scholarly journals Human Laboratory Models of Cannabis Use: Applications for Clinical and Translational Psychiatry Research

2021 ◽  
Vol 12 ◽  
Author(s):  
Reilly R. Kayser ◽  
Margaret Haney ◽  
Helen Blair Simpson
Keyword(s):  
Psychiatric Treatment ◽  
Psychiatric Symptoms ◽  
Cannabis Use ◽  
Future Research ◽  
Psychiatric Illnesses ◽  
Medicinal Cannabis ◽  
Laboratory Procedures ◽  
Psychiatric Conditions ◽  
Laboratory Models ◽  
Human Laboratory

Cannabis is increasingly used by individuals with mental health diagnoses and often purported to treat anxiety and various other psychiatric symptoms. Yet support for using cannabis as a psychiatric treatment is currently limited by a lack of evidence from rigorous placebo-controlled studies. While regulatory hurdles and other barriers make clinical trials of cannabis challenging to conduct, addiction researchers have decades of experience studying cannabis use in human laboratory models. These include methods to control cannabis administration, to delineate clinical and mechanistic aspects of cannabis use, and to evaluate potential treatment applications for cannabis and its constituents. In this paper, we review these human laboratory procedures and describe how each can be applied to study cannabis use in patients with psychiatric disorders. Because anxiety disorders are among the most common psychiatric illnesses affecting American adults, and anxiety relief is also the most commonly-reported reason for medicinal cannabis use, we focus particularly on applying human laboratory models to study cannabis effects in individuals with anxiety and related disorders. Finally, we discuss how these methods can be integrated to study cannabis effects in other psychiatric conditions and guide future research in this area.

scholarly journals Progress in psychoradiology, the clinical application of psychiatric neuroimaging

2019 ◽  
Vol 92 (1101) ◽  
pp. 20181000 ◽  
Author(s):  
Xiaoqi Huang ◽  
Qiyong Gong ◽  
John A. Sweeney ◽  
Bharat B. Biswal
Keyword(s):  
Imaging Techniques ◽  
Clinical Work ◽  
Work Flow ◽  
Future Research ◽  
Clinical Settings ◽  
Psychiatric Illnesses ◽  
High Prevalence ◽  
Psychiatric Conditions ◽  
Selection For ◽  
Understanding Of Illness

Psychoradiology is an emerging field that applies radiological imaging technologies to psychiatric conditions. In the past three decades, brain imaging techniques have rapidly advanced understanding of illness and treatment effects in psychiatry. Based on these advances, radiologists have become increasingly interested in applying these advances for differential diagnosis and individualized patient care selection for common psychiatric illnesses. This shift from research to clinical practice represents the beginning evolution of psychoradiology. In this review, we provide a summary of recent progress relevant to this field based on their clinical functions, namely the (1) classification and subtyping; (2) prediction and monitoring of treatment outcomes; and (3) treatment selection. In addition, we provide guidelines for the practice of psychoradiology in clinical settings and suggestions for future research to validate broader clinical applications. Given the high prevalence of psychiatric disorders and the importance of increased participation of radiologists in this field, a guide regarding advances in this field and a description of relevant clinical work flow patterns help radiologists contribute to this fast-evolving field.

Human Laboratory Models of Cannabis Use Disorder

2018 ◽  
pp. 75-84 ◽  
Author(s):  
Caroline A. Arout ◽  
Evan Herrmann ◽  
Margaret Haney
Keyword(s):  
Cannabis Use ◽  
Cannabis Use Disorder ◽  
Laboratory Models ◽  
Human Laboratory

Getting High or Getting By? An Examination of Motives, Misuse, and Concurrent Psychopathology in a Sample of General Community Adults

2021 ◽  
Author(s):  
Molly Scarfe ◽  
Candice Muir ◽  
Karen Rowa ◽  
Iris Balodis ◽  
James MacKillop
Keyword(s):  
Negative Reinforcement ◽  
Psychiatric Symptoms ◽  
Cannabis Use ◽  
Treatment Target ◽  
Mediation Analyses ◽  
Symptoms Of Depression ◽  
Coping Motives ◽  
Psychiatric Conditions ◽  
The Relationship ◽  
General Community

Objective: Research conducted with young adults has consistently identified cannabis use motives as a predictor for cannabis use and problems, but comparatively few studies have examined cannabis motives in adult samples. Furthermore, although substantive evidence has identified links between cannabis use and psychiatric conditions, limited research has examined the intersection of cannabis use, motives, and psychopathology. The present study sought to characterize cannabis use motives in an adult sample and investigate whether those motives would link relationships between cannabis misuse and psychiatric symptoms. Method: Participants (N=395; M age=34.8; %F=47.6; % White = 81.3%) completed assessments related to cannabis misuse, cannabis use motives, and symptoms of depression, anxiety, PTSD, and somatic experiences. Bivariate correlations, hierarchical regressions, and subsequently, mediation analyses were performed to examine associations between motives and cannabis misuse, and to investigate whether particular motives would link the relationship between cannabis misuse and psychiatric symptoms. Results: Analyses revealed statistically significant, unique associations between cannabis misuse and Social (β = .13), Enhancement (β = .12) and, particularly, Coping motives (β = .48). Further, Coping fully linked the relationship between level of cannabis misuse and depressive, anxiety, PTSD, and somatic symptoms. Conclusion: These results lend support for a negative reinforcement motivational profile as the predominant pattern in adult cannabis users, especially with regard to concurrent symptoms of cannabis use disorder and psychopathology. These results suggest that targeting maladaptive coping with cannabis may prove an effective treatment target in addressing co-occurring cannabis misuse and psychopathology.

Synthesis

2020 ◽  
pp. 421-428
Author(s):  
Lauren Brookman-Frazee ◽  
Amy Drahota ◽  
Colby Chlebowski ◽  
Yael Koenig ◽  
Katherine Nguyen Williams ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
Autism Spectrum ◽  
Future Research ◽  
Research Directions ◽  
Course Assessment ◽  
Academic Partnerships ◽  
Assessment And Treatment ◽  
Important Field ◽  
Future Research Directions ◽  
Psychiatric Conditions

Recent research and clinical attention devoted to co-occurring psychiatric conditions within autism spectrum disorder (ASD) has led to significant advances in the understanding of and ability to assess and treat co-occurring problems effectively. This chapter summarizes those advances while also highlighting the substantial gaps that remain in the understanding of co-occurring problems in people with ASD. The chapter provides recommendations for future research directions in the areas of etiology, developmental course, assessment, and treatment. It also offers suggestions for improving the representativeness of research participants and strengthening community–academic partnerships in this important field of study.

Sport-Related and Psychosocial Factors Associated With Motives and Consequences Of Alcohol and Cannabis Use Among NCAA Athletes: A Systematic Review

2021 ◽  
Author(s):  
Callon M Williams ◽  
Michael T Shaw ◽  
Nadine R Mastroleo ◽  
Emily L Zale
Keyword(s):  
Sensation Seeking ◽  
Positive Reinforcement ◽  
National Collegiate Athletic Association ◽  
Cannabis Use ◽  
Drinking Motives ◽  
Future Research ◽  
Reference List ◽  
Psychosocial Correlates ◽  
Ncaa Athletes ◽  
Meta Analyses

Abstract Aims To review differences in alcohol- and cannabis-related motives and consequences among National Collegiate Athletic Association (NCAA) athletes as a function of athlete characteristics (e.g. gender and competition season status). Methods Procedures followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. PubMed, PsycINFO and manual reference list review were used to identify studies that reported alcohol- or cannabis-related motives and consequences among NCAA athletes as a function of gender, race, season status, division level or sport-type through December 2019. Relevant findings and any reported psychosocial correlates were extracted by two independent reviewers. Results The majority of studies (K = 15) focused on alcohol-related motives or consequences, with one examining cannabis-related motives, and no studies examined cannabis-related consequences. Social drinking motives were strongest among men and White NCAA athletes, and athlete-specific motives were most salient for men and in-season athletes. Cannabis use motives for positive reinforcement (e.g. enhancement) and coping were also strongest during the in-season. Negative alcohol-related consequences were greatest among men, athletes of color and out-of-season athletes, although women and in-season athletes experienced more consequences in athletic performance. Our exploratory aim revealed two studies that examined psychosocial correlates, and the results indicate that sensation-seeking, stress and negative affect were associated with more alcohol-related consequences. Conclusion NCAA athletes are a heterogenous population, and their motives and consequences of use appear to vary across multiple athlete factors (e.g., gender). This review highlights the gaps in the literature and suggests future research directions to identify the risk and protective factors for substance use among NCAA athletes.

scholarly journals Understanding the psychiatric symptoms of COVID-19: a meta-analysis of studies assessing psychiatric symptoms in Chinese patients with and survivors of COVID-19 and SARS by using the Symptom Checklist-90-Revised

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Qin Xie ◽  
Xiao-Bo Liu ◽  
Yan-Min Xu ◽  
Bao-Liang Zhong
Keyword(s):  
Psychiatric Treatment ◽  
Psychosocial Support ◽  
Psychiatric Symptoms ◽  
Chinese Literature ◽  
Wide Spectrum ◽  
Meta Analysis ◽  
Chinese Patients ◽  
Symptom Checklist ◽  
Early Recovery ◽  
Late Recovery

AbstractUnderstanding the psychiatric symptoms of COVID-19 could facilitate the clinical management of COVID-19 patients. However, the profile of psychiatric symptoms among COVID-19 patients has been understudied. We performed a meta-analysis of studies assessing psychiatric symptoms of COVID-19 and SARS patients and survivors by using the Symptom Checklist-90-Revised (SCL-90-R), an instrument covering a wide spectrum of psychiatric symptoms. Studies reporting SCL-90-R subscale scores among patients with and survivors of COVID-19 and SARS were retrieved from major English and Chinese literature databases. Patients’ pooled SCL-90-R subscale scores were compared to the Chinese normative SCL-90-R data, and Cohen’s d values were calculated to indicate the severity of psychiatric symptoms. The Joanna Briggs Institute Critical Appraisal Checklist for Studies Reporting Prevalence Data was used to assess the quality of the included studies. The search yielded 25 Chinese studies with 1675 acute COVID-19 and 964 acute SARS patients, 30 COVID-19 and 552 SARS survivors during very early recovery (up to 1 month since discharge), 291 SARS survivors during early recovery (1–6 months after discharge), and 48 SARS survivors during late recovery (12 months after discharge). None of the included studies were rated as good quality. The ten SCL-90-R-defined psychiatric symptoms, which were of medium-to-severe severity (d = 0.68–3.01), were all exhibited in acute COVID-19 patients, and the severity of these symptoms decreased to mild-to-medium during very early recovery (d = 0.17–0.73). SARS patients presented eight psychiatric symptoms with mild-to-severe severity during the acute stage (d =0.43–1.88), and thereafter, the severity of symptoms decreased over the follow-up period. However, somatization (d = 0.30) and anxiety (d = 0.28) remained at mild levels during late recovery. A wide variety of severe psychiatric symptoms have been reported by acute COVID-19 patients, and these symptoms, despite decreasing in severity, persist in very early recovery. The changing trajectory observed with SARS suggests that psychiatric symptoms of COVID-19 may persist for a long time after discharge, and therefore, periodic monitoring of psychiatric symptoms, psychosocial support, and psychiatric treatment (when necessary) may be necessary for COVID-19 patients from the acute to convalescent stages.

The prevalence and co-morbidity of subthreshold psychiatric conditions

2004 ◽  
Vol 34 (4) ◽  
pp. 613-622 ◽  
Author(s):  
PETER M. LEWINSOHN ◽  
STEWART A. SHANKMAN ◽  
JEFFREY M. GAU ◽  
DANIEL N. KLEIN
Keyword(s):  
Clinical Practice ◽  
Adolescent Depression ◽  
Internalizing Disorders ◽  
Externalizing Disorders ◽  
Diagnostic Interview ◽  
Future Research ◽  
Co Morbidity ◽  
Psychiatric Conditions ◽  
Dsm Iv ◽  
Males And Females

Background. In previous studies of subthreshold conditions, co-morbidity has been largely ignored. The purpose was to examine rates of co-morbidity among subthreshold disorders and between subthreshold and full-syndrome disorders for the major non-psychotic classes of disorders from DSM-IV.Method. Participants came from the Oregon Adolescent Depression Project (mean age=16·6 years; females=52·1%). On the basis of a diagnostic interview (K-SADS), participants were assigned to eight subthreshold disorders (MDD, bipolar, eating, anxiety, alcohol use, substance use, conduct, ADHD).Results. Of the 1704 adolescents in the analyses, 52·5% had at least one subthreshood disorder. Of those, 40·0% had also experienced a co-morbid subthreshold condition, and 29·9% of those had a second co-morbid subthreshold condition. Of those with a subthreshold, 36·4% also had a full syndrome. The subthreshold forms of externalizing disorders were co-morbid with each other. As expected, subthreshold anxiety was co-morbid with subthreshold MDD but subthreshold anxiety was also co-morbid with subthreshold alcohol, conduct, and ADHD. The pattern of co-morbidities was nearly identical for males and females.Conclusions. The hypotheses that externalizing disorders would be co-morbid with other externalizing disorders and that internalizing disorders would be co-morbid with other internalizing disorders was partially supported. Co-morbidities between subthreshold disorders and between subthreshold disorders and full syndrome should impact future research and clinical practice. The assessment of subthreshold disorders needs to include the assessment of other subthreshold and full-syndrome conditions.

Comorbid depression and ulcerative colitis – is there a connection?

2017 ◽  
Vol 41 (S1) ◽  
pp. S534-S534
Author(s):  
A. Melada ◽  
I. Krišto-Mađura ◽  
A. Vidović
Keyword(s):  
Ulcerative Colitis ◽  
Psychiatric Treatment ◽  
Psychiatric Symptoms ◽  
Specific Treatment ◽  
Unknown Etiology ◽  
Suicidal Thoughts ◽  
Symptoms Of Depression ◽  
Bidirectional Communication ◽  
History Of ◽  
Competing Interest

Ulcerative colitis (UC) is a subset disorder of inflammatory bowel disease (IBD) with chronic course and symptoms such as fatigue, gastrointestinal pain, fever, etc. IBD is associated with psychological manifestations including depression and anxiety. There is an increased number of studies trying to link these comorbidities. The gut-brain axis is regulated by intestinal microbiota and this bidirectional communication including immune, neural, endocrine and metabolic mechanisms may bring us closer to the answer. The following case concerns a 56-year-old patient with history of major depressive disorder who was in continuous psychiatric care and treated with antidepressants. Several years after the beginning of psychiatric treatment, he was hospitalized for diagnostic examination due to subfebrility of unknown etiology, but with no final somatic diagnosis. After two years he was referred to our department and at administration the patient showed symptoms of depression, anxiety, lack of motivation and suicidal thoughts and tendencies. Subfebrility was still present at that time. His psychopharmacotherapy was revised and there was a slight improvement in mood and behaviour. During outpatient follow-ups the symptoms of depression were still prominent and remission was not achieved even with modulation of antidepressant pharmacotherapy. The following year the patient was diagnosed with UC and started specific treatment after he presented with diarrhea in addition to subfebrility. Subsequently his mood improved, suicidal thoughts were diminished and ultimately remission was achieved. This case suggests that only after UC was being treated the psychiatric symptoms also withdrew which implicates that inflammatory mediators were involved in pathogenesis of depression.Disclosure of interestThe authors have not supplied their declaration of competing interest.

scholarly journals Affect and cannabis use in daily life: a review and recommendations for future research

2018 ◽  
Vol 191 ◽  
pp. 223-233 ◽  
Author(s):  
Andrea M. Wycoff ◽  
Jane Metrik ◽  
Timothy J. Trull
Keyword(s):  
Daily Life ◽  
Cannabis Use ◽  
Future Research

scholarly journals Role of Immunity in Pathogenesis of Psychosis

2021 ◽  
Author(s):  
Wafa Abdelghaffar ◽  
Oussama Sidhom ◽  
Lilia Laadhar ◽  
Rym Rafrafi
Keyword(s):  
Mental Health ◽  
Immune System ◽  
Psychiatric Symptoms ◽  
Scientific Evidence ◽  
Health Conditions ◽  
Future Research ◽  
Antineuronal Antibodies ◽  
System Components ◽  
The Brain

The involvement of immunity in the pathogenesis of schizophrenia and related psychoses was suspected a century ago but was shadowed by the dopaminergic hypothesis after the discovery of antipsychotics. We currently know that this latter theory has many limits and cannot account for the wide variety of psychotic conditions. The immune-inflammatory theory is now one of the most promising axes of research in terms of pathogenesis of several mental health conditions. Immunity and inflammation play a role at least in a subgroup of patients with psychosis. The immune system is complex with a variety of components and mediators that can all have effects on the brain and thus mediate psychiatric symptoms. In this chapter we will explore the scientific evidence of the role of immune system in pathophysiology of psychosis. The sections of this chapter will discuss the role of innate system components (cytokines, microglia, inflammation.), the role of adaptive system (lymphocytes and antibodies) with a section focusing on auto-immunity and particularly antineuronal antibodies. Finally we will discuss how this research can impact patients management and elaborate recommendations for future research.

Sign in / Sign up

Export Citation Format

Share Document