scholarly journals Colorectal Cancer Survivors Suffering From Sensory Chemotherapy-Induced Peripheral Neuropathy Are Not a Homogenous Group: Secondary Analysis of Patients’ Profiles With Oxaliplatin-Induced Peripheral Neuropathy

2021 ◽  
Vol 12 ◽  
Author(s):  
Nicolas Kerckhove ◽  
Marie Selvy ◽  
Céline Lambert ◽  
Coralie Gonneau ◽  
Gabrielle Feydel ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Peripheral Neuropathy ◽  
Cancer Survivors ◽  
Depressive Disorders ◽  
Secondary Analysis ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Homogenous Group ◽  
Colorectal Cancer Survivors ◽  
Cluster 2

Oxaliplatin, a pivotal drug in the management of colorectal cancer, causes chemotherapy-induced peripheral neuropathy (CIPN) in a third of cancer survivors. Based on a previous cross-sectional study assessing oxaliplatin-related sensory CIPN in colorectal cancer survivors, a secondary analysis was designed to explore the possibility that different clusters of patients may co-exist among a cohort of patients with oxaliplatin-related CIPN. Other objectives were to characterize these clusters considering CIPN severity, anxiety, depression, health-related quality of life (HRQOL), patients’ characteristics and oxaliplatin treatments. Among the 96 patients analyzed, three clusters were identified (cluster 1: 52, cluster 2: 34, and cluster 3: 10 patients). Clusters were significantly different according to CIPN severity and the proportion of neuropathic pain (cluster 1: low, cluster 2: intermediate, and cluster 3: high). Anxiety, depressive disorders and HRQOL alteration were lower in cluster 1 in comparison to clusters 2 and 3, but not different between clusters 2 and 3. This study underlines that patients with CIPN are not a homogenous group, and that CIPN severity is associated with psychological distress and a decline of HRQOL. Further studies are needed to explore the relation between clusters and CIPN management.

scholarly journals Self-Management of Oxaliplatin-Related Peripheral Neuropathy in Colorectal Cancer Survivors

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Cindy Tofthagen ◽  
Laura Gonzalez ◽  
Constance Visovsky ◽  
Alex Akers
Keyword(s):  
Colorectal Cancer ◽  
Peripheral Neuropathy ◽  
Cancer Survivors ◽  
Nutritional Supplement ◽  
Cross Sectional Study ◽  
Self Management ◽  
Painful Neuropathy ◽  
Cross Sectional ◽  
Colorectal Cancer Survivors ◽  
Temporary Relief

Purpose. The purpose of this study was to evaluate medications that cancer survivors with oxaliplatin-induced peripheral neuropathy take to control neuropathic symptom, and to explore self-management techniques used at home to provide temporary relief of painful neuropathy. This was a mixed methods, descriptive, cross-sectional study using self-reported data from colorectal cancer survivors previously treated with oxaliplatin. We analyzed demographic and medication data obtained from participants, along with written comments from an open-ended question regarding methods participants had tried to self-manage symptoms of neuropathy. Results. Twenty-nine percent of the sample reported taking some type of nutritional supplement with potential neuroprotective qualities. Opioids were being taken by 10% of the sample, and nonsteroidal anti-inflammatory and over-the-counter medications were taken by 15% of participants. Twelve percent of participants were taking antidepressants and 10% were taking anticonvulsants, primarily gabapentin. Recurrent themes for nonpharmacologic treatment included avoiding the cold/keeping warm, keeping moving, massaging or rubbing the affected area, and living with it. Conclusions. Patients treated with oxaliplatin for colorectal cancer utilize a variety of traditional pharmacologic agents and nutritional supplements in an effort to self-manage neuropathic symptoms. Patients also employ a variety of home-based therapies to provide temporary relief of peripheral neuropathy symptoms.

Peripheral Neuropathy: Comparison of Symptoms and Severity Between Colorectal Cancer Survivors and Patients With Diabetes

2021 ◽  
Vol 25 (4) ◽  
pp. 395-403
Author(s):  
Chih-Jung Wu ◽  
Kuan-Jung Huang ◽  
Yi-Chuan Tsai ◽  
Tzu-Pei Yeh ◽  
Chia-Fen Hsieh ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Peripheral Neuropathy ◽  
Cancer Survivors ◽  
Colorectal Cancer Survivors ◽  
Patients With Diabetes

scholarly journals Characterizing employment of colorectal cancer survivors using electronic health records

JAMIA Open ◽  
2021 ◽  
Vol 4 (3) ◽  
Author(s):  
Alexandra Varga ◽  
Inga Gruß ◽  
Debra P Ritzwoller ◽  
Cathy J Bradley ◽  
Andrew T Sterrett ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Clinical Practice ◽  
Cancer Survivors ◽  
Employment Status ◽  
Secondary Analysis ◽  
Free Text ◽  
Colorectal Cancer Survivors ◽  
Combining Data ◽  
Integrated Health Care System ◽  
Electronic Health

Abstract Objective Although the value of collecting occupational data is well-established, these data are not systematically collected in clinical practice. We assessed the availability of electronic health record (EHR)-based occupation data within a large integrated health care system to determine the feasibility of its use in research. Materials and Methods We used a mixed-methods approach to extract EHR data and define employment status, employer, and employment industry of 1107 colorectal cancer survivors. This was a secondary analysis of a subset of the Patient Outcomes Research to Advance Learning (PORTAL) colorectal cancer cohort. Results We categorized the employment industry for 46% of the cohort. Employment status was available for 58% of the cohort. The employer was missing for over 95% of the cohort. Conclusion By combining data from structured and free-text EHR fields, we identified employment status and industry for approximately half of our sample. Findings demonstrate limitations of EHR data and underscore the need for systematic collection of occupation data in clinical practice.

scholarly journals Peripheral neuropathy in colorectal cancer survivors: The influence of oxaliplatin administration. Results from the population-based PROFILES registry

2015 ◽  
Vol 54 (4) ◽  
pp. 463-469 ◽  
Author(s):  
Antoinetta J. M. Beijers ◽  
Floortje Mols ◽  
Vivianne C. G. Tjan-Heijnen ◽  
Catharina G. Faber ◽  
Lonneke V. van de Poll-Franse ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Peripheral Neuropathy ◽  
Cancer Survivors ◽  
Population Based ◽  
Colorectal Cancer Survivors
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