scholarly journals Precision Postoperative Radiotherapy in Sinonasal Carcinomas after Endonasal Endoscopic Surgery

Cancers ◽  
2021 ◽  
Vol 13 (19) ◽  
pp. 4802
Author(s):  
Juliette Thariat ◽  
Florent Carsuzaa ◽  
Pierre Yves Marcy ◽  
Benjamin Verillaud ◽  
Ludovic de Gabory ◽  
...  
Keyword(s):  
Endoscopic Surgery ◽  
Malignant Tumors ◽  
Postoperative Radiotherapy ◽  
Intensity Modulated Radiotherapy ◽  
Particle Therapy ◽  
Sinonasal Cancer ◽  
Endonasal Endoscopic Surgery ◽  
Charged Particle Therapy ◽  
Recent Developments ◽  
Oncological Results

Radiotherapy plays an important role in the treatment of sinonasal cancer, mainly in the adjuvant setting after surgical resection. Many technological approaches have been described, including intensity-modulated radiotherapy, concomitant chemoradiotherapy, charged particle therapy or combined approaches. The choice is based on general criteria related to the oncological results and morbidity of each technique and their availability, as well as specific criteria related to the tumor (tumor extensions, pathology and quality of margins). The aims of this review are: (i) to provide an overview of the radiotherapy techniques available for the management of sinonasal malignant tumors and (ii) to describe the constraints and opportunities of radiotherapy owing to the recent developments of endonasal endoscopic surgery. The indication and morbidity of the different techniques will be discussed based on a critical literature review.

scholarly journals Surgical Management of Sinonasal Cancers: A Comprehensive Review

Cancers ◽  
2021 ◽  
Vol 13 (16) ◽  
pp. 3995
Author(s):  
Florian Chatelet ◽  
François Simon ◽  
Vincent Bedarida ◽  
Nicolas Le Clerc ◽  
Homa Adle-Biassette ◽  
...  
Keyword(s):  
Malignant Tumors ◽  
Surgical Techniques ◽  
Surgical Approaches ◽  
Special Focus ◽  
Sinonasal Cancer ◽  
Histologic Subtype ◽  
Tumor Pathology ◽  
Comprehensive Literature Review ◽  
Recent Developments ◽  
Oncological Results

Surgery plays an important role in the treatment of sinonasal cancer. Many surgical approaches have been described, including open, endoscopic, or combined approaches. The choice is based on several criteria: general criteria related to the oncological results and morbidity of each technique, specific criteria related to the tumor (tumor extensions, tumor pathology), the patient, or the surgeon himself. The aims of this review are (i) to provide a complete overview of the surgical techniques available for the management of sinonasal malignant tumors, with a special focus on recent developments in the field of transnasal endoscopic surgery; (ii) to summarize the criteria that lead to the choice of one technique over another. In particular, the oncological outcomes, the morbidity of the different techniques, and the specificities of each histologic subtype will be discussed based on a comprehensive literature review.

scholarly journals Symptom assessment after nasal irrigation with xylitol in the postoperative period of endonasal endoscopic surgery

2020 ◽  
Author(s):  
Caroline Feliz Fonseca Sepeda da Silva ◽  
Flávia Emilly Rodrigues da Silva ◽  
Henrique Furlan Pauna ◽  
Johann Gustavo Guilhermo Melcherts Hurtado ◽  
Marco Cesar Santos
Keyword(s):  
Endoscopic Surgery ◽  
Postoperative Period ◽  
Symptom Assessment ◽  
Nasal Irrigation ◽  
Endonasal Endoscopic Surgery

Endoscopic Surgery for Malignant Tumors of the Sinonasal Tract and Adjacent Skull Base: A 10-year Experience

2008 ◽  
Vol 22 (3) ◽  
pp. 308-316 ◽  
Author(s):  
Piero Nicolai ◽  
Paolo Battaglia ◽  
Maurizio Bignami ◽  
Andrea Bolzoni Villaret ◽  
Giovanni Delù ◽  
...  
Keyword(s):  
Skull Base ◽  
Endoscopic Surgery ◽  
Malignant Tumors ◽  
Sinonasal Tract

scholarly journals A Case of Endonasal Endoscopic Surgery for Intraorbital Metastasis of Gastric Ring Cell Carcinoma

2020 ◽  
pp. 014556132094337
Author(s):  
Yukinori Tsuruta ◽  
Yohei Maeda ◽  
Yoshiyuki Kitaguchi ◽  
Masaki Hayama ◽  
Satoshi Nojima ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Endoscopic Surgery ◽  
Vision Loss ◽  
Signet Ring Cell Carcinoma ◽  
Signet Ring Cell ◽  
Orbital Decompression ◽  
Endonasal Endoscopic Surgery ◽  
Orbital Wall ◽  
Signet Ring ◽  
Ring Cell

Gastric signet ring cell carcinoma has well-known metastatic features, including peritoneal dissemination and carcinomatous lymphangitis of the lung, but no intraorbital metastases were reported previously. A woman in her 60s developed left eye pain, sudden vision loss, and headache 12 years after gastric cancer treatment. Symptoms did not improve despite steroid pulses. Craniotomy showed no malignant findings. The patient was referred to our department for symptomatic relief and biopsy due to the lack of a definitive diagnosis and no improvement in her ocular pain. Endonasal endoscopic surgery was performed for diagnostic purposes and to relieve symptoms through orbital decompression. Preoperative computed tomography examination revealed a tumor at the left medial orbit, extending to the orbital apex. Orbital decompression through the open left medial orbital wall was performed with biopsy of the intraorbital tumor. Pathological findings were consistent with metastatic signet ring cell carcinoma. Pain and subjective improvement of visual acuity were noted the day after surgery. Twelve months postoperatively, diplopia remains, but there has been no worsening of symptoms.

scholarly journals Cost-effectiveness analysis (CEA) of IMRT plus C12 boost vs IMRT only in adenoid cystic carcinoma (ACC) of the head and neck

2019 ◽  
Vol 14 (1) ◽  
Author(s):  
A D Jensen ◽  
Jürgen Debus
Keyword(s):  
Cost Effectiveness ◽  
Local Control ◽  
Recurrent Disease ◽  
Treatment Options ◽  
Combined Treatment ◽  
Intensity Modulated Radiotherapy ◽  
Experimental Treatment ◽  
Clinical Results ◽  
Particle Therapy ◽  
Combination Regimen

Abstract Background Particle therapy provides steep dose gradients to facilitate dose escalation in challenging anatomical sites which has been shown not only to improve local control but also overall survival in patients with ACC. Cost-effectiveness of intensity-modulated radiotherapy (IMRT) plus carbon ion (C12) boost vs IMRT alone was performed in order to objectivise and substantiate more widespread use of this technology in ACC. Methods Patients with pathologically confirmed ACC received a combination regimen of IMRT plus C12 boost. Patients presenting outside C12 treatment slots received IMRT only. Clinical results were published; economic analysis on patient-level data was carried out from a healthcare purchaser’s perspective based on costs of healthcare utilization. Cost histories were generated from resource use recorded in individual patient charts and adjusted for censoring using the Lin I method. Cost-effectiveness was measured as incremental cost-effectiveness ratio (ICER). Sensitivity analysis was performed regarding potentially differing management of recurrent disease. Results The experimental treatment increased overall costs by € 18,076 (€13,416 – €22,922) at a mean survival benefit of 0.86 years. Despite improved local control, following costs were also increased in the experimental treatment. The ICER was estimated to 26,863 €/LY. After accounting for different management of recurrent disease in the two cohorts, the ICER was calculated to 20,638 €/LY. Conclusion The combined treatment (IMRT+C12 boost) substantially increased initial and overall treatment cost. In view of limited treatment options in ACC, costs may be acceptable though. Investigations into quality of life measures may support further decisions in the future.

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