scholarly journals The Regional EEG Pattern of the Sleep Onset Process in Older Adults

2021 ◽  
Vol 11 (10) ◽  
pp. 1261
Author(s):  
Maurizio Gorgoni ◽  
Serena Scarpelli ◽  
Ludovica Annarumma ◽  
Aurora D’Atri ◽  
Valentina Alfonsi ◽  
...  
Keyword(s):  
Older Adults ◽  
Young Adults ◽  
Time Course ◽  
Healthy Aging ◽  
Sleep Onset ◽  
The Elderly ◽  
Specific Pattern ◽  
Alpha Power ◽  
Delta Activity ◽  
Eeg Pattern

Healthy aging is characterized by macrostructural sleep changes and alterations of regional electroencephalographic (EEG) sleep features. However, the spatiotemporal EEG pattern of the wake-sleep transition has never been described in the elderly. The present study aimed to assess the topographical and temporal features of the EEG during the sleep onset (SO) in a group of 36 older participants (59–81 years). The topography of the 1 Hz bins’ EEG power and the time course of the EEG frequency bands were assessed. Moreover, we compared the delta activity and delta/beta ratio between the older participants and a group of young adults. The results point to several peculiarities in the elderly: (a) the generalized post-SO power increase in the slowest frequencies did not include the 7 Hz bin; (b) the alpha power revealed a frequency-specific pattern of post-SO modifications; (c) the sigma activity exhibited only a slight post-SO increase, and its highest bins showed a frontotemporal power decrease. Older adults showed a generalized reduction of delta power and delta/beta ratio in both pre- and post-SO intervals compared to young adults. From a clinical standpoint, the regional EEG activity may represent a target for brain stimulation techniques to reduce SO latency and sleep fragmentation.

Processing gender stereotypes in dementia patients and older healthy adults: a self-paced reading study

2019 ◽  
Vol 5 (s2) ◽  
Author(s):  
Daniel Müller-Feldmeth ◽  
Katharina Ahnefeld ◽  
Adriana Hanulíková
Keyword(s):  
Older Adults ◽  
Young Adults ◽  
Sentence Processing ◽  
Gender Stereotypes ◽  
Time Course ◽  
Healthy Adults ◽  
Control Group ◽  
Healthy Older Adults ◽  
Dementia Patients ◽  
Age Related

AbstractWe used self-paced reading to examine whether stereotypical associations of verbs with women or men as prototypical agents (e.g. the craftsman knits a sweater) are activated during sentence processing in dementia patients and healthy older adults. Effects of stereotypical knowledge on language processing have frequently been observed in young adults, but little is known about age-related changes in the activation and integration of stereotypical information. While syntactic processing may remain intact, semantic capacities are often affected in dementia. Since inferences based on gender stereotypes draw on social and world knowledge, access to stereotype information may also be affected in dementia patients. Results from dementia patients (n = 9, average age 86.6) and healthy older adults (n = 14, average age 79.5) showed slower reading times and less accuracy in comprehension scores for dementia patients compared to the control group. While activation of stereotypical associations of verbs was visible in both groups, they differed with respect to the time-course of processing. The effect of stereotypes on comprehension accuracy was visible for healthy adults only. The evidence from reading times suggests that older adults with and without dementia engage stereotypical inferences during reading, which is in line with research on young adults.

scholarly journals Aging is associated with increased propensity for central apnea during NREM sleep

2018 ◽  
Vol 124 (1) ◽  
pp. 83-90 ◽  
Author(s):  
Susmita Chowdhuri ◽  
Sukanya Pranathiageswaran ◽  
Hillary Loomis-King ◽  
Anan Salloum ◽  
M. Safwan Badr
Keyword(s):  
Carbon Dioxide ◽  
Older Adults ◽  
Young Adults ◽  
Nrem Sleep ◽  
The Elderly ◽  
Central Apnea ◽  
Elderly Adults ◽  
Rapid Eye Movement Sleep ◽  
Controller Gain ◽  
Central Apneas

The reason for increased sleep-disordered breathing with predominance of central apneas in the elderly is unknown. We hypothesized that the propensity to central apneas is increased in older adults, manifested by a reduced carbon-dioxide (CO2) reserve in older compared with young adults during non-rapid eye movement sleep. Ten elderly and 15 young healthy adults underwent multiple brief trials of nasal noninvasive positive pressure ventilation during stable NREM sleep. Cessation of mechanical ventilation (MV) resulted in hypocapnic central apnea or hypopnea. The CO2 reserve was defined as the difference in end-tidal CO2 ([Formula: see text]) between eupnea and the apneic threshold, where the apneic threshold was [Formula: see text] that demarcated the central apnea closest to the eupneic [Formula: see text]. For each MV trial, the hypocapnic ventilatory response (controller gain) was measured as the change in minute ventilation (V̇e) during the MV trial for a corresponding change in [Formula: see text]. The eupneic [Formula: see text] was significantly lower in elderly vs. young adults. Compared with young adults, the elderly had a significantly reduced CO2 reserve (−2.6 ± 0.4 vs. −4.1 ± 0.4 mmHg, P = 0.01) and a higher controller gain (2.3 ± 0.2 vs. 1.4 ± 0.2 l·min−1·mmHg−1, P = 0.007), indicating increased chemoresponsiveness in the elderly. Thus elderly adults are more prone to hypocapnic central apneas owing to increased hypocapnic chemoresponsiveness during NREM sleep. NEW & NOTEWORTHY The study describes an original finding where healthy older adults compared with healthy young adults demonstrated increased breathing instability during non-rapid eye movement sleep, as suggested by a smaller carbon dioxide reserve and a higher controller gain. The findings may explain the increased propensity for central apneas in elderly adults during sleep and potentially guide the development of pathophysiology-defined personalized therapies for sleep apnea in the elderly.

Responses to Moral Dilemmas Involving Self versus Others

1984 ◽  
Vol 18 (1) ◽  
pp. 73-77 ◽  
Author(s):  
John M. Rybash ◽  
William J. Hoyer ◽  
Paul A. Roodin
Keyword(s):  
Older Adults ◽  
Young Adults ◽  
The Elderly ◽  
Moral Dilemmas ◽  
Defining Issues Test ◽  
Moral Judgments ◽  
Affective Factors ◽  
Reasoning Abilities ◽  
Children And Young Adults ◽  
Other Orientation

Forty older adults were administered the standard version (i.e. Other-orientation) of Rest et al.'s Defining Issues Test (DIT) and a modified version (i.e., Self-orientation) of the same instrument on two separate occasions. Contrary to the results of previous studies with children and young adults, the self/other manipulation in the present study failed to influence significantly older adults' moral judgments. The role of cognitive/perspective-taking and personal/affective factors in the moral reasoning abilities of the elderly, as well as those of children and young adults, are discussed.

scholarly journals MORE OR LESS? A DECADE’S TREND OF SOCIAL PARTICIPATION AMONG CHINESE OLDER ADULTS: BASED ON A LONGITUDINAL SURVEY

2019 ◽  
Vol 3 (Supplement_1) ◽  
pp. S630-S630
Author(s):  
Chenxin Tan ◽  
Yun Zhou
Keyword(s):  
Older Adults ◽  
Social Participation ◽  
Healthy Aging ◽  
Latent Class ◽  
The Elderly ◽  
Health Condition ◽  
Chinese Older Adults ◽  
The Family ◽  
Family Centered ◽  
Over Time

Abstract Social participation is of great significance in healthy aging. While studies on social participation among Chinese elderly are growing, there is a lack of understanding the changes over time of the participation. Using datasets from the Chinese Longitudinal Healthy Longevity Survey (CLHLS), this paper presents a comprehensive analysis on a decade’s trend of social participation among Chinese older adults. First, we use the method of Latent Class Analysis (LCA) to identify types of social participation; in this study, we concluded three types, no participation, the family-centered, and the society-oriented. Second, we examine the characteristics of the elderly by types of participation in terms of demographic, socioeconomic and health condition and analyze the changes in the characteristics over time. And third, we interpret the trend of social participation with broader social environment, or the fluctuant structural and institutional differences under the context of China’s unique social system. Our general conclusion is that while the overall level of participation holds relatively steady, there is a dynamic micro progress and complex mechanisms in this long period. In addition, although both the family-centered participants and the society-oriented possess broader scopes of social participation, the related attributes are different across time. This paper contributes to our knowledge of life of the elderly under the circumstances of fast aging process in China.

scholarly journals Effect of Montelukast 10 mg in Elderly Patients with Mild and Moderate Asthma Compared with Young Adults. Results of a Cohort Study

2018 ◽  
Vol 12 (1) ◽  
pp. 67-74
Author(s):  
Guillermo Sánchez ◽  
Diana Buitrago
Keyword(s):  
Older Adults ◽  
Young Adults ◽  
Cohort Study ◽  
Elderly Patients ◽  
Inhaled Corticosteroids ◽  
Age Groups ◽  
The Elderly ◽  
Moderate Asthma ◽  
Beta 2

Background: The clinical characteristics and physio-pathogenic mechanisms of asthma in patients older than 60 years appear to differ from the behavior described for other age groups. Therefore, the effectiveness of medications for elderly patients with asthma should not be extrapolated from studies conducted on teenagers or young adults. Objective: The study aimed to establish the clinical effect of montelukast 10 mg in elderly patients with mild and moderate asthma compared to its effect on young adults. Method: A prospective cohort study was conducted during 12 weeks of follow-up, which consecutively included the total population of adult patients attended by a group of 21 general practitioners, between July and December 2016. Young adults (18-59 years) and older adults were included (60 years or older) with mild or moderate asthma, which, according to the criteria of his treating physician, had been prescribed montelukast 10 mg/day. The variables of interest were: use of inhaled corticosteroids during the last month, use of inhaled beta-2 adrenergic agonists as a rescue in the last month, having attended the emergency service during the last month due to an asthma attack, presence of wheezing in the physical examination, the number of attacks in the last month and the number of days without symptoms in the last month. Results: A total of 126 patients entered the cohort and 104 completed the follow-up, of which 29% were older adults. On admission, 65.4% of patients (68/104) had used rescue inhaled beta2 in the last month and had been using schemes with corticosteroids. After 12 weeks of follow-up, 58.1% (43/74) of the young adults required treatment schedules with corticosteroids, while in the elderly, only 36.7% of the patients (11/30) required this treatment scheme (p-value: 0.047). Regarding the use of rescue inhaled beta-2 at 12 weeks, 55% of young adults reported using them, compared to 33.3% of older adults (p-value: 0.041). Conclusion: In this cohort of patients, treated with montelukast 10 mg/day for 12 weeks, there was a reduction of broncho-obstructive symptoms and exacerbations of the disease. In older adults compared to young adults, a greater reduction in the use of beta2 agonists rescue medications and in the concomitant use of inhaled corticosteroid schemes was documented.

scholarly journals Age-related Neural Changes during Memory Conjunction Errors

2010 ◽  
Vol 22 (7) ◽  
pp. 1348-1361 ◽  
Author(s):  
Kelly S. Giovanello ◽  
Elizabeth A. Kensinger ◽  
Alana T. Wong ◽  
Daniel L. Schacter
Keyword(s):  
Older Adults ◽  
Young Adults ◽  
Healthy Aging ◽  
Parahippocampal Gyrus ◽  
Neural Basis ◽  
Laboratory Procedure ◽  
Conjunction Errors ◽  
Age Related ◽  
Memory Distortions ◽  
Memory Conjunction Errors

Human behavioral studies demonstrate that healthy aging is often accompanied by increases in memory distortions or errors. Here we used event-related fMRI to examine the neural basis of age-related memory distortions. We used the memory conjunction error paradigm, a laboratory procedure known to elicit high levels of memory errors. For older adults, right parahippocampal gyrus showed significantly greater activity during false than during accurate retrieval. We observed no regions in which activity was greater during false than during accurate retrieval for young adults. Young adults, however, showed significantly greater activity than old adults during accurate retrieval in right hippocampus. By contrast, older adults demonstrated greater activity than young adults during accurate retrieval in right inferior and middle prefrontal cortex. These data are consistent with the notion that age-related memory conjunction errors arise from dysfunction of hippocampal system mechanisms, rather than impairments in frontally mediated monitoring processes.

When estimating reachability in space, young children and the elderly are similar

1970 ◽  
Vol 6 (3) ◽  
Author(s):  
Carl Gabbard ◽  
Priscila Caçola
Keyword(s):  
Older Adults ◽  
Young Adults ◽  
Motor Imagery ◽  
Mental Representation ◽  
Brain Structure ◽  
The Elderly ◽  
Extrapersonal Space ◽  
Age Related ◽  
Reach Space ◽  
Total Accuracy

Abstract: This study examined the age-related ability to mentally represent action in the context of reach estimation via use of motor imagery in children, young adults, and a group of older adults. Participants were instructed to estimate whether randomly presented targets in peripersonal (within actual reach) and extrapersonal (beyond reach) space were within or out of reach of their dominant limb while seated. In regard to total accuracy, results indicated that children and older adults were similar, but scores were significantly lower than those of young adults. Whereas all groups displayed greater error in extrapersonal space, once again children and older adults were similar, but significantly different than young adults. That is, children and older adults displayed greater overestimation responses. Although other factors are discussed, the literature provides a hint that differences are due in part to distinctions in brain structure and functioning. Key Words: Mental representation, motor imagery, action processing. 

When estimating reachability in space, young children and the elderly are similar

2011 ◽  
Vol 6 (3) ◽  
pp. 7-13
Author(s):  
Carl Gabbard ◽  
Priscila Caçola
Keyword(s):  
Older Adults ◽  
Young Adults ◽  
Young Children ◽  
Motor Imagery ◽  
Brain Structure ◽  
The Elderly ◽  
Extrapersonal Space ◽  
Age Related ◽  
Reach Space ◽  
Total Accuracy

This study examined the age-related ability to mentally represent action in the context of reach estimation via use of motor imagery in children, young adults, and a group of older adults. Participants were instructed to estimate whether randomly presented targets in peripersonal (within actual reach) and extrapersonal (beyond reach) space were within or out of reach of their dominant limb while seated. In regard to total accuracy, results indicated that children and older adults were similar, but scores were significantly lower than those of young adults. Whereas all groups displayed greater error in extrapersonal space, once again children and older adults were similar, but significantly different than young adults. That is, children and older adults displayed greater overestimation responses. Although other factors are discussed, the literature provides a hint that differences are due in part to distinctions in brain structure and functioning.

scholarly journals Gerontechnology: Providing a Helping Hand When Caring for Cognitively Impaired Older Adults—Intermediate Results from a Controlled Study on the Satisfaction and Acceptance of Informal Caregivers

2012 ◽  
Vol 2012 ◽  
pp. 1-19 ◽  
Author(s):  
Anelia Mitseva ◽  
Carrie Beth Peterson ◽  
Christina Karamberi ◽  
Lamprini Ch. Oikonomou ◽  
Athanasios V. Ballis ◽  
...  
Keyword(s):  
Older Adults ◽  
Assistive Technology ◽  
User Satisfaction ◽  
Healthy Aging ◽  
Real Life ◽  
The Elderly ◽  
Controlled Study ◽  
Cognitively Impaired ◽  
Current Standard ◽  
System Acceptance

The incidence of cognitive impairment in older age is increasing, as is the number of cognitively impaired older adults living in their own homes. Due to lack of social care resources for these adults and their desires to remain in their own homes and live as independently as possible, research shows that the current standard care provisions are inadequate. Promising opportunities exist in using home assistive technology services to foster healthy aging and to realize the unmet needs of these groups of citizens in a user-centered manner. ISISEMD project has designed, implemented, verified, and assessed an assistive technology platform of personalized home care (telecare) for the elderly with cognitive impairments and their caregivers by offering intelligent home support services. Regions from four European countries have carried out long-term pilot-controlled study in real-life conditions. This paper presents the outcomes from intermediate evaluations pertaining to user satisfaction with the system, acceptance of the technology and the services, and quality of life outcomes as a result of utilizing the services.

scholarly journals Retrospective Attention in Short-Term Memory Has a Lasting Effect on Long-Term Memory Across Age

2018 ◽  
Vol 74 (8) ◽  
pp. 1317-1325 ◽  
Author(s):  
Jonathan Strunk ◽  
Lauren Morgan ◽  
Sarah Reaves ◽  
Paul Verhaeghen ◽  
Audrey Duarte
Keyword(s):  
Older Adults ◽  
Young Adults ◽  
Healthy Aging ◽  
Short Term Memory ◽  
Effective Means ◽  
Long Term Memory ◽  
Short Term ◽  
Term Memory ◽  
Short And Long Term

Abstract Objectives Declines in both short- and long-term memory are typical of healthy aging. Recent findings suggest that retrodictive attentional cues (“retro-cues”) that indicate the location of to-be-probed items in short-term memory (STM) have a lasting impact on long-term memory (LTM) performance in young adults. Whether older adults can also use retro-cues to facilitate both STM and LTM is unknown. Method Young and older adults performed a visual STM task in which spatially informative retro-cues or noninformative neutral-cues were presented during STM maintenance of real-world objects. We tested participants’ memory at both STM and LTM delays for objects that were previously cued with retrodictive or neutral-cues during STM order to measure the lasting impact of retrospective attention on LTM. Results Older adults showed reduced STM and LTM capacity compared to young adults. However, they showed similar magnitude retro-cue memory benefits as young adults at both STM and LTM delays. Discussion To the best of our knowledge, this is the first study to investigate whether retro-cues in STM facilitate the encoding of objects into LTM such that they are more likely to be subsequently retrieved by older adults. Our results support the idea that retrospective attention can be an effective means by which older adults can improve their STM and LTM performance, even in the context of reduced memory capacity.

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