BDNF val66met polymorphism influences age differences in microstructure of the corpus callosum

Objective The brain-derived neurotrophic factor (BDNF) Val66Met (rs6265) polymorphism is suggested to be associated with the pathophysiology of anxiety disorders, including panic disorder (PD). Although the fronto-limbic white matter (WM) microstructures have been investigated, the corpus callosum (CC) has not yet been studied regarding its relationship with BDNF Val66Met polymorphism in PD.Methods Ninety-five PD patients were enrolled. The Neuroticism, the Anxiety Sensitivity Inventory-Revised, Panic Disorder Severity Scale, and Beck Depression Inventory-II (BDI-II) were administered. Voxel-wise statistical analysis of diffusion tensor imaging data was performed within the CC regions using Tract-Based Spatial Statistics.Results The GG genotype in BDNF Val66Met polymorphism has significantly higher fractional anisotropy (FA) values of the body and splenium of the CC, neuroticism and depressive symptom scale scores than the non-GG genotype in PD. The FA values of the body of the CC in the two groups were significantly different independent of age, sex, neuroticism, and BDI-II.Conclusion Our findings demonstrate that the BDNF Val66Met polymorphism is associated with WM connectivity of the body and splenium of the CC, and may be related to neuroticism and depressive symptoms in PD. Additionally, the CC connectivity according to BDNF polymorphism may play a role in the pathophysiology of PD.

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Effects of BDNF Val66Met Polymorphism on White Matter Microalterations of the Corpus Callosum in Patients with Panic Disorder in Korean Populations

Psychiatry Investigation ◽

10.30773/pi.2020.0186e ◽

2021 ◽

Vol 18 (11) ◽

pp. 1144-1144

Author(s):

Hyun-Ju Kim ◽

Minji Bang ◽

Kang Soo Lee ◽

Tai Kiu Choi ◽

Chun Il Park ◽

...

Keyword(s):

White Matter ◽

Panic Disorder ◽

Corpus Callosum ◽

Val66met Polymorphism ◽

Bdnf Val66met Polymorphism

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Supplemental Material for BDNF Val66Met Polymorphism to Generalized Anxiety Disorder Pathways: Indirect Effects via Attenuated Parasympathetic Stress-Relaxation Reactivity

Journal of Abnormal Psychology ◽

10.1037/abn0000507.supp ◽

2020 ◽

Keyword(s):

Anxiety Disorder ◽

Stress Relaxation ◽

Generalized Anxiety Disorder ◽

Indirect Effects ◽

Generalized Anxiety ◽

Val66met Polymorphism ◽

Bdnf Val66met Polymorphism

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The Brain-Derived Neurotrophic Factor (BDNF) Val66Met polymorphism modulates the effects of serious life events on impulsive aggression in patients with Borderline Personality Disorder

Pharmacopsychiatry ◽

10.1055/s-0029-1240244 ◽

2009 ◽

Vol 42 (05) ◽

Author(s):

S Wagner ◽

Ö Baskaya ◽

K Lieb ◽

N Dahmen ◽

A Tadic

Keyword(s):

Borderline Personality Disorder ◽

Personality Disorder ◽

Life Events ◽

Neurotrophic Factor ◽

Brain Derived Neurotrophic Factor ◽

Borderline Personality ◽

Val66met Polymorphism ◽

Impulsive Aggression ◽

Bdnf Val66met Polymorphism ◽

The Brain

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Reduced glutamatergic metabolism in the anterior cingulate cortex in carriers of the Met-allele of the BDNF Val66Met polymorphism

10.26226/morressier.5971be80d462b80290b52367 ◽

2017 ◽

Author(s):

Louise Martens

Keyword(s):

Anterior Cingulate Cortex ◽

Cingulate Cortex ◽

Anterior Cingulate ◽

Val66met Polymorphism ◽

Bdnf Val66met Polymorphism

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Depressed Caucasians with Met allele of BDNF Val66Met polymorphism have more deleterious metabolic changes after antidepressant treatment than Val/Val

10.26226/morressier.5971be84d462b80290b530cb ◽

2017 ◽

Author(s):

Séverine Martin

Keyword(s):

Antidepressant Treatment ◽

Metabolic Changes ◽

Val66met Polymorphism ◽

Bdnf Val66met Polymorphism

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Faculty Opinions recommendation of BDNF val66met polymorphism is associated with modified experience-dependent plasticity in human motor cortex.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.14213.471715 ◽

2006 ◽

Author(s):

Nick Ward

Keyword(s):

Motor Cortex ◽

Val66met Polymorphism ◽

Human Motor Cortex ◽

Dependent Plasticity ◽

Bdnf Val66met Polymorphism ◽

Human Motor

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The genetic influence of the brain-derived neurotrophic factor Val66Met polymorphism in chronic low back pain

Advances in Rheumatology ◽

10.1186/s42358-021-00183-7 ◽

2021 ◽

Vol 61 (1) ◽

Author(s):

Angela Shiratsu Yamada ◽

Flavia Tasmim Techera Antunes ◽

Camila Ferraz ◽

Alessandra Hubner de Souza ◽

Daniel Simon

Keyword(s):

Low Back Pain ◽

Back Pain ◽

Chronic Low Back Pain ◽

Neurotrophic Factor ◽

Central Sensitization ◽

Low Back ◽

Bdnf Gene ◽

Val66met Polymorphism ◽

Bdnf Val66met Polymorphism ◽

The Brain

Abstract Background The Val66Met polymorphism of the brain-derived neurotrophic factor (BDNF) gene is a potential biomarker of vulnerability to pain. Thus, the present study aimed to investigate the association of this polymorphism with clinical and biopsychosocial factors in patients with chronic low back pain (CLBP). Methods A total of 107 individuals with CLBP answered questionnaires that were validated and adapted for the Brazilian population, including the Brief Inventory of Pain, the Central Sensitization Inventory, the Roland Morris Disability Questionnaire, the Tampa Scale for Kinesiophobia, the Pain Catastrophizing Scale, the Survey of Pain Attitude-Brief, and the Hospital Anxiety and Depression Scale. All of the subjects were genotyped for the BDNF Val66Met polymorphism. Results The sample showed moderate scores of disability, central sensitization, and kinesiophobia, in addition to mild anxiety, hopelessness, and ruminant thoughts. No significant association was observed between the Val66Met polymorphism and the variables analyzed. Besides, there was no relationship between the BDNF Val66Met polymorphism with CSI, catastrophization, or disabilities that were generated by CLBP. Conclusion The results showed that the Val66Met polymorphism of the BDNF gene was not associated with clinical and biopsychosocial characteristics of CLBP in the sample studied.

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