scholarly journals Bioactive Herbal Extracts of Traditional Chinese Medicine Applied with the Biomaterials: For the Current Applications and Advances in the Musculoskeletal System

2021 ◽  
Vol 12 ◽  
Author(s):  
Haotao Li ◽  
Rongjie Wu ◽  
Haiyang Yu ◽  
Qiujian Zheng ◽  
Yuanfeng Chen
Keyword(s):  
Tissue Engineering ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Musculoskeletal Diseases ◽  
Herbal Extracts ◽  
Musculoskeletal Tissue ◽  
Additive Manufacturing Technology ◽  
Attractive Candidate ◽  
Multiple Signaling ◽  
Anti Inflammation

Traditional Chinese medicine (TCM) has demonstrated superior therapeutic effect for musculoskeletal diseases for thousands of years. Recently, the herbal extracts of TCM have received rapid advances in musculoskeletal tissue engineering (MTE). A literature review collecting both English and Chinese references on bioactive herbal extracts of TCM in biomaterial-based approaches was performed. This review provides an up-to-date overview of application of TCMs in the field of MTE, involving regulation of multiple signaling pathways in osteogenesis, angiogenesis, anti-inflammation, and chondrogenesis. Meanwhile, we highlight the potential advantages of TCM, opening the possibility of its extensive application in MTE. Overall, the superiority of traditional Chinese medicine turns it into an attractive candidate for coupling with advanced additive manufacturing technology.

scholarly journals Application of Herbal Medicines with Heat-Clearing Property to Anti-Microinflammation in the Treatment of Diabetic Kidney Disease

2019 ◽  
Vol 2019 ◽  
pp. 1-6 ◽  
Author(s):  
Jing Guo ◽  
Yabin Gao ◽  
Yaoxian Wang ◽  
Wei Jing Liu ◽  
Jingwei Zhou ◽  
...  
Keyword(s):  
Chinese Medicine ◽  
Kidney Disease ◽  
Traditional Chinese Medicine ◽  
Diabetic Kidney Disease ◽  
Herbal Medicines ◽  
Pathogenic Factor ◽  
Diabetic Kidney ◽  
Global Pandemic ◽  
Anti Inflammation ◽  
Made In

Diabetic kidney disease (DKD) is a global pandemic, and microinflammation has been reported as an important pathogenic factor of DKD. Traditional Chinese Medicine (TCM) has been used in the treatment of DKD for thousands of years, and modern Chinese medicine studies have found that herbal medicines with heat-clearing property have a curative anti-inflammation effect in DKD. This article reviews the new clinical and experimental progress made in herbal medicines with heat-clearing property, in the treatment of DKD, as well as their safety aspects.

scholarly journals The Effects of Bairesi Complex Prescription (a Uyghur Medicine Prescription) and Its Five Crude Herbal Extracts on Melanogenesis in G-361 Cells

2016 ◽  
Vol 2016 ◽  
pp. 1-7 ◽  
Author(s):  
Xuedan Huang ◽  
Masayuki Ishikawa ◽  
Arkin Mansur ◽  
Aynur Emet ◽  
Ezimet Nasir ◽  
...  
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Hot Water ◽  
Herbal Extracts ◽  
Melanin Production ◽  
Water Extracts ◽  
Melanin Formation ◽  
Medicine Prescription

Vitiligo is considered a preimmune stage of a disease that is not well clarified. This condition is difficult to treat because there is no definite cure. Uyghur medicine is an important part of traditional Chinese medicine. There are many types of prescriptions that are used for the treatment of vitiligo. Bairesi complex prescription is one of the active prescriptions for vitiligo that is used in the clinic. However, the intensities of melanogenesis due to uses of Bairesi complex prescription and its five constituent crude herbs have not been reported yet. In the present study, we found that the hot water extracts of Bairesi complex prescription and the crude herbs were more effective in eliciting melanin production in G-361 cells than the EtOH extracts. Furthermore, the Bairesi complex prescription exhibited less cytotoxicity and was more effective in melanin formation than the five crude herbal extracts. In the present study, we also discuss the mechanisms of melanogenesis due to the use of the Bairesi complex prescription and its single crude herbal extracts.

scholarly journals Research Progress of Anti-Tumor Angiogenesis in Traditional Chinese Medicine

2021 ◽  
Vol 5 (6) ◽  
pp. 30-33
Author(s):  
Tao Gou ◽  
Hailong Si
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Tumor Angiogenesis ◽  
Malignant Tumors ◽  
Hot Spot ◽  
Research Progress ◽  
Herbal Extracts ◽  
Strong Inhibition ◽  
Chinese Herbal ◽  
Tumor Neovascularization

In recent years, seeking effective anti-angiogenic components and therapeutic methods from traditional Chinese Medicine (TCM) has been a hot spot in the treatment of malignant tumors. In particular, the active ingredients found in Chinese herbal extracts have shown strong inhibition of tumor neovascularization.

scholarly journals A Traditional Chinese Medicine Plant Extract Prevents Alcohol-Induced Osteopenia

2021 ◽  
Vol 12 ◽  
Author(s):  
Dongyang Qian ◽  
Hui Zhou ◽  
Pan Fan ◽  
Tao Yu ◽  
Anish Patel ◽  
...  
Keyword(s):  
Chinese Medicine ◽  
Alcohol Consumption ◽  
Traditional Chinese Medicine ◽  
Bone Diseases ◽  
Syzygium Aromaticum ◽  
Herbal Extracts ◽  
Male Mice ◽  
Middle Aged ◽  
Excessive Alcohol Consumption ◽  
Excessive Alcohol

Traditional Chinese medicine (TCM) has been practiced in the treatment of bone diseases and alcoholism. Chronic excessive alcohol use results in alcohol-induced bone diseases, including osteopenia and osteoporosis, which increases fracture risk, deficient bone repair, and osteonecrosis. This preclinical study investigated the therapeutic effects of TCM herbal extracts in animal models of chronic excessive alcohol consumption-induced osteopenia. TCM herbal extracts (Jing extracts) were prepared from nine Chinese herbal medicines, a combinative herbal formula for antifatigue and immune regulation, including Astragalus, Cistanche deserticola, Dioscorea polystachya, Lycium barbarum, Epimedium, Cinnamomum cassia, Syzygium aromaticum, Angelica sinensis, and Curculigo orchioides. In this study, Balb/c male mice were orally administrated alcohol (3.2 g/kg/day) with/without TCM herbal extracts (0.125 g/kg, 0.25 g/kg, or 0.5 g/kg) by gavage. Our results showed that after 50 days of oral administration, TCM herbal extracts prevented alcohol-induced osteopenia demonstrated by μ-CT bone morphological analysis in young adults and middle-aged/old Balb/c male mice. Biochemical analysis demonstrated that chronic alcohol consumption inhibits bone formation and has a neutral impact on bone resorption, suggesting that TCM herbal extracts (Jing extracts) mitigate the alcohol-induced abnormal bone metabolism in middle-aged/old male mice. Protocatechuic acid, a natural phenolic acid in Jing extracts, mitigates in vivo alcohol-induced decline of alkaline phosphatase (ALP) gene expression in the bone marrow of Balb/c male mice and in vitro ALP activity in pre-osteoblast MC3T3-E1 cells. Our study suggests that TCM herbal extracts prevent chronic excessive alcohol consumption-induced osteopenia in male mice, implying that traditional medicinal plants have the therapeutic potential of preventing alcohol-induced bone diseases.

scholarly journals Insights into the Action Mechanisms of Traditional Chinese Medicine in Osteoarthritis

2017 ◽  
Vol 2017 ◽  
pp. 1-13 ◽  
Author(s):  
Linfu Li ◽  
Haiqing Liu ◽  
Weimei Shi ◽  
Hai Liu ◽  
Jianqiong Yang ◽  
...  
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Cartilage Destruction ◽  
Degenerative Joint Disease ◽  
Joint Disease ◽  
Action Mechanism ◽  
Action Mechanisms ◽  
Inflammatory Drugs ◽  
Anti Inflammation ◽  
Modern Technologies

Osteoarthritis (OA) is a chronic degenerative joint disease characterized by articular cartilage destruction, synovial inflammation, and osteophyte formation. No effective treatments are available. The current pharmacological medications such as nonsteroidal anti-inflammatory drugs (NSAIDs) and analgesics, accompanied by possible adverse effects, might ameliorate OA symptoms. But they do not arrest the progression of OA. Traditional Chinese medicine (TCM) provides medical value by modification of disease and symptoms in OA. Valuable work on exploring TCM merits for OA patients has been investigated using modern technologies, although the complicated interacting network among the numerous components indicates the uncertainty of target specification. This review will provide an overview of the action mechanism of TCM in the last 5 years, discussing the TCM activities of anti-inflammation, antiapoptosis, antioxidation, anticatabolism, and proliferation in OA. TCM is a proposed medical option for OA treatment.

scholarly journals Renal-Protective Effects and Potential Mechanisms of Traditional Chinese Medicine after Ischemia-Reperfusion Injury

2021 ◽  
Vol 2021 ◽  
pp. 1-6
Author(s):  
Demin Liu ◽  
Songling Tang ◽  
Lu Gan ◽  
Wei Cui
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Mitochondrial Fission ◽  
Hypovolemic Shock ◽  
Kidney Injury ◽  
Protective Effects ◽  
Underlying Mechanisms ◽  
Anti Inflammation

Renal ischemia-reperfusion (I/R) injury mainly causes acute kidney injury (AKI) after renal transplantation, trauma, sepsis, and hypovolemic shock. Patients with renal I/R injury are frequently associated with a poor prognosis. Traditional Chinese medicine (TCM) has been used for the prevention and treatment of various diseases in China and other Asian countries for centuries. Many studies have shown the protective effect of TCM on renal I/R injury, due to its diverse bioactive components. The potential mechanisms of TCMs on renal I/R injury include anti-inflammation, antioxidative effect, anti-cell death, downregulation of adhesion molecule expression, regulation of energy metabolism by restoring Na+-K+-ATPase activity, and mitochondrial fission. This review summarizes the major developments in the effects and underlying mechanisms of TCMs on the renal I/R injury.

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