scholarly journals A Mini-Review of Relationships Between Cannabis Use and Neural Foundations of Reward Processing, Inhibitory Control and Working Memory

2021 ◽  
Vol 12 ◽  
Author(s):  
Kristen P. Morie ◽  
Marc N. Potenza
Keyword(s):  
Working Memory ◽  
Inhibitory Control ◽  
Process Model ◽  
Social Acceptance ◽  
Neural Correlates ◽  
Reward Processing ◽  
Cannabis Use ◽  
Dual Process ◽  
Addictive Behaviors ◽  
Neural Underpinnings

Cannabis is commonly used, and use may be increasing in the setting of increasing legalization and social acceptance. The scope of the effects of cannabis products, including varieties with higher or lower levels of Δ9-tetrahydrocannabinol (THC) or cannabidiol (CBD), on domains related to addictive behavior deserves attention, particularly as legalization continues. Cannabis use may impact neural underpinnings of cognitive functions linked to propensities to engage in addictive behaviors. Here we consider these neurocognitive processes within the framework of the dual-process model of addictions. In this mini-review, we describe data on the relationships between two main constituents of cannabis (THC and CBD) and neural correlates of reward processing, inhibitory control and working memory.

scholarly journals Inhibitory control and problematic Internet-pornography use – The important balancing role of the insula

2020 ◽  
Vol 9 (1) ◽  
pp. 58-70
Author(s):  
Stephanie Antons ◽  
Brand Matthias
Keyword(s):  
Image Processing ◽  
Inhibitory Control ◽  
Symptom Severity ◽  
Inferior Frontal Gyrus ◽  
Dual Process ◽  
Stop Signal Task ◽  
Addictive Behaviors ◽  
Control Performance ◽  
Internet Pornography

Abstract Background and aims Diminished control over a specific behavior is a core characteristic in addictive behaviors such as problematic Internet-pornography (IP) use. First studies suggest that a hyperactivity of the impulsive system is one reason for impulsive behaviors in the context of problematic IP use. The tripartite-process theory of addiction explains neurocognitive mechanisms beyond common dual-process theories in addictive behaviors. However, the role of the reflective and interoceptive system is still unresolved. Methods The study comprised a stop-signal task (SST) including neutral and pornographic images during fMRI and questionnaires to investigate associations between symptoms of problematic IP use, craving, and neural activity of the impulsive, reflective, and interoceptive system. We examined 28 heterosexual males with varying symptom severity of problematic IP use. Results Data indicates that individuals with more symptoms of problematic IP use showed better performance in the SST which was linked to decreased insula and inferior frontal gyrus activity during pornographic image processing. An increase in craving was associated with lower activity of the ventral striatum during pornographic image processing. The interoceptive system showed varying effects. Increased insula activity during inhibitory control and decreased activity during pornographic image processing were associated with higher inhibitory control performance. Discussion and Conclusion Effects of tolerance and motivational aspects may explain the better inhibitory control performance in individuals with higher symptom severity which was associated with differential activity of the interoceptive and reflective system. Diminished control over IP use presumably results from the interaction between the impulsive, reflective, and interoceptive systems.

scholarly journals Response inhibition in problematic social network sites use: an ERP study

2021 ◽  
Author(s):  
Tania Moretta ◽  
Giulia Buodo
Keyword(s):  
Social Network ◽  
Inhibitory Control ◽  
Response Inhibition ◽  
Social Network Sites ◽  
Reaction Times ◽  
Event Related Potentials ◽  
Neural Correlates ◽  
Addictive Behaviors ◽  
Related Potentials ◽  
Picture Content

AbstractGiven the current literature debate on whether or not Problematic Social Network Sites Use (PSNSU) can be considered a behavioral addiction, the present study was designed to test whether, similarly to addictive behaviors, PSNSU is characterized by a deficit in inhibitory control in emotional and addiction-related contexts. Twenty-two problematic Facebook users and 23 nonproblematic users were recruited based on their score on the Problematic Facebook Use Scale. The event-related potentials were recorded during an emotional Go/Nogo Task, including Facebook-related, unpleasant, pleasant, and neutral pictures. The amplitudes of the Nogo-N2 and the Nogo-P3 were computed as measures of the detection of response conflict and response inhibition, respectively. Reaction times and accuracy also were measured. The results showed that problematic users were less accurate on both Go and Nogo trials than nonproblematic users, irrespective of picture content. For problematic users only, the Nogo-P3 amplitude was lower to Facebook-related, pleasant, and neutral than to unpleasant stimuli, suggesting less efficient inhibition with natural and Facebook-related rewards. Of note, all participants were slower to respond to Facebook-related and pleasant Go trials compared with unpleasant and neutral pictures. Consistently, the Nogo-N2 amplitude was larger to Facebook-related than all other picture contents in both groups. Overall, the findings suggest that PSNSU is associated with reduced inhibitory control. These results should be considered in the debate about the neural correlates of PSNSU, suggesting more similarities than differences between PSNSU and addictive behaviors.

scholarly journals Multimethod Investigation of the Neurobiological Basis of ADHD Symptomatology in Children Aged 9-10: Baseline Data from the ABCD Study

2020 ◽  
Author(s):  
Max Michael Owens ◽  
Nicholas Allgaier ◽  
Sage Hahn ◽  
Dekang Yuan ◽  
Matthew Albaugh ◽  
...  
Keyword(s):  
Working Memory ◽  
Inhibitory Control ◽  
Internalizing Symptoms ◽  
Memory Task ◽  
Reward Processing ◽  
Continuous Measure ◽  
Neurocognitive Deficits ◽  
Brain Morphometry ◽  
The Brain ◽  
Adhd Symptomatology

Attention deficit/hyperactivity disorder is associated with numerous neurocognitive deficits including poor working memory and difficulty inhibiting undesirable behaviors that cause academic and behavioral problems in children. Prior work has attempted to determine how these differences are instantiated in the structure and function of the brain, but much of that work has been done in small samples, focused on older adolescents or adults, and used statistical approaches that were not robust to model overfitting. The current study used cross-validated elastic net regression to predict a continuous measure of ADHD symptomatology using brain morphometry and activation during tasks of working memory, inhibitory control, and reward processing, with separate models for each MRI measure. The best model using activation during the working memory task to predict ADHD symptomatology had an out-of-sample R2 = 2% and was robust to residualizing the effects of age, sex, race, parental income and education, handedness, pubertal status, and internalizing symptoms from ADHD symptomatology. This model used reduced activation in task positive regions and reduced deactivation in task negative regions to predict ADHD symptomatology. The best model with morphometry alone predicted ADHD symptomatology with an R2 = 1% but this effect dissipated when including covariates. The inhibitory control and reward tasks did not yield generalizable models. In summary, these analyses show, with a large and well-characterized sample, that the brain correlates of ADHD symptomatology are modest in effect size and captured best by brain morphometry and activation during a working memory task.

scholarly journals Fiske & Holmboe (2018): Neural Substrates of Early Executive Function Development

2018 ◽  
Author(s):  
Abigail Fiske ◽  
Karla Holmboe
Keyword(s):  
Working Memory ◽  
Prefrontal Cortex ◽  
Executive Function ◽  
Inhibitory Control ◽  
Neural Substrates ◽  
Set Shifting ◽  
Brain Areas ◽  
Recent Developments ◽  
Neural Underpinnings ◽  
Neuroimaging Techniques

In the last decade, advances in neuroimaging technologies have given rise to a large number of research studies that investigate the neural underpinnings of executive function (EF). EF has long been associated with the prefrontal cortex (PFC) and involves both a unified, general element, as well as the distinct, separable elements of working memory, inhibitory control and set shifting. We will highlight the value of utilising advances in neuroimaging techniques to uncover answers to some of the most pressing questions in the field of early EF development. First, this review will explore the development and neural substrates of each element of EF. Second, the structural, anatomical and biochemical changes that occur in the PFC during infancy and throughout childhood will be examined, in order to address the importance of these changes for the development of EF. Third, the importance of connectivity between regions of the PFC and other brain areas in EF development is reviewed. Finally, throughout this review more recent developments in neuroimaging techniques will be addressed alongside the implications for further elucidating the neural substrates of early EF development in the future.

scholarly journals Multimethod investigation of the neurobiological basis of ADHD symptomatology in children aged 9-10: baseline data from the ABCD study

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Max M. Owens ◽  
Nicholas Allgaier ◽  
Sage Hahn ◽  
DeKang Yuan ◽  
Matthew Albaugh ◽  
...  
Keyword(s):  
Working Memory ◽  
Inhibitory Control ◽  
Internalizing Symptoms ◽  
Memory Task ◽  
Reward Processing ◽  
Continuous Measure ◽  
Neurocognitive Deficits ◽  
Brain Morphometry ◽  
The Brain ◽  
Adhd Symptomatology

AbstractAttention deficit/hyperactivity disorder is associated with numerous neurocognitive deficits, including poor working memory and difficulty inhibiting undesirable behaviors that cause academic and behavioral problems in children. Prior work has attempted to determine how these differences are instantiated in the structure and function of the brain, but much of that work has been done in small samples, focused on older adolescents or adults, and used statistical approaches that were not robust to model overfitting. The current study used cross-validated elastic net regression to predict a continuous measure of ADHD symptomatology using brain morphometry and activation during tasks of working memory, inhibitory control, and reward processing, with separate models for each MRI measure. The best model using activation during the working memory task to predict ADHD symptomatology had an out-of-sample R2 = 2% and was robust to residualizing the effects of age, sex, race, parental income and education, handedness, pubertal status, and internalizing symptoms from ADHD symptomatology. This model used reduced activation in task positive regions and reduced deactivation in task negative regions to predict ADHD symptomatology. The best model with morphometry alone predicted ADHD symptomatology with an R2 = 1% but this effect dissipated when including covariates. The inhibitory control and reward tasks did not yield generalizable models. In summary, these analyses show, with a large and well-characterized sample, that the brain correlates of ADHD symptomatology are modest in effect size and captured best by brain morphometry and activation during a working memory task.

scholarly journals Smooth coping: an embodied, Heideggerian approach to dual-process theory

2021 ◽  
pp. 105971232110173
Author(s):  
Zachariah A Neemeh
Keyword(s):  
Working Memory ◽  
Process Model ◽  
High Capacity ◽  
Dual Process ◽  
Dual Process Theory ◽  
Process Theory ◽  
Reflective Thought ◽  
Dual Process Theories

Dual-process theories divide cognition into two kinds of processes: Type 1 processes that are autonomous and do not use working memory, and Type 2 processes that are decoupled from the immediate situation and use working memory. Often, Type 1 processes are also fast, high capacity, parallel, nonconscious, biased, contextualized, and associative, while Type 2 processes are typically slow, low capacity, serial, conscious, normative, abstract, and rule-based. This article argues for an embodied dual-process theory based on the phenomenology of Martin Heidegger. According to Heidegger, the basis of human agents’ encounters with the world is in a prereflective, pragmatically engaged disposition marked by readiness-to-hand ( Zuhandenheit), sometimes equated with “smooth coping.” Examples of smooth coping include walking, throwing a ball, and other embodied actions that do not require reflective thought. I argue that smooth coping primarily consists of Type 1 processes. The Heideggerian dual-process model yields distinctly different hypotheses from Hubert Dreyfus’ model of smooth coping, and I will critically engage with Dreyfus’ work.

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