scholarly journals Clinicopathological Features as Prognostic Predictors of Poor Outcome in Papillary Thyroid Carcinoma

Cancers ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 3186
Author(s):  
Antónia Afonso Póvoa ◽  
Elisabete Teixeira ◽  
Maria Rosa Bella-Cueto ◽  
Miguel Melo ◽  
Maria João Oliveira ◽  
...  
Keyword(s):  
Venous Invasion ◽  
Lateral Compartment ◽  
Male Gender ◽  
Clinicopathological Features ◽  
Lymph Vessel ◽  
Resection Margins ◽  
Papillary Thyroid ◽  
Lymph Vessel Invasion ◽  
Vessel Invasion

Papillary thyroid cancer (PTC) has an indolent nature and usually excellent prognosis. Some PTC clinicopathological features may contribute to the development of aggressive metastatic disease. In this work, we want to evaluate PTC clinicopathological features that are presurgical prognostic predictors of patients’ outcomes and find which indicators are more adequate for tailoring surgical procedures and follow-up. We studied a series of 241 PTC patients submitted to surgery. All patients’ files and histological tumor samples were reviewed. The 8th edition AJCC/UICC (American Joint Committee on Cancer/Union for International Cancer) Controlstaging system and the 2015 American Thyroid Association risk stratification system were used. Total thyroidectomy was performed in 228 patients, lymphadenectomy in 28 patients. Gross extrathyroidal extension (ETE) was present in 10 patients and 31 tumor resection margins were incomplete. Cervical lymph node metastases (LNMs) were present in 34 patients and distant metastases at diagnosis in four patients. In multivariate analysis, male gender (OR = 15.4, p = 0.015), venous invasion (OR = 16.7, p = 0.022), and lateral compartment LNM (OR = 26.7, p = 0.004) were predictors of mortality; psammoma bodies (PBs) (OR = 4.5, p = 0.008), lymph vessel invasion (OR = 6.9, p < 0.001), and gross ETE (OR = 16.1, p = 0.001) were predictors of structural disease status; male gender (OR = 2.9, p = 0.011), lymph vessel invasion (OR = 2.8, p = 0.006), and incomplete resection margins (OR = 4.6, p < 0.001) were predictors of recurrent/persistent disease. Our study supports that the factors helping to tailor patient’s surgery are male gender, presence of PBs, gross ETE, and lateral compartment LNM. Together with pathological factors, lymph vessel invasion, venous invasion, necrosis, and incomplete surgical resection, should be taken into consideration regarding treatment and follow-up of patients.

Lymph vessel invasion as negative predictor in pN0 prostate cancer patients after radical prostatectomy

2021 ◽  
Vol 79 ◽  
pp. S1724-S1725
Author(s):  
R.M. Pose ◽  
C. Würnschimmel ◽  
F. Stolzenbach ◽  
S. Knipper ◽  
P. Tennstedt ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Radical Prostatectomy ◽  
Cancer Patients ◽  
Lymph Vessel ◽  
Lymph Vessel Invasion ◽  
Vessel Invasion ◽  
Negative Predictor

scholarly journals Incomplete inside-out growth pattern in invasive breast carcinoma: association with lymph vessel invasion and recurrence-free survival

2011 ◽  
Vol 458 (2) ◽  
pp. 159-169 ◽  
Author(s):  
Sayaka Kuba ◽  
Hiroshi Ohtani ◽  
Junzo Yamaguchi ◽  
Hiroko Hayashi ◽  
Tatsuya Uga ◽  
...  
Keyword(s):  
Breast Carcinoma ◽  
Growth Pattern ◽  
Invasive Breast Carcinoma ◽  
Lymph Vessel ◽  
Recurrence Free Survival ◽  
Free Survival ◽  
Lymph Vessel Invasion ◽  
Vessel Invasion ◽  
Inside Out

scholarly journals Supraclavicular Approach of Lobectomy Improves Quality of Life for Patients With Unilateral Papillary Thyroid Microcarcinoma: A Prospective Cohort Study

2022 ◽  
Vol 12 ◽  
Author(s):  
Shuai Xue ◽  
Qiuli Wang ◽  
Guang Chen ◽  
Peisong Wang ◽  
Li Zhang
Keyword(s):  
Quality Of Life ◽  
Clinicopathological Features ◽  
Papillary Thyroid ◽  
Central Lymph Node ◽  
Supraclavicular Approach ◽  
Thyroid Microcarcinoma ◽  
Postoperative Symptoms ◽  
Central Lymph

ObjectivePostoperative neck symptoms, including pain, swelling, uncomfortable feelings during swallowing, and incision adhesion formation, are common in patients after lobectomy through the traditional middle neck approach. A new unilateral supraclavicular approach is proposed to protect the anterior cervical region and reduce related complications. The aim of this study is to investigate the efficacy, safety, and advantages of the supraclavicular approach in lobectomy for unilateral papillary thyroid microcarcinoma (PTMC).MethodsTwo hundred sixty-three patients were recruited into either a conventional middle group (CM) or a new supraclavicular (NS) group. Clinicopathological features, surgically related variables, and postoperative symptoms were recorded. Quality of life (QOL) of all patients was assessed by the 12-item short-form health survey (SF-12) and thyroid cancer-specific QOL (THYCA-QoL) questionnaire in 3 and 12 months.ResultsThere were no statistically significant differences in clinicopathological features (including sex, age, multifocality, extrathyroidal extension, histological variants, largest tumor diameter, Hashimoto’s thyroiditis, metastasized central lymph node, removed central lymph node, surgeon, BRAF mutation, and follow-up duration), hospitalization (including hospital cost, surgery time, and blood loss during surgery), and complications between the two groups. Patients who underwent lobectomy through the NS approach had significantly better SF-12 physical, mental, and THYCA-QoL than the CM group patients in both 3 and 12 months (all p &lt; 0.001). Moreover, the NS group had a shorter hospitalization time.ConclusionIn conclusion, the NS approach for lobectomy is a safe and effective method for reducing postoperative symptoms and increasing QOL in patients with unilateral PTMC in both 3 and 12 months’ follow-up.

scholarly journals Significance of lymph vessel invasion identified by the endothelial lymphatic marker D2-40 in node negative breast cancer

2007 ◽  
Vol 20 (2) ◽  
pp. 183-191 ◽  
Author(s):  
Angel Arnaout-Alkarain ◽  
Harriette J Kahn ◽  
Steven A Narod ◽  
Ping A Sun ◽  
Alexander N Marks
Keyword(s):  
Breast Cancer ◽  
Lymph Vessel ◽  
Node Negative ◽  
Lymph Vessel Invasion ◽  
Vessel Invasion ◽  
Node Negative Breast Cancer

Prognostic Impact of Perineural, Blood and Lymph Vessel Invasion for Esophageal Cancer Patients

2012 ◽  
Vol 172 (2) ◽  
pp. 239-240
Author(s):  
M. Tachezy ◽  
A. Tiebel ◽  
F. Gebauer ◽  
A. Marx ◽  
K. Pantel ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Cancer Patients ◽  
Lymph Vessel ◽  
Prognostic Impact ◽  
Lymph Vessel Invasion ◽  
Vessel Invasion

scholarly journals Long-Term Clinical Outcome in Familial and Sporadic Papillary Thyroid Carcinoma

2020 ◽  
Vol 9 (4) ◽  
pp. 213-220 ◽  
Author(s):  
Marco Capezzone ◽  
Noemi Fralassi ◽  
Chiara Secchi ◽  
Silvia Cantara ◽  
Lucia Brilli ◽  
...  
Keyword(s):  
Clinical Outcome ◽  
Clinical Presentation ◽  
Initial Therapy ◽  
Clinicopathological Features ◽  
Significant Trend ◽  
Papillary Thyroid ◽  
Term Outcome ◽  
Long Term Outcome

Background: The definition and the behaviour of familial papillary thyroid cancer (FPTC) compared to the sporadic form (SPTC) are still debated. Some authors believe that only families with 3 or more affected members represent an actual example of familial diseases. Objectives: The objective of the study was to analyse the clinicopathological features and the outcome of sporadic and familial PTC patients also according to the number of affected members. Methods: Among 731 patients, we identified 101 (13.8%) with familial diseases, 79 with 2 affected members (FPTC-2) and 22 with 3 or more affected members (FPTC-3) followed for a mean period of 10 years. Results: FPTC patients had more frequently bilateral tumour (p = 0.007). No difference was found between the 2 groups for the other evaluated variables. At the time of the first follow-up (1–2 years after initial therapy), FPTC patients had a higher rate of persistent disease. However, at the last follow-up, the clinical outcome was not different between sporadic and familial patients. When the comparison between SPTC and FPTC was performed, according to the number of affected members, a significant trend between the 3 groups was observed for tumour diameter (p = 0.002) and bilaterality (p = 0.003), while we did not observe a significant trend for both response to initial therapy (p = 0.15) and last clinical outcome (p = 0.22). Conclusions: Our results suggest that, although the clinicopathological features of FPTC may be more aggressive, the long-term outcome is similar between FPTC and SPTC. A possible explanation is that PTC has a favourable prognosis, even when clinical presentation is more aggressive.

scholarly journals Distinguishing blood and lymph vessel invasion in breast cancer: a prospective immunohistochemical study

2006 ◽  
Vol 94 (11) ◽  
pp. 1643-1649 ◽  
Author(s):  
G G Van den Eynden ◽  
I Van der Auwera ◽  
S J Van Laere ◽  
C G Colpaert ◽  
P van Dam ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Immunohistochemical Study ◽  
Lymph Vessel ◽  
Lymph Vessel Invasion ◽  
Vessel Invasion
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