scholarly journals Like Mother Like Child: Do Fearful Sows Have Fearful Piglets?

Animals ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 1232
Author(s):  
Hazel B. Rooney ◽  
Oceane Schmitt ◽  
Alexandra Courty ◽  
Peadar G. Lawlor ◽  
Keelin O’Driscoll
Keyword(s):  
Open Field ◽  
Field Test ◽  
Open Field Test ◽  
Age And Growth ◽  
Maternal Behaviour ◽  
Human Contact ◽  
Fear Level ◽  
Behavioural Profile ◽  
D 20 ◽  
Gestational Stress

Gestational and early life experiences affect subsequent behavioural and physical development. The objective of the current study was to investigate associations between gilts’ fear of humans, gestational stress level, and feeding and maternal behaviour, as well as how these related to aspects of the personality and growth of their offspring. A total of 37 gilts were used. Four human approach tests were performed between d 104 and d 111 of gestation to classify gilts as fearful or friendly. Gilt feeding behaviour and salivary cortisol concentration was measured between d 90 and d 108 of gestation, and gilt nursing behaviour assessed at d 13 of lactation. Piglets were subject to a back test at d 13 of age, to an open field test and a human approach test at d 20 of age, and growth was monitored to weaning (d 26 of age). Gilts classified as having a fearful behavioural profile had higher cortisol levels than friendly gilts (p < 0.05). Human fear level did not affect reproductive performance or the growth of offspring (p > 0.05). The offspring of friendly gilts tended to have a more active response to the back test (p = 0.09), less freezing response in the open field test (p < 0.05), and received human contact more than piglets from fearful gilts (p < 0.05). The present study shows that gilt human fear level is linked to their stress levels, which can affect the personality of their piglets.

scholarly journals A dizájner drog metiléndioxi-pirovaleron hatása a fejlődő idegrendszerre kísérletes állatmodellben

2015 ◽  
Vol 156 (30) ◽  
pp. 1221-1225
Author(s):  
László István Gerecsei ◽  
Ágota Ádám
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Locomotor Activity ◽  
Grip Strength ◽  
Open Field ◽  
Field Test ◽  
Motor Coordination ◽  
Open Field Test ◽  
Strength Test ◽  
Maternal Behaviour

Introduction: The designer drug methylenedioxypyrovalerone is a frequently used psychoactive drug of abuse. Aim: The aim of this study was to determine the effect of methylenedioxypyrovalerone, administrated from the 8th to the 14th day of the gestation, on the development of central nervous system and on the behaviour of offspring mice. Method: Pregnant mice were treated during this period either with subcutaneous injection of 1×10 mg/kg body weight methylenedioxypyrovalerone or vehicle (saline). Maternal behaviour (pup retrieval test), locomotor activity (open field test) and motor coordination (grip strength test) of dams were evaluated. Locomotor activity at the 7th and 21st postnatal day (open field test) and motor coordination at the 21st postnatal day (grip strength test) were examined. Results: Reduced maternal behaviour among treated animals was observed. There was no difference in the results of the open field test between treated and control groups. Decrease of locomotor activity was observed in the pups of the methylenedioxypyrovalerone treated dams. Conclusions: The results suggest that cathinones (in particular methylenedioxypyrovalerone) may adversely affect neural integrity of the developing central nervous system. Orv. Hetil., 2015, 156(30), 1221–1225.

scholarly journals Toxicity and Neuropharmacological Effects of Elenine

2011 ◽  
Vol 2011 ◽  
pp. 1-10 ◽  
Author(s):  
Eduardo Navarro ◽  
S. J. Alonso ◽  
R. Navarro
Keyword(s):  
Open Field ◽  
Field Test ◽  
Chemical Structure ◽  
Open Field Test ◽  
Control Group ◽  
General Behaviour ◽  
Similar Chemical ◽  
Sedative Effects ◽  
Traction Test ◽  
Central Depressant

Elenine is the aglycone of elenoside, a cytotoxic arylnaphthalene lignan (NSC 644013-W/1) derived fromJusticia hyssopifolia. (Family: Acanthaceae). Elenoside is a β-D-glucoside, with a similar chemical structure to etoposide, exhibiting central depressant activity. In the present study, elenine was given to mice and rats at doses of 10, 20, and 40 mg/kg. Acute toxicity (24 h) and general behaviour in mice was studied as well as its effects on muscular relaxant activity, locomotor activity (Varimex test), and the open-field test and were compared with 10 mg/kg of chlorpromazine. Elenine produced a reduction in the permanence time in muscular relaxant activity (traction test). Spontaneous activity was lower in the Varimex test. The ambulation and rearing were lower compared with the control group, and an increase in boluses was observed in the open-field test. Thus, it can be concluded that elenine has central sedative effects at lower doses than those used with elenoside and has a possible application in conditions of anxiety.

scholarly journals Participation ofGABAAChloride Channels in the Anxiolytic-Like Effects of a Fatty Acid Mixture

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Juan Francisco Rodríguez-Landa ◽  
Rosa Isela García-Ríos ◽  
Jonathan Cueto-Escobedo ◽  
Blandina Bernal-Morales ◽  
Carlos M. Contreras
Keyword(s):  
Open Field ◽  
Field Test ◽  
Chloride Channels ◽  
Wistar Rats ◽  
Elevated Plus Maze ◽  
Open Field Test ◽  
Acid Mixture ◽  
Plus Maze ◽  
Gaba Binding ◽  
Defensive Burying

Human amniotic fluid and a mixture of eight fatty acids (FAT-M) identified in this maternal fluid (C12:0, lauric acid, 0.9 μg%; C14:0, myristic acid, 6.9 μg%; C16:0, palmitic acid, 35.3 μg%; C16:1, palmitoleic acid, 16.4 μg%; C18:0, stearic acid, 8.5 μg%; C18:1cis, oleic acid, 18.4 μg%; C18:1trans, elaidic acid, 3.5 μg%; C18:2, linoleic acid, 10.1 μg%) produce anxiolytic-like effects that are comparable to diazepam in Wistar rats, suggesting the involvement ofγ-aminobutyric acid-A (GABAA) receptors, a possibility not yet explored. Wistar rats were subjected to the defensive burying test, elevated plus maze, and open field test. In different groups, threeGABAAreceptor antagonists were administered 30 min before FAT-M administration, including the competitive GABA binding antagonist bicuculline (1 mg/kg),GABAAbenzodiazepine antagonist flumazenil (5 mg/kg), and noncompetitiveGABAAchloride channel antagonist picrotoxin (1 mg/kg). The FAT-M exerted anxiolytic-like effects in the defensive burying test and elevated plus maze, without affecting locomotor activity in the open field test. TheGABAAantagonists alone did not produce significant changes in the behavioral tests. Picrotoxin but not bicuculline or flumazenil blocked the anxiolytic-like effect of the FAT-M. Based on the specific blocking action of picrotoxin on the effects of the FAT-M, we conclude that the FAT-M exerted its anxiolytic-like effects throughGABAAreceptor chloride channels.

Acute effects of ethanol on behavioral responses of male and female zebrafish in the open field test with the influence of a non-familiar object

2021 ◽  
pp. 104474
Author(s):  
Thiele P. Souza ◽  
Francini Franscescon ◽  
Flavia V. Stefanello ◽  
Talise E. Müller ◽  
Laura W. Santos ◽  
...  
Keyword(s):  
Open Field ◽  
Field Test ◽  
Open Field Test ◽  
Behavioral Responses ◽  
Familiar Object ◽  
Acute Effects ◽  
Male And Female ◽  
Female Zebrafish

Garcinia Camobogia Extract Alters Anxiety, Sociability, and Dopamine Turnover in Male Swiss Albino Mice

2021 ◽  
Author(s):  
Michael K. Ibrahim ◽  
Marina Aboelsaad ◽  
Fatma Tony ◽  
Moustafa Sayed
Keyword(s):  
Open Field ◽  
Field Test ◽  
Open Field Test ◽  
Modern Medicine ◽  
Receptor Expression ◽  
Dopamine Turnover ◽  
Male Mice ◽  
Garcinia Cambogia ◽  
Swiss Albino Mice ◽  
Albino Mice

Abstract Background: Obesity is a global concern, closely allied with somatic and psychosomatic disorders. Herbal drugs are available in modern medicine to treat obesity. Garcinia camobogia being used by so many people trying to lose weight produces various systemic side effects. The study was conducted to assess its effect on anxiety, sociability, and dopamine turnover in male mice. Methodology: Male Swiss albino mice of either were divided into three groups with seven mice in each group. Different groups were given distilled water (0.5ml p.o.) and Garcinia cambogia extract at two different doses (100mg/kg and 500 mg/kg p.o.). Effect of test drugs on anxiety was evaluated using open field test. Sociability and social novelty were evaluated using three chambers test. Results (mean ± standard deviation) were analyzed using one-way ANOVA test followed by Tukey’s test. Result: Garcinia cambogia extract significantly increased the time spent in the corners in the open field test, significantly reduced sociability and social novelty in the three chamber test, significantly reduced dopamine turnover and increased D2 receptor expression in ventral tegmental area. Conclusion: Garcinia cambogia extract have significant anxiogenic effect along with reduced sociability and social novelty in male mice. Moreover, these effects could be related to the altered dopamine turnover and D2 receptor expression in mice brain.

Early deprivation increases high-leaning behavior, a novel anxiety-like behavior, in the open field test in rats

2017 ◽  
Vol 123 ◽  
pp. 27-35 ◽  
Author(s):  
Hiroshi Kuniishi ◽  
Satoshi Ichisaka ◽  
Miki Yamamoto ◽  
Natsuko Ikubo ◽  
Sae Matsuda ◽  
...  
Keyword(s):  
Open Field ◽  
Field Test ◽  
Open Field Test ◽  
Early Deprivation

scholarly journals A comparative analysis of anxiolytic activity of Arnica montana and alprazolam in rats using open field test

2018 ◽  
Vol 7 (4) ◽  
pp. 718
Author(s):  
Puja Jha ◽  
Seema Bhalerao ◽  
Mrunal Dhole
Keyword(s):  
Open Field ◽  
Field Test ◽  
Open Field Test ◽  
Physical Dependence ◽  
Forced Swim Test ◽  
Anxiolytic Activity ◽  
Combination Group ◽  
Control Group ◽  
Arnica Montana ◽  
Group I

Background: Anxiety affects around 7.3% of the total population worldwide. Benzodiazepines are preferred anxiolytic agents and are still frequently used in spite of the side effect profile including muscle relaxation, memory disturbances, sedation, physical dependence. Arnica montana, a traditional herb is known to possess significant anxiolytic effect at the dose of 100mg/kg. In this study, Arnica montana has been compared for the first time with alprazolam, a most commonly used anxiolytic drug.Methods: Forced swim test was used to induce anxiety. Anxiolytic action of study drugs which were given orally, was evaluated using Open field test (OFT) in healthy wistar rats of either sex. Behavior of rats, locomotion and number of squares crossed was recorded. Rats were divided into four groups with eight rats in each group. Study groups were Group I Control; Group II Alprazolam 0.08mg/kg; Group III Arnica montana extract (AME) 100mg/kg; Group IV AME + Alprazolam group 100mg/kg+0.08mg/kg. Statistical analysis was done using ANOVA followed by Tukey’s test (p<0.05).Results: Increase in frequency of rearing was significant (p<0.05) in AME group and highly significant (p<0.001) in Alprazolam and combination group in comparison to control. Decrease in frequency of grooming was highly significant (p<0.001) in Alprazolam and combination group. AME also showed significant (p<0.05) decrease in grooming activity.Conclusions: Arnica montana extract showed anxiolytic activity and can be used as an add on drug after further studies and validation in the treatment of anxiety disorders.

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