Insights into the mechanism of atrial tachycardia with over two types of reentrant circuits: the important role of the convertibility of functional conduction block regions in maintaining multiple reentrant circuit pathways

Background: Multiple atrial tachycardias (ATs) in one patient usually require more complex ablation procedures. Despite the superior accuracy and understanding of conduction features provided by high-resolution mapping, Multiple ATs are still associated with high recurrence rates, and other mechanisms may play a role. Therefore, we aimed to uncover the substrates maintaining these multiple reentrant circuits and the probable mechanisms for the high occurrence of arrhythmia. Methods: Mapping via the Carto system was carried out in 8 patients with more than two types of reentrant circuits during ablation. Functional conduction block (FCB) regions were marked and further analyzed. Results: Twenty sustained ATs were mapped in the 8 patients. Five of these patients exhibited a potential FCB region that changed between different ATs. The potentials of these regions converted between double potentials (DPs), fractionated potentials (FPs) and normal potential due to the different ATs. The FCB regions were the main obstacles and the center of the reentrant circuit in 8 of 14 ATs, and in the other ATs, these regions played a role in reorganizing the conduction pathway. In the activation mapping, the FCB areas were never the target ablation site. Conclusion: The potential FCB region is common in ATs with more than two types of reentrant circuits, especially in scar-related localized reentry. The convertibility of FCB regions provide one of the critical substrates in maintaining multiple ATs. The changefulness of this substrate may be one of the important causes of the high recurrence of related ATs

Evaluation of the ventilometric parameters of two football teams in different leagues

Introduction: Spirometry testing is a physiological test measuring lung volume and flows. Compared to the other components of the respiratory system, training does not result into significant improvements as for the increase of the expiratory flow. The assessment of the respiratory function may indicate certain disorders of the bronchi and of the lungs, but, on the other hand, it offers little information on the aerobic capacity of the individuals or the effects of physical exercises.Aim: The purpose of this research was to study the respiratory volumes in two football teams that are part of two different leagues (2nd league, and 5th league, respectively), and to compare these results with the ones at the international level.Materials and methods: We included in this research two football teams in two different leagues (2nd league, and 5th league, respectively) and, from each team, we chose the players with the highest number of minutes spent playing throughout the championship return phase. In order to perform spirometry, we used a portable spirometer (Spirotube Spirometer, PC Spirometer). The prediction method used by the spirometer software was the one presented by the European Respiratory Society and Kudson.Results: By comparing the environments of the two groups we can see that, in terms of height and weight, the two samples present close values. According to the results recorded with the help of the spirometer, the value of the forced vital capacity (FVC = 4.50) represents 98% of the normal level, and the Expiratory volume per second FEV1 (FEV1 = 4.50) represents 97% of the normal level. Within the ASU group, the value of the forced vital capacity (FVC = 5.19) represents 95% of the normal level, and the Expiratory volume per second (FEV1 = 4.45) represents 95% of the normal level. As we can see, neither of the groups reaches the normal potential. However, the CS UVT group reaches a higher percentage than the other, although they play their matches in a lower league.Conclusions: Considering that we could not compare the types of training that the two teams had during the preparation phase, we cannot say whether such trainings had a certain effect on the subjects. Further research should be carried out in order to determine if the type of training had a beneficial effect in the case of the CS UVT group.

Geothermal Potential Based on Physical Characteristics of the Region (Case Study: Mount Karang, Pandeglang Regency and Banten Province)

This research is about geothermal potential of Mount Karang, Banten Province which is based on the characteristics of the region. This research method used is geochemistry sample of hot springs and integrated with GIS method for spatial of geothermal potential. Based on the geothermal potential, Mount Karang is divided into three regions, ie high potential, normal potential, and low potential. The high geothermal potential region covers an area of 24.16 Km2and which there are Cisolong and Banjar 2 hot springs. The normal potential covers Kawah hot spring. Index of the fault of Mount Karang region is one of the significant physical characteristics to determine geothermal potential.

USES AND FUNCTIONS OF MUSIC IN CONGENITAL AMUSIA

THE GOAL OF THIS STUDY WAS TO ASCERTAIN whether deficits in music perception impact upon music appreciation. Likert ratings were gathered from congenital amusics and matched controls concerning the degree to which individuals incorporate music in their everyday lives, are able to achieve certain psychological states through music, and feel positively about music imposed upon them. Those with amusia reported incorporating music into everyday activities to a lesser degree than controls. They also reported experiencing fewer changes in psychological states when listening to music and felt more negatively about imposed music compared to controls. However, the scores of some amusic individuals fell within the control range on these questionnaires, providing some evidence for a developmental dissociation between music perception (impaired) and music appreciation (normal). Potential reasons for this dissociation are discussed.

380 FULL-TERM DEVELOPMENT OF MOUSE EMBRYOS PRODUCED FROM RECONSTRUCTED GIANT OOCYTES BY INTRACYTOPLASMIC SPERM HEAD INJECTION

In mammals, unusually large diploid giant oocytes are ovulated occasionally, but as any fertilized embryos would be triploid, the potential of the cytoplasm to support normal development is unknown. However, if such giant oocytes possess normal cytoplasm, the oocytes or their excessive cytoplasm would have potential applications in the treatment of human infertility and would enhance the study of basic biology, such as the influence of cytoplasmic factors on genomic reprogramming. We reconstructed oocytes 2 to 9 times normal volume by electrofusion or mechanical fusion between intact and enucleated oocytes. First, we examined the in vitro developmental potential of 2- to 9-times giant oocytes after parthenogenetic activation. Second, 2-times giant oocytes were reconstructed by fusing with intact and enucleated oocytes; then we examined the in vitro and in vivo developmental potential of these giant oocytes after intracytoplasmic sperm injection (ICSI). Third, somatic cell nuclear transfer (SCNT) was carried out using enucleated giant oocytes. When the giant oocytes were activated parthenogenetically, most developed into morulae or blastocysts, irrespective of the original size. When sperm heads were injected into 2-times giant oocytes, these were fertilized and developed normally in vitro; after embryo transfer, we obtained 12 healthy offspring (3 female, 3 male, and 6 cannibalized the next day) by Caesarian section. All survivors grew to adulthood and demonstrated normal fertility. However, we failed to generate cloned mice by SCNT. In conclusion, reconstructed giant oocytes have normal potential for development after activation and fertilization. The reconstructed giant oocytes will provide us with interesting tools for basic biology, such as providing new material for the study of nuclear reprogramming and genomic imprinting, and may be important in widening the treatment options in human assisted reproductive technology.