scholarly journals Health Risk Assessment of Banned Veterinary Drugs and Quinolone Residues in Shrimp through Liquid Chromatography–Tandem Mass Spectrometry

2019 ◽  
Vol 9 (12) ◽  
pp. 2463 ◽  
Author(s):  
Ming-Yang Tsai ◽  
Chuen-Fu Lin ◽  
Wei-Cheng Yang ◽  
Chien-Teng Lin ◽  
Kuo-Hsiang Hung ◽  
...  
Keyword(s):  
Health Risk ◽  
Daily Intake ◽  
Grass Shrimp ◽  
Veterinary Drugs ◽  
World Health ◽  
Veterinary Drug ◽  
Antibiotic Residues ◽  
Veterinary Drug Residues ◽  
Drug Residues ◽  
Whiteleg Shrimp

The presence of antibiotic residues in seafood and their effect on public health constitute a matter of concern for consumers worldwide. Antibiotic residues can have adverse effects on both humans and animals, especially residues of banned veterinary drugs. In this study, we applied a validated method to analyze veterinary drug residues in shrimp, including the levels of banned chloramphenicol, malachite green, leucomalachite green, and four nitrofuran metabolites as well as thiamphenicol, florfenicol, and five quinolones, which have no recommended maximum residual levels in shrimp tissues in Taiwan. We collected 53 samples of whiteleg, grass, or giant river shrimp from Taiwanese aquafarms and production areas from July 2016 to December 2017. We found 0.31 ng/g of a chloramphenicol in one grass shrimp, 5.62 ng/g of enrofloxacin in one whiteleg shrimp, 1.52 ng/g of flumequine in one whiteleg shrimp, and 1.01 ng/g of flumequine in one giant river shrimp, indicating that 7.55% of the samples contained veterinary drug residues. We evaluated the health risk by deriving the estimated daily intake (EDI). The quinolone residue EDI was below 1.0% of the acceptable daily intake recommended by the United Nations Food and Agriculture Organization and World Health Organization. The risk was thus discovered to be negligible, indicating no immediate health risk associated with shrimp consumption. The present findings can serve as a reference regarding food safety and in monitoring of the veterinary drug residues present in aquatic organisms. Continual monitoring of residues in shrimp is critical for further assessment of possible effects on human health.

scholarly journals Assessment of various veterinary drug residues in animal originated food products

2021 ◽  
pp. 1650-1664
Author(s):  
Jagdish Kumar Parmar ◽  
Kundan Kumar Chaubey ◽  
Vikas Gupta ◽  
Manthena Nava Bharath
Keyword(s):  
Limit Of Detection ◽  
Analytical Techniques ◽  
Food Products ◽  
Veterinary Drugs ◽  
Animal Origin ◽  
Veterinary Drug ◽  
Veterinary Drug Residues ◽  
Drug Residues ◽  
Validation Parameters ◽  
The Government

The veterinary drugs are broad-spectrum antibacterial antibiotics; it uses to cure the animal disease. Many countries have banned veterinary drug residues like nitrofurans metabolites, chloramphenicol. However, the people were administrated veterinary drugs to animals as illegal to increase the milk production in animals for economic benefit. The results of illegally use of veterinary drugs remain as a residue in animal product like milk and it is very harmful to whom consume it cause cancer and allergic for human being which has entered the concern among milk consumers. To control illegal use of veterinary drugs, the government of India has restricted its use in animals. For the identification and confirmation of veterinary drug residues in animal products, analytical techniques such as liquid chromatography and mass spectrometry are available. These are very sophisticated equipments which are available nowadays and their methodologies for the analytical method validation are described by European commission 2002/657/EC. The use of veterinary drugs is a big challenge to effectively identify and authorization of their use. There are so many analytical techniques are using very effectively and taking very less time to protect the consumers from their adverse effects. These techniques take very less time to identify more groups of compounds such as tetracycline, sulfonamides, anthelmintic, and macrolides in single multi-residue method. These methods having validation parameters include system precision, calibration curve, accuracy, limit of detection, and quantification. Therefore, improvement in the existing technologies and accessibility of new screening methodologies will give opportunities for automation that helps in obtaining the results in very less time and improved sensitivity and specificity which contribute to better safety assurance, standard, and quality of various food products of animal origin.

Rapid Screening and Quantification of Multi-Class Multi-Residue Veterinary Drugs in Pork by a Modified Quechers Protocol Coupled to UPLC-QOrbitrap HRMS

2020 ◽  
Vol 16 (7) ◽  
pp. 863-879
Author(s):  
Liya Wang ◽  
Chunyan Qi ◽  
Lidan Wang ◽  
Tingcai Wang ◽  
Yi Lei ◽  
...  
Keyword(s):  
Veterinary Drugs ◽  
Rapid Screening ◽  
Accurate Mass ◽  
Coefficient Of Determination ◽  
Veterinary Drug ◽  
Veterinary Drug Residues ◽  
Drug Residues ◽  
Relative Standard ◽  
Accuracy And Repeatability ◽  
Pork Samples

Background: A rapid and simple analytical method for the screening and quantification of multi-residues was established by a quick, easy, cheap, effective, rugged and safe (QuEChERS) approach coupled to ultra-performance liquid chromatography and electrospray ionization quadrupole orbitrap high-resolution mass spectrometry (UPLC-Q-Orbitrap HRMS). A total number of 59 veterinary drugs were investigated, which belonged to 12 classes, such as β-agonist, quinolones, sulfonamides, tetracyclines, lincomycin series, triphenylmethane, nitroimidazoles, macrolides, amide alcohols, quinoxalines, steroid hormone and sedatives. Methods: The factors which influence the determination of veterinary drugs residues, such as mobile phase, extract solvent, clean up sorbent, and re-dissolved solvent, were optimized by the single factor experiment. The method was sufficiently validated by using the parameters of linearity, sensitivity, accuracy, and repeatability. Results: The response of the detector was linear for 59 veterinary drug residues in extensive range (two to three orders of magnitude) with a high coefficient of determination (R2) (0.9995-0.9998). The limit of quantification (LOQ) ranged from 0.1μg/kg to 2.0μg/kg for 59 veterinary drug residues in pork samples. The repeatability was in the range of 1.0%-9.5%. Average recoveries of 59 veterinary drugs at three spiked levels ranged from 53.7%-117.8% with relative standard deviation (RSD) of 1.9%-13.9%. The full MS scan coupled with data-dependent MS/MS mode was applied for screening the target compounds to simultaneously obtain the accurate mass of parent ion and the mass spectrum of fragments. Elemental composition, accurate mass, and retention time and characteristic fragment ions were used to establish a homemade database. Conclusion: The ability of the homemade database was verified by analyzing the real pork samples, and the result was satisfactory.

scholarly journals Rapid Multi-Residue Detection Methods for Pesticides and Veterinary Drugs

Molecules ◽  
2020 ◽  
Vol 25 (16) ◽  
pp. 3590
Author(s):  
Min Jia ◽  
Zhongbo E ◽  
Fei Zhai ◽  
Xin Bing
Keyword(s):  
Near Infrared ◽  
Veterinary Drugs ◽  
Detection Methods ◽  
Veterinary Drug ◽  
Veterinary Drug Residues ◽  
Drug Residues ◽  
Molecular Imprinted Polymers ◽  
Residue Detection ◽  
Recent Developments ◽  
Recognition Elements

The excessive use or abuse of pesticides and veterinary drugs leads to residues in food, which can threaten human health. Therefore, there is an extremely urgent need for multi-analyte analysis techniques for the detection of pesticide and veterinary drug residues, which can be applied as screening techniques for food safety monitoring and detection. Recent developments related to rapid multi-residue detection methods for pesticide and veterinary drug residues are reviewed herein. Methods based on different recognition elements or the inherent characteristics of pesticides and veterinary drugs are described in detail. The preparation and application of three broadly specific recognition elements—antibodies, aptamers, and molecular imprinted polymers—are summarized. Furthermore, enzymatic inhibition-based sensors, near-infrared spectroscopy, and SERS spectroscopy based on the inherent characteristics are also discussed. The aim of this review is to provide a useful reference for the further development of rapid multi-analyte analysis of pesticide and veterinary drug residues.

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