scholarly journals Abnormal Habituation of the Auditory Event-Related Potential P2 Component in Patients With Schizophrenia

2021 ◽  
Vol 12 ◽  
Author(s):  
Prune Mazer ◽  
Inês Macedo ◽  
Tiago O. Paiva ◽  
Fernando Ferreira-Santos ◽  
Rita Pasion ◽  
...  
Keyword(s):  
Auditory Processing ◽  
Event Related Potentials ◽  
Event Related Potential ◽  
Diagnostic Tools ◽  
First Episode ◽  
Control Group ◽  
Bird Songs ◽  
Auditory Event ◽  
Complex Sounds ◽  
Related Potentials

Auditory event-related potentials (ERP) may serve as diagnostic tools for schizophrenia and inform on the susceptibility for this condition. Particularly, the examination of N1 and P2 components of the auditory ERP may shed light on the impairments of information processing streams in schizophrenia. However, the habituation properties (i.e., decreasing amplitude with the repeated presentation of an auditory stimulus) of these components remain poorly studied compared to other auditory ERPs. Therefore, the current study used a roving paradigm to assess the modulation and habituation of N1 and P2 to simple (pure tones) and complex sounds (human voices and bird songs) in 26 first-episode patients with schizophrenia and 27 healthy participants. To explore the habituation properties of these ERPs, we measured the decrease in amplitude over a train of seven repetitions of the same stimulus (either bird songs or human voices). We observed that, for human voices, N1 and P2 amplitudes decreased linearly from stimulus 1–7, in both groups. Regarding bird songs, only the P2 component showed a decreased amplitude with stimulus presentation, exclusively in the control group. This suggests that patients did not show a fading of neural responses to repeated bird songs, reflecting abnormal habituation to this stimulus. This could reflect the inability to inhibit irrelevant or redundant information at later stages of auditory processing. In turn schizophrenia patients appear to have a preserved auditory processing of human voices.

scholarly journals Nicotine enhances an auditory Event-Related Potential component which is inversely related to habituation

2017 ◽  
Vol 31 (7) ◽  
pp. 861-872 ◽  
Author(s):  
Theresa Veltri ◽  
Naira Taroyan ◽  
Paul G Overton
Keyword(s):  
Cognitive Processes ◽  
Auditory Processing ◽  
Event Related Potentials ◽  
Attentional Focus ◽  
Event Related Potential ◽  
Music Appreciation ◽  
Auditory Event ◽  
Complex Tones ◽  
Related Potentials ◽  
Potential Component

Nicotine is a psychoactive substance that is commonly consumed in the context of music. However, the reason why music and nicotine are co-consumed is uncertain. One possibility is that nicotine affects cognitive processes relevant to aspects of music appreciation in a beneficial way. Here we investigated this possibility using Event-Related Potentials. Participants underwent a simple decision-making task (to maintain attentional focus), responses to which were signalled by auditory stimuli. Unlike previous research looking at the effects of nicotine on auditory processing, we used complex tones that varied in pitch, a fundamental element of music. In addition, unlike most other studies, we tested non-smoking subjects to avoid withdrawal-related complications. We found that nicotine (4.0 mg, administered as gum) increased P2 amplitude in the frontal region. Since a decrease in P2 amplitude and latency is related to habituation processes, and an enhanced ability to disengage from irrelevant stimuli, our findings suggest that nicotine may cause a reduction in habituation, resulting in non-smokers being less able to adapt to repeated stimuli. A corollary of that decrease in adaptation may be that nicotine extends the temporal window during which a listener is able and willing to engage with a piece of music.

Phonetic Encoding Contributes to the Processing of Linguistic Prosody at the Word Level: Cross-Linguistic Evidence From Event-Related Potentials

2021 ◽  
pp. 1-11
Author(s):  
Luodi Yu ◽  
Jiajing Zeng ◽  
Suiping Wang ◽  
Yang Zhang
Keyword(s):  
Auditory Processing ◽  
Event Related Potentials ◽  
Event Related Potential ◽  
Acoustic Cues ◽  
Prosodic Features ◽  
Speech Stimuli ◽  
Word Level ◽  
Acoustic Control ◽  
Related Potentials ◽  
Prosodic Phonology

Purpose This study aimed to examine whether abstract knowledge of word-level linguistic prosody is independent of or integrated with phonetic knowledge. Method Event-related potential (ERP) responses were measured from 18 adult listeners while they listened to native and nonnative word-level prosody in speech and in nonspeech. The prosodic phonology (speech) conditions included disyllabic pseudowords spoken in Chinese and in English matched for syllabic structure, duration, and intensity. The prosodic acoustic (nonspeech) conditions were hummed versions of the speech stimuli, which eliminated the phonetic content while preserving the acoustic prosodic features. Results We observed language-specific effects on the ERP that native stimuli elicited larger late negative response (LNR) amplitude than nonnative stimuli in the prosodic phonology conditions. However, no such effect was observed in the phoneme-free prosodic acoustic control conditions. Conclusions The results support the integration view that word-level linguistic prosody likely relies on the phonetic content where the acoustic cues embedded in. It remains to be examined whether the LNR may serve as a neural signature for language-specific processing of prosodic phonology beyond auditory processing of the critical acoustic cues at the suprasyllabic level.

scholarly journals Event related potentials in cases of amblyaudia

2020 ◽  
Vol 6 (4) ◽  
pp. 747
Author(s):  
Wessam Mostafa Essawy
Keyword(s):  
Auditory Processing ◽  
Event Related Potentials ◽  
Speech Development ◽  
Screening Tests ◽  
Control Group ◽  
Auditory Information ◽  
Central Auditory Processing ◽  
Auditory Processing Disorders ◽  
Central Auditory Processing Disorders ◽  
Related Potentials

<p class="abstract"><strong>Background:</strong> Amblyaudia is a weakness in the listener’s binaural processing of auditory information. Subjects with amblyaudia also demonstrate binaural integration deficits and may display similar patterns in their evoked responses in terms of latency and amplitude of these responses. The purpose of this study was to identify the presence of amblyaudia in a population of young children subjects and to measure mismatch negativity (MMN), P300 and cortical auditory evoked potentials (CAEPs) for those individuals.</p><p class="abstract"><strong>Methods:</strong> Subjects included in this study were divided into 2 groups control group that consisted of 20 normal hearing subjects with normal developmental milestones and normal speech development. The study group (GII) consisted of 50 subjects with central auditory processing disorders (CAPDs) diagnosed by central auditory screening tests. </p><p class="abstract"><strong>Results:</strong> With using dichotic tests including dichotic digits test (DDT) and competing sentence test (CST), we could classify these cases into normal, dichotic dysaudia, amblyaudia, and amblyaudia plus with percentages (40%, 14%, 38%, 8% respectively). Using event related potentials, we found that P300 and MMN are more specific in detecting neurocognitive dysfunction related to allocation of attentional resources and immediate memory in these cases.</p><p class="abstract"><strong>Conclusions:</strong> The presence of amblyaudia in cases of central auditory processing disorders (CAPDs) and event related potentials is an objective tool for diagnosis, prognosis and follow up after rehabilitation.</p>

Auditory Mismatch Negativity and P300a Elicited by the “Optimal” Multi-feature Paradigm in Early Schizophrenia

2018 ◽  
Vol 49 (4) ◽  
pp. 238-247 ◽  
Author(s):  
Derek J. Fisher ◽  
Debra J. Campbell ◽  
Shelagh C. Abriel ◽  
Emma M. L. Ells ◽  
Erica D. Rudolph ◽  
...  
Keyword(s):  
Mismatch Negativity ◽  
Early Phase ◽  
Event Related Potentials ◽  
Event Related Potential ◽  
Positive Symptom ◽  
First Episode ◽  
Stimulus Context ◽  
Significant Group ◽  
Related Potentials ◽  
Auditory Change Detection

The mismatch negativity (MMN) is an EEG-derived event-related potential (ERP) elicited by any violation of a predicted auditory “rule,” regardless of whether one is attending to the stimuli and is thought to reflect updating of the stimulus context. Redirection of attention toward a rare, distracting stimulus event, however, can be measured by the subsequent P3a component of the P300. Chronic schizophrenia patients exhibit robust MMN deficits, as well as reductions in P3a amplitude. While, the substantial literature on the MMN in first-episode and early phase schizophrenia in this population reports reduced amplitudes, there also exist several contradictory studies. Conversely, P3a reduction in this population is relatively consistent, although the literature investigating this is small. The primary goal of this study was to contribute to our understanding of whether auditory change detection mechanisms are altered in early phase schizophrenia and, if so, under what conditions. Event-related potentials elicited by duration, frequency, gap, intensity, and location deviants (as elicited by the “optimal” multi-feature paradigm) were recorded in 14 early phase schizophrenia (EP) patients and 17 healthy controls (HCs). Electrical activity was recorded from 15 scalp electrodes. MMN/P3a amplitudes and latencies for each deviant were compared between groups and were correlated with clinical measures in EPs. There were no significant group differences for MMN amplitudes or latencies, though EPs did exhibit reduced P3a amplitudes to gap and duration deviants. Furthermore, PANSS (Positive and Negative Syndrome Scale) positive symptom scores were correlated with intensity MMN latencies and duration P3a amplitudes in EPs. These findings suggest that MMNs may not be as robustly reduced in early phase schizophrenia (relative to chronic illness), but that alterations may be more likely in patients with increased positive symptomatology. Furthermore, these findings offer further support to previous work suggesting that the understudied P3a may have good complementary utility as a marker of early cortical dysfunction in psychosis.

Auditory event-related potentials, neurocognition, and global functioning in drug naïve first-episode schizophrenia and bipolar disorder

2021 ◽  
pp. 1-10
Author(s):  
Xiaojing Li ◽  
Wei Deng ◽  
Rui Xue ◽  
Qiang Wang ◽  
Hongyan Ren ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Rating Scale ◽  
Event Related Potentials ◽  
Event Related Potential ◽  
First Episode ◽  
Oddball Paradigm ◽  
Global Functioning ◽  
Adult Intelligence Scale ◽  
Related Potentials ◽  
Drug Naïve

Abstract Background Deficits in event-related potential (ERP) including duration mismatch negativity (MMN) and P3a have been demonstrated widely in chronic schizophrenia (SZ) but inconsistent findings were reported in first-episode patients. Psychotropic medications and diagnosis might contribute to different findings on MMN/P3a ERP in first-episode patients. The present study examined MMN and P3a in first episode drug naïve SZ and bipolar disorder (BPD) patients and explored the relationships among ERPs, neurocognition and global functioning. Methods Twenty SZ, 24 BPD and 49 age and sex-matched healthy controls were enrolled in this study. Data of clinical symptoms [Positive and Negative Symptoms Scale (PANSS), Young Manic Rating Scale (YMRS), Hamilton Depression Rating Scale (HAMD)], neurocognition [Wechsler Adult Intelligence Scale (WAIS), Cattell's Culture Fair Intelligence Test (CCFT), Delay Matching to Sample (DMS), Rapid Visual Information Processing (RVP)], and functioning [Functioning Assessment Short Test (FAST)] were collected. P3a and MMN were elicited using a passive auditory oddball paradigm. Results Significant MMN and P3a deficits and impaired neurocognition were found in both SZ and BPD patients. In SZ, MMN was significantly correlated with FAST (r = 0.48) and CCFT (r = −0.31). In BPD, MMN was significantly correlated with DMS (r = −0.54). For P3a, RVP and FAST scores were significant predictors in SZ, whereas RVP, WAIS and FAST were significant predictors in BPD. Conclusions The present study found deficits in MMN, P3a, neurocognition in drug naïve SZ and BPD patients. These deficits appeared to link with levels of higher-order cognition and functioning.

scholarly journals S46. IMPAIRED ERROR-PROCESSING IN PATIENTS WITH FIRST-EPISODE PSYCHOSIS: AN EVENT-RELATED POTENTIAL STUDY

2020 ◽  
Vol 46 (Supplement_1) ◽  
pp. S50-S50
Author(s):  
Jihye Park ◽  
Minah Kim ◽  
Wu Jeong Hwang ◽  
Jun Soo Kwon
Keyword(s):  
Correct Response ◽  
Event Related Potentials ◽  
First Episode Psychosis ◽  
Electrode Site ◽  
Event Related Potential ◽  
First Episode ◽  
Conflict Monitoring ◽  
Error Related Negativity ◽  
Episode Psychosis ◽  
Related Potentials

Abstract Background Impaired error/conflict monitoring as reflected in the event-related potentials (ERPs) has consistently reported in patients with schizophrenia. However, whether this impairment exist from the early phase of psychosis such as first-episode psychosis (FEP) is not yet been clearly reported. To investigate the presence of error/conflict monitoring deficit in early psychosis, we examined the error-related negativity (ERN), error-related positivity (Pe), and correct-response negativity (CRN) during the Go/Nogo task in the patients with FEP. Methods 25 patients with and 25 age, sex matched healthy controls (HCs) were participated in electroencephalographic recording during the Go/Nogo task. Trials with error response was analyzed to define ERN at Fz electrode site and Pe at Pz electrode site. Trials with correct response was used for CRN analysis at Fz electrode site. Independent samples t-test was used to compare the amplitudes of ERP components between FEP and HC groups. Pearson’s correlation analysis was performed to reveal the relationship of altered ERP component with symptomatic severity in patients with schizophrenia. Results FEP patients showed significantly smaller ERN amplitude at Fz electrode site compared to HCs (t=-3.294, p=0.002). However, there was no difference of CRN (t=0.017, p=0.986) and Pe (t=1.806, p=0.077) amplitudes between FEP and HC groups. There was no significant correlation of symptomatic severity and ERN amplitude at Fz electrode site in FEP patients. Discussion These findings suggest that impairments in error/conflict monitoring as reflected by ERN amplitude exist from the early course of psychotic disorder. Future study with larger sample size and subjects at earlier phase such as clinical high risk for psychosis would be needed to confirm the findings of current study.

scholarly journals Sequential Effects of Increasing Propofol Sedation on Frontal and Temporal Cortices as Indexed by Auditory Event-related Potentials

2004 ◽  
Vol 100 (3) ◽  
pp. 617-625 ◽  
Author(s):  
Wolfgang Heinke ◽  
Ramona Kenntner ◽  
Thomas C. Gunter ◽  
Daniela Sammler ◽  
Derk Olthoff ◽  
...  
Keyword(s):  
Auditory Cortex ◽  
Cognitive Functions ◽  
Auditory Processing ◽  
Primary Auditory Cortex ◽  
Event Related Potentials ◽  
Sequential Effects ◽  
Auditory Event ◽  
Propofol Sedation ◽  
Related Potentials ◽  
Auditory Event Related Potentials

Background It is an open question whether cognitive processes of auditory perception that are mediated by functionally different cortices exhibit the same sensitivity to sedation. The auditory event-related potentials P1, mismatch negativity (MMN), and early right anterior negativity (ERAN) originate from different cortical areas and reflect different stages of auditory processing. The P1 originates mainly from the primary auditory cortex. The MMN is generated in or in the close vicinity of the primary auditory cortex but is also dependent on frontal sources. The ERAN mainly originates from frontal generators. The purpose of the study was to investigate the effects of increasing propofol sedation on different stages of auditory processing as reflected in P1, MMN, and ERAN. Methods The P1, the MMN, and the ERAN were recorded preoperatively in 18 patients during four levels of anesthesia adjusted with target-controlled infusion: awake state (target concentration of propofol 0.0 microg/ml), light sedation (0.5 microg/ml), deep sedation (1.5 microg/ml), and unconsciousness (2.5-3.0 microg/ml). Simultaneously, propofol anesthesia was assessed using the Bispectral Index. Results Propofol sedation resulted in a progressive decrease in amplitudes and an increase of latencies with a similar pattern for MMN and ERAN. MMN and ERAN were elicited during sedation but were abolished during unconsciousness. In contrast, the amplitude of the P1 was unchanged by sedation but markedly decreased during unconsciousness. Conclusion The results indicate differential effects of propofol sedation on cognitive functions that involve mainly the auditory cortices and cognitive functions that involve the frontal cortices.

scholarly journals Effects of intensity, attention and medication on auditory-evoked potentials in patients with fibromyalgia

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
N. Samartin-Veiga ◽  
A. J. González-Villar ◽  
Y. Triñanes ◽  
C. Gómez-Perretta ◽  
M. T. Carrillo-de-la-Peña
Keyword(s):  
Auditory Processing ◽  
Auditory Evoked Potentials ◽  
Event Related Potentials ◽  
Pathophysiological Mechanism ◽  
Auditory Event ◽  
Significant Relationships ◽  
Sensory Modalities ◽  
Related Potentials ◽  
Auditory Event Related Potentials

AbstractFibromyalgia (FM) has been associated to an increased processing of somatosensory stimuli, but its generalization to other sensory modalities is under discussion. To clarify this, we studied auditory event-related potentials (AEPs) to stimuli of different intensity in patients with FM and healthy controls (HCs), considering the effects of attention mechanisms and medication. We performed two experiments: In study 1 (n = 50 FM, 60 HCs), the stimuli were presented randomly within the sequence; in study 2 (n = 28 FM, 30 HCs), they were presented in blocks of the same intensity. We analyzed intensity and group effects on N1-P2 amplitude and, only for the FM group, the effect of medication and the correlation between AEPs and clinical variables. Contrary to the expectation, the patients showed a trend of reduced AEPs to the loudest tones (study 1) or no significant differences with the HCs (study 2). Medication with central effects significantly reduced AEPs, while no significant relationships between the N1-P2 amplitude/intensity function and patients’ symptoms were observed. The findings do not provide evidence of augmented auditory processing in FM. Nevertheless, given the observed effect of medication, the role of sensory amplification as an underlying pathophysiological mechanism in fibromyalgia cannot be discarded.

An Auditory Event Related Potential Evaluation of Sonar Task Experience and Age

1995 ◽  
Vol 80 (3_suppl) ◽  
pp. 1363-1376 ◽  
Author(s):  
Lex L. Merrill ◽  
David A. Kobus ◽  
F. J. McGuigan
Keyword(s):  
Real World ◽  
Event Related Potentials ◽  
Event Related Potential ◽  
Auditory Task ◽  
Auditory Event ◽  
Age Related ◽  
Younger Age ◽  
Related Potentials ◽  
Potential Evaluation ◽  
Task Experience

To gauge the interaction of real-world sonar-task experience and age on brain electrical activity, the effect of sonar experience and age on event related potentials (ERP) was examined. A three-group design was used and the results suggest that sonar experience and age affect the amplitude and distribution of the ERP component. The results concerning age and ERPs support and extend the results of previous studies and suggest that age-related differences occur at a much younger age than is reported elsewhere. Attentional and stimulus evaluation processes which have been linked to parameters of the ERP component may be enhanced with real-world auditory task experience. Research on ERP should control for the possible confounds of auditory-task experience and age.

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