Cerebrovascular Reactivity Assessment during Carbon Dioxide Inhalation Using SPECT

2021 ◽  
Vol 11 (3) ◽  
pp. 1161
Author(s):  
Yeong-Bae Lee ◽  
Chang-Ki Kang
Keyword(s):  
Carbon Dioxide ◽  
Healthy Subjects ◽  
Healthy Aging ◽  
Single Photon ◽  
Photon Emission ◽  
Clinical Diagnostics ◽  
Cerebrovascular Reactivity ◽  
Emission Computed Tomography ◽  
Brain Vessels ◽  
Quantitative Spect

Background: Perfusion single-photon emission computed tomography (SPECT) using an acetazolamide is an important clinical tool used to assess cerebrovascular reactivity (CVR) in patients, but its use has been limited to clinical diagnostics. This study aimed to preliminarily evaluate the feasibility of perfusion SPECT using carbon dioxide (CO2). Methods: Ten healthy subjects participated in two consecutive SPECT scans using CO2 inhalation. To evaluate brain perfusion after preprocessing, the voxel-by-voxel CVR values were averaged in 13 subgroup regions of interest (ROIs) based on a template. Subsequently, averaged CVR values of each ROI were analyzed based on both cerebellar hemispheres. Results: CVR values in the eight subgroup ROIs, which included vermis, both insula/cingulate, and frontal cortices, showed significant changes (p < 0.05). CVR values were higher in vermis and right insula/cingulate by 3.34% and 3.15%, respectively. Conclusions: This study showed that quantitative SPECT with CO2 inhalation could be used to evaluate the voxel-based CVR in healthy subjects, which could be beneficial for elucidating induced hypercapnic states and for longitudinally investigating the healthy aging in brain vessels. Furthermore, the cerebrovascular hemodynamic parameters induced by CO2 could play an important role as a biomarker to evaluate treatment progress in patients with cerebrovascular disease.

scholarly journals Hibrid képalkotás: klinikai evidenciák, lehetőségek

2015 ◽  
Vol 156 (52) ◽  
pp. 2110-2115
Author(s):  
György Trencsényi ◽  
Sándor Kristóf Barna ◽  
Ildikó Garai
Keyword(s):  
Computed Tomography ◽  
Hybrid Imaging ◽  
Single Photon ◽  
Photon Emission ◽  
Research Process ◽  
Clinical Diagnostics ◽  
The Body ◽  
Drug Candidate ◽  
Emission Computed Tomography

Nowadays the hybrid imaging technologies which combine the modern equipments of radiology and nuclear medicine play an important role in both the translational research process and clinical diagnostics. Among the routine diagnostic imaging procedures positron emission tomography and single photon emission computed tomography combined with computed tomography or magnetic resonance imaging currently belong to the most advanced techniques allowing that functional and morphological images can be superimposed on each other in the same position. The hybrid imaging equipments provide useful information about the pathological processes in the body due to their high sensibility and resolution. Furthermore, with the help of these imaging modalities we can get acquainted with the biochemical and pathobiochemical processes that are essential for understanding and treating diseases, or getting acquainted with the behaviour of a new drug candidate. With the help of the clinical and preclinical non-invasive in vivo molecular imaging systems the drug developing process can be shortened and its costs can be reduced. Orv. Hetil., 2015, 156(52), 2110–2115.

scholarly journals Use of Cerebrovascular Reactivity in Patients with Symptomatic Major Cerebral Artery Occlusion to Predict 5-Year Outcome: Comparison of Xenon-133 and Iodine-123-IMP Single-Photon Emission Computed Tomography

2002 ◽  
Vol 22 (9) ◽  
pp. 1142-1148 ◽  
Author(s):  
Kuniaki Ogasawara ◽  
Akira Ogawa ◽  
Kazunori Terasaki ◽  
Hiroaki Shimizu ◽  
Teiji Tominaga ◽  
...  
Keyword(s):  
Cerebral Artery ◽  
Single Photon ◽  
Independent Predictor ◽  
Photon Emission ◽  
Survival Rates ◽  
Artery Occlusion ◽  
Cerebrovascular Reactivity ◽  
Emission Computed Tomography ◽  
Percent Change ◽  
Cerebral Artery Occlusion

The aim of this prospective study was to investigate whether decreased cerebrovascular reactivity to acetazolamide, as determined by single-photon emission computed tomography (SPECT), is an independent predictor of the 5-year risk of subsequent stroke in patients with symptomatic major cerebral artery occlusion. Cerebrovascular reactivity to acetazolamide in the middle cerebral artery (MCA) territory ipsilateral to the occluded artery was determined on the basis of two different methodologies: cerebral blood flow (CBF) percent change obtained quantitatively from xenon-133 (133Xe) SPECT, and asymmetry index (AI) percent change obtained qualitatively from N-isopropyl- p-[123I]-iodoamphetamine (IMP) SPECT. Seventy patients with unilateral internal carotid artery or MCA occlusion were divided into two groups within each SPECT methodology (normal or decreased CBF percent change and AI percent change) and followed up for 5 years. Cumulative recurrence-free survival rates for patients with decreased CBF percent change were significantly lower than for those with normal CBF percent change ( P = 0.0205). There was no significant difference in cumulative recurrence-free survival rates between patients with decreased AI percent change and those with normal AI percent change. Only decreased CBF percent change was a significant independent predictor of stroke recurrence ( P = 0.0051). The present study demonstrated that decreased cerebrovascular reactivity to acetazolamide determined quantitatively by Xe SPECT is an independent predictor of the 5-year risk of subsequent stroke in patients with symptomatic major cerebral artery occlusion, and that the qualitative method using I-IMP SPECT is a poor predictor of the risk of subsequent stroke in this type of patient.

Serotonin and dopamine transporters in relation to neuropsychological functioning, personality traits and mood in young adult healthy subjects

2010 ◽  
Vol 41 (2) ◽  
pp. 419-429 ◽  
Author(s):  
S. M. Burke ◽  
E. van de Giessen ◽  
M. de Win ◽  
T. Schilt ◽  
M. van Herk ◽  
...  
Keyword(s):  
Personality Traits ◽  
Test Performance ◽  
Healthy Subjects ◽  
Single Photon ◽  
Neuropsychological Functioning ◽  
Memory Function ◽  
Photon Emission ◽  
Emission Computed Tomography ◽  
Dopamine Transporters

BackgroundSerotonin and dopamine neurotransmitter systems are implicated in the regulation of mood, cognition and personality traits and their dysfunction is thought to be implicated in diverse psychopathologies. However, in healthy subjects the relationship between the serotonin and dopamine systems and neuropsychological functioning and personality traits is not clearly established. In the present study we investigated whether neuropsychological functioning, personality traits and mood states of a group of healthy subjects are associated with in vivo measures of serotonin transporters (SERTs) and dopamine transporters (DATs).MethodA total of 188 young healthy subjects underwent neuropsychological and subjective measurements of memory function, depression and impulsivity. Participants' SERT and DAT availability in predefined regions of interest were assessed using single photon emission computed tomography (SPECT) with the radiotracer [123I]β-CIT. Individual magnetic resonance imaging (MRI) scans served as anatomic reference.ResultsWe did not find any significant association between SERT or DAT availability and neuropsychological test performance or self-reported impulsivity and mood. There were no significant sex differences in SERT or DAT availability, but men performed significantly better on some tests of visuospatial functioning than women.ConclusionsRobust negative findings for striatal DAT availability seriously question earlier findings of positive associations between DAT availability and cognitive functions in healthy subjects. Our results also suggest that subcortical SERT availability is not associated with the neuropsychological functions and personality traits assessed. In summary, the present study suggests that neuropsychological and personality measurements in young healthy people are not associated with subcortical SERT or striatal DAT availabilities in the brain.

scholarly journals Sources of Variability of Resting Cerebral Blood Flow in Healthy Subjects: A Study Using 133Xe SPECT Measurements

2013 ◽  
Vol 33 (5) ◽  
pp. 787-792 ◽  
Author(s):  
Otto M Henriksen ◽  
Christina Kruuse ◽  
Jes Olesen ◽  
Lars T Jensen ◽  
Henrik BW Larsson ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Healthy Subjects ◽  
Single Photon ◽  
Large Fraction ◽  
Photon Emission ◽  
Added Value ◽  
Emission Computed Tomography ◽  
Large Variability ◽  
Subject Variability

Measurements of cerebral blood flow (CBF) show large variability among healthy subjects. The aim of the present study was to investigate the relative effect of established factors influencing CBF on the variability of resting CBF. We retrospectively analyzed spontaneous variability in 430 CBF measurements acquired in 152 healthy, young subjects using 133Xe single-photon emission computed tomography. Cerebral blood flow was correlated positively with both end-tidal expiratory PCO2 (PETCO2) and female gender and inversely with hematocrit (Hct). Between- and within-subject CO2 reactivity was not significantly different. Including PETCO2, Hct and gender in the model reduced between-subject and within-subject variance by 14% and 13.5%, respectively. Withinsubject variability was mainly influenced by PETCO2 and between-subject variability mostly by Hct, whereas gender appeared to be of little added value when Hct was also accounted for. The present study confirms large between-subject variability in CBF measurements and that gender, Hct, and PETCO2 explain only a small part of this variability. This implies that a large fraction of CBF variability may be due to unknown factors such as differences in neuron density or metabolism that could be subject for further studies.

scholarly journals Reproducibility of Cerebral Blood Flow Assessment using a Quantitative SPECT Reconstruction Program and Split-Dose 123I-Iodoamphetamine in Institutions with Different γ-Cameras and Collimators

2012 ◽  
Vol 32 (9) ◽  
pp. 1757-1764 ◽  
Author(s):  
Hiroshi Yoneda ◽  
Satoshi Shirao ◽  
Hiroyasu Koizumi ◽  
Fumiaki Oka ◽  
Hideyuki Ishihara ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Vascular Reactivity ◽  
Single Photon ◽  
Photon Emission ◽  
Emission Computed Tomography ◽  
Multicenter Studies ◽  
Quantitative Spect ◽  
Split Dose ◽  
Acetazolamide Challenge

Single photon emission computed tomography (SPECT) is used widely in clinical studies. However, the technique requires image reconstruction and the methods for correcting scattered radiation and absorption are not standardized among SPECT procedures. Therefore, quantitation of cerebral blood flow (CBF) may not be constant across SPECT models. The quantitative SPECT (QSPECT) software package has been developed for standardization of CBF. Using the QSPECT/dual-table autoradiographic (DTARG) method, CBF and cerebral vascular reactivity (CVR) at rest and after acetazolamide challenge can be evaluated using 123I-iodoamphetamine in a single SPECT session. In this study, we examined the reproducibility of quantitative regional CBF and CVR in QSPECT/DTARG using different SPECT models at two facilities. The subjects were nine patients with chronic cerebral ischemic disease who underwent QSPECT/DTARG at both facilities with use of different γ-cameras and collimators. There were significant correlations for CBF at rest and after acetazolamide challenge measured at the two facilities. The consistency of the CBFs of the patients measured at the two facilities were good in all cases. Our results show that CBF measured by QSPECT/DTARG in the same patients is reproducible in different SPECT models. This indicates that standardized evaluation of CBF can be performed in large multicenter studies.

Physiological evaluation of a new quantitative SPECT method measuring regional ventilation and perfusion

2004 ◽  
Vol 96 (3) ◽  
pp. 1127-1136 ◽  
Author(s):  
Johan Petersson ◽  
Alejandro Sánchez-Crespo ◽  
Malin Rohdin ◽  
Stéphanie Montmerle ◽  
Sven Nyrén ◽  
...  
Keyword(s):  
Gas Exchange ◽  
Single Photon ◽  
Photon Emission ◽  
Inert Gas ◽  
Emission Computed Tomography ◽  
Regional Ventilation ◽  
Quantitative Spect ◽  
Respiratory Gases ◽  
Photon Emission Computed Tomography ◽  
Ventilation And Perfusion

We have developed a new quantitative single-photon-emission computed tomography (SPECT) method that uses 113mIn-labeled albumin macroaggregates and Technegas (99mTc) to estimate the distributions of regional ventilation and perfusion for the whole lung. The multiple inert-gas elimination technique (MIGET) and whole lung respiratory gas exchange were used as physiological evaluations of the SPECT method. Regional ventilation and perfusion were estimated by SPECT in nine healthy volunteers during awake, spontaneous breathing. Radiotracers were administered with subjects sitting upright, and SPECT images were acquired with subjects supine. Whole lung gas exchange of MIGET gases and arterial Po2 and Pco2 gases was predicted from estimates of regional ventilation and perfusion. We found a good agreement between measured and SPECT-predicted exchange of MIGET and respiratory gases. Correlations ( r2) between SPECT-predicted and measured inert-gas excretions and retentions were 0.99. The method offers a new tool for measuring regional ventilation and perfusion in humans.

scholarly journals Quantitative bone single-photon emission computed tomography imaging for uninfected nonunion: comparison of hypertrophic nonunion and non-hypertrophic nonunion

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Keisuke Oe ◽  
Feibi Zeng ◽  
Tomoaki Fukui ◽  
Munenobu Nogami ◽  
Takamichi Murakami ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Single Photon ◽  
Photon Emission ◽  
Emission Computed Tomography ◽  
Single Photon Emission ◽  
Quantitative Spect ◽  
Quantitative Parameters ◽  
Emission Computed ◽  
Single Photon Emission Computed ◽  
Photon Emission Computed Tomography

Abstract Background Recently, a standardized uptake value (SUV) has been used to evaluate bone single-photon emission computed tomography (SPECT). The aim of this study was to investigate quantitative SPECT imaging of uninfected nonunion to compare hypertrophic nonunion and non-hypertrophic nonunion using volume-based parameters. Methods We evaluated 23 patients with uninfected nonunion who underwent SPECT acquisition 3 h after an injection of 99mTc-hydroxymethylene diphosphonate or 99mTc-methylene diphosphonate from April 2014 to November 2019. We reconstructed the acquired data and performed voxel-based quantitative analysis using the GI-BONE software. Quantitative parameters, maximum SUV (SUVmax), peak SUV (SUVpeak), and mean SUV (SUVmean) in the high and low uptake areas of nonunion were compared between hypertrophic nonunion and non-hypertrophic nonunion. The contralateral limb was used as a control, and the ratios of the quantitative parameters were calculated. Results The values for the quantitative parameters (high uptake area/low uptake area, respectively), SUVmax control ratio (12.13 ± 4.95/6.44 ± 4.71), SUVpeak control ratio (11.65 ± 4.58/6.45 ± 4.64), and SUVmean control ratio (11.94 ± 5.03/6.28 ± 4.95) for hypertrophic nonunion were higher than those for non-hypertrophic nonunion (7.82 ± 4.76/3.41 ± 2.09 (p = 0.065/0.12), 7.56 ± 4.51/3.61 ± 2.23 (p = 0.065/0.22), and 7.59 ± 5.18/3.05 ± 1.91 (p = 0.076/0.23)). Conclusions SUVmax, SUVpeak, and SUVmean control ratios obtained from bone SPECT images can quantitatively evaluate the biological activity of nonunions and may be an effective evaluation method for treatment decisions, especially the necessity of autologous bone grafting.

scholarly journals Quantitative Bone Single Photon Emission Computed Tomography Imaging for Uninfected Nonunion: Comparison of Hypertrophic Nonunion and Non-Hypertrophic Nonunion

2020 ◽  
Author(s):  
Keisuke Oe ◽  
Feibi Zeng ◽  
Tomoaki Fukui ◽  
Munenobu Nogami ◽  
Takamichi Murakami ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Single Photon ◽  
Photon Emission ◽  
Emission Computed Tomography ◽  
Single Photon Emission ◽  
Quantitative Spect ◽  
Quantitative Parameters ◽  
Emission Computed ◽  
Single Photon Emission Computed ◽  
Photon Emission Computed Tomography

Abstract BackgroundRecently, a standardized uptake value (SUV) has been used to evaluate bone single photon emission computed tomography (SPECT). The aim of this study was to investigate quantitative SPECT imaging of uninfected nonunion to compare hypertrophic nonunion and non-hypertrophic nonunion using volume-based parameters.MethodsWe evaluated 23 patients with uninfected nonunion who underwent SPECT acquisition 3 h after an injection of 99mTc-hydroxymethylene diphosphonate or 99mTc-methylene diphosphonate from April 2014 to November 2019. We reconstructed the acquired data and performed voxel-based quantitative analysis using GI-BONE software. Quantitative parameters, maximum SUV (SUVmax), peak SUV (SUVpeak), and mean SUV (SUVmean) in the high and low uptake areas of nonunion were compared between hypertrophic nonunion and non-hypertrophic nonunion. The contralateral limb was used as a control, and the ratios of the quantitative parameters were calculated. ResultsThe values for the quantitative parameters (high uptake area/low uptake area, respectively), SUVmax control ratio (12.13 ± 4.95/6.44 ± 4.71), SUVpeak control ratio (11.65 ± 4.58/6.45 ± 4.64), and SUVmean control ratio (11.94 ± 5.03/6.28 ± 4.95) for hypertrophic nonunion were higher than those for non-hypertrophic nonunion (7.82 ± 4.76/3.41 ± 2.09 (p = 0.065/0.12), 7.56 ± 4.51/3.61 ± 2.23 (p = 0.065/0.22), and 7.59 ± 5.18/3.05 ± 1.91 (p = 0.076/0.23). ConclusionsSUVmax, peak, mean control ratios obtained from bone SPECT images can quantitatively evaluate the biological activity of nonunions and may be an effective evaluation method for treatment decisions, especially the necessity of autologous bone grafting.

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