Persistent Low-Risk and High-Risk Human Papillomavirus Infections of the Uterine Cervix in HIV-Negative and HIV-Positive Women

Purpose There is a dearth of data on clearance of cervical human papillomavirus (HPV) infection among women in West Africa. We examined the clearance of low-risk (lr) and high-risk (hr) cervical HPV infections, and the factors associated with these measures in HIV-negative and HIV-positive women. Methods We studied 630 Nigerian women involved in a study of HPV infection using short polymerase chain reaction fragment-10 assay and line probe assay-25. Research nurses used a cervical brush to collect samples of exfoliated cervical cells from all the study participants. Cox proportional hazards models were used to estimate associations between HIV and HPV infections. Results The mean age of the study participants was 38 (standard deviation, ± 8) years; 51% were HIV positive. The rate of clearing any HPV infection was 2.0% per month among all women in the study population, 2.5% per month among HIV-negative women, and 1.6% per month, among HIV-positive women. The clearance rate per 1,000 person-months of observation for any lrHPV infection and any hrHPV infection were 9.21 and 8.83, respectively, for HIV-negative women, and 9.38 and 9.37, respectively, for HIV-positive women. In multivariate models, the hazard ratios for HIV-positive compared with HIV-negative women were 0.85 (95% CI, 0.51 to 1.43; P = .55) and 0.95 (95% CI, 0.54 to 1.65; P = .85) for cleared infections with any lrHPV and any hrHPV, respectively. The hazard ratio for HIV-positive compared with HIV-negative women was 0.39 (95% CI, 0.17 to 0.88; P = .02) for cleared infections with any multiple HPV and 0.13 (95% CI, 0.03 to 0.58; P = .007) for cleared infections with multiple hrHPV. Conclusion In this study population, we observed that HIV-positive women were less likely to clear infections with multiple hrHPV types.

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Prevalence of Anal High-Risk Human Papillomavirus Infections Among HIV-Positive and HIV-Negative Men Who Have Sex With Men in Nigeria

Sexually Transmitted Diseases ◽

10.1097/olq.0000000000000431 ◽

2016 ◽

Vol 43 (4) ◽

pp. 243-248 ◽

Cited By ~ 23

Author(s):

Rebecca G. Nowak ◽

Patti E. Gravitt ◽

Xin He ◽

Sosthenes Ketende ◽

Wuese Dauda ◽

...

Keyword(s):

Human Papillomavirus ◽

High Risk ◽

Hiv Positive ◽

Papillomavirus Infections ◽

Sex With Men ◽

Hiv Negative

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Human papillomavirus (HPV) genotypes and HPV16 variants in human immunodeficiency virus-positive Italian women

Journal of General Virology ◽

10.1099/vir.0.83553-0 ◽

2008 ◽

Vol 89 (6) ◽

pp. 1380-1389 ◽

Cited By ~ 26

Author(s):

Maria Lina Tornesello ◽

Maria Luisa Duraturo ◽

Paolo Giorgi-Rossi ◽

Matilde Sansone ◽

Roberto Piccoli ◽

...

Keyword(s):

Human Immunodeficiency Virus ◽

Human Papillomavirus ◽

High Risk ◽

Hiv Positive ◽

Sequencing Analysis ◽

Hiv Positive Women ◽

Immunodeficiency Virus ◽

Hpv Genotypes ◽

Italian Women ◽

Hiv Negative

Human immunodeficiency virus (HIV)-positive women have high rates of cervical squamous intraepithelial lesions (SIL) and concurrent human papillomavirus (HPV) infections with a variety of genotypes whose oncogenic risk is poorly documented. The prevalence and persistence of HPV genotypes and HPV16 variants were analysed in 112 HIV-positive and 115 HIV-negative Italian women. HIV-positive women were more likely than HIV-negative women to be infected by HPV at the initial examination (39.3 vs 13.9 %, P<0.001) and to have a higher period prevalence of HPV infection over a 3-year follow-up (43.8 % vs 17.4 %, P<0.001), regardless of CD4+ cell counts and anti-retroviral therapy. ‘High-risk’ and ‘probable high-risk’ HPVs (types 16, 18, 31, 33, 35, 45, 52, 58 and 66), among the 20 different viral genotypes identified, were predominant in HIV-positive (33.9 %) compared with HIV-negative (13.9 %) women. Among HIV-infected women, with normal cytology as well as with SIL of any grade, the most common genotypes were HPV16 followed by HPV81, -58, -72, -33 and -62. HPV16 isolates from 18 HIV-positive and eight HIV-negative women were classified into variant lineages based on sequencing analysis of E6 and E7 genes and the long control region. Whilst the HPV16 G350 European variant was prevalent in both HIV-positive (10.7 %) and -negative women (3.5 %), HPV16 African 2 variant was only detected in HIV-positive women (3.6 %), suggesting different sexual mixing behaviours. The increased prevalence of uncommon viral genotypes and HPV16 variants in HIV-positive Italian women underscores the need to target a wide range of HPV types in cervical screening of high-risk women.

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Identification of the Human Papillomavirus Genotypes, According to the Human Immunodeficiency Virus Status in a Cohort of Women from Maputo, Mozambique

Viruses ◽

10.3390/v14010024 ◽

2021 ◽

Vol 14 (1) ◽

pp. 24

Author(s):

Cremildo Maueia ◽

Alltalents Murahwa ◽

Alice Manjate ◽

Soren Andersson ◽

Jahit Sacarlal ◽

...

Keyword(s):

Human Immunodeficiency Virus ◽

Human Papillomavirus ◽

High Risk ◽

Hiv Positive ◽

Study Cohort ◽

Hpv Prevalence ◽

Hiv Positive Women ◽

Immunodeficiency Virus ◽

Hpv Types ◽

Hiv Negative

Background: Human papillomavirus (HPV) infection is now a well-established cause of cervical cancer and other anogenital cancers. An association between human immunodeficiency virus (HIV) infection and higher HPV incidence and prevalence are commonly reported. This study was conducted to demonstrate HPV prevalence, genotypes and its characteristics, according to the HIV status in women from Maputo in Mozambique. Methods: A total of 233 participants with ages ranging from fourteen to forty-five were included. Cervical samples were collected, DNA extracted, and HPV genotyping was performed using the HPV Direct Flow CHIP Kit. Results: In total, 177 HIV-negative and 56 HIV-positive women were included in the analysis. The overall HPV prevalence was 63% and was significantly higher among HIV-positive women (79% versus 58% among HIV-negative women; p = 0.005). The prevalence of multiple HPV type infections was 32%. High-risk HPV types 52, 68, 35, 18 and 16 were the most frequent. A higher proportion of HIV-positive women had multiple HPV types compared with HIV-negative women. Conclusions: This study demonstrated a high prevalence of HPV in the study cohort. HIV-positive women were identified as having the highest HPV prevalence and infection with multiple HPV types across all ages. High-risk genotypes were the most commonly found.

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P-B18 Prevalence of anal high-risk human papillomavirus infections among HIV-positive and HIV-negative men who have sex with men (MSM) in Nigeria

JAIDS Journal of Acquired Immune Deficiency Syndromes ◽

10.1097/01.qai.0000479736.51946.de ◽

2016 ◽

Vol 71 ◽

pp. 80

Author(s):

Rebecca Nowak ◽

Patti Gravitt ◽

Xin He ◽

Sosthenes Ketende ◽

Wuese Anom ◽

...

Keyword(s):

Human Papillomavirus ◽

High Risk ◽

Hiv Positive ◽

Papillomavirus Infections ◽

Sex With Men ◽

Hiv Negative

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Risk Factors for High-Risk Human Papillomavirus Detection Among HIV-Negative and HIV-Positive Women From Tanzania

Sexually Transmitted Diseases ◽

10.1097/olq.0000000000000005 ◽

2013 ◽

Vol 40 (9) ◽

pp. 737-743 ◽

Cited By ~ 14

Author(s):

Myassa Dartell ◽

Vibeke Rasch ◽

Christian Munk ◽

Crispin Kahesa ◽

Julius Mwaiselage ◽

...

Keyword(s):

Risk Factors ◽

Human Papillomavirus ◽

High Risk ◽

Hiv Positive ◽

Hiv Positive Women ◽

Hiv Negative

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Identification of Genetic Variants of Human Papillomavirus in a Group of Mexican HIV/AIDS Patients and Their Possible Association with Cervical Cancer

Polish Journal of Microbiology ◽

10.33073/pjm-2021-047 ◽

2021 ◽

Vol 70 (4) ◽

pp. 501-509

Author(s):

FELIPE ORTIZ-GUTIÉRREZ ◽

LILIA SÁNCHEZ-MINUTTI ◽

JOSÉ F. MARTÍNEZ-HERRERA ◽

INDIANA D. TORRES-ESCOBAR ◽

ELIAS B. PEZZAT-SAID ◽

...

Keyword(s):

Cervical Cancer ◽

Human Papillomavirus ◽

Genetic Variants ◽

Direct Relationship ◽

Low Risk ◽

Hiv Positive ◽

Hiv Positive Women ◽

Immunodeficiency Virus ◽

Regional Population ◽

Polymerase Chain

Infections caused by the human immunodeficiency virus (HIV) and human papillomavirus (HPV) cause thousands of deaths worldwide each year. So far, there has been no consensus on whether there is a direct relationship between the incidence of neoplasms and the immunosuppression caused by HIV that could help understand if coinfection increases the likelihood of cervical cancer. The objective of the study was to identify the presence of genetic variants of HPV in a group of HIV-positive women and their possible association with cervical cancer. Cervical samples were taken from HIV-positive patients for cytological analysis to identify the HPV genotype by polymerase chain reaction (PCR) and sequencing. The most preva¬lent L1 capsid protein mutations in the HPV genotype were ana¬lyzed in silico. Various types of HPV were identified, both high-risk (HR) and low-risk (LR). The most prevalent genotype was HPV51. Analysis of the L1 gene sequences of HPV51 isolates showed nucleo¬tide variations. Of the samples analyzed in Puebla, Mexico, HPV51 had the highest incidence (17.5%, 7/40). Different mutations, which could be used as population markers, were detected in this area, and they have not been reported in the L1 databases for HPV51 in Mexico. Genotypes 6, 14, 86, 87, 89, and 91, not detected or reported in samples from patients with HPV in Mexico, were also identified. Data from the population analyzed suggest no direct relationship between HIV immunosuppression and cervical cancer, regardless of the high- or low-risk HPV genotype. Furthermore, it is possible to develop regional population markers for the detection of HPV based on the mutations that occur in the sequence of nucleotides analyzed.

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Prevalence, incidence, and distribution of human papillomavirus types in female sex workers in Kenya

International Journal of STD & AIDS ◽

10.1177/0956462419884454 ◽

2020 ◽

Vol 31 (2) ◽

pp. 109-118

Author(s):

Kristen Sweet ◽

Claire Bosire ◽

Busola Sanusi ◽

Carly J Sherrod ◽

Jessie Kwatampora ◽

...

Keyword(s):

Human Papillomavirus ◽

High Risk ◽

Sex Workers ◽

Female Sex Workers ◽

Sub Saharan Africa ◽

Hiv Positive ◽

Female Sex ◽

Hpv Prevalence ◽

Hiv Negative

Female sex workers (FSWs) have a notably high risk of acquiring human papillomavirus (HPV) infections. Relatively few studies address the type-specific prevalence and incidence of HPV among FSWs in sub-Saharan Africa. FSWs (n = 348) attending the Korogocho clinic in Nairobi, Kenya participated from August 2009 to March 2011. HPV DNA was detected using the SPF10-LiPA25 PCR assay. Baseline prevalence of HPV infection and cervical dysplasia were calculated, stratified by HIV-serostatus. Incidence rate (IR) of infection was calculated as number of new infections from baseline over person-months among 160 HPV-negative participants with complete 12-month follow-up. Baseline HPV prevalence was 23.6% for any HPV and 20.4% for high-risk HPV (hrHPV) types. Most prevalent types were HPV52 (10.1%), HPV35 (2.3%), and HPV51 (2.3%). A quarter (24%) of participants were HIV-positive. HPV prevalence was higher in HIV-positive (32.1%) than HIV-negative (20.8%) participants. hrHPV prevalence was higher in HIV-positive (27.4%) than HIV-negative (18.2%) women. During follow-up, HPV IR was 31.4 (95% CI: 23.8–41.5) for any HPV and 24.2 (95% CI: 17.9–32.8) for hrHPV types. HPV52 had the highest IR (6.0; 95% CI: 6.5–10.3). Overall HPV and hrHPV prevalence were lower than expected, but both prevalence and incidence were higher in HIV-positive than in HIV-negative women.

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