scholarly journals Molecular Biology of Ovarian Cancer: From Mechanisms of Intraperitoneal Metastasis to Therapeutic Opportunities

Cancers ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 1661
Author(s):  
Krzysztof Książek
Keyword(s):  
Ovarian Cancer ◽  
Molecular Biology ◽  
Cause Of Death ◽  
Genital Tract ◽  
Female Genital Tract ◽  
Gynecological Tumors ◽  
Female Genital

Ovarian cancer (OC) is one of the most frequent malignancies of the female genital tract, and is still the leading cause of death from gynecological tumors [...]

scholarly journals Malignant Tumors of the Female Genital Tract – a Hospital Based Analysis

2016 ◽  
Vol 10 (2) ◽  
pp. 24-28
Author(s):  
R Joshi ◽  
G Baral ◽  
K Malla
Keyword(s):  
Ovarian Cancer ◽  
Cervical Cancer ◽  
Endometrial Cancer ◽  
Genital Tract ◽  
Malignant Tumors ◽  
Female Genital Tract ◽  
Limited Data ◽  
Corpus Uteri ◽  
Female Genital

Aims: The incidence of cancer and the cancer related deaths are increasing worldwide. There is limited data regarding  gynecological cancers in Nepal. This study is conducted to analyze the trends of female genital tract malignancies in Paropakar Maternity and Women’s Hospital (PMWH) and compare it with the national/international data.Methods: This was a retrospective study conducted in Department of Obstetrics/Gynecology and Pathology in PMWH.  All female diagnosed with the genital tract malignancies from July 2013 to July 2015 were included in the study.Results: Among 62 cases, cervical cancer was the commonest (71%) followed by ovarian cancer (14%), endometrial cancer (8%) and choriocarcinoma (3%). Majority of women belonged to 50-59 years for each type of tumors. Four-fifth of endometrial, half of the cervical and one-third of ovarian cancers were among grand-multipara. Sixty nine percent of women received treatment with 22 (9 cervical, 9 ovarian, 3 endometrial and one of corpus uteri)  surgical and 21 primary chemo/radiotherapy but 19 (31%) were lost for follow-up. Squamous type of cervical cancer was the commonest (93%).Conclusions: Cervical cancer was the commonest genital tract malignancy followed by ovarian cancer, endometrial cancer and choriocarcinoma. For each type of tumors, 50-59 years was the common age group and grand multiparity was seen in half of the women with the cervical cancer. Squamous type of cervical cancer was the commonest variety.  

scholarly journals Synchronous papillary endometrial and ovarian cancer in a 64-year-old woman

2021 ◽  
Vol 11 (1) ◽  
pp. 252
Author(s):  
Ganesh B. Bharaswadkar ◽  
Nalan Babacan
Keyword(s):  
Ovarian Cancer ◽  
Genital Tract ◽  
Female Genital Tract ◽  
Ovarian Tumors ◽  
Fallopian Tubes ◽  
Metachronous Cancer ◽  
Morphological Unit ◽  
Younger Age ◽  
Synchronous Malignancies ◽  
Female Genital

Obesity, nulliparity, and comparatively younger age may attribute a “hormonal field effect” which leads to the development of synchronous endometrioid cancers. The morphological unit consisting of the uterus, fallopian tubes, and ovary as part of the Mullerian system may explain the synchronous appearance of these malignancies. Synchronous endometrial and ovarian cancer (SEOC) is defined as the simultaneous presence of these dual cancers at the time of diagnosis as opposed to metachronous cancer where these two cancers are diagnosed at different chronologic time points. Synchronous malignancies in the female genital tract are very rare entities. Synchronous endometrial and ovarian tumors must be differentiated from either primary endometrium or ovarian tumors with metastasis. The landmark criteria for diagnosing such cases have been laid down by Ulbright and Roth.

scholarly journals Targeted therapy with monoclonal antibodies: Do we observe progress in the management of female genital tract cancers?

2018 ◽  
Vol 72 ◽  
pp. 192-204
Author(s):  
Jacek R. Wilczyński ◽  
Marek Nowak ◽  
Miłosz Wilczyński
Keyword(s):  
Ovarian Cancer ◽  
Monoclonal Antibodies ◽  
Targeted Therapy ◽  
Genital Tract ◽  
Female Genital Tract ◽  
Malignant Ascites ◽  
Peritoneal Cancer ◽  
Ovarian Cancers ◽  
Intraperitoneal Treatment ◽  
Female Genital

Targeted therapy with monoclonal antibodies (moAbs) has become a valuable supplementation for classic chemo- and radiotherapy. The first part of this review presents in a condensed way the characteristics and mechanism of action of moAbs most commonly used and/or tested for therapy of female genital tract malignancies, including: bevacizumab (anti-VEGF-A moAb), cetuximab (anti-EGFR moAb), trastuzumab (anti-ErbB2/HER2 moAb), catumaxomab (anti-EpCAM/anti-CD3 moAb), oregovomab (anti-MUC16 moAb) and farletuzumab (anti-FR-α moAb). The second part of the review discusses the results of the recent clinical trials devoted to the usefulness of moAbs in the management of cervical, endometrial and ovarian cancers. The unquestionable progress in this field has made possible the introduction of bevacizumab for the treatment of advanced ovarian, Fallopian tube or peritoneal cancer, as well as advanced, recurrent or metastatic cervical cancer. Similarly, catumaxomab has been registered for the intraperitoneal treatment of malignant ascites in EpCAM positive ovarian cancer when standard therapy is no longer available.

scholarly journals Enterobiasis of the Ovary in a Patient With Cervical Carcinoma In Situ

1995 ◽  
Vol 2 (5) ◽  
pp. 231-234 ◽  
Author(s):  
Kevin McCabe ◽  
Patricia A. K. Nahn ◽  
Aysegul A. Sahin ◽  
Michele Follen Mitchell
Keyword(s):  
Ovarian Cancer ◽  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Genital Tract ◽  
Carcinoma In Situ ◽  
Incidental Finding ◽  
Female Genital Tract ◽  
Female Genital

Background: Enterobiasis occurs throughout the female genital tract and may involve peritoneal surfaces. It is generally an incidental finding at surgery or at autopsy but occasionally is symptomatic. Most of the superficial lesions are composed of granulomas with variable fibrosis in which diagnostic eggs are found, often associated with degenerated adult worms. Multiple histologic sections may be required to establish the diagnosis in older lesions.Case: A case of enterobiasis of the ovary in a patient with squamous-cell carcinoma in situ of the cervix is presented. The features of enterobiasis are discussed.Conclusion: The importance of mistaking such lesions for ovarian cancer is discussed.

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