scholarly journals Recent Progress in Electrochemical Immunosensors

Biosensors ◽  
2021 ◽  
Vol 11 (10) ◽  
pp. 360
Author(s):  
Jeeyoung Kim ◽  
Min Park
Keyword(s):  
Molecular Recognition ◽  
Medical Diagnosis ◽  
Recent Progress ◽  
Specific Binding ◽  
Good Sensitivity ◽  
Electrochemical Immunosensors ◽  
Target Analytes ◽  
Biological Solutions

Biosensors used for medical diagnosis work by analyzing physiological fluids. Antibodies have been frequently used as molecular recognition molecules for the specific binding of target analytes from complex biological solutions. Electrochemistry has been introduced for the measurement of quantitative signals from transducer-bound analytes for many reasons, including good sensitivity. Recently, numerous electrochemical immunosensors have been developed and various strategies have been proposed to detect biomarkers. In this paper, the recent progress in electrochemical immunosensors is reviewed. In particular, we focused on the immobilization methods using antibodies for voltammetric, amperometric, impedimetric, and electrochemiluminescent immunosensors.

Comparison and recent progress of Molecular Imprinting Technology and dummy template Molecular Imprinting Technology

2021 ◽  
Author(s):  
Runan Chen ◽  
Shu he Kang ◽  
Jia Li ◽  
Li na Lu ◽  
Xingping Luo ◽  
...  
Keyword(s):  
Molecular Recognition ◽  
Molecular Imprinting ◽  
Chromatographic Separation ◽  
Recent Progress ◽  
Molecular Imprinting Technology ◽  
Dummy Template ◽  
Recognition Function ◽  
Research Hotspots

Molecular Imprinting Technology for the preparation of polymers with specific molecular recognition function had become one of the current research hotspots. It had been widely applied in chromatographic separation, antibody...

scholarly journals Machine learning in dental, oral and craniofacial imaging: a review of recent progress

PeerJ ◽  
2021 ◽  
Vol 9 ◽  
pp. e11451
Author(s):  
Ruiyang Ren ◽  
Haozhe Luo ◽  
Chongying Su ◽  
Yang Yao ◽  
Wen Liao
Keyword(s):  
Artificial Intelligence ◽  
Machine Learning ◽  
Medical Imaging ◽  
Medical Diagnosis ◽  
Recent Progress ◽  
Medical Science ◽  
Research Progress ◽  
Daily Lives ◽  
Major Application ◽  
Machine Learning Models

Artificial intelligence has been emerging as an increasingly important aspect of our daily lives and is widely applied in medical science. One major application of artificial intelligence in medical science is medical imaging. As a major component of artificial intelligence, many machine learning models are applied in medical diagnosis and treatment with the advancement of technology and medical imaging facilities. The popularity of convolutional neural network in dental, oral and craniofacial imaging is heightening, as it has been continually applied to a broader spectrum of scientific studies. Our manuscript reviews the fundamental principles and rationales behind machine learning, and summarizes its research progress and its recent applications specifically in dental, oral and craniofacial imaging. It also reviews the problems that remain to be resolved and evaluates the prospect of the future development of this field of scientific study.

scholarly journals Recent progress in AFM molecular recognition studies

2007 ◽  
Vol 456 (1) ◽  
pp. 237-245 ◽  
Author(s):  
Yves F. Dufrêne ◽  
Peter Hinterdorfer
Keyword(s):  
Molecular Recognition ◽  
Recent Progress

Molecular recognition and activation by polyaza macrocyclic compounds based on host–guest interactions

2016 ◽  
Vol 52 (68) ◽  
pp. 10322-10337 ◽  
Author(s):  
Di-Chang Zhong ◽  
Tong-Bu Lu
Keyword(s):  
Molecular Recognition ◽  
Recent Progress ◽  
Macrocyclic Compounds

This paper highlights the recent progress in the recognition and activation of molecules and anions by polyaza macrocyclic compounds.

scholarly journals Suppressing Non-Specific Binding of Proteins onto Electrode Surfaces in the Development of Electrochemical Immunosensors

Biosensors ◽  
2019 ◽  
Vol 9 (1) ◽  
pp. 15 ◽  
Author(s):  
Jesús Contreras-Naranjo ◽  
Oscar Aguilar
Keyword(s):  
Solid Phase ◽  
Specific Binding ◽  
Point Of Care ◽  
Low Cost ◽  
Electrochemical Techniques ◽  
High Specificity ◽  
Electrode Surfaces ◽  
Solid Phase Immunoassay ◽  
Electrochemical Immunosensors ◽  
Complex Phenomena

Electrochemical immunosensors, EIs, are systems that combine the analytical power of electrochemical techniques and the high selectivity and specificity of antibodies in a solid phase immunoassay for target analyte. In EIs, the most used transducer platforms are screen printed electrodes, SPEs. Some characteristics of EIs are their low cost, portability for point of care testing (POCT) applications, high specificity and selectivity to the target molecule, low sample and reagent consumption and easy to use. Despite all these attractive features, still exist one to cover and it is the enhancement of the sensitivity of the EIs. In this review, an approach to understand how this can be achieved is presented. First, it is necessary to comprise thoroughly all the complex phenomena that happen simultaneously in the protein-surface interface when adsorption of the protein occurs. Physicochemical properties of the protein and the surface as well as the adsorption phenomena influence the sensitivity of the EIs. From this point, some strategies to suppress non-specific binding, NSB, of proteins onto electrode surfaces in order to improve the sensitivity of EIs are mentioned.

scholarly journals The Role of Electrochemical Immunosensors in Clinical Analysis

Biosensors ◽  
2019 ◽  
Vol 9 (3) ◽  
pp. 86 ◽  
Author(s):  
Mollarasouli ◽  
Kurbanoglu ◽  
Ozkan
Keyword(s):  
Specific Binding ◽  
Specific Antigen ◽  
Clinical Analysis ◽  
Electrical Signal ◽  
Clinical Approach ◽  
Electrochemical Immunosensors ◽  
Signal Type ◽  
Electrochemical Transducer

An immunosensor is a kind of affinity biosensor based on interactions between an antigen and specific antigen immobilized on a transducer surface. Immunosensors possess high selectivity and sensitivity due to the specific binding between antibody and corresponding antigen, making them a suitable platform for several applications especially in the medical and bioanalysis fields. Electrochemical immunosensors rely on the measurements of an electrical signal recorded by an electrochemical transducer and can be classed as amperometric, potentiometric, conductometric, or impedimetric depending on the signal type. Among the immunosensors, electrochemical immunosensors have been more perfected due to their simplicity and, especially their ability to be portable, and for in situ or automated detection. This review addresses the potential of immunosensors destined for application in clinical analysis, especially cancer biomarker diagnosis. The emphasis is on the approaches used to fabricate electrochemical immunosensors. A general overview of recent applications of the developed electrochemical immunosensors in the clinical approach is described.

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