scholarly journals Systematic Review on the Safety and Tolerability of Transcranial Direct Current Stimulation in Children and Adolescents

2021 ◽  
Vol 11 (2) ◽  
pp. 212
Author(s):  
Derrick Matthew Buchanan ◽  
Thomas Bogdanowicz ◽  
Neha Khanna ◽  
Guillaume Lockman-Dufour ◽  
Philippe Robaey ◽  
...  
Keyword(s):  
Direct Current ◽  
Transcranial Direct Current Stimulation ◽  
Current Evidence ◽  
Limited Evidence ◽  
Direct Current Stimulation ◽  
Current State ◽  
Objective Evidence ◽  
Safety Studies ◽  
Safety Considerations ◽  
Objective Side

Background: Transcranial direct current stimulation (tDCS) is a safe, tolerable, and acceptable technique in adults. However, there is limited evidence for its safety in youth. Although limited, there are a handful of important empirical articles that have evaluated safety and tolerability outcomes in youth. However, a synthesis of pediatric safety studies is not currently available. Objective: To synthesize objective evidence regarding the safety and tolerability of pediatric tDCS based on the current state of the literature. Methods: Our search and report used PRISMA guidelines. Our method systematically examined investigations purposefully designed to evaluate the safety, tolerability, and acceptability of tDCS in healthy and atypical youth that were submitted to three databases, from the beginning of the database to November 2019. Safety considerations were evaluated by studies utilizing neuroimaging, physiological changes, performance on tasks, and by analyzing reported and objective side effects; tolerability via rate of adverse events; and acceptability via rate of dropouts. Results: We report on 203 sham sessions, 864 active sessions up to 2 mA, and 303 active hours of stimulation in 156 children. A total of 4.4% of the active sessions were in neurotypical controls, with the other 95.6% in clinical subjects. Conclusion: In spite of the fact that the current evidence is sporadic and scarce, the presently reviewed literature provides support for the safety, tolerability, and acceptability, of tDCS in youth for 1–20 sessions of 20 min up to 2 mA. Future pediatric tDCS research is encouraged.

scholarly journals The effects of transcranial direct current stimulation on objective and subjective indexes of exercise performance: a systematic review and meta-analysis.

2018 ◽  
Author(s):  
Darias Holgado ◽  
Miguel A. Vadillo ◽  
Daniel Sanabria
Keyword(s):  
Systematic Review ◽  
Direct Current ◽  
Exercise Performance ◽  
Transcranial Direct Current Stimulation ◽  
Perceived Exertion ◽  
Effect Sizes ◽  
Electrode Placement ◽  
Current Evidence ◽  
Time To Exhaustion ◽  
Direct Current Stimulation

Objective: To examine the effectss of transcranial direct current stimulation (tDCS) on objective and subjective indexes of exercise performance.Design: Systematic review and meta-analysis.Data Sources: A systematic literature search of electronic databases (PubMed, Web of Science, Scopus, Google Scholar) and reference lists of included articles up to June 2018.Eligibility Criteria: Published articles in journals or in repositories with raw data available, randomized sham-controlled trial comparing anodal stimulation with a sham condition providing data on objective (e.g. time to exhaustion or time-trial performance) or subjective (e.g. rate of perceived exertion) indexes of exercise performance.Results: The initial search provided 420 articles of which 31 were assessed for eligibility. Finally, the analysis of effect sizes comprised 24 studies with 386 participants. The analysis indicated that anodal tDCS had a small but positive effect on performance g = 0.34, 95% CI [0.12, 0.52], z = 3.24, p = 0.0012. Effects were not significantly moderated by type of outcome, electrode placement, muscles involved, number of sessions, or intensity and duration of the stimulation. Importantly, the funnel plot showed that, overall, effect sizes tended to be larger in studies with lower sample size and high standard error. Summary: The results suggest that tDCS may have a positive impact on exercise performance. However, the effect is probably small and most likely biased by low quality studies and the selective publication of significant results. Therefore, the current evidence does not provide strong support to the conclusion that tDCS is an effective means to improve exercise performance.

scholarly journals Transcranial Direct Current Stimulation to Facilitate Lower Limb Recovery Following Stroke: Current Evidence and Future Directions

2020 ◽  
Vol 10 (5) ◽  
pp. 310
Author(s):  
Samuel Gowan ◽  
Brenton Hordacre
Keyword(s):  
Direct Current ◽  
Transcranial Direct Current Stimulation ◽  
Lower Limb ◽  
Cortical Neurons ◽  
Brain Activity ◽  
Current Evidence ◽  
Potential Candidate ◽  
Limb Function ◽  
Direct Current Stimulation ◽  
Lower Limb Function

Stroke remains a global leading cause of disability. Novel treatment approaches are required to alleviate impairment and promote greater functional recovery. One potential candidate is transcranial direct current stimulation (tDCS), which is thought to non-invasively promote neuroplasticity within the human cortex by transiently altering the resting membrane potential of cortical neurons. To date, much work involving tDCS has focused on upper limb recovery following stroke. However, lower limb rehabilitation is important for regaining mobility, balance, and independence and could equally benefit from tDCS. The purpose of this review is to discuss tDCS as a technique to modulate brain activity and promote recovery of lower limb function following stroke. Preliminary evidence from both healthy adults and stroke survivors indicates that tDCS is a promising intervention to support recovery of lower limb function. Studies provide some indication of both behavioral and physiological changes in brain activity following tDCS. However, much work still remains to be performed to demonstrate the clinical potential of this neuromodulatory intervention. Future studies should consider treatment targets based on individual lesion characteristics, stage of recovery (acute vs. chronic), and residual white matter integrity while accounting for known determinants and biomarkers of tDCS response.

Transcranial direct current stimulation and retraining in musician's hand dystonia

2009 ◽  
Vol 40 (01) ◽  
Author(s):  
F Buttkus ◽  
V Baur ◽  
HC Jabusch ◽  
M Weidenmüller ◽  
S Schneider ◽  
...  
Keyword(s):  
Direct Current ◽  
Transcranial Direct Current Stimulation ◽  
Direct Current Stimulation ◽  
Hand Dystonia

Bifrontale transkranielle Gleichstromstimulation zur Behandlung der Schizophrenie

2014 ◽  
Vol 33 (05) ◽  
pp. 382-386
Author(s):  
A. Hasan ◽  
S. Dehning ◽  
D. Keeser ◽  
I. Hummel ◽  
P. Falkai ◽  
...  
Keyword(s):  
Direct Current ◽  
Transcranial Direct Current Stimulation ◽  
Sich Eine ◽  
Direct Current Stimulation ◽  
Klinische Relevanz ◽  
Transkranielle Gleichstromstimulation

Zusammenfassung Gegenstand und Ziel: Die transkranielle Gleichstromstimulation (transcranial direct current stimulation, tDCS) wird als neues nicht invasives Hirnstimulationsverfahren für die Behandlung neurologischer und psychiatrischer Erkrankungen untersucht. Mittlerweile gibt es Fallberichte und eine randomisierte, kontrollierte Pilotstudie zur Behandlung akustischer Halluzinationen sowie der Negativsymptomatik bei Schizophrenie. Fallbericht: Im vorliegenden Fallbericht wurde ein Patient mit therapieresistenter Symptomatik bei paranoider Schizophrenie drei Wochen lang mit anodaler tDCS über dem linken dorsolateralen und kathodaler tDCS über dem rechten dorsolateralen Kortex behandelt. Ergebnisse: Es zeigte sich eine Verbesserung von Affektivität und Kognition, die Positivsymptome blieben jedoch nahezu unverändert. Klinische Relevanz: Die bifrontale tDCS stellt eine nebenwirkungsarme neue Behandlungsform dar und sollte in der Anwendung bei Erkrankungen aus dem schizophrenen Formenkreis weiter untersucht werden.

Can Transcranial Direct Current Stimulation Improve Cognitive Functioning in Adults with Schizophrenia?

2017 ◽  
Vol 11 (3) ◽  
pp. 133-142 ◽  
Author(s):  
David J. Schretlen ◽  
Joseph J. van Steenburgh ◽  
Mark Varvaris ◽  
Tracy D. Vannorsdall ◽  
Megan A. Andrejczuk ◽  
...  
Keyword(s):  
Cognitive Functioning ◽  
Direct Current ◽  
Transcranial Direct Current Stimulation ◽  
Direct Current Stimulation
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