scholarly journals Expression of Myoepithelial Markers in Mammary Carcinomas of 119 Pet Rabbits

Animals ◽  
2019 ◽  
Vol 9 (10) ◽  
pp. 740 ◽  
Author(s):  
Sophie Degner ◽  
Heinz-Adolf Schoon ◽  
Sebastian Degner ◽  
Mathias Baudis ◽  
Claudia Schandelmaier ◽  
...  
Keyword(s):  
Tumor Cells ◽  
Smooth Muscle Actin ◽  
Prognostic Significance ◽  
Analysis Data ◽  
Myoepithelial Cells ◽  
Biological Behavior ◽  
Mammary Carcinomas ◽  
Long Term Follow Up

Most mammary tumors in pet rabbits are carcinomas; prognostic factors are unknown. The aim of this study on rabbit mammary carcinomas was to determine the expression of myoepithelial markers that have a prognostic relevance in human cancers. Mammary carcinomas (n = 119) of female or female-spayed pet rabbits were immunostained for cytokeratin AE1/AE3, vimentin, smooth muscle actin (SMA), and calponin; and percentages of non-neoplastic myoepithelial cells (ME cells) and calponin-positive neoplastic cells were determined. Using statistical analysis, data were correlated with the age of the rabbits and histological tumor characteristics. All carcinomas contained retained spindle-shaped ME, while 115 also contained hypertrophic ME (HME). A statistically significant relationship existed between a higher age and an increase in HME. In 111 carcinomas (93%), tumor cells expressed calponin. There was a significant correlation between higher percentages of calponin-positive tumor cells and a lower mitotic count, an increased percentage of tubular growth, and a lower grading score, respectively. Data suggest that pet rabbit mammary carcinomas develop from progression of in situ cancer and that the extent of calponin expression in tumor cells influences their biological behavior. These results provide the basis for a long-term follow-up on the prognostic significance of calponin expression in mammary cancer cells.

scholarly journals Diffuse PRAME Expression Is Highly Specific for Thin Melanomas in the Distinction from Severely Dysplastic Nevi but Does Not Distinguish Metastasizing from Non-Metastasizing Thin Melanomas

Cancers ◽  
2021 ◽  
Vol 13 (15) ◽  
pp. 3864
Author(s):  
Maximilian Gassenmaier ◽  
Matthias Hahn ◽  
Gisela Metzler ◽  
Jürgen Bauer ◽  
Amir Sadegh Yazdi ◽  
...  
Keyword(s):  
Prognostic Significance ◽  
Diagnostic Interpretation ◽  
Dysplastic Nevi ◽  
Melanocytic Tumors ◽  
Invasive Component ◽  
Uncertain Significance ◽  
Long Term Follow Up

Background: PReferentially expressed Antigen in MElanoma (PRAME) immunohistochemistry is increasingly used as diagnostic adjunct in the evaluation of melanocytic tumors. The expression and prognostic significance of PRAME in melanomas ≤1.0 mm and its diagnostic utility in the distinction from severely dysplastic compound nevi (SDN) have not been studied. Methods: We investigated and compared the immunohistochemical PRAME expression in 70 matched thin metastasizing and non-metastasizing melanomas and 45 nevi from patients with long-term follow-up (35 SDN and 10 unequivocally benign compound nevi). Results: Diffuse PRAME staining in >75% of lesional epidermal and dermal melanocytes identified 58.6% of thin melanomas but did not distinguish metastasizing from non-metastasizing melanomas (p = 0.81). A superficial atypical melanocytic proliferation of uncertain significance, in which the final diagnostic interpretation favored a SDN was the only nevus with diffuse PRAME expression (1/45). Melanomas and SDN with PRAME immunoreactivity exhibited different staining patterns. Most melanomas (67.6%) showed uniform PRAME expression in the in situ and invasive component, whereas most SDN (81.0%) showed a decreasing gradient with depth. Conclusion: Diffuse intraepidermal and dermal PRAME staining is highly specific for melanomas in the distinction from SDN. PRAME expression is not a prognostic biomarker in melanomas ≤1.0 mm.

scholarly journals AN INTERVENTIONAL STUDY TO ASSESS THE CYTOLOGICAL AND COLPOSCOPIC CHANGES AFTER INTRAUTERINE CONTRACEPTIVE DEVICES INSERTION IN THE DEPARTMENT OF OBSTETRICS GYNAECOLOGY, SMS MEDICAL COLLEGE, JAIPUR

2021 ◽  
Vol 5 (7) ◽  
Author(s):  
Mamta Prajapat ◽  
Suniti Verma ◽  
R N Sehra ◽  
Jyoti Saini
Keyword(s):  
Trichomonas Vaginalis ◽  
Pap Smear ◽  
Medical College ◽  
Contraceptive Devices ◽  
Exfoliated Cells ◽  
Increased Risk ◽  
Intrauterine Contraceptive ◽  
Long Term Follow Up

Background: Cytology examines exfoliated cells, while colposcopy examines the changes that occur in the vascular structure of the cervix5. Patients with an abnormal pap smear result or patients with a suspicious-looking cervix even if they had a negative pap smear, should be evaluated by colposcopy and colposcopy directed biopsy. Methods: Interventional Prospective study conducted at Department of Obstetrics and Gynaecology, SMS Medical College & associated Hospitals, Jaipur. Results: In this study, among 15 IUCD users, 5 (33.33%) had bacterial vaginosis, 2 (13.33%) had trichomonas vaginalis and 1 (6.66%) were found candidal infection, 1 (6.66%) polymicrobial infection. Conclusion: The present study indicates that there is definite changes in the cervical architecture in IUCD users and the change is also dependent on the duration of use. A simple technique like cytology and colposcopy is highly useful in diagnosing these changes and combating them by early interference whenever necessary. The present study does not reveal any increased risk of cervicitis and dysplasia in IUCD users. We further recommend that a long term follow-up is required to rule out the possibility of any increased risk of dysplasia or carcinoma in-situ. Keywords: IUCD, Colposcopy, Dysplasia.

Myoepithelioma of the Skull

Neurosurgery ◽  
2012 ◽  
Vol 71 (4) ◽  
pp. E901-E904 ◽  
Author(s):  
Karen J. Fritchie ◽  
Mitchel D. Bauman ◽  
Quentin J. Durward
Keyword(s):  
Clinical Presentation ◽  
Histopathological Examination ◽  
Bone Lesion ◽  
Myoepithelial Cells ◽  
The Past ◽  
Lytic Bone Lesion ◽  
Initial Biopsy

Abstract BACKGROUND AND IMPORTANCE: Myoepithelioma of bone is a rare osseous tumor thought to be related to myoepithelial lesions found at other anatomic sites such as the salivary gland and skin. These tumors are composed of varying proportions of epithelial and myoepithelial cells and exhibit a spectrum of biologic behavior ranging from benign to malignant. We present the first reported case of myoepithelioma of the skull. CLINICAL PRESENTATION: A 20-year-old white woman presented with a persistent right parieto-occipital skull nodule, relating its presence to a fall on the site 2 years previously. The nodule had become painful in the past 2 months. Her past medical history and workup were otherwise unremarkable. The initial biopsy was inconclusive for diagnosis. The lytic bone lesion was subsequently resected, and histopathological examination showed a proliferation of epithelioid cells in a myxochondroid background. Fluorescence in situ hybridization studies revealed a rearrangement of the EWSR1 locus. The morphologic and molecular findings were consistent with the diagnosis of myoepithelioma of bone. CONCLUSION: Six months after surgery, the patient is doing well with no evidence of recurrence. This case illustrates the clinical presentation, histopathology, and molecular findings of a myoepithelioma of the skull with successful surgical treatment. Because myoepitheliomas with benign morphological appearance may rarely act aggressively, long-term clinical follow-up is warranted.

Complications of long-term ventilation tubes

2013 ◽  
Vol 127 (5) ◽  
pp. 509-510 ◽  
Author(s):  
H Mohammed ◽  
P Martinez-Devesa
Keyword(s):  
Ventilation Tube ◽  
Material Degradation ◽  
Long Term Follow Up ◽  
Ventilation Tubes ◽  
Chronic Inflammatory Reaction ◽  
Materials Used ◽  
Long Term Ventilation

AbstractObjective:To demonstrate that ventilation tubes can remain in situ much longer than expected, and that the materials used in the manufacturing of these tubes can degrade and cause complications. Long-term follow up and replacement of the tube is recommended.Method:Case report and review of the literature concerning the use of long-term ventilation tubes.Results:In the case reported, the ventilation tube was in place for 19 years, which resulted in chronic ear discharge. When it was removed, it was noted that the tube itself had degraded and had caused a chronic inflammatory reaction.Conclusion:We recommend that the long-term use of ventilation tubes is followed up and that the tube is replaced before material degradation takes place.

Penile Melanoma In Situ: Long Term Follow Up

Urology ◽  
2020 ◽  
Vol 141 ◽  
pp. e51-e52
Author(s):  
Kevin Krughoff ◽  
Amichai Kilchevksy ◽  
Wayne Stadelmann ◽  
Timothy Gorman ◽  
Ramiro Madden-Fuentes
Keyword(s):  
Melanoma In Situ ◽  
Long Term Follow Up

LONG-TERM FOLLOW-UP OF PATIENTS WITH CARCINOMA IN SITU OF THE URINARY BLADDER

1999 ◽  
pp. 116
Author(s):  
Roxann M. Neumann ◽  
Liang Cheng ◽  
John C. Cheville ◽  
Bradley C. Leibovich ◽  
Bruce E. Spotts ◽  
...  
Keyword(s):  
Urinary Bladder ◽  
Carcinoma In Situ ◽  
Long Term Follow Up

Laryngeal Dysplasia: Epidemiology and Treatment Outcome

1995 ◽  
Vol 104 (8) ◽  
pp. 596-602 ◽  
Author(s):  
Keith E. Blackwell ◽  
Thomas C. Calcaterra ◽  
Yao-Shi Fu
Keyword(s):  
Treatment Group ◽  
Carcinoma In Situ ◽  
Invasive Carcinoma ◽  
Endoscopic Therapy ◽  
Partial Laryngectomy ◽  
Severe Dysplasia ◽  
Long Term Follow Up

A retrospective analysis was undertaken of 65 patients with long-term follow-up for laryngeal squamous dysplasia. Based on the degree of dysplasia demonstrated on initial biopsy, 0 of 6 patients showing hyperkeratosis without dysplasia, 3 of 26 patients (12%) showing mild dysplasia, 5 of 15 patients (33%) showing moderate dysplasia, 4 of 9 patients (44%) showing severe dysplasia, and 1 of 9 patients (11%) showing carcinoma in situ eventually progressed to invasive carcinoma. An analysis was made of the impact of various treatment modalities in 33 patients demonstrating moderate dysplasia, severe dysplasia, or carcinoma in situ. Invasive carcinoma developed in 10 of 21 patients (48%) treated endoscopically and 0 of 12 patients treated by more aggressive therapy, including external beam radiotherapy, partial laryngectomy, or total laryngectomy. Of the patients in the endoscopic therapy group who developed invasive carcinoma, all were salvaged successfully. The overall rate of laryngeal preservation was 15 of 21 patients (71%) in the endoscopic treatment group and 11 of 12 patients (92%) in the aggressive treatment group. This difference is not statistically significant. We conclude that there is a moderately high rate of progression to invasive carcinoma in patients undergoing repeated endoscopic therapy for intraepithelial neoplasms of the larynx. However, with close, long-term follow-up, patients undergoing endoscopic therapy have an overall outcome similar to that in patients treated with partial laryngectomy or radiotherapy prior to developing invasive disease.

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