scholarly journals Comparative Transcriptome Analyses of the Developmental Stages of Taenia multiceps

2021 ◽  
Vol 8 ◽  
Author(s):  
Wen-Hui Li ◽  
Yang Yang ◽  
Nian-Zhang Zhang ◽  
Jian-Kui Wang ◽  
Yin-Ju Liu ◽  
...  
Keyword(s):  
Information Processing ◽  
Rna Sequencing ◽  
Developmental Stages ◽  
Central Nervous System Disease ◽  
Read Length ◽  
Taenia Multiceps ◽  
System Disease ◽  
Host Interaction ◽  
Coenurus Cerebralis ◽  
Cerebral Coenurosis

Cerebral coenurosis, caused by the larvae of Taenia multiceps (Coenurus cerebralis), is a fatal central nervous system disease in sheep and other herbivores and occasionally humans. Comparative transcriptomic profiles of the developmental stages of the parasite remain unknown. In this study, RNA sequencing was used to determine the transcriptome profiles of different stages of the life cycle of T. multiceps, including Oncosphere, Coenurus cerebralis (Pro with Cyst), and Adult (Adu), as well as scolex-neck proglottids (Snp), immature–mature proglottids (Imp), and gravid proglottids (Grp) of the adult stage. A total of 42.6 Gb (average 6.1 Gb) Illumina pair-end reads with a 125-bp read length were generated for seven samples. The total number of differentially expressed genes (DEGs) in the various life stages ranged from 2,577 to 3,879; however, for the tissues of the adult worm, the range was from 1,229 to 1,939. Kyoto Encyclopedia of Genes and Genomes analysis showed that the DEGs mainly participated in cellular and metabolic processes, binding and catalytic activity, genetic information processing, and environmental information processing. In addition, a large number of genes related to development and parasite–host interaction were identified. Quantitative reverse transcription-polymerase chain reaction confirmed that the levels of 28 selected DEGs were consistent with those determined using RNA sequencing. The present study provides insights into the mechanisms of the development and parasitic life of T. multiceps.

scholarly journals Cerebral Coenurosis of a Long-Tailed Goral, Naemorhedus caudatus, in Korea

2021 ◽  
Vol 59 (1) ◽  
pp. 55-59
Author(s):  
Sangjin Ahn ◽  
Hyeongseok Oh ◽  
Soo-Young Choi ◽  
Jong-Taek Kim ◽  
Hyeon-Cheol Kim
Keyword(s):  
Magnetic Resonance Imaging ◽  
Computed Tomography ◽  
Cerebral Hemisphere ◽  
Resonance Imaging ◽  
Germinal Layer ◽  
Clear Fluid ◽  
Taenia Multiceps ◽  
Coenurus Cerebralis ◽  
Rescue Center ◽  
Cerebral Coenurosis

We intended to describe a case of cerebral coenurosis in a long-tailed goral, Naemorhedus caudatus, from Hwacheon-gun, Gangwon-do (Province), in the Korea. The goral, a 10-year-old male, was suffering from neurological symptoms, such as turning the circle to one side without lifting the head straight, and died at 30 days after admission to the wildlife medical rescue center in Chuncheon-si, Gangwon-do. A fluid-filled cyst was detected in the left cerebral hemisphere by computed tomography and magnetic resonance imaging. The cyst removed from the deceased goral was transparent, about 3×3 cm in size, contained a clear fluid and approximately 320 protoscolices invaginating from the internal germinal layer. The protoscolex had 4 suckers and a rostellum with 28 hooklets arranged in 2 rows. By the present study, a case of cerebral coenurosis was first confirmed in a long-tailed goral, N. caudatus, from Gangwon-do, in Korea. The residents frequently exposed in the sylvatic environment should be careful the accidental infections of zoonotic metacestode of Taenia multiceps, Coenurus cerebralis, in Korea.

scholarly journals RNA-sequencing reveals oligodendrocyte and neuronal transcripts in microglia relevant to central nervous system disease

Glia ◽  
2014 ◽  
Vol 63 (4) ◽  
pp. 531-548 ◽  
Author(s):  
Anne C. Solga ◽  
Winnie W. Pong ◽  
Jason Walker ◽  
Todd Wylie ◽  
Vincent Magrini ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Rna Sequencing ◽  
Central Nervous System Disease ◽  
Nervous System Disease ◽  
System Disease

scholarly journals Molecular Characterization of Annexin B2, B3 and B12 in Taenia multiceps

Genes ◽  
2018 ◽  
Vol 9 (11) ◽  
pp. 559 ◽  
Author(s):  
Cheng Guo ◽  
Yue Xie ◽  
Yuchen Liu ◽  
Ning Wang ◽  
Jiafei Zhan ◽  
...  
Keyword(s):  
Developmental Stages ◽  
Polyclonal Antibodies ◽  
Parasite Development ◽  
Economic Losses ◽  
Mrna Levels ◽  
Western Blots ◽  
Taenia Multiceps ◽  
Homologous Genes ◽  
Coenurus Cerebralis

Coenurus cerebralis, the metacestode of Taenia multiceps, causes coenurosis, a disease severely affecting goat, sheep, cattle and yak farming and resulting in huge economic losses annually. Annexins bind calcium ions and play an important role in flatworm parasite development. To explore potential functions of annexins in T. multiceps, three homologous genes, namely, TmAnxB2, TmAnxB3 and TmAnxB12, were screened from the transcriptome dataset, amplified from C. cerebralis cDNA and subjected to bioinformatics analysis. Then, polyclonal antibodies recognizing the recombinant TmAnxB2 (rTmAnxB2) and rTmAnxB3 were prepared for localization of TmAnxB2 and TmAnxB3 in different tissues and developmental stages by immunofluorescence. The transcription of all three genes was also measured by relative fluorescent quantitative PCR. The sizes of rTmAnxB2, rTmAnxB3 and rTmAnxB12 were 58.00, 53.06 and 53.51 kDa, respectively, and rTmAnxB12 was unstable. Both rTmAnxB2 and rTmAnxB3 were recognized by goat-positive T. multiceps sera in Western blots. Immunofluorescence revealed that TmAnxB2 and TmAnxB3 were localized in the protoscolex and cyst wall and TmAnxB3 was also detected in adult cortex. TmAnxB2 and TmAnxB12 mRNA levels were determined to be highest in oncospheres and protoscolex, whereas transcription of TmAnxB3 was highest in scolex and immature segments. Taken together, these findings indicate that TmAnxB2 and TmAnxB12 may play critical roles in T. multiceps larvae, while TmAnxB3 may have important functions in adults. These results will lay the foundation for functional research of annexins in T. multiceps.

Vergleich von MRT- und SPECT-Befunden bei Patienten mit zerebraler Mikroangiopathie

1991 ◽  
Vol 30 (05) ◽  
pp. 161-169 ◽  
Author(s):  
C. Weiller ◽  
R. Weigmann ◽  
H.-J. Kaiser ◽  
U. Büll ◽  
R. Schneider ◽  
...  
Keyword(s):  
White Matter Lesions ◽  
Central Nervous System Disease ◽  
Deep White Matter ◽  
Cranial Ct ◽  
System Disease ◽  
Ct Findings ◽  
Hmpao Spect ◽  
Significant Difference ◽  
Cerebral Microangiopathy ◽  
99Mtc Hmpao

Lacunar infarctions and periventricular hypodensity are assumed to be typical CT patterns of cerebral microangiopathy (MA). In 17 patients with such findings and in 6 controls without any signs of central nervous system disease cranial CT, MRT and 99mTc-HMPAO-SPECT were employed. In 7 patients with CT findings of minor MA demonstrated in comparison to controls no significant difference. In 10 cases with CT findings of pronounced MA periventricular rCBF was significantly reduced compared to controls. rCBF of temporal and parietal cortex were not diminished compared to controls. In 14 patients studied with MRT deep white matter lesions were found which appeared solitary, multiple or confluent. Employing 99mTc-HMPAO-SPECT, cerebral MA revealed rCBF reduction in periventricular brain tissue by cerebellar standardization.

Raccoon Roundworm Infection Associated with Central Nervous System Disease and Ocular Disease — Six States, 2013–2015

2016 ◽  
Vol 65 (35) ◽  
pp. 930-933 ◽  
Author(s):  
Anita D. Sircar ◽  
Francisca Abanyie ◽  
Dean Blumberg ◽  
Peter Chin-Hong ◽  
Katrina S. Coulter ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Central Nervous System Disease ◽  
Ocular Disease ◽  
Nervous System Disease ◽  
System Disease

scholarly journals Emerging Pharmacological Treatments for Cerebral Edema: Evidence from Clinical Studies

2020 ◽  
Vol 60 (1) ◽  
pp. 291-309 ◽  
Author(s):  
Jesse A. Stokum ◽  
Volodymyr Gerzanich ◽  
Kevin N. Sheth ◽  
W. Taylor Kimberly ◽  
J. Marc Simard
Keyword(s):  
Central Nervous System ◽  
Clinical Trials ◽  
Nervous System ◽  
Cerebral Edema ◽  
Clinical Studies ◽  
Central Nervous System Disease ◽  
Ancient Egypt ◽  
Nervous System Disease ◽  
Pharmacological Treatments ◽  
System Disease

Cerebral edema, a common and often fatal companion to most forms of acute central nervous system disease, has been recognized since the time of ancient Egypt. Unfortunately, our therapeutic armamentarium remains limited, in part due to historic limitations in our understanding of cerebral edema pathophysiology. Recent advancements have led to a number of clinical trials for novel therapeutics that could fundamentally alter the treatment of cerebral edema. In this review, we discuss these agents, their targets, and the data supporting their use, with a focus on agents that have progressed to clinical trials.

Catalytic nanozymes for central nervous system disease

2021 ◽  
Vol 432 ◽  
pp. 213751
Author(s):  
Ke Chen ◽  
Si Sun ◽  
Junying Wang ◽  
Xiao-Dong Zhang
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Central Nervous System Disease ◽  
Nervous System Disease ◽  
System Disease
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