scholarly journals Increased Inflammatory Markers Detected in Nasal Lavage Correlate with Paranasal Sinus Abnormalities at MRI in Adolescent Patients with Cystic Fibrosis

Antioxidants ◽  
2021 ◽  
Vol 10 (9) ◽  
pp. 1412
Author(s):  
Jaehi Chung ◽  
Felix Wünnemann ◽  
Johanna Salomon ◽  
Sébastien Boutin ◽  
Dario L. Frey ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Paranasal Sinuses ◽  
Neutrophil Elastase ◽  
Inflammatory Markers ◽  
Nasal Lavage ◽  
Sum Score ◽  
Structural Abnormalities ◽  
Alpha1 Antitrypsin ◽  
Multiorgan Disease ◽  
Inflammation Parameters

Chronic rhinosinusitis (CRS) is a characteristic feature of cystic fibrosis (CF) multiorgan disease and develops early in the life of patients with CF. The study aimed to correlate the inflammatory markers and the presence of structural abnormalities detected by MRI in the paranasal sinuses of patients with CF. Methods: Nasal lavage and MRI of the paranasal sinuses was performed in a cohort of 30 CF patients (median age 14 y; range 7–20 y). Morphological abnormalities characteristic of CF were evaluated with a dedicated CRS MRI scoring system and correlated with different inflammation parameters measured in nasal lavage. Inflammation of the paranasal sinuses was positively associated with structural abnormalities in MRI. The concentration of the pro-inflammatory markers neutrophil elastase (NE) and the neutrophil elastase/alpha1-antitrypsin (NE/A1AT) complex correlated significantly with CRS-MRI sum score (p < 0.05, r = 0.416 and p < 0.05, r = 0.366, respectively). S. aureus infection was associated with the increased pro-inflammatory cytokine activity of IL-6 and IL-8, and increased levels of NE/A1AT complex in our patients (p < 0.05, respectively). CRS-MRI sum score and individual sinus MRI scores were positively associated with inflammatory activity as a sign of CRS pathology present in CF.

scholarly journals WS02.2 Role of soluble and membrane-associated neutrophil elastase activity in cystic fibrosis sputum

2017 ◽  
Vol 16 ◽  
pp. S3
Author(s):  
A.S. Dittrich ◽  
I. Kühbandner ◽  
S. Gehrig ◽  
V. Rickert-Zacharias ◽  
C.C. Taggart ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Neutrophil Elastase ◽  
Elastase Activity ◽  
Cystic Fibrosis Sputum

scholarly journals 213 Study evaluating the effect of weekends on activity and inflammatory markers in adult patients with cystic fibrosis

2012 ◽  
Vol 11 ◽  
pp. S111
Author(s):  
C. O'Connor ◽  
C. Reilly ◽  
S. Kelly ◽  
A. Leeney ◽  
C. O'Farrell ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Inflammatory Markers ◽  
Adult Patients

scholarly journals Chronic rhinosinusitis in adult patients with cystic fibrosis: clinical manifestation and therapeutic approaches

2019 ◽  
Vol 29 (3) ◽  
pp. 311-320
Author(s):  
G. L. Shumkova ◽  
E. L. Amelina ◽  
V. M. Svistushkin ◽  
E. V. Sin’kov ◽  
S. A. Krasovskiy ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Surgical Treatment ◽  
Treatment Group ◽  
Chronic Rhinosinusitis ◽  
Paranasal Sinuses ◽  
Endoscopic Sinus Surgery ◽  
Nasal Polyps ◽  
Adult Patients ◽  
Sinus Surgery ◽  
Markers Of Inflammation

The aim of this study was to evaluate prevalence of chronic rhinosinusitis (CRS) and nasal polyps in adult patients with cystic fibrosis (CF) in Russian Federation. Additionally, we investigated the clinical course of CRS and developed the optimal therapeutic strategy.Methods. Three hundred and forty eight CF patients were involved in the study. Physical examination, computed tomography (CT) of paranasal sinuses and audiometry, if needed, were used. CRS and bilateral nasal polyps were diagnosed in 28 patients. Nasal endoscopy, SNOT-20 questionnaire, rhinomanometry, micro - biological examination of sputum and mucus from paranasal sinuses (obtained during puncture or surgery), spirometry, and measurement of serum markers of inflammation were used. Endoscopic sinus surgery was used in 14 patients (the group 1) and others were treated non-surgically (the group 2). Both group were treated during 6 months using intranasal mometasone, mucolytics and antibiotics via PARI SINUSTM nebulizer.Results. An improvement in symptoms, CT signs, rhinomanometry parameters and endoscopic signs was seen in both groups after treatment and was more prominent in the surgical treatment group compared to the non-surgical treatment group. Bacterial load reduction in nasal sinuses, decrease in the rate of pulmonary disease exacerbations, and an improvement in oxygen blood saturation were found in the surgical treatment group only. Treatment of CRS did not affect lung function, sputum microbiology and serum inflammatory markers.Conclusion. Endoscopic sinus surgery followed by intranasal mucolytics and antibacterials is an effective and well-tolerated treatment in adult CF patients with CRS. 

11:06 AM: Microbiology of the Paranasal Sinuses in Cystic Fibrosis

2006 ◽  
Vol 135 (2_suppl) ◽  
pp. P187-P187
Author(s):  
German P. Digoy ◽  
Dwight T Jones
Keyword(s):  
Cystic Fibrosis ◽  
Paranasal Sinuses

scholarly journals Relationship between disease severity and inflammatory markers in cystic fibrosis.

1996 ◽  
Vol 75 (6) ◽  
pp. 498-501 ◽  
Author(s):  
D Y Koller ◽  
M Gotz ◽  
C Wojnarowski ◽  
I Eichler
Keyword(s):  
Cystic Fibrosis ◽  
Disease Severity ◽  
Inflammatory Markers

scholarly journals Neutrophil elastase correlates with increased sphingolipid content in cystic fibrosis sputum

2018 ◽  
Vol 53 (7) ◽  
pp. 872-880 ◽  
Author(s):  
Sophia Karandashova ◽  
Apparao Kummarapurugu ◽  
Shuo Zheng ◽  
Le Kang ◽  
Shumei Sun ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Neutrophil Elastase ◽  
Cystic Fibrosis Sputum

Sputum Neutrophil Elastase in pediatric cystic fibrosis and non-cystic fibrosis bronchiectasis

QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
Eman M Fouda ◽  
Heba A Ali ◽  
Mona A. A Salem ◽  
Heba H Radwan
Keyword(s):  
Cystic Fibrosis ◽  
Neutrophil Elastase ◽  
Severity Index ◽  
Cross Sectional Study ◽  
University Hospital ◽  
Cross Sectional ◽  
Sweat Chloride ◽  
Chronic Lung Diseases ◽  
Severe Group ◽  
Group B

Abstract Objective To assess the value of sputum neutrophil elastase as a biomarker of severity in cases of non-cystic fibrosis bronchectasis & cystic fibrosis. Methods This cross-sectional study was conducted on 50 bronchiectasis patients aged from 1 to 13 years presented to pediatric chest clinic and department of Ain shams university hospital., there were classified into 2 groups; Group A cystic fibrosis patients(30) and group B non-cystic fibrosis bronchiectasis patients(20). Inclusion criteria :children aged from 1 to 16 years, patients were diagnosed with bronchiectasis clinically and with HRCT chest and cystic Fibrosis patients were diagnosed by positive sweat chloride test and genetic study. Exclusion Criteria includes no other known chronic lung diseases. All patients were evaluated by full medical history and full clinical examination, the following lab investigations were done :sweat chloride test, CFTR mutation study, sputum sampling and culture. Quantitative sputum neutrophil elastase assay was done, and the severity of disease was assessed using clinical scores as SK score ,FACED score and bronchiectasis severity index and by using radiological scores as Bhalla and modified Reiff score. Results Steatorrhea was more prevalent among cystic fibrosis patients (80%) than non-CF bronchiectasis patients (0%).(P = 0.00). Clubbing was more prevalent among non -cystic fibrosis bronchectasis (10) (50 %), than cystic fibrosis (2 patients) (6.7 %).(P = 0.00). In cystic fibrosis, neutrophil elastase was significantly higher among severe group (126 ng/mL) than among the moderate (30 ng/mL) and mild (16 ng/mL) groups.(P = 0.00). While in non-CF bronchiectasis patients, neutrophil elastase was significantly higher among severe group (67 ng/mL) than among the moderate (24 ng/mL) and mild (11 ng/mL) groups.(P = 0.00) Conclusion There was a significant correlation between sputum neutrophil elastase and disease severity in bronchiectasis (both cystic fibrosis and non-CF).

Sign in / Sign up

Export Citation Format

Share Document