scholarly journals Effects of BDNF Val66Met Polymorphism on White Matter Microalterations of the Corpus Callosum in Patients with Panic Disorder in Korean Populations

2021 ◽  
Vol 18 (11) ◽  
pp. 1144-1144
Author(s):  
Hyun-Ju Kim ◽  
Minji Bang ◽  
Kang Soo Lee ◽  
Tai Kiu Choi ◽  
Chun Il Park ◽  
...  
Keyword(s):  
White Matter ◽  
Panic Disorder ◽  
Corpus Callosum ◽  
Val66met Polymorphism ◽  
Bdnf Val66met Polymorphism

scholarly journals Effects of BDNF Val66Met Polymorphism on White Matter Microalterations of the Corpus Callosum in Patients with Panic Disorder in Korean Populations

2020 ◽  
Vol 17 (10) ◽  
pp. 967-975
Author(s):  
Hyun-Ju Kim ◽  
Minji Bang ◽  
Kang Soo Lee ◽  
Tai Kiu Choi ◽  
Chun Il Park ◽  
...  
Keyword(s):  
White Matter ◽  
Panic Disorder ◽  
Corpus Callosum ◽  
Diffusion Tensor ◽  
The Body ◽  
Imaging Data ◽  
Symptom Scale ◽  
Val66met Polymorphism ◽  
Scale Scores ◽  
Bdnf Val66met Polymorphism

Objective The brain-derived neurotrophic factor (<i>BDNF</i>) Val66Met (rs6265) polymorphism is suggested to be associated with the pathophysiology of anxiety disorders, including panic disorder (PD). Although the fronto-limbic white matter (WM) microstructures have been investigated, the corpus callosum (CC) has not yet been studied regarding its relationship with <i>BDNF</i> Val66Met polymorphism in PD.Methods Ninety-five PD patients were enrolled. The Neuroticism, the Anxiety Sensitivity Inventory-Revised, Panic Disorder Severity Scale, and Beck Depression Inventory-II (BDI-II) were administered. Voxel-wise statistical analysis of diffusion tensor imaging data was performed within the CC regions using Tract-Based Spatial Statistics.Results The GG genotype in <i>BDNF</i> Val66Met polymorphism has significantly higher fractional anisotropy (FA) values of the body and splenium of the CC, neuroticism and depressive symptom scale scores than the non-GG genotype in PD. The FA values of the body of the CC in the two groups were significantly different independent of age, sex, neuroticism, and BDI-II.Conclusion Our findings demonstrate that the <i>BDNF</i> Val66Met polymorphism is associated with WM connectivity of the body and splenium of the CC, and may be related to neuroticism and depressive symptoms in PD. Additionally, the CC connectivity according to BDNF polymorphism may play a role in the pathophysiology of PD.

scholarly journals BDNF Val66met polymorphism, white matter abnormalities and remission of geriatric depression

2010 ◽  
Vol 125 (1-3) ◽  
pp. 262-268 ◽  
Author(s):  
George S. Alexopoulos ◽  
Charles E. Glatt ◽  
Matthew J. Hoptman ◽  
Dora Kanellopoulos ◽  
Christopher F. Murphy ◽  
...  
Keyword(s):  
White Matter ◽  
Geriatric Depression ◽  
Val66met Polymorphism ◽  
White Matter Abnormalities ◽  
Bdnf Val66met Polymorphism

scholarly journals Effects of the BDNF Val66Met Polymorphism on White Matter Microstructure in Healthy Adults

2012 ◽  
Vol 38 (3) ◽  
pp. 525-532 ◽  
Author(s):  
Heike Tost ◽  
Tajvar Alam ◽  
Matthew Geramita ◽  
Christine Rebsch ◽  
Bhaskar Kolachana ◽  
...  
Keyword(s):  
White Matter ◽  
Healthy Adults ◽  
Val66met Polymorphism ◽  
White Matter Microstructure ◽  
Bdnf Val66met Polymorphism

The Association of BDNF Val66Met Polymorphism With Trait Anxiety in Panic Disorder

2014 ◽  
Vol 26 (4) ◽  
pp. 344-351 ◽  
Author(s):  
Yoshiaki Konishi ◽  
Hisashi Tanii ◽  
Takeshi Otowa ◽  
Tsukasa Sasaki ◽  
Hisanobu Kaiya ◽  
...  
Keyword(s):  
Panic Disorder ◽  
Trait Anxiety ◽  
Val66met Polymorphism ◽  
Bdnf Val66met Polymorphism

scholarly journals Nitric Oxide Synthase Type 1 Methylation Is Associated With White Matter Microstructure in the Corpus Callosum and Greater Panic Disorder Severity Among Panic Disorder Patients

2021 ◽  
Vol 12 ◽  
Author(s):  
Huazhen Xu ◽  
Yuan Zhong ◽  
Shiting Yuan ◽  
Yun Wu ◽  
Zijuan Ma ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
White Matter ◽  
Nitric Oxide Synthase ◽  
Panic Disorder ◽  
Corpus Callosum ◽  
Symptom Severity ◽  
Diffusion Tensor ◽  
Mean Diffusivity ◽  
Mediating Effect ◽  
Oxide Synthase

Objectives: Methylation of the neuronal nitric oxide synthase (NOS1/nNOS) gene has recently been identified as a promising biomarker of psychiatric disorders. NOS1 plays an essential role in neurite outgrowth and may thus affect the microstructure development of white matter (WM) in the corpus callosum (CC), which is known to be altered in panic disorder (PD). We examined the relationship between NOS1 methylation, WM tracts in the CC, and symptoms based on this finding.Methods: Thirty-two patients with PD and 22 healthy controls (HCs) were recruited after age, gender, and the education level were matched. The cell type used was whole-blood DNA, and DNA methylation of NOS1 was measured at 20 CpG sites in the promoter region. Although 25 patients with PD were assessed with the Panic Disorder Severity Scale (PDSS), diffusion tensor imaging (DTI) scans were only collected from 16 participants with PD.Results: We observed that the PD group showed lower methylation than did the HCs group and positive correlations between the symptom severity of PD and methylation at CpG4 and CpG9. In addition, CpG9 methylation was significantly correlated with the fractional anisotropy (FA) and mean diffusivity (MD) values of the CC and its major components (the genu and the splenium) in the PD group. Furthermore, path analyses showed that CpG9 methylation offers a mediating effect for the association between the MD values of the genu of the CC and PD symptom severity (95% CI = −1.731 to −0.034).Conclusions: The results suggest that CpG9 methylation leads to atypical development of the genu of the CC, resulting in higher PD symptom severity, adding support for the methylation of NOS1 as a future prognostic indicator of PD.

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