scholarly journals Longitudinal Assessment of Verbal Learning and Memory in Amnestic Mild Cognitive Impairment: Practice Effects and Meaningful Changes

2017 ◽  
Vol 8 ◽  
Author(s):  
María Campos-Magdaleno ◽  
David Facal ◽  
Cristina Lojo-Seoane ◽  
Arturo X. Pereiro ◽  
Onésimo Juncos-Rabadán
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Learning And Memory ◽  
Verbal Learning ◽  
Amnestic Mild Cognitive Impairment ◽  
Practice Effects ◽  
Longitudinal Assessment

scholarly journals Lexical semantic memory in amnestic mild cognitive impairment and mild Alzheimer's disease

2007 ◽  
Vol 65 (3a) ◽  
pp. 619-622 ◽  
Author(s):  
Marcio L.F. Balthazar ◽  
José E. Martinelli ◽  
Fernando Cendes ◽  
Benito P. Damasceno
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Semantic Memory ◽  
Statistical Significance ◽  
Verbal Learning ◽  
Amnestic Mild Cognitive Impairment ◽  
Memory Tests ◽  
Lexical Semantic

OBJECTIVE: To study lexical semantic memory in patients with amnestic mild cognitive impairment (aMCI), mild Alzheimer's disease (AD) and normal controls. METHOD: Fifteen mild AD, 15 aMCI, and 15 normal control subjects were included. Diagnosis of AD was based on DSM-IV and NINCDS-ADRDA criteria, and that of aMCI, on the criteria of the International Working Group on Mild Cognitive Impairment, using CDR 0.5 for aMCI and CDR 1 for mild AD. All subjects underwent semantic memory tests (Boston Naming-BNT, CAMCOG Similarities item), Rey Auditory Verbal Learning Test (RAVLT), Mini-Mental Status Examination (MMSE), neuropsychological tests (counterproofs), and Cornell Scale for Depression in Dementia. Data analysis used Mann-Whitney test for intergroup comparisons and Pearson's coefficient for correlations between memory tests and counterproofs (statistical significance level was p<0.05). RESULTS: aMCI patients were similar to controls on BNT and Similarities, but worse on MMSE and RAVLT. Mild AD patients scored significantly worse than aMCI and controls on all tests. CONCLUSION: aMCI impairs episodic memory but tends to spare lexical semantic system, which can be affected in the early phase of AD.

Clinical, Neuropsychological, and Neuroimaging Characteristics of Amyloid-positive vs. Amyloid-negative Patients with Clinically Diagnosed Alzheimer’s Disease and Amnestic Mild Cognitive Impairment

2021 ◽  
Vol 18 ◽  
Author(s):  
Yue Wang ◽  
Fanghua Lou ◽  
Yonggang Li ◽  
Fang Liu ◽  
Ying Wang ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Fdg Pet ◽  
Verbal Learning ◽  
Amnestic Mild Cognitive Impairment ◽  
Amyloid Deposition ◽  
Metabolic Pattern ◽  
Affective Symptoms

Background: A significant proportion of patients with clinically diagnosed Alzheimer’s disease (AD) and an even higher proportion of patients with amnestic mild cognitive impairment (aMCI) do not show evidence of amyloid deposition on positron emission tomography (PET) with amyloid-binding tracers such as 11C-labeled Pittsburgh Compound B (PiB). Objective: This study aimed to identify clinical, neuropsychological and neuroimaging factors that might suggest amyloid neuropathology in patients with clinically suspected AD or aMCI. Methods: Forty patients with mild to moderate AD and 23 patients with aMCI who were clinically diagnosed in our memory clinic and had PiB PET scans were included. Clinical, neuropsychologi- cal, and imaging characteristics, such as medial temporal lobe atrophy (MTA) and white matter hy- perintensities (WMH) on MRI and metabolic pattern on 18F-labeled fluorodeoxyglucose (FDG) PET, were compared between patients with PiB positive and negative PET results for AD, aMCI, and all subjects combined, respectively. Results: Compared with PiB positive patients, PiB negative patients had a higher prevalence of hy- pertension history, better performance on the Mini-Mental State Examination, the Rey Auditory Verbal Learning Test, and the Judgement of Line Orientation, lower score of MTA, and were less likely to have temporoparietal-predominant hypometabolism on FDG PET. Affective symptoms were less common in PiB negative patients diagnosed with AD, and the Animal Fluency Test score was higher in PiB negative patients diagnosed with aMCI. Conclusion: : In patients with clinically diagnosed AD or aMCI, absence of a history of hyperten- sion, deficits in verbal learning and memory, visuospatial function, semantic verbal fluency, pres- ence of affective symptoms, MTA on MRI, and temporoparietal hypometabolism on FDG PET suggested amyloid deposition in the brain.

scholarly journals Predictions of Current and Future Episodic Memory Using Grey Matter Volume and Functional Connectome: A Longitudinal Study in Amnestic Mild Cognitive Impairment Patients

2020 ◽  
Author(s):  
Zan Wang ◽  
Hao Shu ◽  
Duan Liu ◽  
Fan Su ◽  
Chunming Xie ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Episodic Memory ◽  
Grey Matter ◽  
Verbal Learning ◽  
Amnestic Mild Cognitive Impairment ◽  
Grey Matter Volume ◽  
Default Mode ◽  
Matter Volume ◽  
Limbic Systems

Abstract Background: Amnestic mild cognitive impairment (aMCI) patients are considered an at-risk group for progression to Alzheimer’s dementia and accurate prediction of aMCI progression could facilitate the optimal decision-making for both clinicians and patients. Based on the baseline whole-brain grey-matter volume (GMV) and resting-state functional connectivity (FC), we used relevance vector regression to predict the baseline and longitudinal Rey’s Auditory Verbal Learning Test Delayed Recall (AVLT-DR) scores of individual aMCI patients.Methods: Fifty aMCI patients completed baseline and 3-year follow-up visits. All patients underwent comprehensive neuropsychological assessments and multimodal brain MRI scans.Results: We found that the GMV pattern predicted the baseline AVLT-DR score, while the pattern of FC predicted the longitudinal AVLT-DR score. In particular, GMV predicted the baseline AVLT-DR score with an accuracy of r = 0.54 (P < 0.001); the regions that contributed the most were within the default mode (e.g., the posterior cingulate gyrus, angular gyrus and middle temporal gyrus) and limbic systems (e.g., the hippocampus and parahippocampal gyrus). The FC predicted the longitudinal AVLT-DR score with an accuracy of r = 0.50 (P < 0.001), and the connections that contributed the most were the within- and between-system connectivity of the default mode and limbic systems. As a complement, we demonstrated that the GMV and FC patterns could also effectively predict the baseline and longitudinal composite episodic memory scores (calculated by averaging three well-known episodic memory test scores).Conclusions: Our results demonstrated the multimodal brain features in the individualized prediction of aMCI patients’ current and future episodic memory performance. These “neural fingerprints” have the potential to be biomarkers for aMCI patients and can help medical professionals optimize individual patient management and longitudinal evaluation.

A Lack of Practice Effects on Memory Tasks Predicts Conversion to Alzheimer Disease in Patients With Amnestic Mild Cognitive Impairment

2020 ◽  
pp. 089198872094424
Author(s):  
Maria Stefania De Simone ◽  
Roberta Perri ◽  
Marta Rodini ◽  
Lucia Fadda ◽  
Massimo De Tollis ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Alzheimer Disease ◽  
Test Performance ◽  
Medial Temporal Lobe ◽  
Amnestic Mild Cognitive Impairment ◽  
Practice Effects ◽  
Large Set ◽  
Neuropsychological Evaluations

The aim of the current study was to test the accuracy of practice effects, that is, improvement in test performance due to repeated neuropsychological evaluations, in identifying patients with amnestic mild cognitive impairment (a-MCI) at greater risk of conversion to Alzheimer disease (AD). For this purpose, we conducted a longitudinal study of 54 patients diagnosed with a-MCI at the first assessment and followed-up for 4 years. During this time, 18 patients converted to AD. Baseline and 6- to 12-month follow-up performances on a large set of neuropsychological tests were analyzed to determine their diagnostic ability to predict later conversion to dementia. Results demonstrate that a lack of practice effects on episodic memory tests is an accurate prognostic indicator of late conversion to AD in a-MCI patients. In fact, even though the performance of both groups was substantially comparable at the baseline evaluation, stable a-MCI patients greatly improved their memory performance at retest after 6 to 12 months; instead, scores of converter a-MCI remained stable or decreased passing from baseline to follow-up. Standardized z-change scores on memory tasks, which were computed as a reliable measure of performance change, classified group membership with very good overall accuracy, which was higher than the classification of converter and stable a-MCIs provided by baseline or follow-up scores. We hypothesize that the lack of practice effects on memory tasks mirrors the early involvement of medial temporal lobe areas in converter a-MCI that are fundamental for the consolidation of new memory traces.

scholarly journals Category verbal fluency performance may be impaired in amnestic mild cognitive impairment

2007 ◽  
Vol 1 (2) ◽  
pp. 161-165 ◽  
Author(s):  
Márcio Luiz Figueredo Balthazar ◽  
Fernando Cendes ◽  
Benito Pereira Damasceno
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Verbal Fluency ◽  
Mood State ◽  
Digit Span ◽  
Statistical Significance ◽  
Verbal Learning ◽  
Poor Performance ◽  
Amnestic Mild Cognitive Impairment ◽  
Significance Level

Abstract To study category verbal fluency (VF) for animals in patients with amnestic mild cognitive impairment (aMCI), mild Alzheimer disease (AD) and normal controls. Method: Fifteen mild AD, 15 aMCI, and 15 normal control subjects were included. Diagnosis of AD was based on DSM-IV and NINCDS-ADRDA criteria, while aMCI was based on the criteria of the International Working Group on Mild Cognitive Impairment, using CDR 0.5 for aMCI and CDR 1 for mild AD. All subjects underwent testing of category VF for animals, lexical semantic function (Boston Naming-BNT, CAMCOG Similarities item), WAIS-R forward and backward digit span, Rey Auditory Verbal Learning (RAVLT), Mini-Mental Status Examination (MMSE), and other task relevant functions such as visual perception, attention, and mood state (with Cornell Scale for Depression in Dementia). Data analysis used ANOVA and a post-hoc Tukey test for intergroup comparisons, and Pearson's coefficient for correlations of memory and FV tests with other task relevant functions (statistical significance level was p<0.05). Results: aMCI patients had lower performance than controls on category VF for animals and on the backward digit span subtest of WAIS-R but higher scores compared with mild AD patients. Mild AD patients scored significantly worse than aMCI and controls across all tests. Conclusion: aMCI patients may have poor performance in some non-memory tests, specifically category VF for animals in our study, where this could be attributable to the influence of working memory.

scholarly journals Predictions of Current and Future Episodic Memory Using Gay Matter Volume and Functional Connectome: A Longitudinal Study in Amnestic Mild Cognitive Impairment Patients

2020 ◽  
Author(s):  
Zan Wang ◽  
Hao Shu ◽  
Duan Liu ◽  
Fan Su ◽  
Chunming Xie ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Episodic Memory ◽  
Verbal Learning ◽  
Amnestic Mild Cognitive Impairment ◽  
Angular Gyrus ◽  
Grey Matter Volume ◽  
Default Mode ◽  
Matter Volume ◽  
Limbic Systems

Abstract Background: Amnestic mild cognitive impairment (aMCI) patients are considered an at-risk group for progression to Alzheimer’s dementia and accurate prediction of aMCI progression could facilitate the optimal decision-making for both clinicians and patients. Based on the baseline whole-brain grey-matter volume (GMV) and resting-state functional connectivity (FC), we used relevance vector regression to predict the baseline and longitudinal Rey’s Auditory Verbal Learning Test Delayed Recall (AVLT-DR) scores of individual aMCI patients.Methods: Fifty aMCI patients completed baseline and 3-year follow-up visits. All patients underwent comprehensive neuropsychological assessments and multimodal brain MRI scans.Results: We found that the GMV pattern predicted the baseline AVLT-DR score, while the pattern of FC predicted the longitudinal AVLT-DR score. In particular, GMV predicted the baseline AVLT-DR score with an accuracy of r = 0.54 (P < 0.001); the regions that contributed the most were within the default mode (e.g., the posterior cingulate gyrus, angular gyrus and middle temporal gyrus) and limbic systems (e.g., the hippocampus and parahippocampal gyrus). The FC predicted the longitudinal AVLT-DR score with an accuracy of r = 0.50 (P < 0.001), and the connections that contributed the most were the within- and between-system connectivity of the default mode and limbic systems. As a complement, we demonstrated that the GMV and FC patterns could also effectively predict the baseline and longitudinal composite episodic memory scores (calculated by averaging three well-known episodic memory test scores).Conclusions: Our results demonstrated the multimodal brain features in the individualized prediction of aMCI patients’ current and future episodic memory performance. These “neural fingerprints” have the potential to be biomarkers for aMCI patients and can help medical professionals optimize individual patient management and longitudinal evaluation.

Cerebral Vasomotor Reactivity in Amnestic Mild Cognitive Impairment

2020 ◽  
Vol 77 (1) ◽  
pp. 191-202
Author(s):  
Tsubasa Tomoto ◽  
Takashi Tarumi ◽  
Jason Chen ◽  
Evan P. Pasha ◽  
C. Munro Cullum ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Executive Function ◽  
Mild Cognitive Impairment ◽  
Cognitive Performance ◽  
Verbal Learning ◽  
Normal Subjects ◽  
Amnestic Mild Cognitive Impairment ◽  
Logical Memory ◽  
Vasomotor Reactivity ◽  
Cerebral Vasomotor Reactivity

Background: Cerebral blood flow (CBF) is sensitive to changes in arterial CO2, referred to as cerebral vasomotor reactivity (CVMR). Whether CVMR is altered in patients with amnestic mild cognitive impairment (aMCI), a prodromal stage of Alzheimer disease (AD), is unclear. Objective: To determine whether CVMR is altered in aMCI and is associated with cognitive performance. Methods: Fifty-three aMCI patients aged 55 to 80 and 22 cognitively normal subjects (CN) of similar age, sex, and education underwent measurements of CBF velocity (CBFV) with transcranial Doppler and end-tidal CO2 (EtCO2) with capnography during hypocapnia (hyperventilation) and hypercapnia (rebreathing). Arterial pressure (BP) was measured to calculate cerebrovascular conductance (CVCi) to normalize the effect of changes in BP on CVMR assessment. Cognitive function was assessed with Mini-Mental State Examination (MMSE) and neuropsychological tests focused on memory (Logical Memory, California Verbal Learning Test) and executive function (Delis-Kaplan Executive Function Scale; DKEFS). Results: At rest, CBFV and MMSE did not differ between groups. CVMR was reduced by 13% in CBFV% and 21% in CVCi% during hypocapnia and increased by 22% in CBFV% and 20% in CVCi% during hypercapnia in aMCI when compared to CN (all p < 0.05). Logical Memory recall scores were positively correlated with hypocapnia (r = 0.283, r = 0.322, p < 0.05) and negatively correlated with hypercapnic CVMR measured in CVCi% (r = –0.347, r = –0.446, p < 0.01). Similar correlations were observed in D-KEFS Trail Making scores. Conclusion: Altered CVMR in aMCI and its associations with cognitive performance suggests the presence of cerebrovascular dysfunction in older adults who have high risks for AD.

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