scholarly journals Endothelial Dysfunction: From Pathophysiology to Novel Therapeutic Approaches

Biomedicines ◽  
2021 ◽  
Vol 9 (11) ◽  
pp. 1571
Author(s):  
Byeong Hwa Jeon
Keyword(s):  
Endothelial Dysfunction ◽  
Vascular Endothelium ◽  
Crucial Role ◽  
Therapeutic Approaches ◽  
Vascular Homeostasis ◽  
Novel Therapeutic

The vascular endothelium is an active tissue that plays a crucial role in the maintenance of vascular homeostasis [...]

Endothelial Dysfunction and Atherosclerosis: Focus on Novel Therapeutic Approaches

2012 ◽  
Vol 7 (1) ◽  
pp. 21-32 ◽  
Author(s):  
Alexandros Briasoulis ◽  
Dimitris Tousoulis ◽  
Emmanuel S. Androulakis ◽  
Nikolaos Papageorgiou ◽  
George Latsios ◽  
...  
Keyword(s):  
Endothelial Dysfunction ◽  
Therapeutic Approaches ◽  
Novel Therapeutic

Endothelial dysfunction in conduit arteries and in microcirculation. Novel therapeutic approaches

2014 ◽  
Vol 144 (3) ◽  
pp. 253-267 ◽  
Author(s):  
Dimitris Tousoulis ◽  
Chryssa Simopoulou ◽  
Nikos Papageorgiou ◽  
Evangelos Oikonomou ◽  
George Hatzis ◽  
...  
Keyword(s):  
Endothelial Dysfunction ◽  
Therapeutic Approaches ◽  
Novel Therapeutic

scholarly journals Macrophages and hepatocellular carcinoma

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Zhiqiang Tian ◽  
Xiaojuan Hou ◽  
Wenting Liu ◽  
Zhipeng Han ◽  
Lixin Wei
Keyword(s):  
Hepatocellular Carcinoma ◽  
Tumor Microenvironment ◽  
Chronic Inflammation ◽  
Crucial Role ◽  
Human Population ◽  
Deep Understanding ◽  
Regenerative Process ◽  
Liver Inflammation ◽  
Therapeutic Approaches ◽  
Novel Therapeutic

Abstract Hepatocellular carcinoma (HCC) is among the most prevalent and lethal cancers in the human population. HCC is an inflammation-associated cancer caused by different etiological factors. The chronic inflammation leads to continuous cycles of hepatocytes destructive–regenerative process and contributes to HCC initiation and progression. Macrophages play a crucial role in chronic liver inflammation. The tumor microenvironment plays a key role in the progression of HCC. Tumor-associated macrophages are a well-known component of the tumor microenvironment and abundantly infiltrate HCC microenvironment. The roles of macrophages in the development and progression of HCC have been recognized. The deep understanding of macrophages in HCC will be critical for developing effective HCC therapy. Targeting of macrophages might provide novel therapeutic approaches for HCC patients and is an emerging field of interest. This review summarizes the knowledge on the contribution of macrophages in the development and progression of HCC, as well as potential immunotherapy being explored in targeting macrophages.

Oxidized Haemoglobin–Driven Endothelial Dysfunction and Immune Cell Activation: Novel Therapeutic Targets for Atherosclerosis

2013 ◽  
Vol 20 (37) ◽  
pp. 4806-4814 ◽  
Author(s):  
Brigitta Buttari ◽  
Elisabetta Profumo ◽  
Rita Businaro ◽  
Luciano Saso ◽  
Raffaele Capoano ◽  
...  
Keyword(s):  
Endothelial Dysfunction ◽  
Cell Activation ◽  
Immune Cell ◽  
Therapeutic Targets ◽  
Immune Cell Activation ◽  
Novel Therapeutic

Coronary Artery Disease and Endothelial Dysfunction: Novel Diagnostic and Therapeutic Approaches

2020 ◽  
Vol 27 (7) ◽  
pp. 1052-1080 ◽  
Author(s):  
Evangelos Oikonomou ◽  
Gerasimos Siasos ◽  
Vasiliki Tsigkou ◽  
Evanthia Bletsa ◽  
Maria-Evi Panoilia ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Endothelial Dysfunction ◽  
Endothelial Function ◽  
Stable Coronary Artery Disease ◽  
Therapeutic Interventions ◽  
Therapeutic Approaches ◽  
Cardiovascular Prognosis ◽  
Ultrasound Evaluation ◽  
Artery Disease

Coronary artery disease is the leading cause of morbidity and mortality worldwide. The most common pathophysiologic substrate is atherosclerosis which is an inflammatory procedure that starts at childhood and develops throughout life. Endothelial dysfunction is associated with the initiation and progression of atherosclerosis and is characterized by the impaired production of nitric oxide. In general, endothelial dysfunction is linked to poor cardiovascular prognosis and different methods, both invasive and non-invasive, have been developed for its evaluation. Ultrasound evaluation of flow mediated dilatation of the branchial artery is the most commonly used method to assessed endothelial function while intracoronary administration of vasoactive agents may be also be used to test directly endothelial properties of the coronary vasculature. Endothelial dysfunction has also been the subject of therapeutic interventions. This review article summarizes the knowledge about evaluation of endothelial function in acute coronary syndromes and stable coronary artery disease and demonstrates the current therapeutic approaches against endothelial dysfunction.

Adipocytes-released Peptides Involved in the Control of Gastrointestinal Motility

2019 ◽  
Vol 20 (6) ◽  
pp. 614-629 ◽  
Author(s):  
Eglantina Idrizaj ◽  
Rachele Garella ◽  
Roberta Squecco ◽  
Maria Caterina Baccari
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Adipose Tissue ◽  
Gastrointestinal Motility ◽  
Diagnostic Tools ◽  
Therapeutic Approaches ◽  
Motor Responses ◽  
Gastrointestinal Motor ◽  
Treatment Of Obesity ◽  
Novel Therapeutic

The present review focuses on adipocytes-released peptides known to be involved in the control of gastrointestinal motility, acting both centrally and peripherally. Thus, four peptides have been taken into account: leptin, adiponectin, nesfatin-1, and apelin. The discussion of the related physiological or pathophysiological roles, based on the most recent findings, is intended to underlie the close interactions among adipose tissue, central nervous system, and gastrointestinal tract. The better understanding of this complex network, as gastrointestinal motor responses represent peripheral signals involved in the regulation of food intake through the gut-brain axis, may also furnish a cue for the development of either novel therapeutic approaches in the treatment of obesity and eating disorders or potential diagnostic tools.

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