scholarly journals Dark-Field Hyperspectral Microscopy for Carbon Nanotubes Bioimaging

2021 ◽  
Vol 11 (24) ◽  
pp. 12132
Author(s):  
Ilnur Ishmukhametov ◽  
Rawil Fakhrullin
Keyword(s):  
Carbon Nanotubes ◽  
Carbon Nanotube ◽  
Optical Microscopy ◽  
Biomedical Applications ◽  
Dark Field ◽  
Chemical Identification ◽  
Nanoscale Particles ◽  
Spectral Identification ◽  
Tyndall Effect ◽  
Dark Field Microscopy

Carbon nanotubes have emerged as a versatile and ubiquitous nanomaterial, finding applications in industry and biomedicine. As a result, biosafety concerns that stimulated the research focused on evaluation of carbon nanotube toxicity. In addition, biomedical applications of carbon nanotubes require their imaging and identification in biological specimens. Among other methods, dark-field microscopy has become a potent tool to visualise and identify carbon nanotubes in cells, tissues, and organisms. Based on the Tyndall effect, dark-field optical microscopy at higher magnification is capable of imaging nanoscale particles in live objects. If reinforced with spectral identification, this technology can be utilised for chemical identification and mapping of carbon nanotubes. In this article we overview the recent advances in dark-field/hyperspectral microscopy for the bioimaging of carbon nanotubes.

Future trends in carbon nanotubes: Process towards a viable biomedical solution

2021 ◽  
Vol 06 ◽  
Author(s):  
Raja Murugesan ◽  
Sureshkumar Raman ◽  
Arun Radhakrishnan
Keyword(s):  
Carbon Nanotubes ◽  
Carbon Nanotube ◽  
Biomedical Applications ◽  
Scale Up ◽  
Diagnostic Techniques ◽  
Nano Composite ◽  
Methods Of Synthesis ◽  
In Trans ◽  
Functionalization Of Carbon Nanotubes

Background: Recently, Nanomaterials based nano-composite materials play the role of various field. Especially, Carbon nanotube based materials are involved in the bio-medical applications.Since, their exclusive and exciting property, researchers worldwide have extensively involved in trans-modulating the carbon nanotubes into a viable medico-friendly system. Objective: These active researches paved the path towards targeted drug delivery, diagnostic techniques, and bio-analytical applications. Despite these exciting properties, which accomplish the probable for biomedical applications, they hold Biosafety issues. Methods: This broad-spectrum review has discussed different aspects of carbon nanotubes and carbon nanotube-based systems related to biomedical applications. Results: Adding to this, a short chronological description of these tiny yet powerful particles given, followed by a discussion regarding their types, properties, methods of synthesis, scale-up, purification techniques and characterization aspects of carbon nanotubes. Conclusion: In the later part, the functionalization of carbon nanotubes was reviewed in detail, which is important to make them biocompatible and stable in biological systems and render them a great property of loading various biomolecules diagnostic and therapeutic moieties. Lastly, an inclusive description of the potential biomedical applications has been given followed by insights into the future.

scholarly journals Qualitative Assessment of Carbon Nanotube Toxicity to Mouse Liver using Dark‐field Microscopy

2020 ◽  
Vol 34 (S1) ◽  
pp. 1-1
Author(s):  
Steven E. Angtuaco ◽  
Alena Savenka ◽  
Todd Fite ◽  
Shijie Liu ◽  
Mariya Khodakovskaya ◽  
...  
Keyword(s):  
Carbon Nanotube ◽  
Mouse Liver ◽  
Dark Field ◽  
Qualitative Assessment ◽  
Dark Field Microscopy

Biocompatibility studies of macroscopic fibers made from carbon nanotubes: Implications for carbon nanotube macrostructures in biomedical applications

Carbon ◽  
2021 ◽  
Vol 173 ◽  
pp. 462-476
Author(s):  
J. Stephen Yan ◽  
Marco Orecchioni ◽  
Flavia Vitale ◽  
Julia A. Coco ◽  
Guillaume Duret ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Carbon Nanotube ◽  
Biomedical Applications

Evaluation of Novel Strategies for Carbon Nanotube Functionalization by TGA/Chemometrics

2021 ◽  
Vol 885 ◽  
pp. 59-66
Author(s):  
Giuseppina Gullifa ◽  
Roberta Risoluti
Keyword(s):  
Carbon Nanotubes ◽  
Drug Delivery ◽  
Endothelial Cells ◽  
Carbon Nanotube ◽  
Thermogravimetric Analysis ◽  
Experimental Design ◽  
Biomedical Applications ◽  
Recorded Data ◽  
Selection Of

Innovative preparation strategies for nanomaterial functionalization were proposed to provide novel tool to be used as drug delivery vectors for biomedical applications. In particular, three different carbon nanotubes were considered in this study such as the very small CNTs, the carboxylated CNTs (CNT-COOH) and the buckypapers and two polymers were used to study the functionalization. Different preparation procedures were investigated by thermogravimetric analysis (TGA), including the selection of the most performing polymer to be linked to the nanomaterial between PEI and PAMAM, the percentage of the polymer and the time of suspension. To simultaneously evaluate all these variables, an experimental design was planned and the recorded data were processed by chemometrics to identify the preparing procedure providing new nanomaterials able to conjugate microRNAs and to transfect efficiently endothelial cells.

DISPERSION OF PRISTINE MULTI-WALLED CARBON NANOTUBES IN COMMON ORGANIC SOLVENTS

NANO ◽  
2010 ◽  
Vol 05 (02) ◽  
pp. 103-109 ◽  
Author(s):  
GUOXING SUN ◽  
ZHENGPING LIU ◽  
GUANGMING CHEN
Keyword(s):  
Electron Microscopy ◽  
Carbon Nanotubes ◽  
Transmission Electron Microscopy ◽  
Optical Microscopy ◽  
Organic Solvents ◽  
Colloidal Systems ◽  
Transmission Electron ◽  
Tyndall Effect ◽  
Multi Walled Carbon Nanotubes ◽  
Walled Carbon Nanotubes

The dispersion of pristine multi-walled carbon nanotubes in various common organic solvents and water has been investigated. Sedimentation tests, optical microscopy, transmission electron microscopy and Tyndall effect tests are employed. The results clearly show that N-methyl-2-pyrrolodone, acetone, tetrahydrofuran and dichloromethane are good solvents to debundle and disperse the multi-walled carbon nanotubes. In contrast, much precipitation can be obviously observed for systems of the carbon nanotubes in water, ethanol and toluene. Additionally, Tyndall effect tests suggest that the upper dispersions of the carbon nanotubes in acetone, tetrahydrofuran and dichloromethane with a concentration of 0.1 mg/mL and the dispersion of carbon nanotubes in N-methyl-2-pyrrolodone with a concentration of 0.05 mg/mL are colloidal systems rather than solutions. Finally, based on the above results, a possible mechanism is briefly discussed.

Elastic Scattering in Electron Microscopy

1973 ◽  
Vol 31 ◽  
pp. 252-253
Author(s):  
J. Langmore ◽  
M. Isaacson ◽  
J. Wall ◽  
A. V. Crewe
Keyword(s):  
Electron Microscopy ◽  
Elastic Scattering ◽  
Cross Section ◽  
Quantum Noise ◽  
Dark Field ◽  
Elastic Cross Section ◽  
Biological Molecules ◽  
Dark Field Microscopy ◽  
Field Systems ◽  
Effects Of Radiation

High resolution dark field microscopy is becoming an important tool for the investigation of unstained and specifically stained biological molecules. Of primary consideration to the microscopist is the interpretation of image Intensities and the effects of radiation damage to the specimen. Ignoring inelastic scattering, the image intensity is directly related to the collected elastic scattering cross section, σɳ, which is the product of the total elastic cross section, σ and the eficiency of the microscope system at imaging these electrons, η. The number of potentially bond damaging events resulting from the beam exposure required to reduce the effect of quantum noise in the image to a given level is proportional to 1/η. We wish to compare η in three dark field systems.

Simulated Dark-Field Electron Micrographs of Point Defects and Organometallics

1975 ◽  
Vol 33 ◽  
pp. 200-201
Author(s):  
William Krakow
Keyword(s):  
Electron Micrographs ◽  
Point Defects ◽  
Structure Determination ◽  
Atomic Structure ◽  
Image Interpretation ◽  
Dark Field ◽  
Field Electron ◽  
Dark Field Microscopy ◽  
Dark Field Electron

Tilted beam dark-field microscopy has been applied to atomic structure determination in perfect crystals, several synthesized molecules with heavy atcm markers and in the study of displaced atoms in crystals. Interpretation of this information in terms of atom positions and atom correlations is not straightforward. Therefore, calculated dark-field images can be an invaluable aid in image interpretation.

Fabrication of Carbon Nanotube Triode Using Helicon Plasma Cvd with Electroplated Nico Catalyst

2003 ◽  
Vol 772 ◽  
Author(s):  
Masakazu Muroyama ◽  
Kazuto Kimura ◽  
Takao Yagi ◽  
Ichiro Saito
Keyword(s):  
Carbon Nanotubes ◽  
Carbon Nanotube ◽  
Metal Catalyst ◽  
Ni Catalyst ◽  
Plasma Cvd ◽  
Helicon Plasma ◽  
Plasma Enhanced Cvd ◽  
Turn On ◽  
Aligned Carbon Nanotubes ◽  
Vertically Aligned

AbstractA carbon nanotube triode using Helicon Plasma-enhanced CVD with electroplated NiCo catalyst has been successfully fabricated. Isolated NiCo based metal catalyst was deposited at the bottom of the cathode wells by electroplating methods to control the density of carbon nanotubes and also reduce the activation energy of its growth. Helicon Plasma-enhanced CVD (HPECVD) has been used to deposit nanotubes at 400°C. Vertically aligned carbon nanotubes were then grown selectively on the electroplated Ni catalyst. Field emission measurements were performed with a triode structure. At a cathode to anode gap of 1.1mm, the turn on voltage for the gate was 170V.

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