  
Hannah Crooke ◽  
Monica Kobayashi ◽  
Brian Mitchell ◽  
Esmond Nwokeji ◽  
Melissa Laurie ◽  
...  
Keyword(s):  
United States ◽  
Survival Rates ◽  
Stage Iv ◽  
Relative Survival ◽  
The United States ◽  
Stage At Diagnosis ◽  
Stage Iiia ◽  
Ajcc Stage ◽  
Seer Data ◽  
Age And Sex

587 Background: Patient survival is impacted by several factors, one of which is stage at diagnosis. From 1976 to 2014, CRC death rate in the United States (US) declined by 51%. This retrospective study was conducted using US Surveillance, Epidemiology and End Results (SEER) data to evaluate 1- and 5-year relative survival for patients with CRC by American Joint Committee on Cancer (AJCC) stage, age and sex at diagnosis. Methods: The study included adults (age ≥20 years) in the SEER-18 registry diagnosed with CRC in 2004-2014. One- and 5-year relative survival rates were stratified by AJCC stage, age group (20-64 vs. ≥65 years) and sex. Results: One- and 5-year survival was calculated by age and stage at diagnosis (Table), and by sex (data not shown). Overall, 5-year survival rates declined compared to 1-year rates, with the biggest decline observed in stage IV patients. Survival was higher in the younger cohort than in patients ≥65 years of age regardless of stage. Both men and women diagnosed with stage IIB CRC had lower 1- and 5-year survival compared to stage IIIA and IIIB groups, consistent with previous findings. Patients with stage IV had the lowest survival irrespective of age or sex. Conclusions: Overall trends in 1- and 5-year relative survival for CRC varied by AJCC stage, age and sex. Since survival is lowest among CRC patients diagnosed at stage IV, particularly in elderly patients, it reinforces the need for early diagnosis and availability of innovative late stage therapies in this population. [Table: see text]

scholarly journals A Conversation with Jacob Nachmias

2019 ◽  
Vol 5 (1) ◽  
pp. 1-13
Author(s):  
Jacob Nachmias ◽  
J. Anthony Movshon ◽  
Brian A. Wandell ◽  
David H. Brainard
Keyword(s):  
Signal Detection Theory ◽  
The United States ◽  
Harvard University ◽  
University Of Pennsylvania ◽  
National Academy Of Sciences ◽  
Swarthmore College ◽  
Cornell University ◽  
The University ◽  
Academy Of Sciences

We are sad to report that Professor Jacob (Jack) Nachmias passed away on March 2, 2019. Nachmias was born in Athens, Greece, on June 9, 1928. To escape the Nazis, he and his family came to the United States in 1939. He received his undergraduate degree from Cornell University and then an MA from Swarthmore College, where he worked with Hans Wallach and Wolfgang Kohler; his PhD in Psychology was from Harvard University. Nachmias spent the majority of his career as a Professor of Psychology at the University of Pennsylvania. He made fundamental contributions to our understanding of vision, most notably through the study of eye movements, the development of signal detection theory and forced-choice psychophysical methods, and the psychophysical characterization of spatial-frequency-selective visual channels. Nachmias' work was recognized by his election to the National Academy of Sciences and receipt of the Optical Society's Tillyer Award.

scholarly journals Performance of Mumps PCR and Serologic Testing During a University-Associated Mumps Outbreak in Charleston, SC

2020 ◽  
Vol 41 (S1) ◽  
pp. s19-s19
Author(s):  
Kristen Stoltz ◽  
Shruti Puri ◽  
Scott Curry
Keyword(s):  
Chart Review ◽  
Diagnostic Testing ◽  
The United States ◽  
Case Definition ◽  
Case Finding ◽  
Reference Laboratory ◽  
Duration Of Symptoms ◽  
Serologic Testing ◽  
Buccal Swabs ◽  
The University

Background: Sensitive diagnostic testing is critical in responses to mumps outbreaks. PCR testing of buccal swabs is the most sensitive diagnostic test, but IgM serology remains standard in much of the United States. We provided testing guidance stressing use of mumps PCR to ambulatory clinics and emergency departments in addition to the standard serologic testing for acute mumps beginning in 2018. We compared the performance of PCR and IgM serology to assess cases of parotitis presenting during a community outbreak of mumps in fall 2019 associated with a university in Charleston, SC. Methods: All patients tested for mumps who presented to our facility (ER and ambulatory clinics) with mumps PCR and/or mumps IgM ordered between September 2019 and January 2020 were included. Mumps PCRs were sent to a commercial reference laboratory (ARUP). Confirmed cases were defined as having a positive mumps PCR and/or IgM with parotitis. Clinical characteristics of mumps patients including age, duration of symptoms, MMR history, and association with the university were obtained by chart review. Results: Mumps was confirmed in 15 of 44 tested patients (34%), with 15 of 15 mumps patients (100%) having positive PCR and 1 of 15 patients (7%) and 1 of 15 patients (7%) having positive and equivocal mumps IgM serologies, respectively. Only 1 patient who did not meet our mumps case definition (no CT imaging evidence of parotitis, no fevers, chronic sinus symptoms) had a positive PCR and had recent receipt of a third MMR dose in response to the ongoing outbreak. Median age for mumps patients was 22 years (range, 15–48) with 8 of 15 cases (53%) detected among university students and an additional 2 cases having close connections to the university associated with the outbreak. Only 1 of 15 mumps patients (6.7%) was febrile at presentation (median temperature, 37.2°C) and mumps cases presented for testing ≤3 days for 7 of 15 cases (47%) (range, 0–13 days from symptom onset). No cases were diagnosed by IgM only, and 10 of 15 mumps cases had some recollection of remote MMR immunization, whereas 6 of 15 (40%) had 2 documented MMR doses at <5 years of age. Conclusion: Serologic IgM testing for diagnosis of mumps appears insensitive for detection of cases in outbreaks within highly immunized adult patients. Although our recommended shift to PCR likely enhanced case finding during this outbreak, the potential for false-positive PCRs due to vaccine strain shedding following third-dose MMR immunization may also be considered a threat to the specificity of the test during outbreak situations.Funding: NoneDisclosures: None

African Archaeology in the United States, 1968

1969 ◽  
Vol 12 (01) ◽  
pp. 27-33
Author(s):  
Creighton Gabel
Keyword(s):  
United States ◽  
Labor Force ◽  
National Science Foundation ◽  
The United States ◽  
University Of Kentucky ◽  
African Archaeology ◽  
National Science ◽  
The Republic ◽  
The University ◽  
Student Assistants

This is the second in a series of progress reports on African archaeology in the United States. These reports are being produced at the request of the Archaeology Committee of the African Studies Association as a means of indicating the nature and extent of current North American participation in this aspect of African research. William Y. Adams of the University of Kentucky is leading an archaeological expedition to excavate the medieval Nubian village site of Kulubnarti in the Republic of the Sudan. The object of the expedition is to try to discover evidence of Islamization in the fifteenth and sixteenth centuries -- a historical problem which received almost no attention during the recent High Dam salvage campaign in Nubia. Work will be carried on from January to May 1969 under the direction of Dr. and Mrs. Adams with four student assistants and a labor force of 125. The expedition is sponsored by the Department of Anthropology, University of Kentucky, under a grant from the National Science Foundation.

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