scholarly journals A Prospective Study of Vitamin D Supplement in Thyroidectomy Patients Based on Relative Decline of Parathyroid Hormone

2021 ◽  
Vol 12 ◽  
Author(s):  
Qing Hao ◽  
Yun Qin ◽  
Wanjun Zhao ◽  
Lingyun Zhang ◽  
Han Luo

Background: In postthyroidectomy patients, hypocalcemia is the most common complication to prolong hospital stay and decrease patients’ satisfaction. Based on current evidence, it is recommended to supply vitamin D to patients with high risk of developing hypocalcemia. However, how to stratify the risk of patients remains challenging.Aim: We conducted a prospective study to evaluate the effect of vitamin D supplement (calcitriol) on high-risk hypocalcemia patients based on relative decline of parathyroid hormone (RDP).Method: RDP was calculated by the difference between preoperative and postoperative first-day PTH divided by preoperative PTH and presented as percentage. Patients who underwent total thyroidectomy in addition to bilateral central compartment dissection were enrolled prospectively and were divided into two cohorts: Cohort I: patients with RDP ≤70% and Cohort II: patients with RDP >70%. Patients in Cohort I were then randomly assigned to Group A or B, and patients in Cohort II were randomly assigned to Group C or D. All groups received oral calcium, and patients in Groups B and D also received calcitriol. All patients were followed for one year. In the study, standard procedure dictates that only oral calcium is given to patients whose RDP ≤70% and that oral calcium and calcitriol are given to patients whose RDP >70%. Therefore, Cohort I Group A and Cohort II Group D are controls in this study.Results: The incidence of clinical hypocalcemia in Groups A and D (the controls) was 11.0% (10/91), and 17.6% (16/91) required additional intravenous calcium. Of note, no patients developed permanent hypocalcemia. Furthermore, calcitriol supplement did not have significant impact on clinical outcomes between Group A and B in Cohort I. By contrast, calcitriol supplement distinctly improved clinical outcome by comparing Groups C and D (Cohort II), as marked by clinical hypocalcemia, need of requiring intravenous calcium, and long-termed decreased levels of PTH.Conclusion: Supplying calcitriol based on RDP cutoff of 70% may be a wise practice in thyroidectomy patients, and RDP 70% may be a useful predictor to stratify high-risk patients.

2018 ◽  
Vol 218 (1) ◽  
pp. S258
Author(s):  
Courtney Olson-Chen ◽  
Kam Szlachetka ◽  
Dzhamala Gilmandyar ◽  
Erica Faske ◽  
Elizabeth Fountaine ◽  
...  

Author(s):  
Irene Karampela ◽  
Evangelia Chrysanthopoulou ◽  
George Skyllas ◽  
Panagiotis Simitsis ◽  
Gerasimos Socrates Christodoulatos ◽  
...  

BMC Surgery ◽  
2013 ◽  
Vol 13 (Suppl 2) ◽  
pp. S11 ◽  
Author(s):  
Salvatore Tolone ◽  
Ruggiero Roberto ◽  
Gianmattia del Genio ◽  
Luigi Brusciano ◽  
Domenico Parmeggiani ◽  
...  

2017 ◽  
Vol 21 (4) ◽  
pp. 498 ◽  
Author(s):  
Dhalapathy Sadacharan ◽  
Krishnan Ravikumar ◽  
Sankaran Muthukumar ◽  
Thalavai Sundarram ◽  
Selladurai Periyasamy ◽  
...  

2018 ◽  
Vol 109 (5) ◽  
Author(s):  
Željka Savić ◽  
Vladimir Vračarić ◽  
Nataša Milić ◽  
Dijana Nićiforović ◽  
Dragomir Damjanov ◽  
...  

Author(s):  
Marianne Vogsen ◽  
Jeanette Dupont Jensen ◽  
Ivar Yannick Christensen ◽  
Oke Gerke ◽  
Anne Marie Bak Jylling ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document