scholarly journals Histopathological Signatures of the Femoral Head in Patients with Osteonecrosis and Potential Applications in a Multi-Targeted Approach: A Pilot Study

2020 ◽  
Vol 10 (11) ◽  
pp. 3945
Author(s):  
Giovanna Desando ◽  
Livia Roseti ◽  
Isabella Bartolotti ◽  
Dante Dallari ◽  
Cesare Stagni ◽  
...  
Keyword(s):  
Pilot Study ◽  
Femoral Head ◽  
Treatment Options ◽  
Histopathological Features ◽  
Intact Cartilage ◽  
Potential Applications ◽  
Post Traumatic ◽  
Osteochondral Unit ◽  
Targeted Approach ◽  
Stem Cell Pool

(1) Background: Osteonecrosis (ON) of the femoral head is a disabling disease for which limited treatment options exist. Identifying therapeutic targets of its evolution could provide crucial insights into multi-targeted approaches. The aim of this pilot study was to assess the histopathological features of patients with non-traumatic femoral head (NTFH) and post-traumatic femoral head (PTFH) ON to produce a fresh vision for clinical use. (2) Methods: We got biopsies from patients with different ON stages, according to the ARCO system. Samples from multi-organ donors were used as controls. Histological and immunohistochemical evaluations were performed on the osteochondral unit. (3) Results: The PTFH group displayed several fibrotic reactions, a small stem cell pool and a lower international cartilage repair society (ICRS)-I score than NTFH, which instead presented intact cartilage similar to the controls. Immunostaining for collagen I and autotaxin confirmed these features in the PTFH group, which displayed top levels of MMP-13 involved in cartilage loss and reduced CB-2 in the underlying bone. Both groups manifested a similar pattern of apoptotic and pain mediators. (4) Conclusions: The different histopathological features suggest a multi-disciplinary and multi-targeted approach for ON. Further studies are necessary to measure the effect size to gain clinical evidence.

scholarly journals Multigene profiling to identify alternative treatment options for glioblastoma: a pilot study

2014 ◽  
Vol 67 (7) ◽  
pp. 550-555 ◽  
Author(s):  
Tania Tabone ◽  
Hazem J Abuhusain ◽  
Anna K Nowak ◽  
Wendy N Erber ◽  
Kerrie L McDonald ◽  
...  
Keyword(s):  
Pilot Study ◽  
Alternative Treatment ◽  
Treatment Options

scholarly journals Neuroanatomical Correlates of Depression in Post Traumatic Brain Injury: Preliminary Results of a Pilot Study

2010 ◽  
Vol 22 (2) ◽  
pp. 231-235 ◽  
Author(s):  
Vani Rao ◽  
Cynthia A. Munro ◽  
Paul Rosenberg ◽  
Julianna Ward ◽  
Melaine Bertrand ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Pilot Study ◽  
Preliminary Results ◽  
Post Traumatic

Thyroid Cancer Treatment Choice: A Pilot Study of a Tool to Facilitate Conversations with Patients with Papillary Microcarcinomas Considering Treatment Options

Thyroid ◽  
2018 ◽  
Vol 28 (10) ◽  
pp. 1325-1331 ◽  
Author(s):  
Juan P. Brito ◽  
Jae Hoon Moon ◽  
Rebecca Zeuren ◽  
Sung Hye Kong ◽  
Yeo Goon Kim ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Pilot Study ◽  
Cancer Treatment ◽  
Treatment Options ◽  
Treatment Choice ◽  
Papillary Microcarcinomas

A review on post-traumatic stress disorder (PTSD): “Symptoms, Therapies and Recent Case Studies”

2021 ◽  
Vol 14 ◽  
Author(s):  
Amandeep Thakur ◽  
Diksha Choudhary ◽  
Bhupinder Kumar ◽  
Amit Chaudhary
Keyword(s):  
Case Studies ◽  
Post Traumatic Stress Disorder ◽  
Traumatic Stress ◽  
Selective Serotonin Reuptake Inhibitors ◽  
Stress Disorder ◽  
Treatment Options ◽  
Mood Stabilizers ◽  
Post Traumatic Stress ◽  
Unexpected Death ◽  
Post Traumatic

: Post-traumatic stress disorder (PTSD), previously known as battle fatigue syndrome or shell shock, is a severe mental disturbance condition that is normally triggered by the experience of some frightening/scary events or trauma where a person undergoes some serious physical or mental harm or threatened. PTSD is a long-life effect of the continuous occurrence of traumatic conditions which, leading the production of feelings of helplessness, intense fear, and horror in the person. There are various examples of events that can cause PTSD, such as physical, mental, or sexual assault at home or working place by others, unexpected death of a loved one, an accidental event, war, or some kind of natural disaster. Treatment of PTSD includes the removal or reduction of these emotional feelings or symptoms with the aim to improve the daily life functioning of a person. Problems which are needed to be considered in case of PTSD like ongoing trauma, abusive or bad relationships. Various drugs which are used for the treatment of PTSD include selective serotonin reuptake inhibitors (SSRIs) (citalopram, fluvoxamine, fluoxetine, etc.); tricyclic antidepressants (amitriptyline and isocarboxazid); mood stabilizers (Divalproex and lamotrigine); atypical antipsychotics (aripiprazole and quetiapine), etc. In this review, we have covered the different risk factors, case studies related to various treatment options with different age group peoples in PTSD and their effects on them. We have also covered the symptoms and associated disorders which can play a key role in the development of PTSD.

Falling Out of Performance: Pragmatic Breakdown in Veterans’ Storytelling

2015 ◽  
Author(s):  
Kristiana Willsey
Keyword(s):  
Traumatic Stress ◽  
Combat Veterans ◽  
Treatment Options ◽  
Military Veterans ◽  
Post Traumatic Stress ◽  
The Public ◽  
Post Traumatic ◽  
The Military ◽  
War Stories ◽  
Careful Management

Unfortunately, coming to terms with disability and trauma are all too familiar foes for American combat veterans, many of whom receive inadequate, delayed, or nonexistent treatment options upon returning home. We conclude this volume with chapter 10, “Falling Out of Performance: Pragmatic Breakdown in Veterans’ Storytelling,” in which Kristiana Willsey provides new insights into the ways in which U.S. military veterans of Iraq and Afghanistan make meaning and process trauma through the sharing of narratives. She argues that naturalizing the labor of narrative—by assuming stories are inherently transformative, redemptive, or unifying—obscures the responsibilities of the audience as co-authors, putting the burden on veterans to both share their experiences of war, and simultaneously scaffold those experiences for an American public that (with the ongoing privatization of the military and the ever-shifting fronts of global warfare) is increasingly alienated from its military. Importantly, Willsey asserts that the public exhortations in which veterans tell their stories in an effort to cultivate a kind of cultural catharsis can put them in an impossible position: urged to tell their war stories; necessitating the careful management of those stories for audiences uniquely historically disassociated from their wars; and then conflating the visible management of those stories with the “spoiled identity” of post-traumatic stress disorder (PTSD).

380 FULL-TERM DEVELOPMENT OF MOUSE EMBRYOS PRODUCED FROM RECONSTRUCTED GIANT OOCYTES BY INTRACYTOPLASMIC SPERM HEAD INJECTION

2007 ◽  
Vol 19 (1) ◽  
pp. 305
Author(s):  
S. Wakayama ◽  
S. Kishigami ◽  
V. T. Nguyen ◽  
H. Ohta ◽  
T. Hikichi ◽  
...  
Keyword(s):  
Treatment Options ◽  
Developmental Potential ◽  
Potential Applications ◽  
New Material ◽  
Basic Biology ◽  
Original Size ◽  
Genomic Reprogramming ◽  
Normal Potential

In mammals, unusually large diploid giant oocytes are ovulated occasionally, but as any fertilized embryos would be triploid, the potential of the cytoplasm to support normal development is unknown. However, if such giant oocytes possess normal cytoplasm, the oocytes or their excessive cytoplasm would have potential applications in the treatment of human infertility and would enhance the study of basic biology, such as the influence of cytoplasmic factors on genomic reprogramming. We reconstructed oocytes 2 to 9 times normal volume by electrofusion or mechanical fusion between intact and enucleated oocytes. First, we examined the in vitro developmental potential of 2- to 9-times giant oocytes after parthenogenetic activation. Second, 2-times giant oocytes were reconstructed by fusing with intact and enucleated oocytes; then we examined the in vitro and in vivo developmental potential of these giant oocytes after intracytoplasmic sperm injection (ICSI). Third, somatic cell nuclear transfer (SCNT) was carried out using enucleated giant oocytes. When the giant oocytes were activated parthenogenetically, most developed into morulae or blastocysts, irrespective of the original size. When sperm heads were injected into 2-times giant oocytes, these were fertilized and developed normally in vitro; after embryo transfer, we obtained 12 healthy offspring (3 female, 3 male, and 6 cannibalized the next day) by Caesarian section. All survivors grew to adulthood and demonstrated normal fertility. However, we failed to generate cloned mice by SCNT. In conclusion, reconstructed giant oocytes have normal potential for development after activation and fertilization. The reconstructed giant oocytes will provide us with interesting tools for basic biology, such as providing new material for the study of nuclear reprogramming and genomic imprinting, and may be important in widening the treatment options in human assisted reproductive technology.

scholarly journals Neurosurgical applications of MRI guided laser interstitial thermal therapy (LITT)

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Usama Salem ◽  
Vinodh A. Kumar ◽  
John E. Madewell ◽  
Donald F. Schomer ◽  
Dhiego Chaves de Almeida Bastos ◽  
...  
Keyword(s):  
Treatment Options ◽  
Thermal Therapy ◽  
Invasive Technique ◽  
Laser Device ◽  
Invasive Treatment ◽  
Laser Interstitial Thermal Therapy ◽  
Alternative Treatment Option ◽  
Selective Ablation ◽  
Potential Applications ◽  
Mri Guided

Abstract MRI-guided laser interstitial thermal therapy (LITT) is the selective ablation of a lesion or a tissue using heat emitted from a laser device. LITT is considered a less invasive technique compared to open surgery that provides a nonsurgical solution for patients who cannot tolerate surgery. Although laser ablation has been used to treat brain lesions for decades, recent advances in MRI have improved lesion targeting and enabled real-time accurate monitoring of the thermal ablation process. These advances have led to a plethora of research involving the technique, safety, and potential applications of LITT. LITT is a minimally invasive treatment modality that shows promising results and is associated with decreased morbidity. It has various applications, such as treatment of glioma, brain metastases, radiation necrosis, and epilepsy. It can provide a safer alternative treatment option for patients in whom the lesion is not accessible by surgery, who are not surgical candidates, or in whom other standard treatment options have failed. Our aim is to review the current literature on LITT and provide a descriptive review of the technique, imaging findings, and clinical applications for neurosurgery.

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